Author: "Redon, A." / Language: english / Publication Year Range: Last 3 years / Search Limiters: Peer Reviewed - Searchworks@Jio Institute Digital Library Search Results

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380 results on '"Redon, A."'

1. Episignatures in practice: independent evaluation of published episignatures for the molecular diagnostics of ten neurodevelopmental disorders

Author: Husson, Thomas, Lecoquierre, François, Nicolas, Gaël, Richard, Anne-Claire, Afenjar, Alexandra, Audebert-Bellanger, Séverine, Badens, Catherine, Bilan, Frédéric, Bizaoui, Varoona, Boland, Anne, Bonnet-Dupeyron, Marie-Noëlle, Brischoux-Boucher, Elise, Bonnet, Céline, Bournez, Marie, Boute, Odile, Brunelle, Perrine, Caumes, Roseline, Charles, Perrine, Chassaing, Nicolas, Chatron, Nicolas, Cogné, Benjamin, Colin, Estelle, Cormier-Daire, Valérie, Dard, Rodolphe, Dauriat, Benjamin, Delanne, Julian, Deleuze, Jean-François, Demurger, Florence, Denommé-Pichon, Anne-Sophie, Depienne, Christel, Dieux, Anne, Dubourg, Christèle, Edery, Patrick, El Chehadeh, Salima, Faivre, Laurence, Fergelot, Patricia, Fradin, Mélanie, Garde, Aurore, Geneviève, David, Gilbert-Dussardier, Brigitte, Goizet, Cyril, Goldenberg, Alice, Gouy, Evan, Guerrot, Anne-Marie, Guimier, Anne, Harzalla, Inès, Héron, Delphine, Isidor, Bertrand, Lacombe, Didier, Le Guillou Horn, Xavier, Keren, Boris, Kuechler, Alma, Lacaze, Elodie, Lavillaureix, Alinoë, Lehalle, Daphné, Lesca, Gaëtan, Lespinasse, James, Levy, Jonathan, Lyonnet, Stanislas, Morel, Godeliève, Jean-Marçais, Nolwenn, Marlin, Sandrine, Marsili, Luisa, Mignot, Cyril, Nambot, Sophie, Nizon, Mathilde, Olaso, Robert, Pasquier, Laurent, Perrin, Laurine, Petit, Florence, Pingault, Veronique, Piton, Amélie, Prieur, Fabienne, Putoux, Audrey, Planes, Marc, Odent, Sylvie, Quélin, Chloé, Quemener-Redon, Sylvia, Rama, Mélanie, Rio, Marlène, Rossi, Massimiliano, Schaefer, Elise, Rondeau, Sophie, Saugier-Veber, Pascale, Smol, Thomas, Sigaudy, Sabine, Touraine, Renaud, Mau-Them, Frederic Tran, Trimouille, Aurélien, Van Gils, Julien, Vanlerberghe, Clémence, Vantalon, Valérie, Vera, Gabriella, Vincent, Marie, Ziegler, Alban, Guillin, Olivier, Campion, Dominique, and Charbonnier, Camille
Published: 2024
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2. Adherence to clinical practice guidelines for using electroconvulsive therapy in elderly depressive patients

Author: Antoine Yrondi, Olivier Blanc, Loic Anguill, Christophe Arbus, Ludivine Boudieu, Marie-Camille Patoz, Adeline Arnould, Thomas Charpeaud, Jean-Baptiste Genty, Racan Abidine, Maximilien Redon, Romain Rey, Bruno Aouizerate, Djamila Bennabi, Wissam El-Hage, Bruno Etain, Jérôme Holtzmann, Marion Leboyer, Fanny Molière, Raphaelle Marie Richieri, Florian Stéphan, Guillaume Vaiva, Anne Sauvaget, Emmanuel Poulet, Emmanuel Haffen, Philippe Courtet, Philippe Fossati, Pierre-Michel Llorca, and Ludovic Samalin
Subjects: ECT, Mood disorder, Major depressive disorder, Bipolar disorder, Geriatric patients, Psychiatry, RC435-571
Abstract: Abstract Objectives Electroconvulsive therapy (ECT) is one of the most effective treatments in mood disorders, mainly in major depressive episode (MDE) in the context of either unipolar (MDD) or bipolar disorder (BD). However, ECT remains a neglected and underused treatment. Older people are at high risk patients for the development of adverse drug reactions. In this context, we sought to determine the duration of MDEs and the number of lines of treatment before the initiation of ECT in patients aged 65 years or over according to the presence or absence of first-line indications for using ECT from international guidelines. Methods In this multicenter, retrospective study including patients aged 65 years or over with MDEs in MDD or BD who have been treated with ECT for MDEs, data on the duration of MDEs and the number of lines of treatment received before ECT were collected. The reasons for using ECT, specifically first-line indications (suicidality, urgency, presence of catatonic and psychotic features, previous ECT response, patient preference) were recorded. Statistical comparisons between groups used standard statistical tests. Results We identified 335 patients. The mean duration of MDEs before ECT was about 9 months. It was significantly shorter in BD than in MDD- about 7 and 10 months, respectively. The co-occurrence of chronic medical disease increased the duration before ECT in the MDD group. The presence of first-line indications for using ECT from guidelines did not reduce the duration of MDEs before ECT, except where there was a previous response to ECT. The first-line indications reduced the number of lines of treatment before starting ECT. Conclusion Even if ECT seems to be a key treatment in the elderly population due to its efficacity and safety for MDEs, the delay before this treatment is still too long.
Published: 2024
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3. 15 years of Big Data: a systematic literature review

