1. Prolonged 3-year spontaneous remission of diffuse large B-cell lymphoma upon withdrawal of infliximab and late relapse in a patient with psoriasis: a case report and review of the literature.
- Author
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Asimakopoulos, John V., Dolkiras, Filippos, Lakiotaki, Eleftheria, Rondogianni, Phivi, Tsourouflis, Gerasimos, Siakantaris, Marina P., Angelopoulou, Maria K., Rondogianni, Dimitra, Korkolopoulou, Penelope, Vlahoyiannopoulos, Panayiotis, and Vassilakopoulos, Theodoros P.
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DIFFUSE large B-cell lymphomas , *LITERATURE reviews , *DISEASE relapse , *CUTANEOUS T-cell lymphoma , *INFLIXIMAB , *MUCOSA-associated lymphoid tissue lymphoma - Abstract
Yet, the description of a polymorphic cell infiltration in LN biopsy, the absence of clinical lymphadenopathy at presentation, the history of psoriatic arthritis as well as the preceded treatment with anti-tumor necrosis factor (TNF)- and cyclosporine raised diagnostic concerns. Although the patient could not finally avoid R-CHOP immunochemotherapy, this case highlights that a trial of NBA withdrawal under very close monitoring could be a rational therapeutic choice even in patients with aggressive ID-LPDs. Keywords: diffuse large B-cell lymphoma; psoriasis; infliximab; apremilast; novel biologic agent; anti-TNF EN diffuse large B-cell lymphoma psoriasis infliximab apremilast novel biologic agent anti-TNF 1695 1700 6 10/12/23 20231001 NES 231001 The association of psoriasis with cancer has been a matter of debate, especially in the era of the novel biologic agents (NBA). Lastly, taking into consideration our case with the re-appearance of the lymphoma despite the change of NBA as well as all the other cases described in Table 1, the appearance of LPDs in psoriatic patients is a more complex process influenced by clinical disease duration and extension, the time length of immunosuppression and the nature of the various treatments administered. [Extracted from the article]
- Published
- 2023
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