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139 results on '"Filipovic, Miodrag"'

1. Evaluating the Sum of Eye and Motor Components of the Glasgow Coma Score As a Predictor of Extubation Failure in Patients With Acute Brain Injury

Author

Taran, Shaurya, Perrot, Bastien, Angriman, Federico, Cinotti, Raphael, Abback, Paër-sélim, Codorniu, Anaïs, Citerio, Giuseppe, Ludovica Sala, Vittoria, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Giuseppina Maugeri, Jessica, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Robba, Chiara, Battaglini, Denise, Biston, Patrick, Fathi Al-Gharyani, Mohamed, Chabanne, Russell, ASTIER, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Urs, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Marcel Gerretsen, Benjamin, Xochitl Ortiz-Macias, Iris, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, Vermeijden, Wytze J, Daniel Cornet, Alexander, Reyes Inurrigarro, Sergio, Cirino Lara Domínguez, Rafael, Mercedes Bellini, Maria, Milagros Gomez Haedo, Maria, Lamot, Laura, Orquera, Jose, Biais, Matthieu, Georges, Delphine, Baronia, Arvind, Carlos Miranda-Ackerman, Roberto, José Barbosa-Camacho, Francisco, Porter, John, Lopez-Morales, Miguel, Geeraerts, Thomas, Compagnon, Baptiste, Pérez-Torres, David, Prol-Silva, Estefanía, Basheer Yahya, Hana, Khaled, Ala, Ghula, Mohamed, Neville Andrea, Cracchiolo, Maria Daniela, Palma, Deana, Cristian, Vetrugno, Luigi, Rivera Chavez, Manuel J., Mendoza Trujillo, Rocio, LEGROS, Vincent, Brochet, Benjamin, Huet, Olivier, Geslain, Marie, van der Jagt, Mathieu, van Steenkiste, Job, Ahmed, Hazem, Edward Coombs, Alexander, Welbourne, Jessie, Velarde Pineda, Ana Alicia, Nubert Castillo, VÍctor Hugo, Azab, Mohammed A, Azzam, Ahmed Y, Paul van Meenen, David Michael, Adrian Gasca, Gilberto, Arellano, Alfredo, Galicia-Espinosa, Forttino, Carlos García-Ramos, José, Yadav, Ghanshyam, Kumar Jha, Amarendra, Robert-Edan, Vincent, Rodie-Talbere, Pierre-Andre, Jain, Gaurav, Panda, Sagarika, Agarwal, Sonika, Deewan, Yashbir, Adrian Gasca, Gilberto, Arellano, Alfredo, Tariq Reza, Syed, Hossain, Md. Mozaffer, Papadas, Christos, Chantziara, Vasiliki, Sklavou, Chrysanthi, Hourmant, Yannick, Grillot, Nicolas, van Steenkiste, Job, van der Jagt, Mathieu, Pirracchio, Romain, Akkari, Abdelraouf, Abdelaty, Mohamed, Hashim, Ahmed, Launey, Yoann, Masseret, Elodie, Lasocki, Sigismond, Gergaud, Soizic, Mouclier, Nicolas, Saxena, Sulekha, Agrawal, Avinash, Bedanta Mishra, Shakti, Samal, Samir, Cesar Mijangos, Julio, Haënggi, Mattias, Gurjar, Mohan, Schultz, Marcus J, Kaye, Callum, Agustin Godoy, Daniela, Alvarez, Pablo, Ioakeimidou, Aikaterini, Ueno, Yoshitoyo, Badenes, Rafael, Suei Elbuzidi, Abdurrahmaan Ali, Piagnerelli, Michaël, Elhadi, Muhammed, Tariq Reza, Syed, Atef Azab, Mohammed, Catherine Digitale, Jean, Fong, Nicholas, Campos Cerda, Ricardo, de la Torre Peredo, Norma, Pirracchio, Romain, and David Stevens, Robert

Published
2024
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2. Pathological findings associated with the updated European Society of Cardiology 2022 guidelines for preoperative cardiac testing: an observational cohort modelling study

Author

Kemper, Johann, Kohaupt, Lena, Witzler, Jette, Tuzhikov, Michael, Roth, Sebastian, Stroda, Alexandra, M’Pembele, René, Tenge, Theresa, Schultze, Cornelia, Verbarg, Nele, Gehrke, Christian, Klemann, Anna Katharina, Hagebölling, Friederike, Albrecht, Svenja, Stroeder, Jakob, Schubert, Ann-Kristin, Espeter, Florian, Russe, Benedikt, Weigand, Markus A., Bergmann, Lars, Unterberg, Matthias, Bischoff, Petra, Pirzer, Raphael, Rach, Patric Rene, Ott, Klaus, Zarbock, Alexander, Kowark, Ana, Neumann, Claudia, Marchand, Bahareh, Sponholz, Christoph, Rueffert, Henrik, Kramer, Mira, Zacharowski, Kai, Meybohm, Patrick, Lindau, Simone, Carollo, Melissa, Novazzi, Cecilia, Toso, Fiorenza, Bacuzzi, Alessandro, Ragazzi, Riccardo, Volta, Carlo Alberto, De Giorgi, Francesco, Bacer, Barbara, Federico, Antonio, Chiumello, Davide, Vetrugno, Luigi, Castella, Alberto, Tesoro, Simonetta, Cotoia, Antonella, Bignami, Elena, Bellissima, Agrippino, Cortegiani, Andrea, Crisman, Marco, Toninelli, Arturo, Piazza, Ornella, Mirabella, Lucia, Bossolasco, Matteo, Bona, Francesco, Perdomo, Juan Manuel, Coca-Martinez, Miquel, Carramiñana, Albert, Servén, Marta Giné, González, Astrid Batalla, Gil Sánchez, José Maria, Becerra-Bolaños, Ángel, Rodríguez-Pérez, Aurelio, Soler, Anna Artigas, Basso, Morena, Font, Anna Peig, Vernetta, Diana, Santos, Julia Hernando, Muñoz, Enrique Alday, Olivares, Mercedes Cabellos, Marco, Gregorio, Lopez, Maria Bermudez, Barrio, Javier, Forés, María Isabel, Boix, Estefanía, Ayuso, Mercedes, Petre, Bogdan Sorel, Oprea, Ioana Sorina, Latiș, Mihai Dan, Margarit, Simona, Vasian, Horatiu, Tomescu, Dana, Cîndea, Iulia, Dirzu, Dan Sebastian, Copotoiu, Sanda-Maria, Moise, Alida, Bubenek-Turconi, Serban, Valeanu, Liana, Wanner, Patrick Mark, Djurdjevic, Mirjana, Nuth, Sandra, Seeberger, Esther, Goettel, Nicolai, Kamber, Firmin, Ganter, Michael Thomas, Gerber, Thomas Jan, Schneebeli, Daniela, Pregernig, Andreas, Grape, Sina, Tomala, Simon, Pinto, Bernardo Bollen, Żukowski, Maciej, Zegan-Barańska, Małgorzata, Karolak, Igor, Krzych, Lukasz, Czajka, Szymon, Studzińska, Dorota, Kluzik, Anna, Koszel, Tomasz, Pabjańczyk, Izabela, Gajdosz, Anna, Erkoc, Suheyla Karadag, Meco, Basak Ceyda, Koltka, Ahmet Kemalettin, Dincer, Muserref Beril, Ekmekçi, Perihan, Saracoglu, Kemal Tolga, Solmaz, Filiz Alkaya, Ozcelik, Menekse, Arun, Oguzhan, Dilmen, Ozlem Korkmaz, Preckel, Benedikt, Hollmann, Markus W., Hazen, Yannick, Donald de Boer, Hans, Epema, Anne, Koopman, Seppe, Van Lier, Felix, Pinto, Rita, Carrão, André, Ribeiro, Daniel, Mourão, Joana, Coelho, Miguel, Losa, Nuno, Santos, Nuno, Cabral, Luis, Afonso, Diana, Zenha, Sérgio, Ramos, Cristina, Hipólito, Carla, Vasilaki, Maria, Andreeva, Antonia, Zaimi, Donika, Chalkias, Athanasios, Spyraki, Maria, Rekatsina, Martina, Tsaousi, Georgia, Short, Anthony, Meier, Sonja, Madhuri, Thumuluru Kavitha, Latham, Scott, Knock, James, Drummond, Andrew, Ramsden, Fiona, Kubisz-Pudelko, Agnieszka, Walker, James, Moppett, Iain, White, Louise, Jackson, Matthew, Reschreiter, Henrik, Innes, Richard, Chew, Michelle, Kalman, Sigridur, Wallden, Jakob, Schening, Anna, Jonikaite, Lina, Enlund, Anna, De Baerdemaeker, Luc, Morrison, Stuart, Rex, Steffen, Alexis, Alexandros, Khoronenko, Viktoria E., Ovezov, Alexey, Belskii, Vladislav, Kaznacheeva, Kseniya, Gritsan, Alexey, Kuzmanovska, Biljana, Malinovska-Nikolovska, Liljana, Barisin, Stjepan, Poredos, Peter, Arabadzhieva, Daniela, Unic-Stojanovic, Dragana, Golubović, Mladjan, Fleischmann, Edith, Kotzinger, Oskar, Des Deserts, Marc Danguy, Ducrocq, Nicolas, Buggy, Donal J., Bonnet, Jean François, Cusack, Barbara, Calleja, Paul, Hasani, Antigona, Nallbani, Rajmonda, Mauermann, Eckhard, Ionescu, Daniela, Szczeklik, Wojciech, De Hert, Stefan, Filipovic, Miodrag, Beck Schimmer, Beatrice, Spadaro, Savino, Matute, Purificación, Ganter, Michael T., Turhan, Sanem C., van Waes, Judith, Lagarto, Filipa, Theodoraki, Kassiani, Gupta, Anil, Gillmann, Hans-Jörg, Guzzetti, Luca, Kotfis, Katarzyna, Larmann, Jan, Corneci, Dan, Howell, Simon J., and Lurati Buse, Giovanna

Published
2024
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4. Risk assessment for major adverse cardiovascular events after noncardiac surgery using self-reported functional capacity: international prospective cohort study

