32 results on '"MELO, NICOLAS"'
Search Results
2. Structural basis of antibacterial photodynamic action of curcumin against S. aureus
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Dias, Lucas D., Aguiar, Antônio S.N., de Melo, Nícolas J., Inada, Natalia M., Borges, Leonardo L., de Aquino, Gilberto L.B., Camargo, Ademir J., Bagnato, Vanderlei S., and Napolitano, Hamilton B.
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- 2023
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3. Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluation
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Melo, Nicolas Junhiti de, Tovar, Johan S.D., Dovigo, Lívia Nordi, Dias, Lucas D., Bagnato, Vanderlei Salvador, and Inada, Natalia Mayumi
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- 2023
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4. T follicular helper cells in cancer
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Gutiérrez-Melo, Nicolás and Baumjohann, Dirk
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- 2023
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5. Refusal of cervical spine immobilization after blunt trauma: Implications for initial evaluation and management: A retrospective cohort study
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Tatum, James M., Dhillon, Navpreet K., Ko, Ara, Smith, Eric J.T., Melo, Nicolas, Barmparas, Galinos, and Ley, Eric J.
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- 2017
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6. Prospective Trial of House Staff Time to Response and Intervention in a Surgical Intensive Care Unit: Pager vs. Smartphone
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Tatum, James M., White, Terris, Kang, Christopher, Ley, Eric J., Melo, Nicolas, Bloom, Matthew, and Alban, Rodrigo F.
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- 2017
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7. Assault in children admitted to trauma centers: Injury patterns and outcomes from a 5-year review of the national trauma data bank
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Barmparas, Galinos, Dhillon, Navpreet K., Smith, Eric J.T., Tatum, James M., Chung, Rex, Melo, Nicolas, Ley, Eric J., and Margulies, Daniel R.
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- 2017
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8. Work Hour Reduction: Still Room for Improvement
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Liou, Douglas Z., Barmparas, Galinos, Harada, Megan, Chung, Rex, Melo, Nicolas, Ley, Eric J., Salim, Ali, and Bukur, Marko
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- 2016
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9. Laparoscopy and Penetrating Trauma.
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Melo, Nicolas and Margulies, Daniel R.
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- 2017
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10. Validation of a field spinal motion restriction protocol in a level I trauma center.
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Tatum, James M., Melo, Nicolas, Ko, Ara, Dhillon, Navpreet K., Smith, Eric J.T., Yim, Dorothy A., Barmparas, Galinos, and Ley, Eric J.
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TRAUMA centers , *BLUNT trauma , *EMERGENCY medical services , *THERAPEUTICS , *SPINAL cord injuries , *MEDICAL statistics - Abstract
Background Spinal motion restriction (SMR) after traumatic injury has been a mainstay of prehospital trauma care for more than 3 decades. Recent guidelines recommend a selective approach with cervical spine clearance in the field when criteria are met. Materials and methods In January 2014, the Department of Health Services of the City of Los Angeles, California, implemented revised guidelines for cervical SMR after blunt mechanism trauma. Adult patients (aged ≥18 y) with an initial Glasgow Coma Scale (GCS) score of ≥13 presented to a single level I trauma center after blunt mechanism trauma over the following 1-y period were retrospectively reviewed. Demographics, injury data, and prehospital data were collected. Cervical spine injury (CSI) was identified by International Classification of Disease, Ninth Revision, codes. Results Emergency medical services transported 1111 patients to the emergency department who sustained blunt trauma. Patients were excluded if they refused c-collar placement or if documentation was incomplete. A total of 997 patients were included in our analysis with 172 (17.2%) who were selective cleared of SMR per protocol. The rate of Spinal Cord Injury was 2.2% (22/997) overall and 1.2% (2/172) in patients without SMR. The sensitivity and specificity of the protocol are 90.9% (95% confidence interval: 69.4-98.4) and 17.4% (95% confidence interval: 15.1-20.0), respectively, for CSI. Patients with CSI who arrived without immobilization having met field clearance guidelines, were managed without intervention, and had no neurologic compromise. Conclusions Guidelines for cervical SMR have high sensitivity and low specificity to identify CSI. When patients with injuries were not placed on motion restrictions, there were no negative clinical outcomes. [ABSTRACT FROM AUTHOR]
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- 2017
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11. Surgical Management of Appendicitis and Cholecystitis during Pregnancy: A National Analysis
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Ko, Ara, Do-Nguyen, Amy, Aquino, Lia, Harada, Megan, Melo, Nicolas, Margulies, Daniel R., and Alban, Rodrigo F.
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- 2016
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12. Early propranolol after traumatic brain injury is associated with lower mortality.
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Ko, Ara, Harada, Megan Y., Barmparas, Galinos, Thomsen, Gretchen M., Alban, Rodrigo F., Bloom, Matthew B., Chung, Rex, Melo, Nicolas, Margulies, Daniel R., and Ley, Eric J.
