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[Display omitted] • This study proposes novel auxetic medical stents. • Two-dimensional metamaterials were fabricated through additive manufacturing technique. • Finite element analysis was employed to investigate the mechanical behaviour. • An excellent correlation was observed between the FEA and experimental results. • The modifications made to the rib-unit cells had a significant effect on the stent's recoil behaviour. Due to the significant mortality rate associated with atherosclerosis-induced cardiovascular disease, the utilization of advanced intravascular stents with superior mechanical performance is imperative for the restoration of obstructed arteries. This study proposes novel auxetic medical stents that aim to enhance critical parameters of biomedical stents. This includes load-bearing capacity, expanded opening percentage, and reduced recoil percentage. On this matter, the missing rib auxetic unit cell has been considered and geometrically modified to achieve these objectives. Two-dimensional (2D) metamaterials were fabricated through additive manufacturing technique and subjected to experimental testing. Then, finite element analysis (FEA) was employed to gain comprehensive insights into the mechanical behaviour of the proposed medical stents. Remarkably, an excellent correlation was observed between the FEA and experimental results, validating the high precision of the analysis. The findings reveal that the stents classified as "E-category" exhibit the highest final opening percentage while concurrently demonstrating the lowest recoil percentage. The base stent exhibited a relatively high recoil percentage of 15.56%, indicating a significant amount of recoil or spring-back after deformation. In contrast, the modified "E-category" stent displayed a substantially lower recoil percentage of 1.62%. This notable reduction in recoil percentage indicates that the modifications made to the rib-unit cells had a significant and beneficial effect on the stent's recoil behaviour and minimizing potential damage to arterial tissue during stent deployment (angioplasty) and balloon pressure. The modified design likely enhances the stent's ability to maintain its shape and resist recoil, making it more effective and reliable in its intended application. Additionally, more aspects of biomedical stents such as foreshortening, and dog-boning of the modified missing rib stents were meticulously examined through FEA. [ABSTRACT FROM AUTHOR]

Sparse linear arrays (SLAs) provide a high number of degrees of freedom (DOF) and reduce the mutual coupling effect between sensors of the array. Many design methods for SLAs have been proposed in the last two decades but most of the existing SLA design methods fail to achieve minimum number of sensors for a desired DOF. In this paper, a design method is proposed which utilizes the branch and bound (B & B) optimization algorithm to give a SLA with the desired DOF and minimum number of physical sensors. The proposed SLA design method is obtained by generalizing the minimum sensor array (MSA) design method which is recently proposed in the literature. This generalized method provides the same DOF as the MSA method but with a smaller number of physical sensors. In addition, a version of this design method is proposed which provides more robustness against mutual coupling effect between the sensors of the array. Simulation results demonstrate the superiority of the performance of the SLAs obtained with the proposed method over the arrays obtained with the MSA method and also over the other existing SLAs. [ABSTRACT FROM AUTHOR]

Electronic properties of (n,0) zigzag tungsten disulfide WS 2 nanotubes and transport properties of (7,0) zigzag nanotube heterojunction are investigated by utilizing non-equilibrium Green's function formalism (NEGF). The results reveal that inclusion of the spin-orbit (SO) coupling significantly reduces the value of the band gap about 15.52\%. Additionally, strong negative differential resistances take place in voltage regions between −0.2 and −0.4 V as well as between −0.5 and −0.6 V. Moreover, temperature dependent transport properties are elaborately investigated in this work. The results show that, as the temperature increases to 600 K the stronger negative differential resistance occurs in both positive and negative bias voltages. Finally, a reasonably large degree of rectification ratio can be established. Our analysis can provide a comprehensive perspective on the NDR effect and current rectification in WS 2 nanotubes and can be used as a beneficial guide for future designing of novel logical and nanoelectronic and spintronic devices. • All electronic calculations were carried out using ab-initio DFT-NEGF method. • Transport characteristics were discussed with and without SO coupling. • Reduction of band gap and strong NDR were obtained in the percent of SO coupling. • Stronger NDR was occurred by temperature increasing. [ABSTRACT FROM AUTHOR]

One of the most important dimensions of cooperative systems, which have existed in Iran since 1974, is cooperative rural production enterprises. In this study, the performance of rural production cooperatives in Iran is examined in relation to the social capital components of the members. This study's statistical population consisted of 16,870 members from 41 cooperatives. 217 samples of cooperative members and 98 samples of the cooperative's management and board of directors were selected using the Cochran formula, and questionnaires were filled out for each group. The results showed that from the viewpoint of the members of rural cooperatives, the most important factor in improving the performance of cooperatives was the use of effective extension training (model-extension sites). The results also showed that members' satisfaction and training members of cooperatives can play an important role in improving the performance of cooperatives. The results of this research, while emphasizing the role of education (especially extension activities), can help rural development planners in improving the performance of rural cooperatives in their regions. [Display omitted] • The study identified the impacts of social capitals on the performance of rural production cooperatives. • The most important factor in improving the performance was the use the extension trainings. • Members' satisfaction and training play an important role in improving the performance. • The level of education in production cooperatives has a direct relationship with trust and satisfaction. • Cooperatives do not perform well in the fields of sales, marketing and insurance. [ABSTRACT FROM AUTHOR]