Author

Lurati, Giovanna, Spadaro, Savino, Matute, Purificación, Ionescu, Daniela, Bolliger, Daniel, Szczeklik, Wojciech, Turhan, Sanem Cakar, van Waes, Judith, Lagarto, Filipa, Theodoraki, Kassiani, Howell, Simon J., Gupta, Anil, De Hert, Stefan, Ovezov, Alexey, Tollinche, Luis E., Kuzmanovska, Biljana, Barisin, Stjepan, Poredos, Peter, Arabadzhieva, Daniela, Unic-Stojanovic, Dragana, Fleischmann, Edith, Meistelman, Claude, Buggy, Donal J., Calleja, Paul, Hasani, Antigona, Kemper, Johann, Kohaupt, Lena, Witzler, Jette, Tuzhikov, Michael, Roth, Sebastian, Stroda, Alexandra, Schultze, Cornelia, Verbarg, Nele, Gehrke, Christian, Klemann, Anna Katharina, Hagebölling, Friederike, Albrecht, Svenja, Stroeder, Jakob, Schubert, Ann-Kristin, Espeter, Florian, Russe, Benedikt, Weigand, Markus A., Bergmann, Lars, Unterberg, Matthias, Bischoff, Petra, Pirzer, Raphael, Rach, Patric Rene, Ott, Klaus, Zarbock, Alexander, Kowark, Ana, Neumann, Claudia, Marchand, Bahareh, Sponholz, Christoph, Rueffert, Henrik, Kramer, Mira, Piekarski, Florian, Carollo, Melissa, Novazzi, Cecilia, Toso, Fiorenza, Bacuzzi, Alessandro, Ragazzi, Riccardo, Volta, Carlo Alberto, De Giorgi, Francesco, Bacer, Barbara, Federico, Antonio, Chiumello, Davide, Vetrugno, Luigi, Castella, Alberto, Tesoro, Simonetta, Cotoia, Antonella, Bignami, Elena, Bellissima, Agrippino, Cortegiani, Andrea, Crisman, Marco, Toninelli, Arturo, Piazza, Ornella, Mirabella, Lucia, Bossolasco, Matteo, Bona, Francesco, Perdomo, Juan Manuel, Coca-Martinez, Miquel, Carramiñana, Albert, Servén, Marta Giné, González, Astrid Batalla, Gil Sánchez, José Maria, Becerra-Bolaños, Ángel, Rodríguez-Pérez, Aurelio, Soler, Anna Artigas, Basso, Morena, Font, Anna Peig, Vernetta, Diana, Santos, Julia Hernando, Muñoz, Enrique Alday, Olivares, Mercedes Cabellos, Marco, Gregorio, Lopez, Maria Bermudez, Barrio, Javier, Forés, María Isabel, Boix, Estefanía, Ayuso, Mercedes, Petre, Bogdan Sorel, Oprea, Ioana Sorina, Latiș, Mihai Dan, Margarit, Simona, Vasian, Horatiu, Tomescu, Dana, Cîndea, Iulia, Dirzu, Dan Sebastian, Copotoiu, Sanda-Maria, Moise, Alida, Bubenek-Turconi, Serban, Valeanu, Liana, Wanner, Patrick Mark, Djurdjevic, Mirjana, Nuth, Sandra, Seeberger, Esther, Goettel, Nicolai, Kamber, Firmin, Ganter, Michael Thomas, Gerber, Thomas Jan, Schneebeli, Daniela, Pregernig, Andreas, Grape, Sina, Tomala, Simon, Pinto, Bernardo Bollen, Żukowski, Maciej, Zegan-Barańska, Małgorzata, Karolak, Igor, Krzych, Lukasz, Czajka, Szymon, Studzińska, Dorota, Kluzik, Anna, Koszel, Tomasz, Pabjańczyk, Izabela, Gajdosz, Anna, Erkoc, Suheyla Karadag, Meco, Basak Ceyda, Koltka, Ahmet Kemalettin, Dincer, Muserref Beril, Ekmekçi, Perihan, Saracoglu, Kemal Tolga, Solmaz, Filiz Alkaya, Ozcelik, Menekse, Arun, Oguzhan, Dilmen, Ozlem Korkmaz, Preckel, Benedikt, Hollmann, Markus W., Hazen, Yannick, Donald de Boer, Hans, Epema, Anne, Koopman, Seppe, Van Lier, Felix, Pinto, Rita, Carrão, André, Ribeiro, Daniel, Mourão, Joana, Coelho, Miguel, Losa, Nuno, Santos, Nuno, Cabral, Luis, Afonso, Diana, Zenha, Sérgio, Ramos, Cristina, Hipólito, Carla, Vasilaki, Maria, Andreeva, Antonia, Zaimi, Donika, Chalkias, Athanasios, Spyraki, Maria, Rekatsina, Martina, Tsaousi, Georgia, Short, Anthony, Meier, Sonja, Madhuri, Thumuluru Kavitha, Latham, Scott, Knock, James, Drummond, Andrew, Ramsden, Fiona, Kubisz-Pudelko, Agnieszka, Walker, James, Moppett, Iain, White, Louise, Jackson, Matthew, Reschreiter, Henrik, Innes, Richard, Chew, Michelle, Kalman, Sigridur, Wallden, Jakob, Schening, Anna, Jonikaite, Lina, Enlund, Anna, De Baerdemaeker, Luc, Morrison, Stuart, Rex, Steffen, Alexis, Alexandros, Khoronenko, Viktoria E., Belskii, Vladislav, Kaznacheeva, Kseniya, Gritsan, Alexey, Yeoh, Cindy B., Malinovska-Nikolovska, Liljana, Golubović, Mladjan, Kotzinger, Oskar, Des Deserts, Marc Danguy, Ducrocq, Nicolas, Bonnet, Jean François, Cusack, Barbara, Nallbani, Rajmonda, Daamen, Sylvia, Plichon, Benoit, Harlet, Pierre, Farsi, Slama, Sepehr, Saman Homayun, Espinosa, David, Lurati Buse, Giovanna A., Mauermann, Eckhard, Filipovic, Miodrag, Beck-Schimmer, Beatrice, Gillmann, Hans-Jörg, Guzzetti, Luca, Kotfis, Katarzyna, Wulf, Hinnerk, Larmann, Jan, Corneci, Dan, and Chammartin-Basnet, Frederique

Published
2023
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5. Factors associated with failed epidural blood patch after accidental dural puncture in obstetrics: a prospective, multicentre, international cohort study

Author

Casier, Isabelle, Bryon, Bart, Soetens, Filiep, Dewandre, Pierre-Yves, Lambert, Geraldine, Christiaen, Jan, Schepers, Roel, Van Houwe, Patrick, Kalmar, Alain, Vanoverschelde, Henk, Bauters, Monique, Roofthooft, Eva, Devroe, Sarah, Van de Velde, Marc, Jadrijevic, Ana, Jokic, Aleksandra, Marin, Damjan, Sklebar, Ivan, Mihaljević, Slobodan, Kosinova, Martina, Stourac, Petr, Adamus, Milan, Kufa, Christian, Volfová, Ivana, Zaoralová, Blažena, Froeslev-Friis, Christina, Mygil, Bjoern, Krebs Albrechtsen, Charlotte, Kavasmaa, Tomi, Alahuhta, Seppo, Mäyrä, Anne, Mennander, Susanna, Rautaneva, Kati, Hiekkanen, Tuula, Kontinen, Vesa, Linden, Kirsti, Toivakka, Sara, Boselli, Emmanuel, Greil, Pierre-Édouard, Mascle, Olivier, Courbon, Aurelie, Lutz, Jean., Simonet, Thérèse, Barbier, Marie, Hlioua, Tarik, Meniolle d’Hauthville, Fleur, Quintin, Christine, Bouattour, Karim, Lecinq, Agnès, Mercier, Frederic, Bonnet, Marie-Pierre, Carbonniere, Mathieu, Fischer, Catherine, Picard, Paola-Carla, Bonnin, Martine, Storme, Brigitte, Bouthors, Anne-Sophie, Detente, Thomas, Nguyen, Truong Minh, Keita, Hawa, Nebout, Sophie, Osse, Lauranne, Delmas, Anne, Vial, Florence, Kaufner, Lutz, Hoefing, Christoph, Mueller, Stefan, Becke, Karin, Blobner, Manfred, Lewald, Heidrun, Schaller, Stefan Josef, Muggleton, Ellis, Bette, Birgit, Neumann, Claudia, Weber, Stefan, Grünewald, Matthias, Ohnesorge, Henning, Helf, Antonia, Jelting, Yvonne, Kranke, Peter, von Heymann, Christian, Welfle, Sabine, Staikou, Chryssoula, Stavrianopoulou, Antonia, Stamelos, Mattheios, Kalopita, Konstantina, Loukeri, Anastasia, Valsamidis, Dimitrios, Matsota, Paraskevi, Thorsteinsson, Adalbjörn, Tome, Riad, Eidelman, Leonid A., Davis, Atara, Orbach-Zinger, Sharon, Ioscovich, Alexander, Ramona, Iacob, De Simone, Luigi, Pesetti, Barbara, Brazzi, Luca, Zito, Alessandro, Camorcia, Michela, Della Rocca, Giorgio, Aversano, Marco, Frigo, Maria Grazia, Todde, Cristina, Macas, Andrius, Keraitiene, Grazina, Rimaitis, Kestutis, Borg, Francis, Tua, Carl, Kuijpers-Visser, Agnes Geertje, Schyns-van den Berg, Alexandra, Hollmann, Markus W., van den Berg, Tijs, Koolen, Eric, Dons, Ilse, van der Knijff, Anouk, van der Marel, Caroline, Ruysschaert, Nele, Pelka, Michal, Pluymakers, Christine, Koopman, Seppe, Teunissen, Aart-Jan, Cornelisse, Dick, van Dasselaar, Nick, Verdouw, Bastiaan, Beenakkers, Ingrid, Dahl, Vegard, Hagen, Robert, Vivaldi, Francesco, Eriksen, John Reidar, Wiszt, Radovan, Aslam Tayyba, Naz, Ringvold, Else-Marie, Chutkowski, Radosław, Skirecki, Tomasz, Wódarski, Bartłomiej, Faria, Maria Aida, Ferreira, Amélia, Sampaio, Ana Catarina, Ferreira, Irene, Matias, Bernardo, Teixeira, Joana, Araujo, Rita, Cabido, Herminia, Fortuna, Rosario, Lemos, Paulo, Cardoso, Carolina, Moura, Fernando, Pereira, Cristiana, Pereira, Sandra, Abecasis, Manuel, Lança, Filipa, Muchacho, Paulo, Ormonde, Lucindo, Guedes-Araujo, Isabel, Pinho-Oliveira, Vitor, Paredes, Paulo, Bentes, Carla, Gouveia, Francisco, Milheiro, Ana, Castanheira, Cláudia, Neves, Miriam, Pacheco, Vânia, Cortez, Mara, Tranquada, Raquel, Tareco, Glória, Furtado, Inês, Pereira, Estela, Marinho, Luísa, Seabra, Manuel, Bulasevic, Aleksandra, Kendrisic, Mirjana, Jovanovic, Lidija, Pujić, Borislava, Kutlesic, Marija, Grochova, Monika, Simonova, Jana, Pavlovic, Gordana, Rozman, Ales, Blajic, Iva, Graovac, Dragan, Stopar Pintaric, Tatjana, Chiquito, Teresa, Monedero, Pablo, De Carlos-Errea, Joaquin, Guillén-Casbas, Roque, Veiga-Gil, Leonor, Basso, Morena, Garcia Bartolo, Carolina, Hernandez, Cristian, Ricol, Laura, De Santos, Maroto Pinar, Gràcia Solsona, Josep A., López-Baamonde, Manuel, Magaldi Mendaña, Marta, Plaza Moral, Ana María, Vendrell, Marina, Trillo, Lourdes, Perez Garcia, Anibal Ricardo, Alamillo Salas, Clara, Moret, Enric, Ramió, Laura, Aguilar Sanchez, Jose Luis, Soler Pedrola, Maria, Valldeperas Hernandez, Maria Inmaculada, Aldalur, Gorka, Bárcena, Estíbaliz, Herrera, Julia, Iturri, Fernando, Martínez, Alberto, Martínez, Leire, Serna, Rosa, Gilsanz, Fernando, Guasch Arevalo, Emilia, Iannuccelli, Fabrizio, Latorre, Julieta, Rodriguez Roca, Cristina, Pérez Pardo, Osvaldo Ceferino, Sierra Biddle, Natalia, Suárez Castaño, Ceferina, Hernández González, Lourdes, Remacha González, Caridad, Sánchez Nuez, Raquel, Anta, Diego, Beleña, Jose M., García-Cuadrado, Carmen, Garcia, Irene, Manrique, Susana, Suarez, Elena, Hein, Anette, Arbman, Elisabet, Hansson, Helena, Tillenius, Monika, Al-Taie, Ruaa, Ledin-Eriksson, Susanne, Lindén-Söndersö, Anja, Rosén, Ola, Austruma, Evija, Gillberg, Lars, Darvish, Bijan, Gupta, Anil, Jörnvall, Henrik, Nordström, Johan, Persson, Jan, Rosenberg, Jan, Brühne, Lars, Forshammar, Johan, Ugarph Edfeldt, Malin, Rolfsson, Håkan, Hellblom, Anna, Levin, Katarina, Rabow, Sofus, Thorlacius, Karin, Bansch, Peter, Robertson (Baeriswyl), Moira, Stamer, Ulrike, Mathivon, Stanislas, Savoldelli, Georges, Auf der Maur, Pia, Filipovic, Miodrag, Dullenkopf, Alexander, Brunner, Maya, Girard, Thierry, Vonlanthen, Claudia, Ozbilgin, Sule, Gunaydin D, Berrin, Corman Dincer, Pelin, Tas Tuna, Ayca, Daamen, Sylvia, Farsi, Slama, Feijten, Prisca, Harlet, Pierre, Leva, Brigitte, Plichon, Benoît, Magnuson, Anders, Guasch, Emilia, Mercier, Frédéric J., and Schyns-van den Berg, Alexandra M.J.V.