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- 2016
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13. Body mass index strongly impacts the diagnosis and incidence of heparin-induced thrombocytopenia in the surgical intensive care unit.
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Bloom, Matthew B., Zaw, Andrea A., Hoang, David M., Mason, Russell, Alban, Rodrigo F., Rex Chung, Melo, Nicolas, Volod, Oksana, Ley, Eric J., Margulies, Daniel R., and Chung, Rex
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- 2016
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14. Injuries sustained by bicyclists.
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Melo, Nicolas, Berg, Regan J, and Inaba, Kenji
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EPIDEMIOLOGY , *CYCLING accidents , *SAFETY hats , *WOUNDS & injuries , *PREVENTION - Abstract
Although generally a safe activity with considerable health benefit, the wide social prevalence of cycling, its performance by both young and elderly riders, and the increasing operation of bicycles in complex urban environments results in a significant incidence of trauma. Orthopedic injuries, followed by head and facial trauma, are most frequent but all anatomic regions can be affected and the spectrum of injury ranges from minor to severe and potentially fatal. Clinicians need to be aware of the range of injuries and causative mechanisms as many patients may present with relatively minor signs and symptoms despite significant underlying pathology. Non-commuter, recreational cyclists are also at risk for injury due to: variable terrain and environmental conditions; increased competitive and risk-taking behavior; technical equipment failure; and poor compliance with protective equipment. Numerous injury preventative strategies have been advocated including: increased rider training; creation of dedicated traffic lanes for commuting cyclists; bike-awareness education for motorists and interventions to improve cyclist visibility; increased utilization of protective equipment and programs to reduce concomitant drug or alcohol use. Of all preventative strategies, bicycle helmets have received the most study, leading to legislated use in some jurisdictions. As urban environments become more congested for commuter cyclists, and interest in recreational and competitive cycling grows, bicycle injury is likely to become more prevalent. [ABSTRACT FROM AUTHOR]
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- 2014
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15. Patterns of vasopressor utilization during the resuscitation of massively transfused trauma patients.
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Barmparas, Galinos, Dhillon, Navpreet K., Smith, Eric JT, Mason, Russell, Melo, Nicolas, Thomsen, Gretchen M., Margulies, Daniel R., and Ley, Eric J.
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WOUNDS & injuries , *VASOCONSTRICTORS , *RESUSCITATION , *BLOOD transfusion , *EXSANGUINATION , *PATIENTS - Abstract
Background: The use of vasopressors (VP) in the resuscitation of massively transfused trauma patients might be considered a marker of inadequate resuscitation. We sought to characterize the utilization of VP in patients receiving massive transfusion and examine the association of their use with mortality.Methods: Trauma patients admitted from January 2011 to October 2016 receiving massive transfusion, defined as 3 units of pRBC within the first hour from admission, were selected for analysis. Demographics, admission vital signs and labs, use of VP, surgical interventions and outcomes were collected. Standard statistical tools were utilized.Results: Over the 5-year study period, 120 trauma patients met inclusion criteria. The median age was 39 years with 77% being male and 41% sustaining a penetrating injury. Patients who received VP [VP (+)] were more likely to have a lower admission GCS (median 4.5 vs. 14.0, p <0.01) and less likely to have a penetrating injury (31% vs. 54%, p=0.02). The overall mortality was 49% and significantly higher in the VP (+) cohort (60% vs. 34%, AHR: 9.9, adjusted p=0.03). Mortality increased in a stepwise fashion with increasing number of VP utilized, starting at 34% for no VP, to 78% for 3 VP, and 100% for 5 or more. The majority of deaths in the VP (-) group (88%) occurred within one day from admission. For the VP (+) group, 57% of deaths occurred within one day, with the remaining 43% occurring at a later time.Conclusion: In the era of massive transfusion protocols, vasopressors are commonly utilized in exsanguinating trauma patients and their use is associated with a higher mortality risk. Deaths in patients receiving vasopressors are more likely to occur later compared to those in patients who do not receive vasopressors. Further research to characterize the role of these agents in the resuscitation of trauma patients is required. [ABSTRACT FROM AUTHOR]- Published
- 2018
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16. Direct Two-Minute Unassisted Breathing Evaluation (DTUBE) Is an Attractive Alternative to Longer Spontaneous Breathing Trials: A Prospective Observational Study.
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BLOOM, MATTHEW B., LU, JONATHAN, TRAN, TRI, BUKUR, MARKO, CHUNG, REX, LEY, ERIC J., MELO, NICOLAS, SALIM, ALI, and MARGULIES, DANIEL R.