Author: Davide Tosi, Redon Kokaj, and Marco Roccetti
Subjects: Big Data, Systematic literature review, SLR, Data analysis, Artificial intelligence, Computer engineering. Computer hardware, TK7885-7895, Information technology, T58.5-58.64, Electronic computers. Computer science, QA75.5-76.95
Abstract: Abstract Big Data is still gaining attention as a fundamental building block of the Artificial Intelligence and Machine Learning world. Therefore, a lot of effort has been pushed into Big Data research in the last 15 years. The objective of this Systematic Literature Review is to summarize the current state of the art of the previous 15 years of research about Big Data by providing answers to a set of research questions related to the main application domains for Big Data analytics; the significant challenges and limitations researchers have encountered in Big Data analysis, and emerging research trends and future directions in Big Data. The review follows a predefined procedure that automatically searches five well-known digital libraries. After applying the selection criteria to the results, 189 primary studies were identified as relevant, of which 32 were Systematic Literature Reviews. Required information was extracted from the 32 studies and summarized. Our Systematic Literature Review sketched the picture of 15 years of research in Big Data, identifying application domains, challenges, and future directions in this research field. We believe that a substantial amount of work remains to be done to align and seamlessly integrate Big Data into data-driven advanced software solutions of the future.
Published: 2024
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4. TAD boundary deletion causes PITX2-related cardiac electrical and structural defects

Author: Manon Baudic, Hiroshige Murata, Fernanda M. Bosada, Uirá Souto Melo, Takanori Aizawa, Pierre Lindenbaum, Lieve E. van der Maarel, Amaury Guedon, Estelle Baron, Enora Fremy, Adrien Foucal, Taisuke Ishikawa, Hiroya Ushinohama, Sean J. Jurgens, Seung Hoan Choi, Florence Kyndt, Solena Le Scouarnec, Vincent Wakker, Aurélie Thollet, Annabelle Rajalu, Tadashi Takaki, Seiko Ohno, Wataru Shimizu, Minoru Horie, Takeshi Kimura, Patrick T. Ellinor, Florence Petit, Yves Dulac, Paul Bru, Anne Boland, Jean-François Deleuze, Richard Redon, Hervé Le Marec, Thierry Le Tourneau, Jean-Baptiste Gourraud, Yoshinori Yoshida, Naomasa Makita, Claude Vieyres, Takeru Makiyama, Stephan Mundlos, Vincent M. Christoffels, Vincent Probst, Jean-Jacques Schott, and Julien Barc
Subjects: Science
Abstract: Abstract While 3D chromatin organization in topologically associating domains (TADs) and loops mediating regulatory element-promoter interactions is crucial for tissue-specific gene regulation, the extent of their involvement in human Mendelian disease is largely unknown. Here, we identify 7 families presenting a new cardiac entity associated with a heterozygous deletion of 2 CTCF binding sites on 4q25, inducing TAD fusion and chromatin conformation remodeling. The CTCF binding sites are located in a gene desert at 1 Mb from the Paired-like homeodomain transcription factor 2 gene (PITX2). By introducing the ortholog of the human deletion in the mouse genome, we recapitulate the patient phenotype and characterize an opposite dysregulation of PITX2 expression in the sinoatrial node (ectopic activation) and ventricle (reduction), respectively. Chromatin conformation assay performed in human induced pluripotent stem cell-derived cardiomyocytes harboring the minimal deletion identified in family#1 reveals a conformation remodeling and fusion of TADs. We conclude that TAD remodeling mediated by deletion of CTCF binding sites causes a new autosomal dominant Mendelian cardiac disorder.
Published: 2024
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5. Exploring the origins of neurodevelopmental proteasomopathies associated with cardiac malformations: are neural crest cells central to certain pathological mechanisms?

Author: Virginie Vignard, Alban-Elouen Baruteau, Bérénice Toutain, Sandra Mercier, Bertrand Isidor, Richard Redon, Jean-Jacques Schott, Sébastien Küry, Stéphane Bézieau, Anne H. Monsoro-Burq, and Frédéric Ebstein
Subjects: neurodevelopmental proteasomopathies, cardiac malformations, craniofacial anomalies, neural crest cells, protein homeostasis, compensatory pathways, Biology (General), QH301-705.5
Abstract: Neurodevelopmental proteasomopathies constitute a recently defined class of rare Mendelian disorders, arising from genomic alterations in proteasome-related genes. These alterations result in the dysfunction of proteasomes, which are multi-subunit protein complexes essential for maintaining cellular protein homeostasis. The clinical phenotype of these diseases manifests as a syndromic association involving impaired neural development and multisystem abnormalities, notably craniofacial anomalies and malformations of the cardiac outflow tract (OFT). These observations suggest that proteasome loss-of-function variants primarily affect specific embryonic cell types which serve as origins for both craniofacial structures and the conotruncal portion of the heart. In this hypothesis article, we propose that neural crest cells (NCCs), a highly multipotent cell population, which generates craniofacial skeleton, mesenchyme as well as the OFT of the heart, in addition to many other derivatives, would exhibit a distinctive vulnerability to protein homeostasis perturbations. Herein, we introduce the diverse cellular compensatory pathways activated in response to protein homeostasis disruption and explore their potential implications for NCC physiology. Altogether, the paper advocates for investigating proteasome biology within NCCs and their early cranial and cardiac derivatives, offering a rationale for future exploration and laying the initial groundwork for therapeutic considerations.
Published: 2024
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6. Generation of a patient-specific induced pluripotent stem cell line carrying the DES p.R406W mutation, an isogenic control and a DES p.R406W knock-in line

Author: Michelle Geryk, Robin Canac, Virginie Forest, Pierre Lindenbaum, Aurore Girardeau, Manon Baudic, Estelle Baron, Anne Bibonne, Caroline Chariau, Florence Kyndt, Richard Redon, Jean-Jacques Schott, Jean-Baptiste Gourraud, Julien Barc, and Flavien Charpentier
Subjects: Biology (General), QH301-705.5
Abstract: Mutations in the DES gene, which encodes the intermediate filament desmin, lead to desminopathy, a rare disease characterized by skeletal muscle weakness and different forms of cardiomyopathies associated with cardiac conduction defects and arrhythmias. We generated human induced pluripotent stem cells (hiPSC) from a patient carrying the DES p.R406W mutation, and employed CRISPR/Cas9 to rectify the mutation in the patient's hiPSC line and introduced the mutation in an hiPSC line from a control individual unrelated to the patient. These hiPSC lines represent useful models for delving into the mechanisms of desminopathy and developing new therapeutic approaches.
Published: 2024
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7. Ricochet Progress and Status