Published
2022
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6. Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry

Author

Wendel-Garcia, Pedro David, Moser, André, Jeitziner, Marie-Madlen, Aguirre-Bermeo, Hernán, Arias-Sanchez, Pedro, Apolo, Janina, Roche-Campo, Ferran, Franch-Llasat, Diego, Kleger, Gian-Reto, Schrag, Claudia, Pietsch, Urs, Filipovic, Miodrag, David, Sascha, Stahl, Klaus, Bouaoud, Souad, Ouyahia, Amel, Fodor, Patricia, Locher, Pascal, Siegemund, Martin, Zellweger, Nuria, Cereghetti, Sara, Schott, Peter, Gangitano, Gianfilippo, Wu, Maddalena Alessandra, Alfaro-Farias, Mario, Vizmanos-Lamotte, Gerardo, Ksouri, Hatem, Gehring, Nadine, Rezoagli, Emanuele, Turrini, Fabrizio, Lozano-Gómez, Herminia, Carsetti, Andrea, Rodríguez-García, Raquel, Yuen, Bernd, Weber, Anja Baltussen, Castro, Pedro, Escos-Orta, Jesus Oscar, Dullenkopf, Alexander, Martín-Delgado, Maria C., Aslanidis, Theodoros, Perez, Marie-Helene, Hillgaertner, Frank, Ceruti, Samuele, Franchitti Laurent, Marilene, Marrel, Julien, Colombo, Riccardo, Laube, Marcus, Fogagnolo, Alberto, Studhalter, Michael, Wengenmayer, Tobias, Gamberini, Emiliano, Buerkle, Christian, Buehler, Philipp K., Keiser, Stefanie, Elhadi, Muhammed, Montomoli, Jonathan, Guerci, Philippe, Fumeaux, Thierry, Schuepbach, Reto A., Jakob, Stephan M., Que, Yok-Ai, and Hilty, Matthias Peter

Published
2022
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7. The challenge of preventing and containing outbreaks of multidrug-resistant organisms and Candida auris during the coronavirus disease 2019 pandemic: report of a carbapenem-resistant Acinetobacter baumannii outbreak and a systematic review of the literature

Author

Thoma, Reto, Seneghini, Marco, Seiffert, Salomé N., Vuichard Gysin, Danielle, Scanferla, Giulia, Haller, Sabine, Flury, Domenica, Boggian, Katia, Kleger, Gian-Reto, Filipovic, Miodrag, Nolte, Oliver, Schlegel, Matthias, and Kohler, Philipp

Published
2022
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10. Machine learning using the extreme gradient boosting (XGBoost) algorithm predicts 5-day delta of SOFA score at ICU admission in COVID-19 patients

Author

Alfaro-Farias, Mario, Vizmanos-Lamotte, Gerardo, Tschoellitsch, Thomas, Meier, Jens, Aguirre-Bermeo, Hernán, Apolo, Janina, Martínez, Alberto, Jurkolow, Geoffrey, Delahaye, Gauthier, Novy, Emmanuel, Losser, Marie-Reine, Wengenmayer, Tobias, Rilinger, Jonathan, Staudacher, Dawid L., David, Sascha, Welte, Tobias, Stahl, Klaus, Pavlos”, “Agios, Aslanidis, Theodoros, Korsos, Anita, Babik, Barna, Nikandish, Reza, Rezoagli, Emanuele, Giacomini, Matteo, Nova, Alice, Fogagnolo, Alberto, Spadaro, Savino, Ceriani, Roberto, Murrone, Martina, Wu, Maddalena A., Cogliati, Chiara, Colombo, Riccardo, Catena, Emanuele, Turrini, Fabrizio, Simonini, Maria Sole, Fabbri, Silvia, Potalivo, Antonella, Facondini, Francesca, Gangitano, Gianfilippo, Perin, Tiziana, Grazia Bocci, Maria, Antonelli, Massimo, Gommers, Diederik, Rodríguez-García, Raquel, Gámez-Zapata, Jorge, Taboada-Fraga, Xiana, Castro, Pedro, Tellez, Adrian, Lander-Azcona, Arantxa, Escós-Orta, Jesús, Martín-Delgado, Maria C., Algaba-Calderon, Angela, Franch-Llasat, Diego, Roche-Campo, Ferran, Lozano-Gómez, Herminia, Zalba-Etayo, Begoña, Michot, Marc P., Klarer, Alexander, Ensner, Rolf, Schott, Peter, Urech, Severin, Zellweger, Nuria, Merki, Lukas, Lambert, Adriana, Laube, Marcus, Jeitziner, Marie M., Jenni-Moser, Beatrice, Wiegand, Jan, Yuen, Bernd, Lienhardt-Nobbe, Barbara, Westphalen, Andrea, Salomon, Petra, Drvaric, Iris, Hillgaertner, Frank, Sieber, Marianne, Dullenkopf, Alexander, Petersen, Lina, Chau, Ivan, Ksouri, Hatem, Sridharan, Govind Oliver, Cereghetti, Sara, Boroli, Filippo, Pugin, Jerome, Grazioli, Serge, Rimensberger, Peter C., Bürkle, Christian, Marrel, Julien, Brenni, Mirko, Fleisch, Isabelle, Lavanchy, Jerome, Perez, Marie-Helene, Ramelet, Anne-Sylvie, Weber, Anja Baltussen, Gerecke, Peter, Christ, Andreas, Ceruti, Samuele, Glotta, Andrea, Marquardt, Katharina, Shaikh, Karim, Hübner, Tobias, Neff, Thomas, Redecker, Hermann, Moret-Bochatay, Mallory, Bentrup, FriederikeMeyer zu, Studhalter, Michael, Stephan, Michael, Brem, Jan, Gehring, Nadine, Selz, Daniela, Naon, Didier, Kleger, Gian-Reto, Pietsch, Urs, Filipovic, Miodrag, Ristic, Anette, Sepulcri, Michael, Heise, Antje, Franchitti Laurent, Marilene, Laurent, Jean-Christophe, Wendel Garcia, Pedro D., Schuepbach, Reto, Heuberger, Dorothea, Bühler, Philipp, Brugger, Silvio, Fodor, Patricia, Locher, Pascal, Camen, Giovanni, Gaspert, Tomislav, Jovic, Marija, Haberthuer, Christoph, Lussman, Roger F., Colak, Elif, Montomoli, Jonathan, Romeo, Luca, Moccia, Sara, Bernardini, Michele, Migliorelli, Lucia, Berardini, Daniele, Donati, Abele, Carsetti, Andrea, Bocci, Maria Grazia, Wendel Garcia, Pedro David, Fumeaux, Thierry, Guerci, Philippe, Schüpbach, Reto Andreas, Ince, Can, Frontoni, Emanuele, and Hilty, Matthias Peter

Published
2021
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11. Management practices for postdural puncture headache in obstetrics: a prospective, international, cohort study