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AIRWAY extubation , *BREATHING apparatus , *CLINICAL trials , *AXIAL ventilators , *SCIENTIFIC observation , *AIRWAY (Anatomy) , *APACHE (Disease classification system) , *INTENSIVE care units , *LONGITUDINAL method , *PROGNOSIS , *PULMONARY function tests , *RESPIRATORY insufficiency , *TRACHEA intubation , *TREATMENT effectiveness , *PREDICTIVE tests , *GLASGOW Coma Scale ,RESPIRATORY insufficiency treatment - Abstract
We sought to identify a simple bedside method to predict successful extubation outcomes that might be used during rounds. We hypothesized that a direct 2-minute unassisted breathing evaluation (DTUBE) could replace a longer spontaneous breathing trial (SBT). Data were prospectively collected on all patients endotracheally intubated for >48 hours nearing extubation in a tertiary center's mixed trauma/surgical intensive care unit from August 2012 to August 2013. The SBT was performed for at least 30 minutes at 40 per cent FiO2, PEEP 5, and PS 8. DTUBE was performed by physically disconnecting the intubated patient from the ventilator circuit for a 2-minute period of direct observation on room air. Successful extubation was defined freedom from ventilator for greater than 72 hours. Both SBT and DTUBE were performed 128 times, resulting in 90 extubations. The DTUBE correctly predicted success in 75/79 (94.9%) extubations versus 82/89 (92.1%) via SBT. No adverse effects were directly attributed to the DTUBE. The DTUBE is a rapid method of evaluating patients for extubation with prediction accuracy similar to the SBT. [ABSTRACT FROM AUTHOR]
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- 2017
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17. Pain Assessment and Control in the Injured Elderly.
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Ko, Ara, Harada, Megan Y, Smith, Eric J T, Scheipe, Michael, Alban, Rodrigo F, Melo, Nicolas, Margulies, Daniel R, and Ley, Eric J
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INJURY complications , *TRAUMATOLOGY diagnosis , *ANALGESICS , *PAIN management , *AGE distribution , *GERIATRIC assessment , *HOSPITAL emergency services , *PAIN , *RISK assessment , *PAIN measurement , *RETROSPECTIVE studies , *GLASGOW Coma Scale , *TRAUMA severity indices , *PAIN threshold - Abstract
Elderly trauma patients may be at increased risk for underassessment and inadequate pain control in the emergency department (ED). We sought to characterize risk factors for oligoanalgesia in the ED in elderly trauma patients and determine whether it impacts outcomes in elderly trauma patients. We included elderly patients (age ≥55 years) with Glasgow Coma Scale scores 13 to 15 and Injury Severity Score (ISS) ≥9 admitted through the ED at a Level I trauma center. Patient characteristics and outcomes were compared between those who reported pain and received analgesics medication in the ED (MED) and those who did not (NO MED). A total of 183 elderly trauma patients were identified over a three-year study period, of whom 63 per cent had pain assessed via verbal pain score; of those who reported pain, 73 per cent received analgesics in the ED. The MED and NO MED groups were similar in gender, race, ED vitals, ISS, and hospital length of stay. However, NO MED was older, with higher head Abbreviated Injury Scale score and longer intensive care unit length of stay. Importantly, as patients aged they reported lower pain and were less likely to receive analgesics at similar ISS. Risk factors for oligoanalgesia may include advanced age and head injury. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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18. Effect of Thoracentesis on Intubated Patients with Acute Lung Injury.
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BLOOM, MATTHEW B., SERNA-GALLEGOS, DEREK, AULT, MARK, KHAN, AHSAN, CHUNG, REX, LEY, ERIC J., MELO, NICOLAS, and MARGULIES, DANIEL R.
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CHEST paracentesis , *LUNG injuries , *INTUBATION , *ADULT respiratory distress syndrome , *RESPIRATORY insufficiency , *PATIENTS - Abstract
Pleural effusions occur frequently in mechanically ventilated patients, but no consensus exists regarding the clinical benefit of effusion drainage. We sought to determine the impact of thoracentesis on gas exchange in patients with differing severities of acute lung injury (ALI). A retrospective analysis was conducted on therapeutic thoracenteses performed on intubated patients in an adult surgical intensive care unit of a tertiary center. Effusions judged by ultrasound to be 400 mL or larger were drained. Subjects were divided into groups based on their initial P:F ratios: normal >300, ALI 200 to 300, and acute respiratory distress syndrome (ARDS) <200. Baseline characteristics, physiologic variables, arterial blood gases, and ventilator settings before and after the intervention were analyzed. The primary end point was the change in measures of oxygenation. Significant improvements in P:F ratios (mean ± SD) were seen only in patients with ARDS (50.4 ± 38.5, P = 0.001) and ALI (90.6 ± 161.7, P = 0.022). Statistically significant improvement was observed in the pO2 (31.1, P = 0.005) and O2 saturation (4.1, P < 0.001) of the ARDS group. The volume of effusion removed did not correlate with changes in individual patient's oxygenation. These data support the role of therapeutic thoracentesis for intubated patients with abnormal P:F ratios. [ABSTRACT FROM AUTHOR]
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- 2016
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19. Activation of Massive Transfusion for Elderly Trauma Patients.
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MURRY, JASON S., ZAW, ANDREA A., HOANG, DAVID M., MEHRZADI, DEVORAH, TRAN, DANIELLE, NUNO, MIRIAM, BLOOM, MATTHEW, MELO, NICOLAS, MARGULIES, DANIEL R., and LEY, ERIC J.