Author: Augier, C., Beaulieu, G., Belov, V., Berge, L., Billard, J., Bres, G., Bret, J. -L., Broniatowski, A., Calvo, M., Cazes, A., Chaize, D., Chapellier, M., Chaplinsky, L., Chemin, G., Chen, R., Colas, J., de Jesus, M., de Marcillac, P., Dumoulin, L., Exshaw, O., Ferriol, S., Figueroa-Feliciano, E., Filippini, J. -B., Formaggio, J. A., Fuard, S., Gascon, J., Giuliani, A., Goupy, J., Goy, C., Guerin, C., Hirjibehedin, C. F., Harrington, P., Heine, S. T., Hertel, S. A., Heusch, M., Hoarau, C., Hong, Z., Ianigro, J. -C., Jin, Y., Johnston, J. P., Juillard, A., Kazarcev, S., Lamblin, J., Lattaud, H., Lubashevskiy, A., Mayer, D. W., Marnieros, S., Minet, J., Misiak, D., Monfardini, A., Mounier, F., Olivieri, E., Oriol, C., Patel, P. K., Perbet, E., Pinckney, H. D., Ponomarev, D., Poda, D., Rarbi, F., Real, J. -S., Ricol, J. -S., Redon, T., Robert, A., Rozov, S., Rozova, I., Salagnac, T., Sanglard, V., Schmidt, B., Shevchik, Ye., Sibille, V., Soldner, T., Stachurska, J., Stutz, A., Vagneron, L., van de Pontseele, W., Vezzu, F., Weber, S., Winslow, L., Yakushev, E., and Zinatulina, D.
Published: 2023
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8. Cyclic vomiting syndrome, a common language? A 20-year bibliometric study

Author: Redon, Sylvain and Donnet, Anne
Published: 2023
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9. How local reference panels improve imputation in French populations

Author: Anthony F. Herzig, Lourdes Velo‐Suárez, The FrEx Consortium, The FranceGenRef Consortium, Christian Dina, Richard Redon, Jean-François Deleuze, and Emmanuelle Génin
Subjects: Medicine, Science
Abstract: Abstract Imputation servers offer the exclusive possibility to harness the largest public reference panels which have been shown to deliver very high precision in the imputation of European genomes. Many studies have nonetheless stressed the importance of ‘study specific panels’ (SSPs) as an alternative and have shown the benefits of combining public reference panels with SSPs. But such combined approaches are not attainable when using external imputation servers. To investigate how to confront this challenge, we imputed 550 French individuals using either the University of Michigan imputation server with the Haplotype Reference Consortium (HRC) panel or an in-house SSP of 850 whole-genome sequenced French individuals. With approximate geo-localization of both our target and SSP individuals we are able to pinpoint different scenarios where SSP-based imputation would be preferred over server-based imputation or vice-versa. This is achieved by showing to a high degree of resolution the importance of the proximity of the reference panel to target individuals; with a focus on the clear added value of SSPs for estimating haplotype phase and for the imputation of rare variants (minor allele-frequency below 0.01). Such benefits were most evident for individuals from the same geographical regions in France as the SSP individuals. Overall, only 42.3% of all 125,442 variants evaluated were better imputed with an SSP from France compared to an external reference panel, however this rises to 58.1% for individuals from geographic regions well covered by the SSP. By investigating haplotype sharing and population fine-structure in France, we show the importance of including SSP haplotypes for imputation but also that they should ideally be combined with large public panels. In the absence of the unattainable results from a combined panel of the HRC and our French SSP, we put forward a pragmatic solution where server-based and SSP-based imputation outcomes can be combined based on comparing posterior genotype probabilities. We show that such an approach can give a level of imputation accuracy in excess of what could be achieved with either strategy alone. The results presented provide detailed insights into the accuracy of imputation that should be expected from different strategies for European populations.
Published: 2024
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10. Search for 22Na in novae supported by a novel method for measuring femtosecond nuclear lifetimes

Author: Fougères, Chloé, de Oliveira Santos, François, José, Jordi, Michelagnoli, Caterina, Clément, Emmanuel, Kim, Yung Hee, Lemasson, Antoine, Guimarães, Valdir, Barrientos, Diego, Bemmerer, Daniel, Benzoni, Giovanna, Boston, Andrew J., Böttger, Roman, Boulay, Florent, Bracco, Angela, Čeliković, Igor, Cederwall, Bo, Ciemala, Michał, Delafosse, Clément, Domingo-Pardo, César, Dudouet, Jérémie, Eberth, Jürgen, Fülöp, Zsolt, González, Vicente, Gottardo, Andrea, Goupil, Johan, Hess, Herbert, Jungclaus, Andrea, Kaşkaş, Ayşe, Korichi, Amel, Lenzi, Silvia M., Leoni, Silvia, Li, Hongjie, Ljungvall, Joa, Lopez-Martens, Araceli, Menegazzo, Roberto, Mengoni, Daniele, Million, Benedicte, Mrázek, Jaromír, Napoli, Daniel R., Navin, Alahari, Nyberg, Johan, Podolyák, Zsolt, Pullia, Alberto, Quintana, Begoña, Ralet, Damien, Redon, Nadine, Reiter, Peter, Rezynkina, Kseniia, Saillant, Frédéric, Salsac, Marie-Delphine, Sánchez-Benítez, Angel M., Sanchis, Enrique, Şenyiğit, Menekşe, Siciliano, Marco, Smirnova, Nadezda A., Sohler, Dorottya, Stanoiu, Mihai, Theisen, Christophe, Valiente-Dobón, Jose J., Ujić, Predrag, and Zielińska, Magdalena
Published: 2023
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11. RepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter

