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The emergence of algal biorefineries has garnered considerable attention to researchers owing to their potential to ensure carbon neutrality via mitigation of atmospheric greenhouse gases. Algae-derived biofuels, characterized by their carbon-neutral nature, stand poised to play a pivotal role in advancing sustainable development initiatives aimed at enhancing environmental and societal well-being. In this context, algae-based wastewater treatment systems are greatly appreciated for their efficacy in nutrient removal and simultaneous bioenergy generation. These systems leverage the growth of algae species on wastewater nutrients—including carbon, nitrogen, and phosphorus—alongside carbon dioxide, thus facilitating a multifaceted approach to pollution remediation. This review seeks to delve into the realization of carbon neutrality through algae-mediated wastewater treatment approaches. Through a comprehensive analysis, this review scrutinizes the trajectory of algae-based wastewater treatment via bibliometric analysis. It subsequently examines the case studies and empirical insights pertaining to algae cultivation, treatment performance analysis, cost and life cycle analyses, and the implementation of optimization methodologies rooted in artificial intelligence and machine learning algorithms for algae-based wastewater treatment systems. By synthesizing these diverse perspectives, this study aims to offer valuable insights for the development of future engineering applications predicated on an in-depth understanding of carbon neutrality within the framework of circular economy paradigms. • Utilization of algae in wastewater treatment helps in acheiving carbon neutrality. • Research trend of algal wastewater treatment is analyzed via bibliometric analysis. • Chlorella vulgaris is the most investigated species in wastewater treatment system. • Binary culture approach has shown significant benefits over conventional systems. • AI and ML integration in algal system has potential benefits in carbon neutrality. [ABSTRACT FROM AUTHOR]

In the present work, a pigment paste was prepared by adding strontium titanate (SrTiO 3) nanoparticles (NPs) particles to a water and adhesive binder paste. Screen printing was utilized to embed the cotton fabric with the prepared pigment paste. Sonocatalytic induced antibacterial and dye mineralization abilities were evaluated for the printed fabric. The produced samples were examined for efficacy against the pathogens E. coli and S. aureus. The prepared SrTiO 3 embedded cotton fabric inhibited (after 2 h) E. coli and S. aureus by 99.3% and 96.09%, respectively. The coated fabric was able to reduce pathogens by more than 92% even after 15 washing cycles. The Rhodamine B (RhB) dye was mineralized by 53% in 210 min by STO printed fabric as opposed to about 8% by pristine cotton. The results revealed that the intrinsic properties of cotton including tensile, abrasion, and air permeability remained unaffected by the printing of STO-NPs onto fabric. • SrTiO3 nanoparticles were embedded on cotton fabric by employing screen printing. • Coated fabric sonocatalytic dye degradation and antibacterial performance were evaluated. • After a 2 h bacterial contact period, the modified fabric reduced E. coli and S. aureus by 99.3% and 96.09%, respectively. • The coated fabric degraded RhB dye by 53% in 210 min as opposed to about 8% by pristine cotton. [ABSTRACT FROM AUTHOR]

[Display omitted] • Summative view of tail-approach based selective as well as potent hCA IX and XII inhibitors reported in the last decade. • Listing of the most promising molecules in terms of selectivity and potency from the available 181 research papers. • One stop solution to tailor the tail-approach based rational design of novel libraries of carbonic anhydrase inhibitors. Human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII are well established anticancer drug targets and their selective inhibition is highly desired for the proper treatment of cancer. Lack of isoform-selectivity in current clinically used CA inhibitors (CAIs) is a major concern as it leads to undesired side effects, associated with off-target inhibition. Thus, there is need to explore alternative approaches for the design of isoform-selective inhibitors and the leading promising approach for the design of isoform-selective CAIs is "the tail-approach". Virtually, most drug design studies in the last decade were done by considering the tail-approach reported in 1999. The past decade of 2010–2020 witnessed progressive maturation of this approach as a large number of CAIs have been designed and synthesised based on it, many of which turned out to be effective as well as selective hCA IX and hCA XII inhibitors. This review covers the past decade (2010–2020) research, considering selective as well as potent inhibitors of tumor associated isoforms, hCA IX and hCA XII, which include newer generation inhibitors containing sulfonamides or their bioisosteres, non-classical inhibitors (including carboxylic acid/ester, coumarin and sulfocoumarin classes) and various other novel classes of inhibitors belonging to newly identified chemotypes/scaffolds. [ABSTRACT FROM AUTHOR]