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HEMORRHAGIC shock treatment , *TRAUMATOLOGY diagnosis , *WOUND care , *BLOOD transfusion , *COMPARATIVE studies , *HEMORRHAGIC shock , *LENGTH of stay in hospitals , *INTENSIVE care units , *LONGITUDINAL method , *MULTIVARIATE analysis , *PROBABILITY theory , *PROGNOSIS , *TRAUMA centers , *WOUNDS & injuries , *LOGISTIC regression analysis , *RETROSPECTIVE studies , *DESCRIPTIVE statistics , *HOSPITAL mortality , *GLASGOW Coma Scale , *TRAUMA severity indices , *DIAGNOSIS - Abstract
Massive transfusion protocol (MTP) is used to resuscitate patients in hemorrhagic shock. Our goal was to review MTP use in the elderly. All trauma patients who required activation of MTP at an urban Level I trauma center from January 1, 2011 to December 31, 2013 were reviewed retrospectively. Elderly was defined as age ≥ 60 years. Sixty-six patients had MTP activated: 52 nonelderly (NE) and 14 elderly (E). There were no statistically significant differences between the two cohorts for gender, injury severity score, head abbreviated injury scale, emergency department Glasgow Coma Scale, initial hematocrit, intensive care unit length of stay, or hospital length of stay. Mean age for NE was 35 years and 73 years for E (P < 0.01). Less than half (43%) of E patients with activation of MTP received 10 or more units of blood products compared with 69 per cent of the NE (P = 0.07). Mortality rates were similar in the NE and the E (53%vs 50%, P = 0.80). After multivariate analysis with Glasgow Coma Scale, injury severity score, and blunt versus penetrating trauma, elderly age was not a predictor of mortality after MTP (P = 0.35). When MTP is activated, survival to discharge in elderly trauma patients is comparable to younger patients. [ABSTRACT FROM AUTHOR]
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- 2015
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20. Epidural Analgesia after Rib Fractures.
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ZAW, ANDREA A., MURRY, JASON, HOANG, DAVID, CHEN, KEVIN, LOUY, CHARLES, BLOOM, MATTHEW B., MELO, NICOLAS, ALBAN, RODRIGO F., MARGULIES, DANIEL R., and LEY, ERIC J.
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PAIN management , *COMPARATIVE studies , *BLUNT trauma , *CONFIDENCE intervals , *LENGTH of stay in hospitals , *LONGITUDINAL method , *MULTIVARIATE analysis , *PROBABILITY theory , *WOUNDS & injuries , *LOGISTIC regression analysis , *RETROSPECTIVE studies , *DATA analysis software , *DESCRIPTIVE statistics , *EPIDURAL analgesia , *TRAUMA registries , *TRAUMA severity indices , *ODDS ratio , *RIB fractures , *DISEASE complications , *DIAGNOSIS , *THERAPEUTICS - Abstract
Pain associated with rib fractures impairs respiratory function and increases pulmonary morbidity. The purpose of this study was to determine how epidural catheters alter mortality and complications in trauma patients. We performed a retrospective study involving adult blunt trauma patients with moderate-to-severe injuries from January 1, 2004 to December 31, 2013. During the 10-year period, 526 patients met the inclusion criteria; 43/526 (8%) patients had a catheter placed. Mean age of patients with epidural catheter (CATH) was higher compared with patients without epidural catheter (NOCATH) (54 vs 48 years, P = 0.021), Injury Severity Score was similar (26 CATH vs 27 NOCATH, P = 0.84), and CATH had higher mean rib fractures (7.4 vs 4.1, P < 0.001). Mortality was lower in CATH (0% vs 13%, P = 0.006). Deep vein thrombosis (DVT) rate was higher in CATH (12% vs. 5%, P = 0.036). After regression analysis, we found catheter placement to be a predictor for DVT (adjusted odds ratios 2.80, P = 0.036). Our center noted increased use of epidural catheters in patients who present with moderate-to-severe injuries. Patients with catheters were older and had a mean of 7.4 ribs fractured. The epidural cohort had longer hospital LOS and decreased mortality. In contrast to other studies, DVT rates were increased in patients who received epidural catheters. [ABSTRACT FROM AUTHOR]
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- 2015
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21. Impact of body mass index on injury in abdominal stab wounds: implications for management.
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Bloom, Matthew B., Ley, Eric J., Liou, Douglas Z., Tran, Tri, Chung, Rex, Melo, Nicolas, and Margulies, Daniel R.
