In this paper, we introduce a numerical and analytical study of the HIV‐1 infection of CD4+ T‐cells conformable fractional mathematical model. This model is studied analytically by Kudryashov and modified Kudryashov methods and numerically by finite difference method. A comparison between the results of the analytical and numerical methods is investigated. We also give some figures that show how accurate the solutions will be obtained from analytical and numerical methods. [ABSTRACT FROM AUTHOR]