Author: Jo, Jae-Hyun, Park, Jong-Uk, Kim, Yeong-Mu, Ok, Seon-Mi, Kim, Dong-Kyu, Jung, Dong-Hyun, Kim, Hye-Ji, Seong, Hyun-A, Cho, Hyo Je, Nah, Jihoon, Kim, Sangjune, Fu, Haiqing, Redon, Christophe E., Aladjem, Mirit I., and Jang, Sang-Min
Published: 2023
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12. Cardiovascular risk of metabolically healthy obesity in two european populations: Prevention potential from a metabolomic study

Author: Wei, Dongmei, González-Marrachelli, Vannina, Melgarejo, Jesus D, Liao, Chia-Te, Hu, Angie, Janssens, Stefan, Verhamme, Peter, Van Aelst, Lucas, Vanassche, Thomas, Redon, Josep, Tellez-Plaza, Maria, Martin-Escudero, Juan C, Monleon, Daniel, and Zhang, Zhen-Yu
Published: 2023
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13. Influence of surfactant on conductivity, capacitance and doping of electrodeposited polyaniline films

Author: Aihemaiti Kayishaer, Claire Magnenet, Ileana-Alexandra Pavel, Hamdi Ben Halima, Virginie Moutarlier, Boris Lakard, Nathalie Redon, Caroline Duc, and Sophie Lakard
Subjects: electrodeposition, conducting polymers, polyaniline, surfactant, thin films, Technology
Abstract: The electrodeposition of polyaniline films is usually carried out in acid solutions such as hydrochloric acid, perchloric acid or sulfuric acid, and more rarely in organic acids such as camphorsulfonic acid (CSA). In this study, the impact of the presence of a surfactant in the electrolytic solution based on hydrochloric acid or CSA was evaluated by successively using anionic (sodium dodecyl sulfate, SDS), cationic (cetyltrimethylammonium bromide, CTAB), and non-ionic (Tritonx100) surfactants. Whatever the surfactant and the acid used, the electrochemical oxidation of aniline has successfully led to the formation of a thick polyaniline (PANI) film through a quasi-reversible reaction controlled by the diffusion of aniline monomers. The nature of the surfactant was shown to affect physico-chemical properties of the film, in particular its morphological features (morphology, thickness, roughness), electrochemical activity, specific capacitance, and conductivity. For example, PANI films containing SDS had a spongy morphology when PANI films containing Tritonx100 had a more fibrous and compact structure. Glow Discharge Optical Emission Spectroscopy (GDOES) experiments also highlighted differences depending on the acid used since chloride anions, from HCl, were present only on the top surface of the PANI films when camphorsulfonate anions were present everywhere throughout the polymer film, which impacts the doping process and electrochemical activity of the films. Moreover, the specific capacitance of the PANI/CSA films is higher and more sensitive to current density variation than the one of PANI/HCl films. Finally, electrochemical impedance experiments evidenced that the conductivity of PANI films electrodeposited from CSA solutions was much higher than the one of PANI films prepared from HCl solutions, and highly dependent on the nature of the surfactant, the most conductive films being obtained in the presence of SDS and Tritonx100. Therefore, the originality of this work comes from the possibility of modulating the conductivity, capacitance and electroactivity of electrodeposited polyaniline films using surfactants of different polarity, and from the determination of the distribution of ions in the films using the GDOES technique, which is rarely used to characterise organic films.
Published: 2024
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14. Understanding seasonal telomere length dynamics in hibernating species

Author: Redon, Lilian, Constant, Théo, Smith, Steve, Habold, Caroline, and Giroud, Sylvain
Published: 2024
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15. The value of adding black carbon to community monitoring of particulate matter

Author: Sugrue, Rebecca A., Preble, Chelsea V., Butler, James D.A., Redon-Gabel, Alaia J., Marconi, Pietro, Shetty, Karan D., Hill, Lee Ann L., Amezcua-Smith, Audrey M., Lukanov, Boris R., and Kirchstetter, Thomas W.
Published: 2024
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16. Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials

Author: Haney, Margaret, Vallée, Monique, Fabre, Sandy, Collins Reed, Stephanie, Zanese, Marion, Campistron, Ghislaine, Arout, Caroline A., Foltin, Richard W., Cooper, Ziva D., Kearney-Ramos, Tonisha, Metna, Mathilde, Justinova, Zuzana, Schindler, Charles, Hebert-Chatelain, Etienne, Bellocchio, Luigi, Cathala, Adeline, Bari, Andrea, Serrat, Roman, Finlay, David B., Caraci, Filippo, Redon, Bastien, Martín-García, Elena, Busquets-Garcia, Arnau, Matias, Isabelle, Levin, Frances R., Felpin, François-Xavier, Simon, Nicolas, Cota, Daniela, Spampinato, Umberto, Maldonado, Rafael, Shaham, Yavin, Glass, Michelle, Thomsen, Lars Lykke, Mengel, Helle, Marsicano, Giovanni, Monlezun, Stéphanie, Revest, Jean-Michel, and Piazza, Pier Vincenzo
Published: 2023
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17. Persistence and determinants of blood pressure phenotypes according to office and ambulatory blood pressure measurements in youth

Author: Martinez, Fernando, Redon, Josep, Aguilar, Francisco, Calderon, José Miguel, and Lurbe, Empar
Published: 2023
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18. Search for 22Na in novae supported by a novel method for measuring femtosecond nuclear lifetimes

