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Background: Inflammatory and non‐inflammatory acne lesions constitute a significant clinical challenge in acne subjects. Aim: To evaluate the efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid for improving skin conditions. Methods: This randomized controlled trial included adults with comedones, post‐inflammatory erythema (PIE) and/or hyperpigmentation (PIH) in Shanghai, China in July 2021. Participants were randomly assigned 1:1 to receive the study Serum + Mask or serum alone for 8 weeks. Acne severity, comedones, papules, pustules, PIE, PIH, skin pores, skin tone evenness, sebum secretion, skin hydration, and trans‐epidermal water loss were evaluated at T0d, T1d, T7d, T14d, T28d, and T56d. Results: Eighty‐three participants were included, including 41 and 42 in the Serum + Mask and Serum groups, respectively. Acne severity, density of skin pores, skin tone evenness, PIH foci on face, PIE foci on nose, intensity of PIE and PIH, closed comedones on face, open comedones on nose, sebum secretion, and skin hydration were significantly improved from baseline after 8 weeks of treatment in both groups (all p < 0.05). Addition of the mask improved the number of closed comedones (−6.56 ± 0.39 vs. −5.19 ± 0.44, p = 0.022) and acne severity (−0.39 ± 0.08 vs. −0.12 ± 0.09, p = 0.026) substantially more than using the serum alone. No adverse reaction was reported in either group. Conclusions: The study serum improved skin conditions by regulating skin barrier function and achieving a balance of skin hydration and sebum secretion, removing comedones and improving PIE and PIH. Addition of the mask accelerated the effects without compromising safety. [ABSTRACT FROM AUTHOR]

Background: UV rays not only cause oxidative damage to the skin, but also damage its barrier function. The use of sunscreen is crucial in preventing skin from UV radiation, but it may have an impact on the function of the skin barrier. While much research has focused on the protective effects of sunscreen against UV oxidative damage, little is known about the impact of daily sunscreen use on the skin barrier. Objective: This study mainly investigated the changes in skin barrier function of volunteers (including those with sensitive skin) before and after using a ceramide‐containing sunscreen. Methods: A total of 60 volunteers used SPF30 sunscreen containing ceramide every morning. Using non‐invasive methods to detect skin barrier changes in TEWL, hydration, facial redness based on VISIA‐CR image, and Erythema index (EI) value after 4 weeks of using ceramide‐containing sunscreen. Adverse reactions were also assessed. Results: After 4 weeks of using ceramide‐containing sunscreen, significant reductions were observed in skin redness with both an 11.89% decrease in a* value and a 5.68% decrease in skin EI, while there was also a significant decrease in transepidermal water loss (TEWL) with a reduction of 22.96%, and a significant increase in skin hydration with a 21.96% increase in the moisture content of the stratum corneum. No adverse events occurred during the entire testing process. Conclusion: Daily application of ceramide‐containing sunscreen can increase skin hydration while enhancing the function of the skin barrier. [ABSTRACT FROM AUTHOR]

Background: The protection for different skin types with impaired skin barrier in the market is insufficient. Aim: To evaluate the efficacy and safety of a panthenol‐enriched mask (La Roche‐Posay Mask Pro) in addressing various skin barrier impairment subgroups, including dry sensitive, oily sensitive, and oily acne skin. Methods: A total of 177 participants were enrolled in the study and divided into three subgroups based on their skin type. Participants used the mask following the specified protocol, with measurements taken for skin hydration, transepidermal water loss (TEWL), sebum content, and skin redness—factors that are directly influenced by skin barrier function. Assessments were conducted at baseline and after 1 day (tested 15 min post‐application), 7 days, and 14 days of application using Sebumeter, Tewameter, Corneometer, Mexameter, and VISIA. Results: Results showed significant improvements in skin parameters across all subgroups. In the dry sensitive skin subgroup, the mask increased skin hydration, sebum content, and reduced redness. For the oily sensitive skin subgroup, the mask regulated sebum production and improved skin hydration. In the oily acne skin subgroup, the mask reduced sebum content, redness, TEWL, and post‐inflammatory erythema and hyperpigmentation. Tolerance was excellent for all skin types, with no adverse reactions observed. Conclusions: This study highlights the efficacy and safety of the panthenol‐enriched LRP Mask Pro for individuals with distinct skin barrier impairment subgroups. The mask's versatile formulation and proven efficacy make it a valuable skincare product for addressing various skin concerns and achieving healthier, more balanced skin. [ABSTRACT FROM AUTHOR]

Background: Prolonged use of medical masks has increased skin‐related issues. Aim: To evaluate the efficacy of a facial cream and facial mask in mitigating medical mask related skin symptoms. Methods: Healthy women were randomly assigned to apply a facial cream (n = 32) or a facial mask plus a facial cream (n = 32) on half‐faces after wearing medical masks for 4 h (Tb). Transepidermal water loss (TEWL), dryness score, and redness area were assessed at Tb and 10 min after using the cream (T1) in the facial cream group, and at Tb, 1 h after using the facial mask (T2), and 10 min after using the cream (T3) in the combined use group. Results: In the facial cream group, the treated half‐face showed significantly better improvements from Tb to T1 in TEWL (−2.95 ± 0.38 vs. −0.68 ± 0.35 g/h·cm2, p < 0.001) and skin dryness score (−1.00 ± 0.12 vs. 0.00 ± 0.00, p < 0.001). In the combined use group, the treated half‐face showed significantly better improvements from Tb to T2 and T3 in TEWL (T2, −3.46 ± 0.33 vs. −0.09 ± 0.13 g/h·cm2; T3, −4.67 ± 0.31 vs. −0.28 ± 0.22 g/h·cm2) and skin dryness score (T2, −0.63 ± 0.13 vs. 0.03 ± 0.03; T3, −0.94 ± 0.17 vs. 0.19 ± 0.07) (all p < 0.001) then the untreated half‐face. The combined use group had significantly lower TEWL at T3 than T2 (p < 0.05). The reduction in redness area was similar between the treated and untreated half‐faces in both groups. Conclusions: The test facial cream and mask significantly improved skin barrier function and alleviated dryness symptoms associated with medical mask use, with the combined use offering superior benefits. [ABSTRACT FROM AUTHOR]