Author

Casier, Isabelle, Bryon, Bart, Soetens, Filiep, Dewandre, Pierre-Yves, Lambert, Geraldine, Christiaen, Jan, Schepers, Roel, Van Houwe, Patrick, Kalmar, Alain, Vanoverschelde, Henk, Bauters, Monique, Roofthooft, Eva, Devroe, Sarah, Van de Velde, Marc, Jadrijevic, Ana, Jokic, Aleksandra, Marin, Damjan, Sklebar, Ivan, Mihaljević, Slobodan, Kosinova, Martina, Stourac, Petr, Adamus, Milan, Kufa, Christian, Volfová, Ivana, Zaoralová, Blažena, Froeslev-Friis, Christina, Mygil, Bjoern, Krebs Albrechtsen, Charlotte, Kavasmaa, Tomi, Alahuhta, Seppo, Mäyrä, Anne, Mennander, Susanna, Rautaneva, Kati, Hiekkanen, Tuula, Kontinen, Vesa, Linden, Kirsti, Toivakka, Sara, Boselli, Emmanuel, Greil, Pierre-Édouard, Mascle, Olivier, Courbon, Aurelie, Lutz, Jean, Simonet, Thérèse, Barbier, Marie, Hlioua, Tarik, Meniolle d’Hauthville, Fleur, Quintin, Christine, Bouattour, Karim, Lecinq, Agnès, Soued, Mickaël, Bonnet, Marie-Pierre, Carbonniere, Mathieu, Fischer, Catherine, Picard, Paola-Carla, Bonnin, Martine, Storme, Brigitte, Bouthors, Anne-Sophie, Detente, Thomas, Nguyen Troung, Minh, Keita, Hawa, Nebout, Sophie, Osse, Lauranne, Delmas, Anne, Vial, Florence, Kaufner, Lutz, Hoefing, Christoph, Mueller, Stefan, Becke, Karin, Blobner, Manfred, Lewald, Heidrun, Schaller, Stefan Josef, Muggleton, Ellis, Bette, Birgit, Neumann, Claudia, Weber, Stefan, Grünewald, Matthias, Ohnesorge, Henning, Helf, Antonia, Jelting, Yvonne, Kranke, Peter, von Heymann, Christian, Welfle, Sabine, Staikou, Chryssoula, Stavrianopoulou, Antonia, Tsaroucha, Athanasia, Kalopita, Konstantina, Loukeri, Anastasia, Valsamidis, Dimitrios, Matsota, Paraskevi, Thorsteinsson, Adalbjörn, Tome, Riad, Eidelman, Leonid A., Davis, Atara, Orbach-Zinger, Sharon, Ioscovich, Alexander, Ramona, Iacob, De Simone, Luigi, Pesetti, Barbara, Brazzi, Luca, Zito, Alessandro, Camorcia, Michela, Della Rocca, Giorgio, Aversano, Marco, Frigo, Maria Grazia, Todde, Cristina, Morina, Qamile, Macas, Andrius, Keraitiene, Grazina, Rimaitis, Kestutis, Borg, Francis, Tua, Carl, Kuijpers-Visser, Agnes Geertje, Schyns-van den Berg, Alexandra, Hollmann, Markus W., Van den Berg, Tijs, Koolen, Eric, Dons, Ilse, van der Knijff, Anouk, van der Marel, Caroline, Ruysschaert, Nele, Pelka, Michal, Pluymakers, Christine, Koopman, Seppe, Teunissen, Aart-Jan, Cornelisse, Dick, van Dasselaar, Nick, Verdouw, Bastiaan, Beenakkers, Ingrid, Dahl, Vegard, Hagen, Robert, Vivaldi, Francesco, Eriksen, John Reidar, Wiszt, Radovan, Aslam Tayyaba, Naz, Ringvold, Else-Marie, Chutkowski, Radosław, Skirecki, Tomasz, Wódarski, Bartłomiej, Faria, Maria Aida, Ferreira, Amélia, Sampaio, Ana Catarina, Ferreira, Irene, Matias, Bernardo, Teixeira, Joana, Araujo, Rita, Cabido, Herminia, Fortuna, Rosario, Lemos, Paulo, Cardoso, Carolina, Moura, Fernando, Pereira, Cristiana, Pereira, Sandra, Tavares, Francisca, Vasconcelos, Pedro, Abecasis, Manuel, Lança, Filipa, Muchacho, Paulo, Ormonde, Lucindo, Guedes-Araujo, Isabel, Pinho-Oliveira, Vitor, Paredes, Paulo, Bentes, Carla, Gouveia, Francisco, Milheiro, Ana, Castanheira, Cláudia, Neves, Miriam, Pacheco, Vânia, Cortez, Mara, Tranquada, Raquel, Tareco, Glória, Furtado, Inês, Pereira, Estela, Marinho, Luísa, Seabra, Manue, Bulasevic, Aleksandra, Kendrisic, Mirjana, Jovanovic, Lidija, Pujić, Borislava, Kutlesic, Marija, Grochova, Monika, Simonova, Jana, Pavlovic, Gordana, Rozman, Ales, Blajic, Iva, Graovac, Dragan, Stopar Pintraic, Tatjana, Chiquito, Teresa, Monedero, Pablo, Carlos-Errea, De Joaquin, Guillén-Casbas, Roque, Veiga-Gil, Leonor, Basso, Morena, Garcia Bartolo, Carolina, Hernandez, Cristian, Ricol, Laura, De Santos, Maroto Pinar, Gràcia Solsona, Josep A., López-Baamonde, Manuel, Magaldi Mendaña, Marta, Plaza Moral, Ana María, Vendrell, Marina, Trillo, Lourdes, Perez Garcia, Anibal Ricardo, Alamillo Salas, Clara, Moret, Enric, Ramió, Laura, Aguilar Sanchez, Jose Luis, Soler Pedrola, Maria, Valldeperas Hernandez, Maria Inmaculada, Aldalur, Gorka, Bárcena, Estíbaliz, Herrera, Julia, Iturri, Fernando, Martínez, Alberto, Martínez, Leire, Serna, Rosa, Gilsanz, Fernando, Guasch Arevalo, Emilia, Iannuccelli, Fabrizio, Latorre, Julieta, Rodriguez Roca, Cristina, Pérez Pardo, Osvaldo Ceferino, Sierra Biddle, Natalia, Suárez Cendaña, Ceferina, Hernández González, Lourdes, Remacha González, Caridad, Sánchez Nuez, Raquel, Anta, Diego, Beleña, Jose M., García-Cuadrado, Carmen, Garcia, Irene, Manrique, Susana, Suarez, Elena, Hein, Anette, Arbman, Elisabet, Hansson, Helena, Tillenius, Monika, Al-Taie, Ruaa, Ledin-Eriksson, Susanne, Lindén-Söndersö, Anja, Rosén, Ola, Austruma, Evija, Gillberg, Lars, Darvish, Bijan, Gupta, Anil, Nordstöm, Johan L., Persson, Jan, Rosenberg, Jan, Brühne, Lars, Forshammar, Johan, Ugarph Edfeldt, Malin, Rolfsson, Håkan, Hellblom, Anna, Levin, Katarina, Rabow, Sofus, Thorlacius, Karin, Bansch, Peter, Robertson (Baeriswyl), Moira, Stamer, Ulrike, Mathivon, Stanislas, Savoldelli, Georges, Auf der Maur, Pia, Filipovic, Miodrag, Dullenkopf, Alexander, Brunner, Maya, Girard, Thierry, Vonlanthen, Claudia, Ozbilgin, Sule, Gunaydin D, Berrin, Corman Dincer, Pelin, Tas Tuna, Ayca, Magnuson, Anders, Fernando, Roshan, Mercier, Frédéric J., and Schyns-van den Berg, Alexandra M.J.V.

Published
2020
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12. Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort

Author

Alfaro Farias, Mario, Margarit, Antoni, Vizmanos-Lamotte, Gerardo, Tschoellitsch, Thomas, Meier, Jens, Cardona, Francesco S., Skola, Josef, Horakova, Lenka, Aguirre-Bermeo, Hernan, Apolo, Janina, Novy, Emmanuel, Losser, Marie-Reine, Jurkolow, Geoffrey, Delahaye, Gauthier, David, Sascha, Welte, Tobias, Wengenmayer, Tobias, Staudacher, Dawid L., Aslanidis, Theodoros, Babik, Barna, Korsos, Anita, Gal, Janos, Csaba, Hermann, Donati, Abele, Carsetti, Andrea, Turrini, Fabrizio, Simonini, Maria Sole, Ceriani, Roberto, Murrone, Martina, Rezoagli, Emanuele, Vitale, Giovanni, Fogagnolo, Alberto, Spadaro, Savino, Wu, Maddalena Alessandra, Cogliati, Chiara, Colombo, Riccardo, Catena, Emanuele, Facondini, Francesca, Potalivo, Antonella, Gangitano, Gianfilippo, Perin, Tiziana, Bocci, Maria Grazia, Antonelli, Massimo, Gommers, Diederik, Ince, Can, Mayor-Vázquez, Eric, Cruz, Maria, Delgado, Martin, Garcia, Raquel Rodriguez, Gamez Zapata, Jorge, Zalba-Etayo, Begoña, Lozano-Gomez, Herminia, Castro, Pedro, Tellez, Adrian, Jacas, Adriana, Muñoz, Guido, Andrea, Rut, Ortiz, Jose, Quintana, Eduard, Rovira, Irene, Reverter, Enric, Fernandez, Javier, Ferrer, Miquel, Badia, Joan R., Lander Azcona, Arantxa, Orta, Jesus Escos, Bühler, Philipp, Brugger, Silvio, Hofmaenner, Daniel, Unseld, Simone, Ruschitzka, Frank, Moret-Bochatay, Mallory, Yuen, Bernd, Hillermann, Thomas, Ksouri, Hatem, Sridharan, Govind Oliver, Ristic, Anette, Sepulcri, Michael, Filipovic, Miodrag, Pietsch, Urs, Salomon, Petra, Drvaric, Iris, Schott, Peter, Urech, Severin, Lambert, Adriana, Merki, Lukas, Laube, Marcus, Hillgaertner, Frank, Sieber, Marianne, Dullenkopf, Alexander, Petersen, Lina, Grazioli, Serge, Rimensberger, Peter C., Fleisch, Isabelle, Lavanchy, Jerome, Marquardt, Katharina, Shaikh, Karim, Redecker, Hermann, Stephan, Michael, Brem, Jan, Rogdo, Bjarte, Birkenmaier, Andre, Meyer zu Bentrup, Friederike, Fodor, Patricia, Locher, Pascal, Camen, Giovanni, Siegemund, Martin, Zellweger, Nuria, Jeitziner, Marie-Madlen, Jenni-Moser, Beatrice, Bürkle, Christian, Kleger, Gian-Reto, Franchitti Laurent, Marilene, Laurent, Jean-Christophe, Gaspert, Tomislav, Jovic, Marija, Studhalter, Michael, Haberthuer, Christoph, Lussman, Roger F., Selz, Daniela, Naon, Didier, Mauri, Romano, Ceruti, Samuele, Marrel, Julien, Brenni, Mirko, Ensner, Rolf, Gehring, Nadine, Heise, Antje, Huebner, Tobias, Neff, Thomas A., Cereghetti, Sara, Boroli, Filippo, Pugin, Jerome, Marczin, Nandor, Wong, Joyce, Wendel Garcia, Pedro David, Fumeaux, Thierry, Guerci, Philippe, Heuberger, Dorothea Monika, Montomoli, Jonathan, Roche-Campo, Ferran, Schuepbach, Reto Andreas, and Hilty, Matthias Peter

Published
2020
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13. Early sevoflurane sedation in severe COVID-19-related lung injury patients. A pilot randomized controlled trial.

