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[Display omitted] • Depleted continental mantles occur with different mineral chemistry and occurrence. • Mafic dikes were formed from melts via low-degree melting of asthenosphere mantles. • Orthopyroxenites were formed from reaction between SiO 2 -rich melts and peridotites. • Ophiolites were formed in a continental margin that was related to the Meso-Tethys. Whether the ophiolites in the southeast margin of the Gaoligong tectonic belt are related to subduction or rift is hotly debated. The aim of this paper is to present the geological and geochemical data of these ophiolitic blocks in order to understand the significance of these in the tectonic evolution of the Meso–Tethys. The peridotites in the ophiolites are dominantly harzburgites with high Mg# (88.7–92.2) and low Al 2 O 3 (<0.8 wt%) and CaO (<0.5 wt%) contents, and display U-shape chondrite-normalized rare-earth element patterns. However, they show two different groups of mineral chemistries and occurrences. Group I are with olivine Fo 90.6–92.3, orthopyroxene Mg# 91.0–92.6, clinopyroxene Mg# 91.1–93.3, and spinel Cr# 42.1–67.4 and Mg# 62.8–71.6. They exhumed adiabatically and were intruded by mafic dikes from the melts through low-degree melting of asthenospheric mantles and by orthopyroxenites in the Early Jurassic. Group II are with olivine Fo 89.8–95.3, orthopyroxene Mg# 91.3–94.6, and spinel Cr# 62.4–94.1 and Mg# 19.5–51.0. They underwent brittle deformation and medium- to low-temperature fluid replacement. The two group's peridotites have experienced the similar partial melting degrees and are the fragments of subcontinental lithospheric mantles. Extensive continental affinity tholeiites erupted in the Middle Jurassic, coeval with the primary spreading time of the Bangonghu–Nujiang Ocean in the central Tibet. The peridotites, mafic rocks, and marine-facies sediments represent the opening products of the Meso–Tethys in the Jurassic as ophiolites in a continental margin. [ABSTRACT FROM AUTHOR]