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Background: Depression is a common chronic debilitating disease with a heavy social burden. single nucleotide polymorphisms (SNPs) can affect the function of microRNAs (miRNAs), which is in turn associated with neurological diseases. However, the association between SNPs located in the promoter region of miR-17-92 and the risk of depression remains unclear. Therefore, we investigated the association between rs982873, rs9588884 and rs1813389 polymorphisms in the promoter region of miR-17-92 and the incidence of depression in a Chinese population. Methods: we used GWAS (Genome-wide association study) and NCBI (National Center for Biotechnology Information) to screen three SNPs in the miR-17-92 cluster binding sites. A case-control study (including 555 cases and 541 controls) was conducted to investigate the relationship between the SNPs and risk of depression in different regions of China. The gene sequencing ii was used to genotype the collected blood samples. Results: the following genotypes were significantly associated with a reduced risk of depression: rs982873 TC (TC vs. TT: OR = 0.72, 95% CI, 0.54–0.96, P = 0.024; TC/CC vs. TT: OR = 0.74, 95% Cl, 0.56–0.96, P = 0.025); CG genotype of rs9588884 (CG vs. CC: OR = 0.74, 95% CI, 0.55–0.98, P = 0.033; CG/GG vs. CC: OR = 0.75, 95% Cl, 0.57–0.98, P = 0.036); and AG genotype of rs1813389 (AG vs. AA: OR = 0.75, 95% CI, 0.57-1.00, P = 0.049; AG/GG vs. AA: OR = 0.76, 95% Cl, 0.59-1.00, P = 0.047). Stratified analysis showed that there was no significant correlation between the three SNPS and variables such as family history of suicidal tendency (P > 0.05). Conclusions: our findings suggest that rs982873, rs9588884, and rs1813389 polymorphisms may be associated with protective factors for depression. [ABSTRACT FROM AUTHOR]

Background: Depression is among the most common psychiatric disorders, and is a leading cause of the global disease burden. Its pathophysiological mechanism is unclear, which limits the development of therapeutic strategies. Long non-coding RNA (lncRNA) single nucleotide polymorphisms (SNPS) may be related. In this study, we aimed to determine the effects of the rs2242385, rs155979, rs3762983, and rs3762984 polymorphisms in the lncRNA NONHSAT102891 on depression susceptibility in a Chinese population. Methods: We conducted a case-control study in a cohort of 480 patients with depression and 329 healthy controls, and performed genotyping by gene sequencing ii. Results: The rs155979 GC genotype was significantly associated with increased risk of depression compared with healthy controls. Stratified analysis showed a 2.08-fold increased risk of suicide in patients with rs155979 GC or GG genotype. The rs2242385, rs3762983, and rs3762984 polymorphisms were not significantly associated with the risk of depression. Haploid analysis showed linkage disequilibrium between rs155979, rs3762983, and rs3762984, and the CCG haplotype reduced the risk of depression. Limitations: The study sample was relatively small, and was restricted to patients from central and southern China. Further, only peripheral blood was used for DNA extraction. Conclusion: The rs155979 polymorphism may be associated with the occurrence of depression in the Chinese population. However, further studies are needed to verify the reliability of our results in large populations and different ethnic groups. [ABSTRACT FROM AUTHOR]

Objectives: 2D:4D is an anthropometric indicator that may reflect the level of intrauterine sexual hormone exposure before birth. The aromatase gene (CYP19A1) mainly encodes cytochrome P450 aromatase, a key enzyme that catalyzes the conversion of androgens to estrogens in vivo and affects the development of 2D:4D. Studying the association between six single-nucleotide polymorphisms (SNPs) in CYP19A1 and digit ratios in the normal population of China will provide some basis for the biological basis of digit ratio development and promote the practical application of digit ratios.Methods: In this study, six SNPs (rs10046, rs2414095, rs4646, rs4775936, rs749292 and rs936306) in CYP19A1 were tested in 1949 students (692 males and 1247 females) by TaqMan SNP genotyping in Ningxia, China. The digit ratios (right and left 2D:4D and right-left 2D:4D [Dr-l]) of all participants were collected using a photographic record.Results: The frequencies of the genotypes rs2414095 (P < 0.05), rs10046 (P < 0.01) and rs4775936 (P < 0.05) in the CYP19A1 gene and their allele frequencies were significantly different between the Hui and Han populations, and the frequency of the rs2414095 genotype (P < 0.05) was significantly different between males and females in Ningxia, China. There was a sex difference in right and left 2D:4D and in Dr-l. There was no significant association between the six SNPs of the CYP19A1 gene and right and left 2D:4D, although rs4775936 showed a lower 2D:4D ratio in allele T than in allele C, in both male and female subjects. For Dr-l we found that rs4775936 associated with increased Dr-l in females (t787 = -2.441, P < 0.05).Conclusions: We found the different frequencies of rs10046, rs2414095 and rs4775936 between Hui and Han populations in China. There was an association between rs4775936 and Dr-l. We discuss the implications of this association for links between Dr-l and rs4775936 and prenatal sex steroids and for susceptibility to breast cancer. [ABSTRACT FROM AUTHOR]