Author

Beck-Schimmer, Beatrice, Schadde, Erik, Pietsch, Urs, Filipovic, Miodrag, Dübendorfer-Dalbert, Seraina, Fodor, Patricia, Hübner, Tobias, Schuepbach, Reto, Steiger, Peter, David, Sascha, Krüger, Bernard D., Neff, Thomas A., and Schläpfer, Martin

Subjects
LUNG disease treatment, VASCULAR endothelial growth factors, PEARSON correlation (Statistics), SEVOFLURANE, EARLY medical intervention, RESEARCH funding, CRITICALLY ill, PATIENTS, THERAPEUTICS, RENAL replacement therapy, CREATININE, INFLAMMATORY mediators, T-test (Statistics), CYTOKINE release syndrome, MULTIPLE organ failure, PILOT projects, STATISTICAL sampling, SEX distribution, SEVERITY of illness index, RANDOMIZED controlled trials, TERTIARY care, HOSPITAL mortality, DESCRIPTIVE statistics, ACUTE kidney failure, CALCITONIN, CHI-squared test, MANN Whitney U Test, TREATMENT duration, OPERATIVE surgery, LUNG diseases, ARTIFICIAL respiration, DRUG efficacy, RESEARCH, INTRAVENOUS anesthesia, INTENSIVE care units, UREA, ONE-way analysis of variance, COMPARATIVE studies, VASOCONSTRICTORS, LENGTH of stay in hospitals, ADVERSE health care events, ANESTHESIA, COVID-19, INTERLEUKINS, C-reactive protein, CELL receptors, DISEASE incidence, EVALUATION, BLOOD
Abstract

Background: This study aimed to assess a potential organ protective effect of volatile sedation in a scenario of severe inflammation with an early cytokine storm (in particular IL-6 elevation) in patients suffering from COVID-19-related lung injury with invasive mechanical ventilation and sedation. Methods: This is a small-scale pilot multicenter randomized controlled trial from four tertiary hospitals in Switzerland, conducted between April 2020 and May 2021. 60 patients requiring mechanical ventilation due to severe COVID-19-related lung injury were included and randomized to 48-hour sedation with sevoflurane vs. continuous intravenous sedation (= control) within 24 h after intubation. The primary composite outcome was determined as mortality or persistent organ dysfunction (POD), defined as the need for mechanical ventilation, vasopressors, or renal replacement therapy at day 28. Secondary outcomes were the length of ICU and hospital stay, adverse events, routine laboratory parameters (creatinine, urea), and plasma inflammatory mediators. Results: 28 patients were randomized to sevoflurane, 32 to the control arm. The intention-to-treat analysis revealed no difference in the primary endpoint with 11 (39%) sevoflurane and 13 (41%) control patients (p = 0.916) reaching the primary outcome. Five patients died within 28 days in each group (16% vs. 18%, p = 0.817). Of the 28-day survivors, 6 (26%) and 8 (30%) presented with POD (p = 0.781). There was a significant difference regarding the need for vasopressors (1 (4%) patient in the sevoflurane arm, 7 (26%) in the control one (p = 0.028)). Length of ICU stay, hospital stay, and registered adverse events within 28 days were comparable, except for acute kidney injury (AKI), with 11 (39%) sevoflurane vs. 2 (6%) control patients (p = 0.001). The blood levels of IL-6 in the first few days after the onset of the lung injury were less distinctly elevated than expected. Conclusions: No evident benefits were observed with short sevoflurane sedation on mortality and POD. Unexpectedly low blood levels of IL-6 might indicate a moderate injury with therefore limited improvement options of sevoflurane. Acute renal issues suggest caution in using sevoflurane for sedation in COVID-19. Trial registration: The trial was registered on ClinicalTrials.gov (NCT04355962) on 2020/04/21. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Association between self-reported functional capacity and general postoperative complications: analysis of predefined outcomes of the MET-REPAIR international cohort study

Author

Roth, Sebastian, M'Pembele, René, Nienhaus, Johannes, Kemper, Johann, Kohaupt, Lena, Witzler, Jette, Tuzhikov, Michael, Stroda, Alexandra, Tenge, Theresa, Huhn, Ragnar, Schultze, Cornelia, Verbarg, Nele, Gehrke, Christian, Klemann, Anna Katharina, Hagebölling, Friederike, Albrecht, Svenja, Stroeder, Jakob, Schubert, Ann-Kristin, Espeter, Florian, Russe, Benedikt, Weigand, Markus A., Bergmann, Lars, Unterberg, Matthias, Bischoff, Petra, Pirzer, Raphael, Rach, Patric Rene, Ott, Klaus, Zarbock, Alexander, Kowark, Ana, Neumann, Claudia, Marchand, Bahareh, Sponholz, Christoph, Rueffert, Henrik, Kramer, Mira, Piekarski, Florian, Carollo, Melissa, Novazzi, Cecilia, Toso, Fiorenza, Bacuzzi, Alessandro, Ragazzi, Riccardo, Volta, Carlo Alberto, De Giorgi, Francesco, Bacer, Barbara, Federico, Antonio, Chiumello, Davide, Vetrugno, Luigi, Castella, Alberto, Tesoro, Simonetta, Cotoia, Antonella, Bignami, Elena, Bellissima, Agrippino, Cortegiani, Andrea, Crisman, Marco, Toninelli, Arturo, Piazza, Ornella, Mirabella, Lucia, Bossolasco, Matteo, Bona, Francesco, Perdomo, Juan Manuel, Coca-Martinez, Miquel, Carramiñana, Albert, Servén, Marta Giné, González, Astrid Batalla, Gil Sánchez, José Maria, Becerra-Bolaños, Ángel, Rodríguez-Pérez, Aurelio, Soler, Anna Artigas, Basso, Morena, Font, Anna Peig, Vernetta, Diana, Santos, Julia Hernando, Muñoz, Enrique Alday, Olivares, Mercedes Cabellos, Marco, Gregorio, Lopez, Maria Bermudez, Barrio, Javier, Forés, María Isabel, Boix, Estefanía, Ayuso, Mercedes, Petre, Bogdan Sorel, Oprea, Ioana Sorina, Latiș, Mihai Dan, Margarit, Simona, Vasian, Horatiu, Tomescu, Dana, Cîndea, Iulia, Dirzu, Dan Sebastian, Copotoiu, Sanda-Maria, Moise, Alida, Bubenek-Turconi, Serban, Valeanu, Liana, Wanner, Patrick Mark, Djurdjevic, Mirjana, Nuth, Sandra, Seeberger, Esther, Goettel, Nicolai, Kamber, Firmin, Ganter, Michael Thomas, Gerber, Thomas Jan, Schneebeli, Daniela, Pregernig, Andreas, Grape, Sina, Tomala, Simon, Pinto, Bernardo Bollen, Żukowski, Maciej, Zegan-Barańska, Małgorzata, Karolak, Igor, Krzych, Lukasz, Czajka, Szymon, Studzińska, Dorota, Kluzik, Anna, Koszel, Tomasz, Pabjańczyk, Izabela, Gajdosz, Anna, Erkoc, Suheyla Karadag, Meco, Basak Ceyda, Koltka, Ahmet Kemalettin, Dincer, Muserref Beril, Ekmekçi, Perihan, Saracoglu, Kemal Tolga, Solmaz, Filiz Alkaya, Ozcelik, Menekse, Arun, Oguzhan, Dilmen, Ozlem Korkmaz, Preckel, Benedikt, Hollmann, Markus W., Hazen, Yannick, Donald de Boer, Hans, Epema, Anne, Koopman, Seppe, Van Lier, Felix, Pinto, Rita, Carrão, André, Ribeiro, Daniel, Mourão, Joana, Coelho, Miguel, Santos, Nuno, Cabral, Luis, Afonso, Diana, Zenha, Sérgio, Ramos, Cristina, Hipólito, Carla, Vasilaki, Maria, Andreeva, Antonia, Zaimi, Donika, Chalkias, Athanasios, Spyraki, Maria, Rekatsina, Martina, Tsaousi, Georgia, Short, Anthony, Meier, Sonja, Madhuri, Thumuluru Kavitha, Latham, Scott, Knock, James, Drummond, Andrew, Ramsden, Fiona, Kubisz-Pudelko, Agnieszka, Walker, James, Moppett, Iain, White, Louise, Jackson, Matthew, Reschreiter, Henrik, Innes, Richard, Chew, Michelle, Kalman, Sigridur, Wallden, Jakob, Schening, Anna, Jonikaite, Lina, Enlund, Anna, De Baerdemaeker, Luc, Morrison, Stuart, Rex, Steffen, Alexis, Alexandros, Khoronenko, Viktoria E., Ovezov, Alexey, Belskii, Vladislav, Kaznacheeva, Kseniya, Gritsan, Alexey, Kuzmanovska, Biljana, Malinovska-Nikolovska, Liljana, Barisin, Stjepan, Poredos, Peter, Arabadzhieva, Daniela, Unic-Stojanovic, Dragana, Golubović, Mladjan, Fleischmann, Edith, Kotzinger, Oskar, Des Deserts, Marc Danguy, Ducrocq, Nicolas, Buggy, Donal J., Bonnet, Jean François, Cusack, Barbara, Calleja, Paul, Hasani, Antigona, Nallbani, Rajmonda, Mauermann, Eckhard, Ionescu, Daniela, Szczeklik, Wojciech, De Hert, Stefan, Filipovic, Miodrag, Beck-Schimmer, Beatrice, Spadaro, Savino, Matute, Purificación, Bolliger, Daniel, Turhan, Sanem C., van Waes, Judith, Lagarto, Filipa, Theodoraki, Kassiani, Gupta, Anil, Gillmann, Hans-Jörg, Guzzetti, Luca, Kotfis, Katarzyna, Wulf, Hinnerk, Larmann, Jan, Corneci, Dan, Chammartin, Frédérique, Howell, Simon J., and Lurati Buse, Giovanna

Published
2024
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21. Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients