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STAB wounds , *BODY mass index , *OVERWEIGHT persons , *TRAUMA centers , *DEMOGRAPHIC surveys , *CHEST injuries , *PHYSIOLOGY - Abstract
Background Although it is assumed that obese patients are naturally protected against anterior abdominal stab wounds, the relationship has never been formally studied. We sought to examine the impact of body mass index (BMI) on severity of sustained injury, need for operation, and patient outcomes. Materials and methods We conducted a review of all patients presenting with abdominal stab wounds at an urban level I trauma center from January 2000-December 2012. Patients were divided into groups based on their BMI (<18.5, 18.5-29.9, 30-35, and >35). Data abstracted included baseline demographics, physiologic data, and characterization of whether the stab wound had violated the peritoneum, caused intra-abdominal injury, or required an operation that was therapeutic. The one-sided Cochran-Armitage trend test was used for significance testing of the protective effect. Results Of 281 patients with abdominal stab wounds, 249 had complete data for evaluation. Chest and abdomen abbreviated injury scale trends decreased with increasing BMI, as did overall injury severity score, the percent of patients severely injured (injury severity score ≥25), and length of intensive care unit stay. Rates of peritoneal violation (100%, 84%, 77%, and 74%; P = 0.077), visceral injury (83%, 56%, 50%, and 30%; P = 0.022), and injury requiring a therapeutic operation (67%, 45%, 40%, and 20%; P = 0.034) all decreased with increasing BMI. Patients in the thinnest group required an operation three times more often than those in the most obese. Conclusions Increased BMI protects patients with abdominal stab wounds and is associated with lower incidence of severe injury and need for operation. Heavier patients may be more suitable to observation and serial examinations, whereas very thin patients are more likely to require an operation and be critically injured. [ABSTRACT FROM AUTHOR]
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- 2015
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22. Rhabdomyolysis in Obese Trauma Patients.
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CHAN, JOSHUA L., IMAI, TARYNE, BARMPARAS, GALINOS, LEE, JONATHAN B., LAMB, ALEX W., MELO, NICOLAS, MARGULIES, DANIEL, and LEY, ERIC J.
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OBESITY , *RHABDOMYOLYSIS , *WOUNDS & injuries , *SURGICAL intensive care , *CREATINE kinase , *BODY mass index , *PATIENTS - Abstract
Patients sustaining traumatic injuries are at risk for development of rhabdomyolysis. The effect of obesity on this risk is unknown. This study attempted to characterize the role of obesity in the development of rhabdomyolysis after trauma. This was a retrospective review of all trauma patients with creatine kinase (CK) levels admitted to the surgical intensive care unit (SICU) at a Level I trauma center from February 2011 until July 2013. Patients were divided based on their body mass index (BMI): overweight/obese group with BMI25 kg/m² or greater and nonoverweight/obese group with BMI less than 25 kg/m². Primary outcome was CK greater than 10,000 U/L. During the 30-month study period, 198 trauma patients with available CK levels were admitted to the SICU. The majority (27.8%) of patients were involved in a motor vehicle collision. There were 96 patients (48.4%) with BMI 25 kg/m² or greater and 102 (51.5%) with BMI less than 25 kg/m². There was no difference in creatinine levels between the two groups (1.5 ± 1.2 mg/dL vs 1.5 ± 1.4 mg/dL, P = 0.83). BMI 25 kg/m² or greater was independently associated with the development of CK greater than 10,000 U/L (14.6 vs 4.9%; adjusted odds ratio, 3.03; P = 0.04). Patients with BMI 25 kg/m² or greater are at a significantly higher risk for rhabdomyolysis after trauma. Aggressive CK level monitoring to prevent rhabdomyolysis in this population is strongly encouraged. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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23. Aspirin Increases the Risk of Venous Thromboembolism in Surgical Patients.
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BARMPARAS, GALINOS, JAIN, MONICA, MEHRZADI, DEVORAH, MELO, NICOLAS, CHUNG, REX, BLOOM, MATTHEW, LEY, ERIC J., and MARGULIES, DANIEL R.
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THROMBOEMBOLISM , *PLATELET aggregation inhibitors , *DRUG side effects , *HOSPITAL patients , *SURGICAL intensive care , *LOGISTIC regression analysis - Abstract
The risk of venous thromboembolism (VTE) for patients taking an antiplatelet agent is largely unknown. This study aimed to investigate the association between antiplatelet agent use before admission with the risk of in-hospital VTE in surgical intensive care unit (ICU) patients. A retrospective review of all patients admitted to the surgical ICU at a Level I trauma center over 30 months was performed. Patients who underwent diagnostic imaging for VTE were selected. Patients were divided based on whether or not antiplatelet agents were used before admission (APTA vs NAPTA). The primary outcome was VTE occurrence. A forward logistic regression model was used to identify factors independently associated with the primary outcome. During the study period, 461 (24%) patients met inclusion criteria: 70 (15%) APTA and 391 (85%) NAPTA. After adjusting for confounding factors, APTA patients were at a significantly higher risk for developing VTE (59 vs 40%; adjusted odds ratio, 1.8; 95% confidence interval, 1.0 to 3.0; adjusted P = 0.04). Whether or not antiplatelet agents were resumed during the hospital stay and the day on which they were resumed did not affect VTE risk. In conclusion, surgical ICU patients receiving antiplatelet agents before admission are at a significantly higher risk for development of VTE. [ABSTRACT FROM AUTHOR]
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- 2014
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24. Polysubstance-Induced Self-Enucleation after Motor Vehicle Collision.