The present study was undertaken to characterize the distinct immune response in indigenous Ghurrah and exotic Landrace pigs by challenging monocyte-derived macrophages (MDMs) with CSF virus under in-vitro conditions and assessing the variations in the transcriptome profile at 48 h post-infection (hpi). RNA-sequencing was carried out in infected and non-infected MDMs of Ghurrah (n = 3) and Landrace (n = 3) piglets prior- as well as post-stimulation. MDMs of Ghurrah showed greater immune regulation in response to CSF infection with 518 significantly differentially expressed genes (DEG) in infected versus non-infected MDMs, as compared to only 31 DEGs in Landrace MDMs. In Landrace, the principal regulators of inflammation (IL1α , IL1β and TNF) were upregulated in infected cells while in Ghurrah, these were downregulated. Overall, macrophages from indigenous Ghurrah showed more immunological dysregulation in response to virulent CSF virus infection as compared to the exotic Landrace pigs. • The present study aimed to characterize the distinct immune response in indigenous Ghurrah and exotic Landrace pigs against CSF vaccination. • Monocyte-derived macrophages (MDMs) were stimulated with CSF virus under in-vitro conditions. • The variations in the transcriptome profile via RNA-Seq approach were assessed in stimulated cells at 48 h post-infection. • MDMs of Ghurrah showed greater immune regulation in response to CSF infection with 518 significantly differentially expressed genes in infected versus non-infected MDMs, as compared to only 31 DEGs in Landrace MDMs. • In Landrace, the principal regulators of inflammation (IL1α, IL1β and TNF) were upregulated in infected cells while in Ghurrah, these were downregulated. • Macrophages from indigenous Ghurrah showed more immunological dysregulation in response to virulent CSF virus infection as compared to the exotic Landrace pigs. [ABSTRACT FROM AUTHOR]

[Display omitted] • Tail-approach based design, synthesis and characterization of a library of twenty-two arylthiazolylhydrazono-1,2,3-triazoles incorporating sulfanilamide and metanilamide moieties are disclosed. • All newly synthesized compounds were screened in vitro for their inhibition efficacy against hCA I, II, IV and IX isoforms. • Some compounds showed either comparable or better inhibition potential than clinically used reference drug AAZ against the targeted isoforms. • In broader sense, sulfanilamide analogues (4a - 4 k) were found to be better inhibitors of cytosolic hCA I and II isoforms than metanilamide analogues (5a - 5 k), whereas exactly opposite trend was observed in case of inhibition of membrane bound hCA IV and tumor associated transmembrane hCA IX. A library of twenty-two arylthiazolylhydrazono-1,2,3-triazoles incorporating sulfanilamide and metanilamide moieties have been synthesized by utilizing tail-approach and characterized by their IR, 1H NMR, 13C NMR, HRMS and single crystal studies. Further, these newly synthesized compounds were screened in-vitro for their inhibition efficacy against physiologically relevant hCA I, II, IV and IX isoforms. Inhibition data revealed that, in broader sense, sulfanilamide analogues (4a - 4 k) were comparatively better inhibitors of cytosolic hCA I and II isoforms than metanilamide analogues (5a - 5 k), whereas exactly opposite trend was observed in case of inhibition of membrane bound hCA IV and transmembrane hCA IX. For hCA I, more than half of the synthesized compounds were found to be moderate inhibitors and three compounds 4b , 5b and 5e (K i of 40.6, 224.7 and 74.4 nM, respectively) appeared as better inhibitors than reference drug AAZ (K i = 250 nM). hCA II was potently inhibited by 4e - 4 g and 5e with K i of 18.1, 14.1, 14.9 and 17.8 nM, respectively. Interestingly, 4e - 4 g selectively inhibited hCA II with selectivity of > 15-fold over hCA I, IV and IX isoforms. All the compounds presented moderate to weak inhibition profiles against glaucoma associated hCA IV with K i of 88 nM-8.87 μM and except 4f , 5 k , significant inhibition profiles against tumor associated hCA IX isoform with K i spanning in range of 0.113 μM-0.318 μM. Moreover, 5e was the only compound among the whole series which effectively inhibited all the tested isoforms. [ABSTRACT FROM AUTHOR]

