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Actinidia arguta is a climbing, fruit plant that recently generated a spread interest in many regions of the world, due to world globalization and knowledge expansion. During its production, different by-products are generated, such as fruits, leaves, stems, flowers and roots, being characterized by a rich bioactive composition that wise the scientific community for its health effects. Inboard of this panoply of valuable bioactive compounds, vitamin C, chlorogenic and neochlorogenic acids, caffeic acid, quercetin, catechin, kaempferol, p -coumaric acid, minerals and fatty acids play critical roles. As a result, the valorization and reuse of these by-products is a challenge, particularly for producers. This review aims to summarize the potential cosmetic and medical skincare applications of the different bioactive compounds from A. arguta by-products, describing and exploring their potential to contribute as active ingredients based on the biological activities reported. Simultaneously, a critical analysis of the patents available on the market regarding its use as cosmetic and medical skincare ingredient is provided. Cosmetic and medical skincare products could be a sustainable and green option for the use of A. arguta by-products bioactive compounds. Apart from contribute to skin appearance and health, the addition of these active compounds to the final cosmetic and pharmaceutical products may also provide skin beneficial effects such as photoprotection, anti-aging and anti-inflammatory effects, also acting as depigmenting and emollients, among other activities. Besides that, the impact on food by-product valorization and circular economy will be enormous. [Display omitted] • Actinia arguta by-products are rich in bioactive compounds with skin effects. •The use of A. arguta by-products in topical formulations is extremely promising. •Skin health benefits are enormous. •Few patents are available on the market with A. arguta as skin ingredient. •Add value to fruit byproducts. [ABSTRACT FROM AUTHOR]

[Display omitted] • Lycium barbarum L. berries as a source of valuable bioactive compounds. • Response Surface Methodology enabled the optimization of the extraction process. • Phenolic acids, flavanols, and phenylamides were detected. • The extract proved to be safe for intestinal application at doses up to 500 ug/mL. • Different extract's compounds permeated the cell monolayer. Lycium barbarum L. berries have a remarkable chemical composition and extensive biological activities, being a valuable component of health and nutraceutical practices. Nevertheless, a deep insight on the intestinal permeation of the pro-healthy bioactive compounds is urgently needed to predict the real effects on human body. This study attempted, for the first time, to optimize the Ultrasound-Assisted Extraction (UAE) of goji berries using a Response Surface Methodology approach and establish the intestinal permeation of the principal pro-healthy compounds. The optimal extraction conditions were a solid:liquid ratio of 8.75 % for 56.21 min, using an intensity of 59.05 W/m2. The optimal extract displayed a remarkable antioxidant capacity, with LC/DAD-ESI-MS analysis unveiled a diverse phytochemical profile, encompassing different compounds (e.g. glu-lycibarbarspermidine F, 2-glu-kukoamine, rutin, 3,5-dicaffeoylquinic acid). The intestinal co-culture model demonstrated that glu-lycibarbarspermidine F (isomer 2) (73.70 %), 3,5-dicaffeoylquinic acid (52.66 %), and isorhamnetin-3- O -rutinoside (49.31 %) traversed the intestinal cell layer, exerting beneficial health-promoting effects. [ABSTRACT FROM AUTHOR]