Author: Chloé Fougères, François de Oliveira Santos, Jordi José, Caterina Michelagnoli, Emmanuel Clément, Yung Hee Kim, Antoine Lemasson, Valdir Guimarães, Diego Barrientos, Daniel Bemmerer, Giovanna Benzoni, Andrew J. Boston, Roman Böttger, Florent Boulay, Angela Bracco, Igor Čeliković, Bo Cederwall, Michał Ciemala, Clément Delafosse, César Domingo-Pardo, Jérémie Dudouet, Jürgen Eberth, Zsolt Fülöp, Vicente González, Andrea Gottardo, Johan Goupil, Herbert Hess, Andrea Jungclaus, Ayşe Kaşkaş, Amel Korichi, Silvia M. Lenzi, Silvia Leoni, Hongjie Li, Joa Ljungvall, Araceli Lopez-Martens, Roberto Menegazzo, Daniele Mengoni, Benedicte Million, Jaromír Mrázek, Daniel R. Napoli, Alahari Navin, Johan Nyberg, Zsolt Podolyák, Alberto Pullia, Begoña Quintana, Damien Ralet, Nadine Redon, Peter Reiter, Kseniia Rezynkina, Frédéric Saillant, Marie-Delphine Salsac, Angel M. Sánchez-Benítez, Enrique Sanchis, Menekşe Şenyiğit, Marco Siciliano, Nadezda A. Smirnova, Dorottya Sohler, Mihai Stanoiu, Christophe Theisen, Jose J. Valiente-Dobón, Predrag Ujić, and Magdalena Zielińska
Subjects: Science
Abstract: Abstract Classical novae are thermonuclear explosions in stellar binary systems, and important sources of 26Al and 22Na. While γ rays from the decay of the former radioisotope have been observed throughout the Galaxy, 22Na remains untraceable. Its half-life (2.6 yr) would allow the observation of its 1.275 MeV γ-ray line from a cosmic source. However, the prediction of such an observation requires good knowledge of its nucleosynthesis. The 22Na(p, γ)23Mg reaction remains the only source of large uncertainty about the amount of 22Na ejected. Its rate is dominated by a single resonance on the short-lived state at 7785.0(7) keV in 23Mg. Here, we propose a combined analysis of particle-particle correlations and velocity-difference profiles to measure femtosecond nuclear lifetimes. The application of this method to the study of the 23Mg states, places strong limits on the amount of 22Na produced in novae and constrains its detectability with future space-borne observatories.
Published: 2023
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19. Investigating the Role of Proximal Femoral Morphology in Noncontact ACL Injuries: A Comparative Study

Author: Dijon Musliu, Jeton Shatri, Sadi Bexheti, Ardita Kafexholli, Redon Jashari, Agron Mahmuti, Lavdim Berisha, Ardian Karakushi, and Qerim Kida
Subjects: anterior cruciate ligament, alpha angle, femoroacetabular impingement, Medicine
Abstract: Background: Non-contact anterior cruciate ligament (ACL) injury is a common and debilitating injury among athletes, with high recurrence rates and long-term consequences. Identifying individuals at risk of ACL injury can help prevent or reduce the severity of these injuries. The present study aimed to assess the alpha angle (AA) in ACL rupture patients in both the injured (ipsilateral) and non-affected (contralateral) extremities, compared to a control group. Methods and Results: This case-control study included 105 subjects (78.1% male and 21.9% female) aged between 15 and 45 years of both sexes involved in sports. The case group consisted of 54 patients with sport-related, noncontact ACL ruptures identified by MRI. Fifty-one patients, 10(19.6%) of whom were female, with no ACL rupture, were included in the study as a control group. Hip radiographs were taken in all the subjects using the modified Dunn View with the patient in the supine position, hip flexed 45o and abducted 20o. OsiriX software was used to obtain the measurements. Most injuries were caused by football (58.1%), followed by jumping sports (23.8%) and skiing (18.1%). The mean AA was 49.27 o (SD=4.93) for subjects without ACL rupture and 54.84o (SD=6.17) for subjects with ACL rupture, and the difference was statistically significant (P
Published: 2023
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20. RepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter

Author: Jae-Hyun Jo, Jong-Uk Park, Yeong-Mu Kim, Seon-Mi Ok, Dong-Kyu Kim, Dong-Hyun Jung, Hye-Ji Kim, Hyun-A Seong, Hyo Je Cho, Jihoon Nah, Sangjune Kim, Haiqing Fu, Christophe E. Redon, Mirit I. Aladjem, and Sang-Min Jang
Subjects: Megakaryocytic differentiation, RepID, CRL4A, JARID1A, Medicine, Cytology, QH573-671
Abstract: Abstract Background Megakaryocytes (MKs) are platelet precursors, which arise from hematopoietic stem cells (HSCs). While MK lineage commitment and differentiation are accompanied by changes in gene expression, many factors that modulate megakaryopoiesis remain to be uncovered. Replication initiation determinant protein (RepID) which has multiple histone-code reader including bromodomain, cryptic Tudor domain and WD40 domains and Cullin 4-RING E3 ubiquitin ligase complex (CRL4) recruited to chromatin mediated by RepID have potential roles in gene expression changes via epigenetic regulations. We aimed to investigate whether RepID-CRL4 participates in transcriptional changes required for MK differentiation. Methods The PCR array was performed using cDNAs derived from RepID-proficient or RepID-deficient K562 erythroleukemia cell lines. Correlation between RepID and DAB2 expression was examined in the Cancer Cell Line Encyclopedia (CCLE) through the CellMinerCDB portal. The acceleration of MK differentiation in RepID-deficient K562 cells was determined by estimating cell sizes as well as counting multinucleated cells known as MK phenotypes, and by qRT-PCR analysis to validate transcripts of MK markers using phorbol 12-myristate 13-acetate (PMA)-mediated MK differentiation condition. Interaction between CRL4 and histone methylation modifying enzymes were investigated using BioGRID database, immunoprecipitation and proximity ligation assay. Alterations of expression and chromatin binding affinities of RepID, CRL4 and histone methylation modifying enzymes were investigated using subcellular fractionation followed by immunoblotting. RepID-CRL4-JARID1A-based epigenetic changes on DAB2 promoter were analyzed by chromatin-immunoprecipitation and qPCR analysis. Results RepID-deficient K562 cells highly expressing MK markers showed accelerated MKs differentiation exhibiting increases in cell size, lobulated nuclei together with reaching maximum levels of MK marker expression earlier than RepID-proficient K562 cells. Recovery of WD40 domain-containing RepID constructs in RepID-deficient background repressed DAB2 expression. CRL4A formed complex with histone H3K4 demethylase JARID1A in soluble nucleus and loaded to the DAB2 promoter in a RepID-dependent manner during proliferation condition. RepID, CRL4A, and JARID1A were dissociated from the chromatin during MK differentiation, leading to euchromatinization of the DAB2 promoter. Conclusion This study uncovered a role for the RepID-CRL4A-JARID1A pathway in the regulation of gene expression for MK differentiation, which can form the basis for the new therapeutic approaches to induce platelet production. Video Abstract
Published: 2023
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21. Timescale of radium and alkaline earth cations ascent in the trees: Use of isotopic (228Ra/226Ra) ratio