Assessing, predicting, and controlling injection-induced seismicity is a major challenge for developing enhanced geothermal systems (EGS) due to the complexity of coupled thermo-hydro-mechanical (THM) processes. This study aimed to develop a fully coupled numerical model to assess the complex behavior of a low permeable matrix-fracture during non-isothermal single-phase fluid injection process. A thermo-poroelastic displacement discontinuity (DD) method combining with different forms of finite element method are implemented to encapsulate the fractured medium response and transport processes, respectively. The nonlinear characteristics of normal (changing the joint to hydraulic fracture status) and shear (changing the stick to slip fracture status) fracture deformation are taken into account through fracture constitutive relations. Developed numerical approach was applied to simulate cool water injection into fracture/matrix systems, analyzing the role of coupled processes on spatiotemporal variation of matrix-fracture stresses, temperature and pore pressure and assessing induced seismicity (slippage) and permeability alteration. Numerical simulations demonstrate a fully coupled relation between matrix dilation, shrinkage, and non-linear fracture deformation. The redistribution of dynamic and kinematic parameters along with non-linear fracture deformation showed that although the poroelastic effects are dominant in the early stages, thermoelastic effects dominate in the long-term injection stages. • A fully-coupled Thermo-Hydro-Mechanical approach was developed to model injection process in EGS. • Displacement discontinuity and finite element methods were combined to encapsulate fracture deformation and transport processes, respectively. • Fracture constitutive laws were implemented to model non-linear crack deformation. • Poroelastic effects are dominant in the early stages, and thermoelastic effects dominate in the long-term injection stages. [ABSTRACT FROM AUTHOR]

• Effect of key parameters on LIDM hematite beneficiation was determined. • Evolving MLPs' architecture was successfully optimized by PSO. • DOE-RSM and PSO-MLP neural network, successfully modelled LIDM separation. • PSO-MLP model out-performed DOE model in predicting product Fe content and SE. • Optimization of the operating parameters led to the product Fe = 60.1% and SE = 36.1% The low intensity dry magnetic beneficiation of hematite was studied in this study, and the effect of field intensity (FI: 800–2000 G), drum speed (DS: 25–75 rpm), separating gate position (SG: 55–83°), and mean particle size (PS: 0.5–1.18 mm) on the products' Fe content and system separation efficiency were determined. A new hybrid particle swarm optimization enhanced multilayer perceptron (PSO-MLP) neural network and design of experiment have been employed to model and predict such a beneficiation result. Based on the CCD-RSM response surfaces, the effectiveness of variables on both evaluation criteria was determined to be DS > FI > SG. The mutual interaction between DS-SG was a common interaction for both responses, while FI-DS interaction was found to be significant only for separation efficiency. Compared to the desired levels of the statistical evaluators, the trained PSO-MLP outperformed the CCD-RSM model in predicting the hematite beneficiation results. Product Fe grade of 60.1% and corresponding SE of 36.1% was achieved for FI = 1200 G, DS = 75 rpm, SG = 83°, and PS = 0.5 mm, concluded from optimizing the parameters. [ABSTRACT FROM AUTHOR]