Author

Lichtensteiger, Christa, Koblischke, Maximilian, Berner, Fiamma, Jochum, Ann-Kristin, Sinnberg, Tobias, Balciunaite, Beatrice, Purde, Mette-Triin, Walter, Vincent, Abdou, Marie-Therese, Hofmeister, Kathrin, Kohler, Philipp, Vernazza, Pietro, Albrich, Werner C., Kahlert, Christian R., Zoufaly, Alexander, Traugott, Marianna T., Kern, Lukas, Pietsch, Urs, Kleger, Gian-Reto, Filipovic, Miodrag, Kneilling, Manfred, Cozzio, Antonio, Pop, Oltin, Bomze, David, Bergthaler, Andreas, Hasan Ali, Omar, Aberle, Judith, and Flatz, Lukas

Published
2023
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23. Utilization of mechanical power and associations with clinical outcomes in brain injured patients: a secondary analysis of the extubation strategies in neuro-intensive care unit patients and associations with outcome (ENIO) trial

Author

Wahlster, Sarah, Sharma, Monisha, Taran, Shaurya, Town, James A., Stevens, Robert D., Cinotti, Raphaël, Asehoune, Karim, Pelosi, Paolo, Robba, Chiara, Abback, Paër sélim, Codorniu, Anaïs, Citerio, Giuseppe, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Maugeri, Jessica Giuseppina, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Battaglini, Denise, Biston, Patrick, Al-Gharyani, Mohamed Fathi, Chabanne, Russell, Astier, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Urs, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Gerretsen, Benjamin Marcel, Ortiz-Macias, Iris Xochitl, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, van der Jagt, Mathieu, van Steenkiste, Job, Rehabilitation Medicine, Emergency Medicine, Intensive Care, and Internal Medicine

Abstract

Background: There is insufficient evidence to guide ventilatory targets in acute brain injury (ABI). Recent studies have shown associations between mechanical power (MP) and mortality in critical care populations. We aimed to describe MP in ventilated patients with ABI, and evaluate associations between MP and clinical outcomes. Methods: In this preplanned, secondary analysis of a prospective, multi-center, observational cohort study (ENIO, NCT03400904), we included adult patients with ABI (Glasgow Coma Scale ≤ 12 before intubation) who required mechanical ventilation (MV) ≥ 24 h. Using multivariable log binomial regressions, we separately assessed associations between MP on hospital day (HD)1, HD3, HD7 and clinical outcomes: hospital mortality, need for reintubation, tracheostomy placement, and development of acute respiratory distress syndrome (ARDS). Results: We included 1217 patients (mean age 51.2 years [SD 18.1], 66% male, mean body mass index [BMI] 26.3 [SD 5.18]) hospitalized at 62 intensive care units in 18 countries. Hospital mortality was 11% (n = 139), 44% (n = 536) were extubated by HD7 of which 20% (107/536) required reintubation, 28% (n = 340) underwent tracheostomy placement, and 9% (n = 114) developed ARDS. The median MP on HD1, HD3, and HD7 was 11.9 J/min [IQR 9.2–15.1], 13 J/min [IQR 10–17], and 14 J/min [IQR 11–20], respectively. MP was overall higher in patients with ARDS, especially those with higher ARDS severity. After controlling for same-day pressure of arterial oxygen/fraction of inspired oxygen (P/F ratio), BMI, and neurological severity, MP at HD1, HD3, and HD7 was independently associated with hospital mortality, reintubation and tracheostomy placement. The adjusted relative risk (aRR) was greater at higher MP, and strongest for: mortality on HD1 (compared to the HD1 median MP 11.9 J/min, aRR at 17 J/min was 1.22, 95% CI 1.14–1.30) and HD3 (1.38, 95% CI 1.23–1.53), reintubation on HD1 (1.64; 95% CI 1.57–1.72), and tracheostomy on HD7 (1.53; 95%CI 1.18–1.99). MP was associated with the development of moderate-severe ARDS on HD1 (2.07; 95% CI 1.56–2.78) and HD3 (1.76; 95% CI 1.41–2.22). Conclusions: Exposure to high MP during the first week of MV is associated with poor clinical outcomes in ABI, independent of P/F ratio and neurological severity. Potential benefits of optimizing ventilator settings to limit MP warrant further investigation.

Published
2023

25. Long-term outcomes of perioperative myocardial infarction/injury after non-cardiac surgery.

Author

Puelacher, Christian, Gualandro, Danielle M, Glarner, Noemi, Buse, Giovanna Lurati, Lampart, Andreas, Bolliger, Daniel, Steiner, Luzius A, Grossenbacher, Mario, Burri-Winkler, Katrin, Gerhard, Hatice, Kappos, Elisabeth A, Clerc, Olivier, Biner, Laura, Zivzivadze, Zaza, Kindler, Christoph, Hammerer-Lercher, Angelika, Filipovic, Miodrag, Clauss, Martin, Gürke, Lorenz, and Wolff, Thomas

Subjects
SURGICAL complications, MYOCARDIAL infarction, MAJOR adverse cardiovascular events
Abstract

Aims Perioperative myocardial infarction/injury (PMI) following non-cardiac surgery is a frequent cardiac complication. Better understanding of the underlying aetiologies and outcomes is urgently needed. Methods and results Aetiologies of PMIs detected within an active surveillance and response programme were centrally adjudicated by two independent physicians based on all information obtained during clinically indicated PMI work-up including cardiac imaging among consecutive high-risk patients undergoing major non-cardiac surgery in a prospective multicentre study. PMI aetiologies were hierarchically classified into 'extra-cardiac' if caused by a primarily extra-cardiac disease such as severe sepsis or pulmonary embolism; and 'cardiac', further subtyped into type 1 myocardial infarction (T1MI), tachyarrhythmia, acute heart failure (AHF), or likely type 2 myocardial infarction (lT2MI). Major adverse cardiac events (MACEs) including acute myocardial infarction, AHF (both only from day 3 to avoid inclusion bias), life-threatening arrhythmia, and cardiovascular death as well as all-cause death were assessed during 1-year follow-up. Among 7754 patients (age 45–98 years, 45% women), PMI occurred in 1016 (13.1%). At least one MACE occurred in 684/7754 patients (8.8%) and 818/7754 patients died (10.5%) within 1 year. Outcomes differed starkly according to aetiology: in patients with extra-cardiac PMI, T1MI, tachyarrhythmia, AHF, and lT2MI 51%, 41%, 57%, 64%, and 25% had MACE, and 38%, 27%, 40%, 49%, and 17% patients died within 1 year, respectively, compared to 7% and 9% in patients without PMI. These associations persisted in multivariable analysis. Conclusion At 1 year, most PMI aetiologies have unacceptably high rates of MACE and all-cause death, highlighting the urgent need for more intensive treatments. Study registration https://clinicaltrials.gov/ct2/show/NCT02573532. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Extubation in neurocritical care patients: the ENIO international prospective study