Author: Rihs, Sophie, Lascar, Eric, Chabaux, François, Pourcelot, Laurent, Calmon, Philippe, Redon, Paul-Olivier, Galy, Catherine, and Turpault, Marie-Pierre
Published: 2024
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22. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Author: Phelps, Nowell H, Singleton, Rosie K, Zhou, Bin, Heap, Rachel A, Mishra, Anu, Bennett, James E, Paciorek, Christopher J, Lhoste, Victor PF, Carrillo-Larco, Rodrigo M, Stevens, Gretchen A, Rodriguez-Martinez, Andrea, Bixby, Honor, Bentham, James, Di Cesare, Mariachiara, Danaei, Goodarz, Rayner, Archie W, Barradas-Pires, Ana, Cowan, Melanie J, Savin, Stefan, Riley, Leanne M, Aguilar-Salinas, Carlos A, Baker, Jennifer L, Barkat, Amina, Bhutta, Zulfiqar A, Branca, Francesco, Caixeta, Roberta B, Cuschieri, Sarah, Farzadfar, Farshad, Ganapathy, Shubash, Ikeda, Nayu, Iotova, Violeta, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Lin, Hsien-Ho, Ma, Jun, Mbanya, Jean Claude N, Miranda, J Jaime, Pradeepa, Rajendra, Rodríguez-Artalejo, Fernando, Sorić, Maroje, Turley, Maria, Wang, Limin, Webster-Kerr, Karen, Aarestrup, Julie, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdeen, Ziad A, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Abubakar Garba, Jamila, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Adams, Robert J, Adu-Afarwuah, Seth, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agbor, Valirie N, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Ågren, Åsa, Aguenaou, Hassan, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Imran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lahou, Badreya, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Al Qaoud, Nawal M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Aldwairji, Maryam A, Alexius, Sylvia, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkerwi, Ala'a, Alkhatib, Buthaina M, Allin, Kristine, Alomary, Shaker A, Alomirah, Husam F, Alshangiti, Arwa M, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amoah, John, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Ängquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assefa, Nega, Aspelund, Thor, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Aung, May Soe, Aurélio de Valois, Correia Júnior Marco, Auvinen, Juha, Avdičová, Mária, Avi, Shina, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Babu, Bontha V, Bacopoulou, Flora, Bæksgaard Jørgensen, Maja, Baharudin, Azli, Bahijri, Suhad, Bajramovic, Izet, Bakacs, Marta, Balakrishna, Nagalla, Balanova, Yulia, Bamoshmoosh, Mohamed, Banach, Maciej, Banegas, José R, Baran, Joanna, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barreto, Marta, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, 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Alireza, Safarpour, Ali Reza, Safi, Sare, Safiri, Saeid, Saghi, Mohammad Hossien, Saidi, Olfa, Saieva, Calogero, Sakata, Satoko, Saki, Nader, Šalaj, Sanja, Salanave, Benoit, Salazar Martinez, Eduardo, Salhanova, Akkumis, Salmerón, Diego, Salomaa, Veikko, Salonen, Jukka T, Salvetti, Massimo, Samoutian, Margarita, Sánchez-Abanto, Jose, Sánchez Rodríguez, Inés, Sandjaja, Sans, Susana, Santa-Marina, Loreto, Santacruz, Ethel, Santos, Diana A, Santos, Ina S, Santos, Lèlita C, Santos, Maria Paula, Santos, Osvaldo, Santos, Rute, Santos, Tamara R, Saramies, Jouko L, Sardinha, Luis B, Sarrafzadegan, Nizal, Sathish, Thirunavukkarasu, Saum, Kai-Uwe, Savva, Savvas, Savy, Mathilde, Sawada, Norie, Sbaraini, Mariana, Scazufca, Marcia, Schaan, Beatriz D, Schaffrath Rosario, Angelika, Schargrodsky, Herman, Schienkiewitz, Anja, Schindler, Karin, Schipf, Sabine, Schmidt, Börge, Schmidt, Carsten O, Schmidt, Ida Maria, Schneider, Andrea, Schnohr, Peter, Schöttker, Ben, Schramm, Sara, Schramm, Stine, Schröder, Helmut, Schultsz, Constance, Schultz, Gry, Schulze, Matthias B, Schutte, Aletta E, Sebert, Sylvain, Sedaghattalab, Moslem, Selamat, Rusidah, Sember, Vedrana, Sen, Abhijit, Senbanjo, Idowu O, Sepanlou, Sadaf G, Sequera, Guillermo, Serra-Majem, Luis, Servais, Jennifer, Ševčíková, Ľudmila, Sewpaul, Ronel, Shalnova, Svetlana, Shamah-Levy, Teresa, Shamshirgaran, Seyed Morteza, Shanthirani, Coimbatore Subramaniam, Sharafkhah, Maryam, Sharma, Sanjib K, Sharman, Almaz, Shaw, Jonathan E, Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shengelia, Lela, Shi, Zumin, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shimony, Tal, Shiri, Rahman, Shrestha, Namuna, Si-Ramlee, Khairil, Siani, Alfonso, Siantar, Rosalynn, Sibai, Abla M, Sidossis, Labros S, Silitrari, Natalia, Silva, Antonio M, Silva, Caroline Ramos de Moura, Silva, Diego Augusto Santos, Silva, Kelly Samara, Sim, Xueling, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöberg, Agneta, Sjöström, Michael, Skoblina, Elena V, Skoblina, Natalia A, 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Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wartha, Olivia, Weber, Adelheid, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Weres, Aneta, Werner, Bo, Westbury, Leo D, Whincup, Peter H, Wichstrøm, Lars, Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wild, Philipp S, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wirth, James P, Wojtyniak, Bogdan, Woldeyohannes, Meseret, Wolf, Kathrin, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C, Wu, Hon-Yen, Wu, Jianfeng, Wu, Li Juan, Wu, Shouling, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yamborisut, Uruwan, Yan, Li, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yardim, Nazan, Yasuharu, Tabara, Yépez García, Martha, Yiallouros, Panayiotis K, Yngve, Agneta, Yoosefi, Moein, Yoshihara, Akihiro, Yotov, Yoto, You, Qi Sheng, You, San-Lin, Younger-Coleman, Novie O, Yu, Yu-Ling, Yu, Yunjiang, Yusof, Safiah Md, Yusoff, Ahmad Faudzi, Zaccagni, Luciana, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zamrazilová, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Zaw, Ko Ko, Zayed, Ayman A, Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zentai, Andrea, Zhang, Bing, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhecheva, Yanitsa V, Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zimmet, Paul, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuñiga Cisneros, Julio, Zuziak, Monika, and Ezzati, Majid
Published: 2024
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23. Dealing with location uncertainty for modeling network-constrained lattice data

