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The character of arcs varies over time with significant temporal fluctuations in the quantity and spatiotemporal patterns of magmatism. However, the driving mechanisms for this episodic behavior of arcs need more constraints. This paper analyzed the published data along with our new zircon U-Pb dating and Hf isotopic and whole-rock geochemical data of plutonic rocks in the Gangdese belt in southern Tibet to explore the features, potential drivers, and tectonic implications of episodic arc activity in the Gangdese arc. A comprehensive compilation of U-Pb ages and Lu-Hf isotopic analyses of zircon grains from igneous rocks in the Gangdese belt, sedimentary rocks in trench fill sequences, forearc basins and foreland basins, and sands from modern river reveals that: 1) Gangdese arc activity was episodic during Late Cretaceous to Middle Eocene, displaying two magmatic flare-ups (ca. 100–80 and 65–45 Ma) and one magmatic lull (ca. 80–65 Ma), and 2) both flare-up magmas show relatively positive ε Hf (t) values (+5 ~ +15) indicative of juvenile sources suggesting these magmas are dominated by contributions from the depleted mantle. In contrast, the magmatic lull between these two magmatic flare-ups could be caused by flat subduction of the Neotethyan slab beneath the southern margin of the Lhasa terrane. These flare-ups likely contributed greatly to the crustal thickening of the Gangdese belt. Constraints from paleo-elevation and geochemical proxies for crustal thickness showed that the ~100–80 Ma flare-up was accompanied by the formation of a thick arc root while the ~65–45 Ma flare-up likely developed in a thinner crust without an arc root. [Display omitted] • Gangdese arc activity was episodic, displaying magmatic flare-ups (~100–80 and ~65–45 Ma). • Flare-up magmatism contributed to crustal thickening. • Gangdese batholith had an arc root at ~90 Ma. [ABSTRACT FROM AUTHOR]

[Display omitted] • The ~91 Ma Chemen intrusion represents a magmatic product of the Late Cretaceous Gangdese magmatic 'flare-up' event. • The Chemen intrusion was derived from partial melting of Neo-Tethys oceanic crust during ridge subduction. • Compositions of zircon and apatite indicate that the Chemen intrusion has a high mineralization potential. • The mineralization potentials of some other Late Cretaceous intrusions may be limited due to low magma oxygen fugacities. Large-scale Late Cretaceous magmatic intrusions have been recognized in the southern Gangdese magmatic belt, although their genesis and mineralization potential remain controversial. In this paper, we present new zircon U-Pb ages, whole-rock compositions, and major- and trace element compositions of zircon and apatite from the Chemen granodioritic intrusion. When integrated with compiled literature data for other Late Cretaceous igneous rocks in the southern Gangdese belt, our new dataset provides new insight into their genesis and mineralization potential. The Chemen intrusion obtains a zircon U–Pb age of ~91 Ma, similar to the age of Late Cretaceous magmatic intrusions across the entire southern Gangdese belt. Both the Chemen and other Late Cretaceous intrusions have geochemical characteristics that resemble those of adakites. When considered alongside the coeval formation of mafic intrusive rocks, high-temperature adakitic charnockites, and thickening of continental crust in the region, ridge subduction is considered most likely to be responsible for this 'flare-up' event. The Ce4+/Ce3+ ratios in zircon and SO 3 contents of apatite from the Chemen granodiorites both indicate a high oxygen fugacity during crystallization. Further, trace elements in Chemen apatite indicate that the Chemen intrusion has a great mineralization potential; however, no mineralization has been found in some of the Late Cretaceous intrusions in the southern Gangdese belt. Compiled data show that these barren Late Cretaceous intrusions generally formed from magmas with a low oxygen fugacity. Thus, we speculate that the low oxygen fugacity of some Late Cretaceous intrusions may limit the extent to which mineralization may occur. [ABSTRACT FROM AUTHOR]