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Tatum, James M., Barmparas, Galinos, Choi, Mark, Ley, Eric J., and Melo, Nicolas
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GLASGOW Coma Scale , *PATHOLOGICAL psychology , *CARE of people , *PEOPLE with mental illness , *MOTOR vehicles , *CELL enucleation - Abstract
The case study of a 25-year-old man found with patient ambulating and disoriented with a Glasgow Coma Scale of 12 and multiple lacerations. Physical examination revealed filling of left orbital vault with edematous tissue and active bleeding, psychiatric disorders and autoenucleation, and neurosurgical clearance for surgery.
- Published
- 2017
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25. Incorporating Robotic Cholecystectomy in an Acute Care Surgery Practice Model is Feasible.
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Shen A, Barmparas G, Melo N, Chung R, Burch M, Bhatti U, Margulies DR, and Wang A
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Introduction: The role of robotic surgery in the nonelective setting remains poorly defined. Accessibility, patient acuity, and high turn-over may limit its applicability and utilization. The goal is to characterize the role of robotic cholecystectomy (CCY) in a busy acute care surgery (ACS) practice at a quaternary medical center, and compare surgical outcomes and resource utilization between robotic and laparoscopic CCY., Methods: Adult patients who underwent robotic (Da Vinci Xi) or laparoscopic CCY between 01/2021-12/2022 by an ACS attending within 1 week of admission were included. Primary outcomes included time from admission to surgery, off hour (weekend and 6p-6a) cases, operation time, and hospital costs, to reflect "feasibility" of robotic compared to laparoscopic CCY. Secondary outcomes encompassed surgery-related outcomes and complications., Results: The proportion of robotic CCY increased from 5% to 32% within 2 years. In total 361 laparoscopic and 89 robotic CCY were performed. Demographics and gallbladder disease severity were similar. Feasibility measures-operation time, case start time, time from admission to surgery, proportion of off-hour cases, and cost-were comparable between robotic and laparoscopic CCY. There were no differences in surgical complications, common bile duct injury, readmission, or mortality. Conversion to open surgery occurred more often in laparoscopic cases (5% vs 0%, P = .02, OR = 1.05)., Discussion: Robotic CCY is associated with fewer open conversions and otherwise similar outcomes compared to laparoscopic CCY in the non-elective setting. Incorporation of robotic CCY in a busy ACS practice model is feasible with available resources., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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26. Don't Let the Sun Rise on Small Bowel Obstruction Without Surgical Consultation-Redefining Nonoperative Management Pathways.
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Bhatti UF, Shen AS, Melo N, Barmparas G, Wang AS, Margulies DR, and Alban RF
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Introduction: Small bowel obstruction (SBO) is a common cause of hospital admission leading to resource utilization. The majority of these patients require non-operative management (NOM) which can lead to increased length of stay (LOS), readmissions, resource utilization, and throughput delays. Early surgical consultation (SC) for SBO may improve efficiency and outcomes. Methods: We implemented an institution-wide intervention (INT) to encourage early SC (<1 day of diagnosis) for SBO patients in July 2022. A retrospective analysis was performed on all patients with SBO requiring NOM from January 2021 to June 2023, categorized into pre- and post-INT groups. The primary outcome was the number of SC's and secondary outcomes were early SC (<1 day of diagnosis), utilization of SBFT, LOS, 30-day readmission, and costs of admission. Results: A total of 670 patients were included, 438 in the pre-INT and 232 in the post-INT group. Overall, SBFT utilization was significantly higher in cases with SC (17.2% vs 41.4%, P < .001). Post-INT patients were more likely to receive SC (94.0% vs 83.3%, P < .001) and increased SBFT utilization (47.0% vs 33.6%, P = .001). Additionally, early SC improved significantly in the post-INT group (74.3% vs 65.7%, P = .03). There was no difference in LOS between groups (4.0 vs 3.8 days, P = .48). There was a trend toward decreased readmission rates in the INT group at 30 days (7.3% vs 11.0%, P = .13) and reduced direct costs in the INT group (US$/admission = 8467 vs 8708, P = .1). Conclusion: Hospital-wide interventions to increase early surgical involvement proved effective by improving early SC, increased SBFT utilization, and showed a trend towards decreased readmission rates and direct costs., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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27. Vasopressors in traumatic brain injury: Quantifying their effect on mortality.