Author: Briz-Redón, Álvaro
Published: 2024
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24. Real-life study of the use of oto-acoustic emissions in the diagnosis of intracranial hypotension

Author: Pascaud, J., Redon, S., Elzière, M., and Donnet, A.
Published: 2024
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25. 4-(5-Benzyl-3-((4-fluorophenyl)sulfonyl)-5-methyl-4,5-dihydrofuran-2-yl)-2-nitrobenzamide

Author: Oscar Leonardo Avendaño Leon, Christophe Curti, Hussein El-Kashef, Youssef Kabri, Sébastien Redon, and Patrice Vanelle
Subjects: amidoxime, amide, 4,5-dihydrofuran, nitro group, leishmania, Inorganic chemistry, QD146-197
Abstract: As part of our ongoing attempt to broaden the applications of the amidoxime moiety as a potential source of new antileishmanial agents, this study focuses on the product 4-(5-Benzyl-3-((4-fluorophenyl)sulfonyl)-5-methyl-4,5-dihydrofuran-2-yl)-2-nitrobenzamide. This unexpected amide was obtained in an 85% yield as the major product with a conventional amidoxime synthesis protocol (Ethanol/Na2CO3) involving the reaction of hydroxylamine and a nitrile group. The formation of this amide derivative instead of the expected amidoxime can be attributed to two complementary effects: the strong electron effect of the nitro group and the influence of ethanol, a polar protic solvent. Alternatively, the desired amidoxime derivative, 4-(5-benzyl-3-((4-fluorophenyl)sulfonyl)-5-methyl-4,5-dihydrofuran-2-yl)-N′-hydroxy-2-nitrobenzimidamide, was obtained in an 80% yield by an alternative protocol (DMSO/KOtBu). This original compound, featuring a nitro group in the ortho position to the amidoxime, will be further evaluated, both in the field of medicinal chemistry and in other relevant areas, highlighting an unusual method to access amidoximes from hindered substrates.
Published: 2023
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26. Protection against oxygen in the vinification of the red grape Nerello Mascalese affects volatile organic compounds profile

Author: Isabella Taglieri, Lorenzo Landi, Claudio D'Onofrio, Fabrizio Onofrio Fiorino, Gabriele Figoli, Cecile Thibon, Pascaline Redon, Chiara Sanmartin, Philippe Darriet, Andrea Bellincontro, and Fabio Mencarelli
Subjects: winemaking, Nerello mascalese, VOCs, Thiols, Terpenes, C13-norisoprenoids, Agriculture, Botany, QK1-989
Abstract: We hypothesised that the protection against oxygen (PAO) of must and wine during vinification by avoiding contact with air can preserve the primary volatile organic compounds (VOCs) of Nerello Mascalese. PAO was performed in two seasons (2020 and 2021) using carbon dioxide pellets (CO2,s) and gas (CO2,g), inactivated yeasts and ascorbic acid during fermentation; the control wine was made via traditional vinification without adding the aforementioned components. During fermentation, the two winemaking processes mainly differed in terms of the application of aeration during maceration/fermentation in the pump-over and délestage activities, and the care taken to avoid contact with oxygen during racking. In both years, higher concentrations of polyphenols and total anthocyanins were found in the PAO wine (about 16 % and 20 % respectively). The concentrations of nerol, citronellol and geraniol were significantly higher in the PAO wine in both seasons, albeit with small differences which affected the sensory evaluation. The free/bound terpenes ratio was 0.35 (PAO) and 0.55 (Control). Bound C13-norisoprenoids contents were higher than the free ones; in the PAO wine, free 3-oxo-α-ionol and bound vomifoliol concentrations were slightly higher than in the control wine. Thiols were measured in Nerello for the first time. In 2020 in particular, sulfanylhexan-1-ol was present in larger amounts in the PAO wine. Applying PAO in the production of Nerello Mascalese modified certain VOCs, as well as the overall free/bound ratio due to the increase in bound VOCs, thus influencing the aroma of the wine.
Published: 2023
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27. The background model of the CUPID-Mo $$0\nu \beta \beta $$ 0 ν β β experiment