Author

Cinotti, Raphaël, Mijangos, Julio Cesar, Pelosi, Paolo, Haenggi, Matthias, Gurjar, Mohan, Schultz, Marcus J., Kaye, Callum, Godoy, Daniel Agustin, Alvarez, Pablo, Ioakeimidou, Aikaterini, Ueno, Yoshitoyo, Badenes, Rafael, Suei Elbuzidi, Abdurrahmaan Ali, Piagnerelli, Michaël, Elhadi, Muhammed, Reza, Syed Tariq, Azab, Mohammed Atef, McCredie, Victoria, Stevens, Robert D., Digitale, Jean Catherine, Fong, Nicholas, Asehnoune, Karim, Abback, Paër-sélim, Codorniu, Anaïs, Citerio, Giuseppe, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Maugeri, Jessica Giuseppina, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Robba, Chiara, Battaglini, Denise, Biston, Patrick, Al-Gharyani, Mohamed Fathi, Chabanne, Russell, Astier, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Urs, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Gerretsen, Benjamin Marcel, Ortiz-Macias, Iris Xochitl, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, Vermeijden, Wytze J., Cornet, Alexander Daniel, Inurrigarro, Sergio Reyes, Domínguez, Rafael Cirino Lara, Bellini, Maria Mercedes, Haedo, Maria Milagros Gomez, Lamot, Laura, Orquera, Jose, Biais, Matthieu, Georges, Delphine, Baronia, Arvind, Miranda-Ackerman, Roberto Carlos, Barbosa-Camacho, Francisco José, Porter, John, Lopez-Morales, Miguel, Geeraerts, Thomas, Compagnon, Baptiste, Pérez-Torres, David, Prol-Silva, Estefanía, Yahya, Hana Basheer, Khaled, Ala, Ghula, Mohamed, Andrea, Cracchiolo Neville, Daniela, Palma Maria, Deana, Cristian, Vetrugno, Luigi, Chavez, Manuel J. Rivera, Trujillo, Rocio Mendoza, Legros, Vincent, Brochet, Benjamin, Huet, Olivier, Geslain, Marie, van der Jagt, Mathieu, van Steenkiste, Job, Ahmed, Hazem, Coombs, Alexander Edward, Welbourne, Jessie, Pineda, Ana Alicia Velarde, Castillo, Víctor Hugo Nubert, Azab, Mohammed A., Azzam, Ahmed Y., van Meenen, David Michael Paul, Gasca, Gilberto Adrian, Arellano, Alfredo, Galicia-Espinosa, Forttino, García-Ramos, José Carlos, Yadav, Ghanshyam, Jha, Amarendra Kumar, Robert-Edan, Vincent, Rodie-Talbere, Pierre-Andre, Jain, Gaurav, Panda, Sagarika, Agarwal, Sonika, Deewan, Yashbir, Hossain, Md. Mozaffer, Papadas, Christos, Chantziara, Vasiliki, Sklavou, Chrysanthi, Hourmant, Yannick, Grillot, Nicolas, Pirracchio, Romain, Akkari, Abdelraouf, Abdelaty, Mohamed, Hashim, Ahmed, Launey, Yoann, Masseret, Elodie, Lasocki, Sigismond, Gergaud, Soizic, Mouclier, Nicolas, Saxena, Sulekha, Agrawal, Avinash, Mishra, Shakti Bedanta, Samal, Samir, Cinotti, R, Mijangos, J, Pelosi, P, Haenggi, M, Gurjar, M, Schultz, M, Kaye, C, Godoy, D, Alvarez, P, Ioakeimidou, A, Ueno, Y, Badenes, R, Suei Elbuzidi, A, Piagnerelli, M, Elhadi, M, Reza, S, Azab, M, Mccredie, V, Stevens, R, Digitale, J, Fong, N, Asehnoune, K, Abback, P, Codorniu, A, Citerio, G, Sala, V, Astuto, M, Tringali, E, Alampi, D, Rocco, M, Maugeri, J, Bellissima, A, Filippini, M, Lazzeri, N, Cortegiani, A, Ippolito, M, Robba, C, Battaglini, D, Biston, P, Al-Gharyani, M, Chabanne, R, Astier, L, Soyer, B, Gaugain, S, Zimmerli, A, Pietsch, U, Filipovic, M, Brandi, G, Bicciato, G, Serrano, A, Monleon, B, van Vliet, P, Gerretsen, B, Ortiz-Macias, I, Oto, J, Enomoto, N, Matsuda, T, Masui, N, Garcon, P, Zarka, J, Vermeijden, W, Cornet, A, Inurrigarro, S, Dominguez, R, Bellini, M, Haedo, M, Lamot, L, Orquera, J, Biais, M, Georges, D, Baronia, A, Miranda-Ackerman, R, Barbosa-Camacho, F, Porter, J, Lopez-Morales, M, Geeraerts, T, Compagnon, B, Perez-Torres, D, Prol-Silva, E, Yahya, H, Khaled, A, Ghula, M, Andrea, C, Daniela, P, Deana, C, Vetrugno, L, Chavez, M, Trujillo, R, Legros, V, Brochet, B, Huet, O, Geslain, M, van der Jagt, M, van Steenkiste, J, Ahmed, H, Coombs, A, Welbourne, J, Pineda, A, Castillo, V, Azzam, A, van Meenen, D, Gasca, G, Arellano, A, Galicia-Espinosa, F, Garcia-Ramos, J, Yadav, G, Jha, A, Robert-Edan, V, Rodie-Talbere, P, Jain, G, Panda, S, Agarwal, S, Deewan, Y, Hossain, M, Papadas, C, Chantziara, V, Sklavou, C, Hourmant, Y, Grillot, N, Pirracchio, R, Akkari, A, Abdelaty, M, Hashim, A, Launey, Y, Masseret, E, Lasocki, S, Gergaud, S, Mouclier, N, Saxena, S, Agrawal, A, Mishra, S, Samal, S, Cinotti, Raphaël, Mijangos, Julio Cesar, Pelosi, Paolo, Haenggi, Matthia, Gurjar, Mohan, Schultz, Marcus J., Kaye, Callum, Godoy, Daniel Agustin, Alvarez, Pablo, Ioakeimidou, Aikaterini, Ueno, Yoshitoyo, Badenes, Rafael, Suei Elbuzidi, Abdurrahmaan Ali, Piagnerelli, Michaël, Elhadi, Muhammed, Reza, Syed Tariq, Azab, Mohammed Atef, McCredie, Victoria, Stevens, Robert D., Digitale, Jean Catherine, Fong, Nichola, Asehnoune, Karim, Abback, Paër-sélim, Codorniu, Anaï, Citerio, Giuseppe, Sala, Vittoria Ludovica, Astuto, Marinella, Tringali, Eleonora, Alampi, Daniela, Rocco, Monica, Maugeri, Jessica Giuseppina, Bellissima, Agrippino, Filippini, Matteo, Lazzeri, Nicoletta, Cortegiani, Andrea, Ippolito, Mariachiara, Robba, Chiara, Battaglini, Denise, Biston, Patrick, Al-Gharyani, Mohamed Fathi, Chabanne, Russell, Astier, Léo, Soyer, Benjamin, Gaugain, Samuel, Zimmerli, Alice, Pietsch, Ur, Filipovic, Miodrag, Brandi, Giovanna, Bicciato, Giulio, Serrano, Ainhoa, Monleon, Berta, van Vliet, Peter, Gerretsen, Benjamin Marcel, Ortiz-Macias, Iris Xochitl, Oto, Jun, Enomoto, Noriya, Matsuda, Tomomichi, Masui, Nobutaka, Garçon, Pierre, Zarka, Jonathan, Vermeijden, Wytze J., Cornet, Alexander Daniel, Inurrigarro, Sergio Reye, Domínguez, Rafael Cirino Lara, Bellini, Maria Mercede, Haedo, Maria Milagros Gomez, Lamot, Laura, Orquera, Jose, Biais, Matthieu, Georges, Delphine, Baronia, Arvind, Miranda-Ackerman, Roberto Carlo, Barbosa-Camacho, Francisco José, Porter, John, Lopez-Morales, Miguel, Geeraerts, Thoma, Compagnon, Baptiste, Pérez-Torres, David, Prol-Silva, Estefanía, Yahya, Hana Basheer, Khaled, Ala, Ghula, Mohamed, Andrea, Cracchiolo Neville, Daniela, Palma Maria, Deana, Cristian, Vetrugno, Luigi, Chavez, Manuel J. Rivera, Trujillo, Rocio Mendoza, Legros, Vincent, Brochet, Benjamin, Huet, Olivier, Geslain, Marie, van der Jagt, Mathieu, van Steenkiste, Job, Ahmed, Hazem, Coombs, Alexander Edward, Welbourne, Jessie, Pineda, Ana Alicia Velarde, Castillo, Víctor Hugo Nubert, Azab, Mohammed A., Azzam, Ahmed Y., van Meenen, David Michael Paul, Gasca, Gilberto Adrian, Arellano, Alfredo, Galicia-Espinosa, Forttino, García-Ramos, José Carlo, Yadav, Ghanshyam, Jha, Amarendra Kumar, Robert-Edan, Vincent, Rodie-Talbere, Pierre-Andre, Jain, Gaurav, Panda, Sagarika, Agarwal, Sonika, Deewan, Yashbir, Hossain, Md. Mozaffer, Papadas, Christo, Chantziara, Vasiliki, Sklavou, Chrysanthi, Hourmant, Yannick, Grillot, Nicola, Pirracchio, Romain, Akkari, Abdelraouf, Abdelaty, Mohamed, Hashim, Ahmed, Launey, Yoann, Masseret, Elodie, Lasocki, Sigismond, Gergaud, Soizic, Mouclier, Nicola, Saxena, Sulekha, Agrawal, Avinash, Mishra, Shakti Bedanta, Samal, Samir, Intensive Care Medicine, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, ACS - Diabetes & metabolism, and ACS - Microcirculation

Subjects
Intensive Care Units, Tracheostomy, Traumatic brain injury, Extubation, Airway Extubation, Humans, Prospective Studies, Brain injury, Critical Care and Intensive Care Medicine, Intra-cranial haemorrhage, Respiration, Artificial
Abstract

Purpose: Neurocritical care patients receive prolonged invasive mechanical ventilation (IMV), but there is poor specific information in this high-risk population about the liberation strategies of invasive mechanical ventilation. Methods: ENIO (NCT03400904) is an international, prospective observational study, in 73 intensive care units (ICUs) in 18 countries from 2018 to 2020. Neurocritical care patients with a Glasgow Coma Score (GCS) ≤ 12, receiving IMV ≥ 24h, undergoing extubation attempt or tracheostomy were included. The primary endpoint was extubation failure by day 5. An extubation success prediction score was created, with 2/3 of patients randomly allocated to the training cohort and 1/3 to the validation cohort. Secondary endpoints were the duration of IMV and in-ICU mortality. Results: 1512 patients were included. Among the 1193 (78.9%) patients who underwent an extubation attempt, 231 (19.4%) failures were recorded. The score for successful extubation prediction retained 20 variables as independent predictors. The area under the curve (AUC) in the training cohort was 0.79 95% confidence interval (CI95) [0.71–0.87] and 0.71 CI95 [0.61–0.81] in the validation cohort. Patients with extubation failure displayed a longer IMV duration (14 [7–21] vs 6 [3–11] days) and a higher in-ICU mortality rate (8.7% vs 2.4%). Three hundred and nineteen (21.1%) patients underwent tracheostomy without extubation attempt. Patients with direct tracheostomy displayed a longer duration of IMV and higher in-ICU mortality than patients with an extubation attempt (success and failure). Conclusions: In neurocritical care patients, extubation failure is high and is associated with unfavourable outcomes. A score could predict extubation success in multiple settings. However, it will be mandatory to validate our findings in another prospective independent cohort.

Published
2022

28. Erratum to ‘Association between self-reported functional capacity and general postoperative complications: analysis of predefined outcomes of the MET-REPAIR international cohort study’ (Br J Anaesth 2024; 132: 811–4)

Author

Roth, Sebastian, M'Pembele, René, Nienhaus, Johannes, Mauermann, Eckhard, Ionescu, Daniela, Szczeklik, Wojciech, De Hert, Stefan, Filipovic, Miodrag, Beck-Schimmer, Beatrice, Spadaro, Savino, Matute, Purificación, Bolliger, Daniel, Turhan, Sanem C., van Waes, Judith, Lagarto, Filipa, Theodoraki, Kassiani, Gupta, Anil, Gillmann, Hans-Jörg, Guzzetti, Luca, Kotfis, Katarzyna, Wulf, Hinnerk, Larmann, Jan, Corneci, Dan, Chammartin, Frédérique, Howell, Simon J., and Buse, Giovanna L.

Published
2024
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34. Interleukin-6 Is an Early Plasma Marker of Severe Postoperative Complications in Thoracic Surgery: Exploratory Results From a Substudy of a Randomized Controlled Multicenter Trial

Author

Neff, Thomas A, Braun, Julia, Rana, Dhanu, Puhan, Milo, Filipovic, Miodrag, Seeberger, Manfred, Stüber, Frank, Neff, Simona B, Beck-Schimmer, Beatrice, Schläpfer, Martin, and University of Zurich

Subjects
Anesthesiology and Pain Medicine, 10216 Institute of Anesthesiology, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI)
Published
2022

36. Correction: Early sevoflurane sedation in severe COVID19-related lung injury patients. A pilot randomized controlled trial.

Author

Beck-Schimmer, Beatrice, Schadde, Erik, Pietsch, Urs, Filipovic, Miodrag, Dübendorfer-Dalbert, Seraina, Fodor, Patricia, Hübner, Tobias, Schuepbach, Reto, Steiger, Peter, David, Sascha, Krüger, Bernard D., Neff, Thomas A., and Schläpfer, Martin

Subjects
SEVOFLURANE, LUNG injuries, SEVERITY of illness index, ANESTHESIA, COVID-19
Published
2024
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39. The Drug Titration Paradox: Correlation of More Drug With Less Effect in Clinical Data.