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Dhillon NK, Huang R, Mason R, Melo N, Margulies DR, Ley EJ, and Barmparas G
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- Adult, Aged, Aged, 80 and over, Female, Hospital Mortality, Humans, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Brain Injuries, Traumatic drug therapy, Brain Injuries, Traumatic mortality, Vasoconstrictor Agents therapeutic use
- Abstract
Background: The benefits of vasopressor (VP) use to improve clinical outcomes in traumatic brain injury (TBI) is unknown. We sought to characterize the use of VP in TBI patients and evaluate its impact on mortality., Methods: A retrospective review was conducted of all TBI patients admitted to an ICU at a Level I trauma center from January 2014 to August 2016. Patients who had any VP administered (VP+) were compared to those who did not (VP-)., Results: Among the 556 patients analyzed, 83 (14.9%) received VP. The overall mortality was 9.2%, significantly higher in the VP + cohort (42.2% vs. 3.4%, p < 0.01). After adjusting for confounding factors, VP + patients had a significantly higher risk for in-hospital mortality (Adjusted Hazard Ratio: 2.77, adjusted p = 0.01)., Conclusion: Although VP may be temporarily useful in avoiding secondary insult to the brain in TBI patients, their use is not associated with improved survival., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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28. Unexpected complicated appendicitis in the elderly diagnosed with acute appendicitis.
- Author
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Dhillon NK, Barmparas G, Lin TL, Alban RF, Melo N, Yang AR, Margulies DR, and Ley EJ
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- Acute Disease, Adult, Age Factors, Aged, Appendectomy, Appendicitis pathology, Conservative Treatment, Female, Humans, Length of Stay statistics & numerical data, Middle Aged, Prevalence, Retrospective Studies, Appendicitis complications, Appendicitis surgery
- Abstract
Background: This study determined the prevalence of complicated appendicitis in elderly patients diagnosed preoperatively with uncomplicated appendicitis., Methods: Patients with a preoperative diagnosis of uncomplicated appendicitis at an academic hospital from 11/2013 to 05/2017 were reviewed. Patients ≥65 years were compared to those younger. Pathology reports were categorized as either uncomplicated or complicated (COMP). The primary outcome was the prevalence of COMP appendicitis., Results: The prevalence of COMP appendicitis increased with age after 20 years with an abrupt increase after 65 years. Patients ≥65 years were more likely to have COMP appendicitis (48.1% vs. 15.5%; OR: 5.1; p < 0.01) and prolonged stays (3.8 vs. 2.3 days; p < 0.01)., Conclusion: Nearly half of elderly patients had pathologic confirmation of complicated appendicitis despite no preoperative clinical or radiographic suspicion for complicated appendicitis. Nonoperative management of acute appendicitis in the elderly may not be appropriate due to the high rate of unexpected complicated appendicitis., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2019
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29. New cars on the highways: Trends in injuries and outcomes following ejection.
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Manguso N, Barmparas G, Dhillon NK, Ley EJ, Huang R, Melo N, Alban RF, and Margulies DR
- Abstract
Background: Although ejections from motor vehicles are considered a marker of a significant mechanism and a predictor of severe injuries and mortality, scant recent data exist to validate these outcomes. This study investigates whether ejections increase the mortality risk following a motor vehicle crash using data that reflect the introduction of new vehicles to the streets of a large city in the United States., Methods: The Trauma and Emergency Medicine Information System of Los Angeles County was queried for patients ≥ 16 years old admitted following a motor vehicle crash between 2002 and 2012. Ejected patients were compared to nonejected. Primary outcome was mortality. A logistic regression model was used to identify predictors of mortality and severe trauma., Results: A total of 9,742 (6.8%) met inclusion criteria. Of these, 449 (4.6%) were ejected; 368 (82.0%) were passengers and 81 (18.0%) were drivers. The rate of ejection decreased linearly (6.1% in 2002 to 3.4% in 2012). Compared to nonejected patients, ejected patients were more likely to require intensive care unit admission (43.7% vs 22.1%, P < .01), have critical injuries (Injury Severity Score > 25) (24.2% vs 7.3%, P <.01), require emergent surgery (16.3% vs 8.0%, P <.01), and expire in the emergency department (3.6% vs 1.2%, P <.01). Overall mortality was 3.6%: 9.6% for ejected and 3.3% for nonejected patients ( P <.01). In a logistic regression model, ejection and extrication both predicted mortality (adjusted odds ratio: 1.83, P <.01 and 1.87, P <.01, respectively). Ejection also predicted critical injuries (Injury Severity Score > 25) with adjusted odds ratio of 2.48 ( P <.01)., Conclusion: Ejections following motor vehicle crash have decreased throughout the years; however, they remain a marker of critical injuries and predictive of mortality., (© 2019 The Authors.)
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- 2019
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30. Imaging utilization affects negative appendectomy rates in appendicitis: An ACS-NSQIP study.
