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Your search keyword '"Savelyev, E. N."' showing total 9 results
9 results on '"Savelyev, E. N."'

9. Arylation of Adamantanamines: X. Palladium- and Copper-Catalyzed Heteroarylation of Adamantane-Containing Amines with Bromopyridines.

Author

Lyakhovich, M. S., Murashkina, A. V., Averin, A. D., Abel, A. S., Maloshitskaya, O. A., Savelyev, E. N., Orlinson, B. S., and Beletskaya, I. P.

Subjects
ARYLATION, AMINES, PALLADIUM, PYRIDINE, AMINATION
Abstract

The catalytic efficiencies of palladium(0) and copper(I) complexes in the amination of 2-bromopyridine and its fluorine-containing derivatives with (1-adamantyl)methanamine and 2-(1-adamantyloxy)ethanamine were compared. Both types of catalytic systems were shown to be applicable for the preparation of the corresponding N-pyridyl derivatives from 3- and 5-fluoro- and 4-, 5-, and 6-trifluoromethyl-2-bromopyridines. DavePhos was found to be the most efficient ligand in the Pd(0)-catalyzed reactions; however, the reactions with 2-bromo-4-(trifluoromethyl)pyridine and 2-bromo-5-(trifluoromethyl)pyridine were accompanied by formation of a considerable amount of the diarylation product. The diarylation process was significantly suppressed in the presence of copper(I) complexes. [ABSTRACT FROM AUTHOR]

Published
2019
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