The pulp and paper industry consumes a huge amount of water and releases more polluted and colored wastewater every year. Many conventional techniques are used in the treatment of paper industry wastewater. However, for color removal from paper mill effluent, there is no proven method so far, on an industrial scale. Due to high energy input and high cost, there is an urgent need to find out a new technique that must be sustainable, economical, and environment friendly. Various methods have been investigated on bench scale and pilot scale also but no proven method for color removal on an industrial scale. The paper provides an overview of the color removal techniques from different sources of pulp and paper mill wastewater discharged by various industries. The review described various components involved in various processes for color removal from paper mill waste water. The present works focus on processes like chemical, chemical/physical, biological, physicochemical, and electrochemical applied in color removal from paper mill wastewater. The present review gives key information on the effectiveness, use, betterment, and limitations of numerous methods of treatment targeted at color removal from paper mill wastewater using various techniques still under evolution. • A critical study made on color removal from paper mill effluent using various methods. • Examined color removal efficiencies using conventional and advanced techniques. • Study on Cost analysis in color removal from paper mill effluent. • Future research suggestions described for better implementation of the processes. [ABSTRACT FROM AUTHOR]

Anthropogenic influences significantly modify the hydrochemical properties and material flow in riverine ecosystems across Asia, potentially accounting for 40–50% of global emissions. Despite the pervasive impact on Asian rivers, there is a paucity of studies investigating their correlation with carbon dioxide (CO 2) emissions. In this study, we computed the partial pressure of CO 2 (pCO 2) using the carbonate equilibria-based model (pCO 2 SYS) and examined its correlation with hydrochemical parameters from historical records at 91 stations spanning 2013–2021 in the Ganga River. The investigation unveiled substantial spatial heterogeneity in the pCO 2 across the Ganga River. The pCO 2 concentration varied from 1321.76 μatm, 1130.98 μatm, and 1174.33 μatm in the upper, middle, and lower stretch, respectively, with a mean of 1185.29 μatm. Interestingly, the upper stretch exhibited elevated mean pCO 2 and FCO 2 levels (fugacity of CO 2 : 3.63 gm2d−1) compared to the middle and lower stretch, underscoring the intricate interplay between hydrochemistry and CO 2 dynamics. In the context of pCO 2 fluctuations, nitrate concentrations in the upper segment and levels of biological oxygen demand (BOD) and dissolved oxygen (DO) in the middle and lower segments are emerging as crucial explanatory factors. Furthermore, regression tree (RT) and importance analyses pinpointed biochemical oxygen demand (BOD) as the paramount factor influencing pCO 2 variations across the Ganga River (n = 91). A robust negative correlation between BOD and FCO 2 was also observed. The distinct longitudinal patterns of both parameters may induce a negative correlation between BOD and pCO 2. Therefore, comprehensive studies are necessitated to decipher the underlying mechanisms governing this relationship. The present insights are instrumental in comprehending the potential of CO 2 emissions in the Ganga River and facilitating riverine restoration and management. Our findings underscore the significance of incorporating South Asian rivers in the evaluation of the global carbon budget. [Display omitted] • PCO 2 concentration higher in upstream region than downstream region of Ganges. • Nitrate predict pCO 2 well in upstream region. • BOD and DO are best predictors of pCO 2 in downstream regions. • BOD emerged as a crucial influencing factor for pCO 2 across the Ganga River. [ABSTRACT FROM AUTHOR]