• A fully-coupled Thermo-Hydro-Mechanical approach was developed to study injection-induced seismicity and permeability enhancement in low permeable reservoirs. • Fracture deformation and transport processes were modeled using thermo-poroelastic displacement discontinuity method combined with Galerkin and Petrov Galerkin finite element methods. • Constitutive behavior of fault friction was captured using rate-and-state friction model incorporating aging law for history of sliding. • Traffic Light System-based injection protocols yield higher potential in enhancing the fault permeability. • Volume-Controlled fluid injection are far more effective in reducing the seismic risk. In recent years, there has been a substantial increase in the induced seismicity associated with geothermal systems. However, understanding and modeling of injection-induced seismicity have still remained as a challenge. This paper presents a two-dimensional fully thermo-hydro-mechanical (THM) coupled boundary element approach to characterize the fault response to forced fluid injection and assess the effect of different injection protocols on seismic risk mitigation as well as permeability enhancement. The laboratory-derived rate-and-state friction law was used to capture the frictional paradigm observed in mature faults produced in granite rocks. All phases of stick-slip cycles, including aseismic slip, propagation of dynamic rupture, and interseismic periods, were simulated. The modeling results showed that the residual values of effective normal stress and static shear stress after a particular event completely dominate the constitutive behavior of fault friction during the next seismic event. The seismic energy analyses indicated that there is a negative correlation between the seismic magnitude and the total injected volume, such that a prolonged monotonic injection eventually results in the steady slip, rather than the seismic slip. Several fluid injection protocols were designed based on a volume-controlled (VC) approach and traffic light systems (TLS) to explore their effectiveness on the seismic risk mitigation and permeability enhancement. The results showed that cyclic injection based on TLS is the most effective approach for irreversible permeability enhancement of faults through promoting slow and steady slips. Our numerical simulations also revealed that fluid extraction (backflow-fixing bottom hole pressure at atmospheric pressure), regardless of the injection style, can considerably reduce the seismicity-related risks by preventing the fast-accelerated fracture slip during the post-injection stage. This study presents novel insights into modeling the rate-and-state governed faults exposed to forced fluid injection, and provides useful approaches for shear stimulation of faults with reduced seismic risks. [ABSTRACT FROM AUTHOR]

• Administration of selective estrogen receptor modulators (SERMs) in combination with estrogen (E2), could be an effective in the treatment of menopausal diabetes. • Combined treatments of SERMs and E2 were more effective than the effects of E2 or SERMs alone. • E2 or SERMs have beneficial effects on cardiovascular system by improving inflammatory balance and reducing Ang II levels. The beneficial effects of the administration of selective estrogen receptor modulators (SERMs) and estrogen (E2), alone or in combination with each other, have been reported in postmenopausal diabetic cardiovascular dysfunction. In the present study, we determined the mechanism of action of SERMs and E2 on inflammatory balance, angiotensin II (Ang II) serum levels, and glycemic profile in a postmenopausal diabetic rat model. Ovariectomized rats with type 2 diabetes received daily SERMs (tamoxifen and raloxifene) and E2 for one month. After treatment, cardiovascular risk indices, glycemic profile, and serum Ang II, TNF-α and IL-10 levels were measured. Type 2 diabetes caused an abnormal glycemic profile, which was exacerbated by ovariectomy. All treatments inhibited the effects of diabetes and ovariectomy on the glycemic profile, with combined treatments (SERMs + E2) showing stronger effects. Cardiovascular risk indices that became abnormal by diabetes and worsened by ovariectomy were improved in all treatment modalities. Also, combined treatment reduced serum Ang II, TNF-α, and the ratio of TNF-α to IL-10, indicating an improvement in inflammatory balance. Our study showed the administration of SERMs and E2, alone or in combination, could be an effective alternative in the treatment of menopausal diabetes, and generally, the beneficial effects of combined treatments were more effective than the effects of E2 or SERMs alone. It appears that E2 or SERMs benefit the cardiovascular system by improving inflammatory balance and reducing Ang II levels. [ABSTRACT FROM AUTHOR]

The aim of the present study was to evaluate the potential effect of flagellin as adjuvant in Newcastle disease virus (NDV) vaccine on the cellular and humoral immunity in chickens. Fifty-six specific pathogen-free chickens were assigned to seven groups of eight chickens and immunized twice with a two-week interval, intramuscularly. Group 1, received phosphate buffered saline as control (C), groups 2, 3, 4, 5, 6 and 7 were immunized with inactivated NDV [Ag], Ag + full FliC protein [AgF], Ag + truncated Flic protein [AgT], Ag + native Flic protein [AgN], commercial NDV vaccine [Vac] and Vac + N [VacN], respectively. After 45 days, spleen and bursa of Fabricius samples were collected and analyzed by flow cytometry and responses in control/vaccinated chickens were studied by immunophenotyping. Humoral response was also, evaluated by ELISA during the experiment. Results showed that immunized chickens with Ag + flagellin proteins had significantly higher frequency of circulating CD3+, CD4+ and CD8+ T cells in bursa of Fabricius in AgF, AgT and AgN, respectively, compared with other groups. Similar results were observed for spleen; however, the highest frequency of circulating CD3+, CD4+ and CD8+ T cells belonged to AgT and AgF, respectively. ELISA results showed that all flagellin-adjuvanted groups had higher antibody titers than other groups with the highest antibody response in VacN. It can be concluded that flagellin may induce both humoral and cellular immune responses against ND and is suggested for use as an efficient adjuvant. • Flagellin-adjuvanted groups had higher frequency of CD4 and CD8 T cells. • All flagellin-adjuvanted groups had higher antibody titers than other groups. • Native flagellin enhanced antibody response in commercial vaccine. [ABSTRACT FROM AUTHOR]