Author

Schnider, Thomas W., Minto, Charles F., and Filipovic, Miodrag

Subjects
MONTE Carlo method, INTRAVENOUS anesthetics, VOLUMETRIC analysis, PHARMACODYNAMICS, PARADOX, BLOOD pressure
Abstract

While analyzing clinical data where an anesthetic was titrated based on an objective measure of drug effect, we observed paradoxically that greater effect was associated with lesser dose. With this study we sought to find a mathematical explanation for this negative correlation between dose and effect, to confirm its existence with additional clinical data, and to explore it further with Monte Carlo simulations. Automatically recorded dosing and effect data from more than 9,000 patients was available for the analysis. The anesthetics propofol and sevoflurane and the catecholamine norepinephrine were titrated to defined effect targets, i.e., the processed electroencephalogram (Bispectral Index, BIS) and the blood pressure. A proportional control titration algorithm was developed for the simulations. We prove by deduction that the average dose–effect relationship during titration to the targeted effect will associate lower doses with greater effects. The finding of negative correlations between propofol and BIS, sevoflurane and BIS, and norepinephrine and mean arterial pressure confirmed the titration paradox. Monte Carlo simulations revealed two additional factors that contribute to the paradox. During stepwise titration toward a target effect, the slope of the dose–effect data for the population will be "reversed," i.e., the correlation between dose and effect will not be positive, but will be negative, and will be "horizontal" when the titration is "perfect." The titration paradox must be considered whenever data from clinical titration (flexible dose) studies are interpreted. Such data should not be used naively for the development of dosing guidelines. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Association of Troponin Trends and Cardiac Morbidity and Mortality After On-Pump Cardiac Surgery.

Author

Mauermann, Eckhard, Bolliger, Daniel, Fassl, Jens, Grapow, Martin, Seeberger, Esther E., Seeberger, Manfred D., Filipovic, Miodrag, and Lurati Buse, Giovanna A.L.

Abstract

Background Elevated, single-measure, postoperative troponin is associated with adverse events after cardiac surgery. We hypothesized that increases in troponin from the first to the second postoperative day are also associated with all-cause, 12-month mortality and major adverse cardiac events (MACE). Methods This observational study included consecutive adults undergoing on-pump cardiac surgery with cardiac arrest. Troponin T was measured on the first and second postoperative day and was classified as “increasing” (>10%), “unchanged” (10% to –10%), or “decreasing” (<–10%). The primary endpoint was all-cause, 12-month mortality. Secondary endpoints were all-cause 12-month mortality or MACE and both outcomes at 30 days. The main analysis was by multivariable Cox regression. Results Of 1,417 included patients, 99 (7.0%) died and 162 (11.4%) died or suffered MACE at 12 months. A significant interaction ( p < 0.001) between first postoperative day troponin and the troponin trend from the first to the second postoperative day on 12-month, all-cause mortality precluded an analysis independent of first postoperative day troponin. Consequently, we stratified patients by their first postoperative day troponin (cutoff, 0.8 μg/L). Increasing troponin was associated with higher mortality in patients with first postoperative day troponin T ≥ 0.8 μg/L (hazard ratio, 1.98; 95% CI, 1.09 to 3.59; p = 0.025). Conclusions Troponin changes from the first to the second postoperative day should not be interpreted without consideration of the first postoperative day troponin concentration. For patients with a first postoperative day troponin ≥ 0.8 μg/L, an increase by more than 10% from the first to the second postoperative day was significantly associated with all-cause, 12-month mortality and other adverse events. [ABSTRACT FROM AUTHOR]

Published
2017
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44. Significance of new Q waves and their location in postoperative ECGs after elective on-pump cardiac surgery: An observational cohort study.

Author

Mauermann, Eckhard, Bolliger, Daniel, Fassl, Jens, Grapow, Martin, Seeberger, Esther E., Seeberger, Manfred D., Filipovic, Miodrag, Buse, Giovanna A. L. Lurati, Buse, Giovanna A L L, and Lurati Buse, Giovanna A L

Abstract

Background: The clinical significance of new pathological Q waves after on-pump cardiac surgery is uncertain.Objectives: To determine whether or not either the occurrence per se or the location of new pathological Q waves after on-pump cardiac surgery is associated with 12-month, all-cause mortality and/or major adverse cardiac events (MACEs).Design: Observational cohort study.Setting: Single university hospital from January 2007 to October 2010.Patients: Consecutive adult patients undergoing elective on-pump cardiac surgery with MACE-free survival until at least the 7th postoperative day and available ECGs both preoperatively and on the 7th postoperative day (n = 1464). We conducted a subgroup analysis in patients undergoing isolated coronary artery bypass grafting (n = 740).Main Outcome Measure: Our primary endpoint was 12-month, all-cause mortality and/or MACE, defined as acute coronary syndrome, cardiac arrest, congestive heart failure or re-vascularisation at 12 months. Using logistic regression, we examined the prognostic value of new pathological Q waves according to the Minnesota ECG Code, adjusting for the EuroSCORE II, cardiopulmonary bypass time and peak postoperative troponin T concentrations.Results: We included 1464 patients (74% men; mean ± SD age 66 ± 10 years) and observed 103 (7.0%) all-cause deaths and/or MACEs at 12 months. A total of 236 patients (16.1%) had definite or probable new pathological Q waves according to the Minnesota ECG Code. The occurrence of new pathological Q waves per se was not associated with our primary endpoint [adjusted odds ratio, 0.970 (95% confidence interval, 0.540 to 1.648)]. However, the occurrence of a new pathological Q wave in V1 to V5 (anterior) was a strong independent predictor for poor outcome [adjusted odds ratio, 3.461 (95% confidence interval, 1.501 to 7.242)].Conclusion: The current analysis suggests that for patients undergoing elective on-pump cardiac surgery, only new pathological Q waves in V1 to V5 (anterior) in the 7th postoperative day ECG are associated with 12-month, all-cause mortality and/or MACE.Trial Registration: Clinicaltrials.gov identifier: NCT00468598. [ABSTRACT FROM AUTHOR]

Published
2017
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46. Adverse events of postoperative thoracic epidural analgesia: A retrospective analysis of 7273 cases in a tertiary care teaching hospital.

Author

von Hösslin, Thomas, Imboden, Paul, Lüthi, Andreas, Rozanski, Marta J., Schnider, Thomas W., and Filipovic, Miodrag

Subjects
POSTOPERATIVE pain prevention, ACADEMIC medical centers, LONGITUDINAL method, POSTOPERATIVE pain, SURGICAL complications, THORACIC vertebrae, SPECIALTY hospitals, RETROSPECTIVE studies, EPIDURAL analgesia, DIAGNOSIS
Abstract

Background: Thoracic epidural analgesia is a well established technique for postoperative pain relief after major abdominal and thoracic surgery. Safety remains a major concern because of serious adverse events including epidural haematoma, abscess and permanent neurological deficit.Objective: The aim of this study was to evaluate the incidence and the long-term outcome of serious adverse events associated with thoracic epidural analgesia.Design: Retrospective cohort study.Setting: The study was conducted at a single institution, a tertiary care teaching hospital. Data were collected over a 10-year period from 2003 until 2012.Patients: Data from 7430 patients were prospectively entered into a standardised acute pain service database. A total of 7273 study participants met the inclusion criteria and were included in the final analyses. The inclusion criteria involved surgical patients receiving a postoperative thoracic epidural analgesia catheter treatment for pain control. Exclusion criteria were defined as obstetric, non-surgical, non-epidural analgesia patients and epidural analgesia catheters that had not been placed by an anaesthesiologist.Main Outcome Measures: The database was queried for serious adverse events which were defined as spinal or epidural haemorrhage; spinal or epidural abscess; permanent neurological deficits; cardiac arrest; death and incomplete removal of the epidural analgesia catheter. Patients' charts were comprehensively reviewed in case of a major adverse event. Patients with an unclear outcome received a mailed questionnaire or were contacted by telephone to determine long-term sequelae.Results: Seven serious adverse events were identified: epidural abscess [n = 1; incidence 1 : 7273 (0.014%, 95% confidence interval, CI, 0 to 0.08%)], persistent neurological damage [n = 1; incidence 1 : 7273 (0.014%, 95% CI, 0 to 0.08%)], cardiac arrest [n = 1; incidence 1 : 7273 (0.014%, 95% CI, 0 to 0.08%)] and catheter breakage leaving a catheter fragment in situ [n = 4; incidence 1 : 1818 (0.055%, 95% CI, 0.01 to 0.14%)]. Apart from the one patient with persistent neurologic deficit, the patients with serious adverse events associated with thoracic epidural analgesia in our cohort suffered no long-term consequences.Conclusion: In our single-centre study of thoracic epidural analgesia, serious adverse events occurred in 0.1% cases (1 : 1000), whereas long-term outcome was compromised in 0.014% (1.4 : 10 000) which is similar to the serious adverse event rates and outcomes reported in the current literature. [ABSTRACT FROM AUTHOR]

Published
2016
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48. Reduced aspirin responsiveness as assessed by impedance aggregometry is not associated with adverse outcome after cardiac surgery in a small low-risk cohort.

Author

Bolliger, Daniel, Filipovic, Miodrag, Matt, Peter, Tanaka, Kenichi A., Gregor, Michael, Zenklusen, Urs, Seeberger, Manfred D., and Lurati Buse, Giovanna

Subjects
*ASPIRIN, *NONSTEROIDAL anti-inflammatory agents, *CARDIAC surgery, *UNCERTAINTY, *REASONING
Abstract

Reduced aspirin responsiveness (i.e. persistent high platelet reactivity in platelet function testing) might be associated with increased risk of myocardial ischemia and cardiac mortality in patients with coronary disease. However, the impact in patients undergoing coronary artery bypass grafting (CABG) is unclear. The aim of this prospective cohort study was to evaluate the predictive value of reduced aspirin responsiveness on cardiac and thromboembolic events in patients undergoing elective isolated CABG surgery with aspirin intake until at least two days before surgery. We included 304 patients in this prospective single-center cohort study. Impedance platelet aggregometry (Multiplate®) was performed directly before and on the first day after surgery. Reduced aspirin responsiveness was defined as area under the curve in ASPItest (AUCASPI) ≥300 U. The primary outcome was a composite of all-cause mortality and/or major adverse cardiac or thromboembolic events within 1 year. Reduced aspirin responsiveness was found in 13 and 24% of patients pre and postoperatively, respectively. There was no difference in the outcomes between patients with normal and reduced aspirin responsiveness in the preoperative measurement (log-rank test,p = 0.540). Multivariate analysis including logistic EuroSCORE I and postoperative troponin T levels did not show any association of reduced aspirin responsiveness with adverse outcome (hazard ratio, 0.576; (95% CI 0.128–2.585;p = 0.471). Similarly, postoperative reduced aspirin responsiveness was not associated with adverse events. To conclude, reduced aspirin responsiveness as evaluated by Multiplate® platelet function analyzer was not associated with increased incidence of major adverse cardiac and thromboembolic events and mortality after CABG surgery. [ABSTRACT FROM PUBLISHER]

Published
2016
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