The fast development of urbanisation and industrialisation has led to a rise in nitrogen oxide (NO x) emissions, specifically nitric oxide (NO). One effective method for reducing the harmful effects of this dangerous air pollutant on both human health and the environment is the photocatalytic oxidation of NO. Z-scheme heterojunctions enhance incident light utilisation and increase photocatalytic activity, eventually leading to better NO oxidation performance by encouraging the effective separation of charges and migration. A comprehensive discussion of Z-scheme-based heterojunctions is provided in this review paper, with a focus on their applications in the photocatalytic oxidation of NO. Significant progress has been made in the fabrication of efficient photocatalytic devices in recent years, with Z-scheme-based heterojunctions proving to be particularly successful. The review looks into the various methodologies used to create Z-scheme-based heterojunctions as well as photocatalytic NO oxidation mechanisms. Recent studies on photocatalysts employing Z-scheme heterojunctions for the photocatalytic oxidation of NO are also discussed. The possibilities for new opportunities as well as the present challenges, barriers, advances, and solutions have been emphasized. [ABSTRACT FROM AUTHOR]

Peatlands account for a significant fraction of the global carbon stock. However, the complex interplay of abiotic and biotic factors governing anaerobic carbon mineralization in response to warming remains unclear. In this study, peat sediments were collected from a typical northern peatland-Changbai Mountain to investigate the behavior and mechanism of anaerobic carbon mineralization in response to depth (0–200 cm) and temperature (5 °C, 15 °C and 20 °C), by integrating geochemical and microbial analysis. Several indices including humification indexes (HI), aromaticity, and water extractable organic carbon (WEOC) components were applied to evaluate carbon quality, while 16S rRNA sequencing was used to measure microbial composition. Regardless of temperature, degradations of carbon quality and associated reduction in microbial abundance as well as diversity resulted in a decrease in anaerobic carbon mineralization (both CO 2 and CH 4) towards greater depth. Warming either from 5 °C to 15 °C or 20 °C significantly increased anaerobic carbon mineralization in all depth profiles by improving carbon availability. Enhanced carbon availabilities were mediated by the change in microbial composition (p < 0.01) and an increase in metabolic activities, which was particularly evident in the enhanced β-glucosidase activity and microbial collaborations. A remarkable increase of over 10-fold in the relative abundance of the Geothrix genus was observed under warming. Overall, warming resulted in an enhanced contribution of CH 4 emission and a higher ratio of hydrogenotrophic methanogenesis, as evidenced by carbon isotope fractionation factors. In addition, deep peat soils (>100 cm) with recalcitrant carbon demonstrated greater temperature sensitivity (Q 10 : ∼2.0) than shallow peat soils (Q 10 :∼1.2) when temperature increased from 15 °C to 20 °C. The findings of this study have significantly deepened our understanding for mechanisms of carbon quality and microbe-driven anaerobic carbon mineralization in peatlands under global warming. • Carbon quality and temperature control mineralization via modulating microbes. • Relative abundance of Geothrix was 10 times higher at 15 °C and 20 °C than 5 °C. • Warming amplified contribution from CH 4 and hydrogenotrophic pathways. • Deep peat with recalcitrant carbon had larger Q 10 under temperature of 15 °C–20 °C. [ABSTRACT FROM AUTHOR]

