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Infectious bursal disease (IBD) is an acute, highly contagious, immunosuppressive, and fatal infectious disease of young chickens caused by infectious bursal disease virus (IBDV). Since 2017, a new trend has been discovered in the IBDV epidemic, with very virulent IBDV (vvIBDV) and novel variant IBDV (nVarIBDV) becoming the two current dominant strains in East Asia including China. In this study, we compared the biological characteristics of the vvIBDV (HLJ0504 strain), nVarIBDV (SHG19 strain), and attenuated IBDV (attIBDV, Gt strain) using specific-pathogen-free (SPF) chicken infection model. The results showed that vvIBDV distributed in multiple tissues, replicated the fastest in lymphoid organs such as bursa of Fabricius, induced significant viremia and virus excretion, and is the most pathogenic virus with a mortality of more than 80%. The nVarIBDV had a weaker replication capability and did not kill the chickens but caused severe damage to the central immune organ bursa of Fabricius and B lymphocytes and induced significant viremia and virus excretion. The attIBDV strain was found not to be pathogenic. Further studies preliminarily suggested that the expression level of inflammatory factors triggered by HLJ0504 was the highest, followed by the SHG19 group. This study is the first to systematically compare the pathogenic characteristics of three IBDVs closely related to poultry industry from the perspectives of clinical signs, micro-pathology, virus replication, and distribution. It is of great importance to obtain an extensive knowledge of epidemiology, pathogenicity, and comprehensive prevention, and control of various IBDV strains. [ABSTRACT FROM AUTHOR]

Urea electrolysis is regarded as a prospective method for energy-saving hydrogen production. However, the practical application of this technology is limited by the lack of high-performance bifunctional catalysts for hydrogen evolution reaction (HER) and urea oxidation reaction (UOR). Herein, a heterostructure catalyst composed of NiFe layered double hydroxide (LDH) and sulfides (NiFe LDH-NiFeSx/NF) catalysts is prepared via a simple one-step hydrothermal approach. Remarkably, the prepared NiFe LDH-NiFeSx/NF required 138 mV and 1.34 V to achieve 10 mA cm−2 for HER and UOR in 1 M KOH and 0.33 M urea, respectively. Furthermore, when NiFe LDH-NiFeSx/NF is used as a cathode for urea electrolysis, only 1.44 V is required at 10 mA cm−2, which is much lower than the 1.53 V needed for overall water splitting. [ABSTRACT FROM AUTHOR]

Artificial intelligence is developing rapidly in the direction of intellectualization and humanization. Recent studies have shown the vulnerability of many deep learning models to adversarial examples, but there are fewer studies on adversarial examples attacking facial expression recognition systems. Human–computer interaction requires facial expression recognition, so the security demands of artificial intelligence humanization should be considered. Inspired by facial expression recognition, we want to explore the characteristics of facial expression recognition adversarial examples. In this paper, we are the first to study facial expression adversarial examples (FEAEs) and propose an adversarial attack method on facial expression recognition systems, a novel measurement method on the adversarial hardness of FEAEs, and two evaluation metrics on FEAE transferability. The experimental results illustrate that our approach is superior to other gradient-based attack methods. Finding FEAEs can attack not only facial expression recognition systems but also face recognition systems. The transferability and adversarial hardness of FEAEs can be measured effectively and accurately. [ABSTRACT FROM AUTHOR]

The avian leukosis virus (ALV) strain DL00766 was isolated from a farm in China. The phylogenetic analysis showed that env had the highest homology with the E subgroup reference strain, ranging from 94.5% to 94.9%, whereas gp85 had the highest homology with the B and E subgroups, which were 89.0% to 91.3% and 91.3% to 91.8%. In addition, point mutation analysis of gp85 showed that a 400 bp long fragment in gp85 of DL00766 had the highest homology with subgroup B, ranging from 90.1% to 97.5%, and only 82.7% to 83.1% with E subgroup. These results indicate, DL00766 may be an AVL subgroup E isolate with a subgroup B-like gp85 region. This is also the first finding that the E subgroup is used as a recombinant subject, and the subgroup B provides a recombinant virus of an exogenous gene. [ABSTRACT FROM AUTHOR]

[Display omitted] • A surface functional group regulation strategy was proposed for H 2 O 2 production. • The optimized CoNCF-HNO 3 exhibits satisfactory 2e− ORR selectivity in acid medium. • Positive correlation between C-O-C content and 2e− ORR selectivity was disclosed. • A sterilization system for water disinfection was developed based on CoNCF-HNO 3. Electrochemical synthesis has emerged as a promising alternative method for industrial production of hydrogen peroxide (H 2 O 2). Although transition metal-nitrogen-carbon moieties have been regarded as efficient catalysts for oxygen reduction reaction (ORR), they are generally established for four-electron (4e−) pathway, rather than two-electron (2e−) one for selective generation of H 2 O 2. Herein, we propose a strategy to achieve cobalt-carbon hybrids with high 2e− selectivity for H 2 O 2 production in acidic media via tailoring their surface structure and coordination environment. The correlation between 2e− ORR selectivity of the fabricated monolithic electrodes, i.e. Co nanoparticles embedded in N-doped oxo carbon framework (CoNCF), and their oxygen-containing functional groups is revealed. In particular, an excellent H 2 O 2 selectivity over 91 % in 0.05 M H 2 SO 4 is achieved, which exceeds most of previously reported 2e− ORR electrocatalysts. Moreover, a sterilization system for water disinfection is constructed, demonstrating potential practical applications. The smart design of multi-active sites and porous monolithic architecture opens a new avenue for preparing advanced electrode for H 2 O 2 generation and other environment/energy-related systems. [ABSTRACT FROM AUTHOR]

Infectious bursal disease virus (IBDV) is a non-enveloped, bi-segmented double-stranded RNA virus and the causative agent of a poultry immunosuppressive disease known as infectious bursal disease (IBD). The novel variant IBDV (nVarIBDV) recently posed a great threat to the development of the poultry industry. In this study, we identified a novel segment-reassortant IBDV strain, IBDV-JS19-14701 (Genotype A2dB3). Phylogenic analysis showed that Segments A and B of IBDV-JS19-14701 were derived from emerging nVarIBDV (Genotype A2dB1) and long-prevalent HLJ0504-like strains (Genotype A3B3) in China, respectively. The pathogenicity of IBDV-JS19-14701 was further evaluated via animal experiments. IBDV-JS19-14701 exhibited a similar virulence to chickens with the nVarIBDV. The identification of this reassortment event is beneficial for understanding the epidemiology of nVarIBDV and will contribute to the efficient prevention and control of IBD. [ABSTRACT FROM AUTHOR]