- Author
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Tseng J, Cohen T, Melo N, and Alban RF
- Subjects
- Adult, Aged, Appendicitis surgery, Databases, Factual, Diagnostic Errors prevention & control, Female, Humans, Logistic Models, Magnetic Resonance Imaging statistics & numerical data, Male, Middle Aged, Multivariate Analysis, Tomography, X-Ray Computed statistics & numerical data, Ultrasonography statistics & numerical data, United States, Appendectomy statistics & numerical data, Appendicitis diagnostic imaging, Diagnostic Errors statistics & numerical data, Practice Patterns, Physicians' statistics & numerical data, Procedures and Techniques Utilization statistics & numerical data, Unnecessary Procedures statistics & numerical data
- Abstract
Background: Negative appendectomy rates (NAR) historically ranged from 15 to 25%, but have decreased recently., Methods: Using the 2016 ACS-NSQIP database, we identified patients who underwent appendectomies for appendicitis. Patients with and without appendicitis on pathology were compared. Multivariate analysis was used to identify predictors of negative appendectomies., Results: 11,841 patients underwent appendectomies, with a NAR of 4.5%. Utilization rates of US, CT and MRI were 14.9%, 86.1%, and 1.1%. NAR's of US, CT, and MRI were 9.7%, 2.5%, and 7.1%, and 19.2% for patients without imaging. An ultrasound consistent with appendicitis has a NAR of 4.8%; adding a CT decreases it to 0.6%. Predictors of NA include females, smoking, no imaging, and ultrasounds. Factors with lower odds of NA include leukocytosis, sepsis, and CTs., Conclusions: The NAR in the 2016 ACS-NSQIP population is 4.5%. CTs are the most frequently used imaging modality and have the lowest NAR. Obtaining a CT in addition to an ultrasound is associated with lower NAR. This should be further explored with a cost-benefit analysis between multiple imaging studies versus negative appendectomies., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2019
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31. Surgical outcomes and failure-to-rescue events after colectomy in teaching hospitals: a nationwide analysis.
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Ko A, Aquino L, Melo N, and Alban RF
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- Adult, Aged, Databases, Factual, Female, Hospitalization statistics & numerical data, Humans, Male, Middle Aged, Retrospective Studies, United States, Colectomy adverse effects, Colectomy mortality, Failure to Rescue, Health Care statistics & numerical data, Hospitals, Teaching, Postoperative Complications mortality
- Abstract
Background: The relationship between failure-to-rescue (FTR) after colectomy is not well understood, particularly in teaching institutions. We sought to examine this relationship using a large national database., Methods: Patients undergoing colectomy from 2010 to 2012 were identified in the Nationwide Inpatient Sample database. FTR events were defined as deaths following deep vein thrombosis or pulmonary embolism, sepsis, gastrointestinal bleed, acute myocardial infarction, acute kidney injury, pneumonia, respiratory failure, shock. We compared outcomes between teaching hospitals (TH) and nonteaching hospitals (NTH)., Results: A total of 220,369 patients underwent colectomy; 50.2% were performed at TH. Overall mortality was 3.7% with 96% of deaths attributed to at least one FTR event. More complications occurred in NTH, but there was no difference in mortality or FTR rates. However, TH had higher incidences of deep vein thrombosis or pulmonary embolism and sepsis leading to postoperative mortality, whereas NTH had higher rates of acute myocardial infarction and gastrointestinal bleed., Conclusions: A substantial proportion of mortality is attributed to FTR events after colectomy in both TH and NTH. Further investigation targeting specific complications is warranted., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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32. Needs assessment for a focused radiology curriculum in surgical residency: a multicenter study.
- Author
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Butler KL, Chang Y, DeMoya M, Feinstein A, Ferrada P, Maduekwe U, Maung AA, Melo N, Odom S, Olasky J, Reinhorn M, Smink DB, Stassen N, Wilson CT, Fagenholz P, Kaafarani H, King D, Yeh DD, Velmahos G, and Stefanidis D
- Subjects
- Attitude of Health Personnel, Clinical Competence, Cross-Sectional Studies, Faculty, Medical, Humans, Needs Assessment, Students, Medical, Surveys and Questionnaires, United States, Curriculum, General Surgery education, Internship and Residency methods, Radiology education
- Abstract
Background: Patient instability and limited radiology staffing may compel surgeons to make clinical decisions based on their independent interpretations of imaging studies. Despite potential implications for patients, no research to date has assessed the need for a diagnostic radiology curriculum in general surgery residency., Methods: We performed a cross-sectional study of surgery faculty and residents at 13 teaching hospitals across the United States. Survey responses were summarized using frequency and percentage, and analyzed by chi-square, Mantel-Haenszel chi-square, and McNemar tests., Results: Surveys were distributed to 465 faculty and 520 residents, with response rates of 26% and 30%, respectively. Most respondents reported making decisions based on their independent imaging interpretation at least sometimes, with higher frequency in acute scenarios. The majority voiced a need for a dedicated radiology curriculum, with teaching in chest x-rays, abdominal x-rays, abdominal computed tomography, chest computed tomography, and focused assessment with sonography in trauma examinations., Conclusions: Surgeons and surgical residents enact treatment plans based on their independent interpretation of imaging studies, especially during acute patient scenarios. Further curricular development efforts are warranted to ensure trainee accuracy in radiologic interpretation., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
- Full Text
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