Heavy carbon industries produce solid side stream materials that contain inorganic chemicals like Ca, Na, or Mg, and other metals such as Fe or Al. These inorganic compounds usually react efficiently with CO 2 to form stable carbonates. Therefore, using these side streams instead of virgin chemicals to capture CO 2 is an appealing approach to reduce CO 2 emissions. Herein, we performed an experimental study of the mineral carbonation potential of three industrial steel slags via aqueous, direct carbonation. To this end, we studied the absorption capacities, reaction yields, and physicochemical characteristics of the carbonated samples. The absorption capacities and the reaction yields were analyzed through experiments carried out in a reactor specifically designed to work without external stirring. As for the physicochemical characterization, we used solid-state Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscope (SEM). Using this reactor, the absorption capacities were between 5.8 and 35.3 g/L and reaction yields were in the range of 81–211 kg CO 2 /ton of slag. The physicochemical characterization of the solid products with solid FTIR, XRD and SEM indicated the presence of CaCO 3. This suggests that there is potential to use the carbonated products in commercial applications. • Mineral aqueous carbonation of three industrial steel slags. • Absorption capacities are between 5.8 and 35.3 g/L. • Reaction yields obtained were in the range of 81–211 kg CO 2 /ton of slag. • In situ analysis showed evidence for the formation of carbonate ions. • The physicochemical characterization showed CaCO 3 in the solid products. [ABSTRACT FROM AUTHOR]

[Display omitted] • A new pyrimidine hybrids was synthesized with the help of WELPSA as an effective catalyst through a multicomponent one-pot Biginelli reaction. • Synthesized compounds were evaluated for α-amylase and α-glucosidase inhibition assays. • All the compounds were found remarkable with excellent IC 50 values than the standard drug acarbose. • DFT calculations were performed using Gaussian 09 software. • Molecular docking study of the synthesized compounds was performed using Auto dock Vina. A green catalyst WELPSA-catalyzed three-component condensation (Biginelli) process involving an aldehyde, barbituric/thiobarbituric/1,3-dimethylbarbituric acid, and urea/thiourea/guanidine hydrochloride in a single pot in presence of a green solvent for the production of DHPM have been presented. The catalyst is reusable and this methodology is scalable. By using the in vitro experiments, the antidiabetic potentiality of synthesized compounds that inhibit α-amylase along with α-glucosidase efficiencies was assessed. All the synthesized compounds except for 4a and 4e , showed the most significant inhibition for α-amylase and α-glucosidase activities. Among the synthesized DHPM compounds, 4c and 4b exhibited significant inhibition profiles compared to the standard antidiabetic drug acarbose. Furthermore, synthesized substances' energy-minimized structures, 3D structures, and DFT calculations were performed using Gaussian 09 software, hybrid models, and MM2 force approaches. Strong hydrogen bonds with amino acid residues Arg-672, Arg-600, Trp-613, Asp-404, Asp-282, and Asp-616 indicate that an α-glucosidase-inhibitory peptide may have hypoglycemic efficacy confirmed by the molecular docking study of the synthesized DHPM. [ABSTRACT FROM AUTHOR]

Anthropogenic land use and land cover changes are major drivers of environmental degradation and declining soil health across heterogeneous landscapes in Central India. To examines the land cover changes and spatio-temporal variations in forest carbon stock and soil organic carbon (SOC) over the past 25 years in central India. Geospatial techniques, coupled with ground measurements were employed to detect changes in land cover, carbon stocks in vegetation, and soil carbon in various vegetation types. The results indicate that forested areas have decreased, while agriculture and habitation have expanded between 1997 and 2022. Vegetation C stocks varied significantly (P < 0.05) from 39.42 to 139.95 Mg ha−1 and the SOC varied from 7.02 to 17.98 Mg ha−1 under different soil profiles across vegetation types, which decreased with soil depth, while the pH and bulk density increased. The maximum bulk density in the soil was found at a depth of 40–60 cm (lower profile) in Bamboo Brake, while the minimum was observed under Dense Mixed Forest at a depth of 0–20 cm (top profile). The topsoil profile contributed 33.6%–39%, the middle profile (20–40 cm) was 33.6%–34.4%, and the lower profile was 26.5%–30.8% of soil organic carbon. The study site has experienced rapid carbon losses due to changes in land cover, such as illegal expansion of agriculture, encroachments into forest fringes, and activities like selective logging and overgrazing, which have degraded dense forests. The ecological engineering of degraded ecosystems poses a great challenge and application of complex biological, mechanical and engineering measures is highly cumbersome, expensive, uneconomical and practically not feasible for upscaling. Nevertheless, proposed nature-based solutions mimic natural reparation and processes provide sustainable interventions for the reclamation of ruined landscapes besides improving ecological integrity and rendering many co-benefits to ecosystems and human societies. • Anthropogenic LULCC are major drivers of environmental degradation and declining soil health. • Vegetation C stocks varied significantly from 39.42 to 139.95 Mg ha−1 • SOC varied from 7.02 to 17.98 Mg ha−1 under different soil profiles across vegetation types. • Proposed nature-based solutions helps in eco-restoration of degraded landscape. [ABSTRACT FROM AUTHOR]

Identifying the new tree crop combinations plays an important function in transforming the low input agriculture into land units with high economic returns, increasing carbon (C) sink and nutrients storage capacity, and acting as a panacea to achieve Sustainability Development Goals (SDGs). The present study aims to evaluate various tree-crop combinations for (i) biomass production, (ii) carbon accumulation, and (iii) soil nutrient enrichment of traditional and commercially evolved eight agroforestry systems (AFSs), including agri-silvi-horticulture system, agri-silviculture system, silvi-pasture, fruit tree, fodder tree, bamboo, melia and poplar based AFSs with sole cropping system in the mid-hill zone of the north-western Himalaya. The results demonstrated that poplar based AFS accumulated a higher amount of biomass (130.87 Mg ha−1) and carbon (65.44 Mg ha−1) closely followed by melia-based AFS. The C stored in leaf litter was higher (0.66 Mg ha−1) in poplar-based AFS, however, soil C stock was maximum (114.69 Mg ha−1) under bamboo-based AFS. Overall, the Melia based AFS exhibited a higher rate of carbon dioxide mitigation (19.30 Mg ha−1 yr−1) and C-sequestration (5.26 Mg ha−1 yr−1) than other studied AFSs. Moreover, soil macro-nutrients (available N, P, K, S and Ca) were maximum under bamboo-based AFS, on the other hand, the fruit-based AFS had the higher concentrations of micro-nutrients i.e., Cu (3.05), Fe (31.10 mg g−1) and Mn (17.31 mg g−1). The soil microbial counts were higher in poplar-based AFS, whereas, the soil quality index improved significantly under bamboo based and fruit tree based AFSs. Hence, it can be concluded that the experimentally evolved AFSs represent an effective approach for boosting C-sequestration, soil fertility, regenerating the soil and sustainability of hill agriculture in the north-western Himalayas over traditional AFSs and sole cropping. • Agroforestry systems (AFSs) contribute significantly to biomass production & carbon storage. • Poplar- and bamboo based AFSs accumulated maximum biomass & soil C stock, respectively. • Melia based AFSs exhibited highest rate of C-sequestration. • Bamboo based AFSs maintained the highest soil quality index. [ABSTRACT FROM AUTHOR]

Landfills are commonly used to manage solid waste, but they can contribute to microplastic (MPs) pollution. As plastic waste degrades in landfills, MPs are released into the surrounding environment, contaminating soil, groundwater, and surface water. This poses a threat to human health and the environment, as MPs can adsorb toxic substances. This paper provides a comprehensive review of the degradation process of macroplastics into microplastics, the types of MPs found in landfill leachate (LL), and the potential toxicity of microplastic pollution. The study also evaluates various physical-chemical and biological treatment methods for removing MPs from wastewater. The concentration of MPs in young landfills is higher than in old landfills, and specific polymers such as polypropylene, polystyrene, nylon, and polycarbonate contribute significantly to microplastic contamination. Primary treatments such as chemical precipitation and electrocoagulation can remove up to 60–99% of total MPs from wastewater, while tertiary treatments such as sand filtration, ultrafiltration, and reverse osmosis can remove up to 90–99%. Advanced techniques, such as a combination of membrane bioreactor, ultrafiltration, and nanofiltration (MBR + UF + NF), can achieve even higher removal rates. Overall, this paper highlights the importance of continuous monitoring of microplastic pollution and the need for effective microplastic removal from LL to protect human and environmental health. However, more research is needed to determine the actual cost and feasibility of these treatment processes at a larger scale. [Display omitted] • Degradation pathway of macroplastic to microplastics in landfills are discussed. • Occurrence of microplastic polymers and their characteristics in landfill leachates are covered. • Microplastics toxicity and human health impacts are reviewed. • Various techniques for microplastic removal from leachate are included. [ABSTRACT FROM AUTHOR]

In the present work, mixed-spinel ferrite anchored onto graphitic carbon nitride (GCN) was synthesized for mineralization of antibiotic pollutant from waste water. A Z-scheme g-C 3 N 4 /Ni 0.5 Zn 0.5 Fe 2 O 4 nano heterojunction was fabricated by three step procedure: pyrolysis, solution combustion and mechanical grinding followed by annealing. The prepared photocatlyst was tested for degradation of Doxycycline (DC) drug under the natural sun light. Results revealed that the prepared heterojunction has maximum degradation efficiency of 97.10% pollutant in 60 min experiment. The Z-scheme heterojunction between g-C 3 N 4 and Ni–Zn ferrite improves the photoinduced charges separation and protection of redox capability and therby increases the photo degradation efficiency. The scavenging experiments suggested that O 2 −● and h+ as main active species responsible for degradation of the antibiotic. In addition, the dopant variation can drive the shists in band gap and energy band positiong too which makes then excellent candidates for synthesizing tunable heterostructures with organic semiconductors. The work focusses on designing and developing of saimpler but efficient magnetic heterojunctions with superior redox capability for solar powered waste water treatment. [Display omitted] [ABSTRACT FROM AUTHOR]

The heatwave is a disastrous hazard having significant impacts on health and society. This study analyses the heatwave hazards and risk for India's current and future scenarios using socioeconomic vulnerability and temperature datasets during the summer (April–June) season. The Census of India (CoI) 2011 datasets were considered to assess current vulnerability and projected from the SocioEconomic Data And Application Center (SEDAC) population at Shared Socioeconomic Pathway (SSP) 4 for future vulnerability. Whereas IMD temperature data used for hazard assessment for the present scenario (1958–2005) while projected temperature data from regional earth system model REMO-OASIS-MPIOM (ROM) were used for the future (2006–2099) scenario. The study exhibited the most hazardous, vulnerable, and risk-prone regions identified as the south-eastern coast and Indo-Gangetic plains and some populous districts with metropolitan regions (Mumbai, Delhi, and Kolkata) under the current scenario. The coupled model ROM has efficiently captured the critical districts with higher and lower risk, showing its future projection capability. The study highlighted that the heatwave hazard-risk would significantly worsen in future scenarios in all districts under enhanced global warming and largely affecting the districts in the eastern and middle Indo-Gangetic plains and Malabar region. The present study will provide sufficient insights into designing mitigation strategies and future adaptive planning for the heatwave risk, which is one of the targets under Sustainable Development Goal 13 (Goal 13: Climate Action). • The present and future vulnerability and risk are assessed over India using a regional earth system model ROM. • The ROM efficiently captured the high and low heatwave risk districts of India. • Southern coastal regions and Indo-Gangetic plains are at higher risk during the baseline period 1980–2005. • The heatwave risk will exacerbate in all districts of India with the highest increment over Indo-Gangetic plains. [ABSTRACT FROM AUTHOR]