Author: C. Augier, A. S. Barabash, F. Bellini, G. Benato, M. Beretta, L. Bergé, J. Billard, Yu. A. Borovlev, L. Cardani, N. Casali, A. Cazes, E. Celi, M. Chapellier, D. Chiesa, I. Dafinei, F. A. Danevich, M. De Jesus, P. de Marcillac, T. Dixon, L. Dumoulin, K. Eitel, F. Ferri, B. K. Fujikawa, J. Gascon, L. Gironi, A. Giuliani, V. D. Grigorieva, M. Gros, D. L. Helis, H. Z. Huang, R. Huang, L. Imbert, J. Johnston, A. Juillard, H. Khalife, M. Kleifges, V. V. Kobychev, Yu. G. Kolomensky, S. I. Konovalov, J. Kotila, P. Loaiza, L. Ma, E. P. Makarov, R. Mariam, L. Marini, S. Marnieros, X.-F. Navick, C. Nones, E. B. Norman, E. Olivieri, J. L. Ouellet, L. Pagnanini, L. Pattavina, B. Paul, M. Pavan, H. Peng, G. Pessina, S. Pirro, D. V. Poda, O. G. Polischuk, S. Pozzi, E. Previtali, Th. Redon, A. Rojas, S. Rozov, V. Sanglard, J. A. Scarpaci, B. Schmidt, Y. Shen, V. N. Shlegel, V. Singh, C. Tomei, V. I. Tretyak, V. I. Umatov, L. Vagneron, M. Velázquez, B. Welliver, L. Winslow, M. Xue, E. Yakushev, M. Zarytskyy, and A. S. Zolotarova
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract CUPID-Mo, located in the Laboratoire Souterrain de Modane (France), was a demonstrator for the next generation $$0\nu \beta \beta $$ 0 ν β β decay experiment, CUPID. It consisted of an array of 20 enriched Li $$_{2}$$ 2 $$^{100}$$ 100 MoO $$_4$$ 4 bolometers and 20 Ge light detectors and has demonstrated that the technology of scintillating bolometers with particle identification capabilities is mature. Furthermore, CUPID-Mo can inform and validate the background prediction for CUPID. In this paper, we present a detailed model of the CUPID-Mo backgrounds. This model is able to describe well the features of the experimental data and enables studies of the $$2\nu \beta \beta $$ 2 ν β β decay and other processes with high precision. We also measure the radio-purity of the Li $$_{2}$$ 2 $$^{100}$$ 100 MoO $$_4$$ 4 crystals which are found to be sufficient for the CUPID goals. Finally, we also obtain a background index in the region of interest of 3.7 $$^{+0.9}_{-0.8}$$ - 0.8 + 0.9 (stat) $$^{+1.5}_{-0.7}$$ - 0.7 + 1.5 (syst) $$\times ~10 ^{-3}$$ × 10 - 3 counts/ $$\Delta E_{\text {FWHM}}/\text {mol}_{\text {iso}}/\text {year},$$ Δ E FWHM / mol iso / year , the lowest in a bolometric $$0\nu \beta \beta $$ 0 ν β β decay experiment.
Published: 2023
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28. Assessment of the interactions between soil–biosphere–atmosphere (ISBA) land surface model soil hydrology, using four closed-form soil water relationships and several lysimeters

Author: A. Sobaga, B. Decharme, F. Habets, C. Delire, N. Enjelvin, P.-O. Redon, P. Faure-Catteloin, and P. Le Moigne
Subjects: Technology, Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract: Soil water drainage is the main source of groundwater recharge and river flow. It is therefore a key process for water resource management. In this study, we evaluate the soil hydrology and the soil water drainage, simulated by the interactions between soil–biosphere–atmosphere (ISBA) land surface model currently used for hydrological applications from the watershed scale to the global scale, where parameters are generally not calibrated. This evaluation is done using seven lysimeters from two long-term model approach sites measuring hourly water dynamics between 2009 and 2019 in northeastern France. These 2 m depth lysimeters are filled with different soil types and are either maintained as bare soil or covered with vegetation. Four closed-form equations describing soil water retention and hydraulic conductivity functions are tested, namely the commonly used equations from Brooks and Corey (1966) and van Genuchten (1980), a combination of the van Genuchten (1980) soil water retention function with the Brooks and Corey (1966) unsaturated hydraulic conductivity function, and, for the very first time in a land surface model (LSM), a modified version of the van Genuchten (1980) equations, with a new hydraulic conductivity curve proposed by Iden et al. (2015). The results indicate good performance by ISBA with the different closure equations in terms of soil volumetric water content and water mass. The drained flow at the bottom of the lysimeter is well simulated, using Brooks and Corey (1966), while some weaknesses appear with van Genuchten (1980) due to the abrupt shape near the saturation of its hydraulic conductivity function. The mixed form or the new van Genuchten (1980) hydraulic conductivity function from Iden et al. (2015) allows the solving of this problem and even improves the simulation of the drainage dynamic, especially for intense drainage events. The study also highlights the importance of the vertical heterogeneity of the soil hydrodynamic parameters to correctly simulate the drainage dynamic, in addition to the primary influence of the parameters characterizing the shape of the soil water retention function.
Published: 2023
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29. Pituitary Adenoma Presenting with True Bitemporal Hemianopsia: A Case Report

Author: Afrim Shabani, Flamur Mushica, Besim Latifaj, Jeton Shatri, Ardita Kafexholli, Dijon Musliu, Art Deva, Redon Jashari, and Premtim Rashiti
Subjects: pituitary adenoma, sellar mass, bitemporal hemianopsia, Medicine
Abstract: Pituitary adenomas grow from the anterior pituitary gland and can cause compression of surrounding structures, including the optic chiasm, leading to visual field defects such as bitemporal hemianopia, visual acuity or color perception reduction. In this case report, we present the case of a 45-year-old male patient who presented with long-lasting headaches and visual disturbances, including diplopia and a decline in visual acuity. Despite being initially diagnosed with migraine by a neurologist, a thorough ophthalmological examination revealed visual field defects consistent with true bitemporal hemianopsia. MRI results confirmed the presence of sellar mass, and the patient was referred to the neurosurgery department for immediate intervention. The patient underwent surgical removal of the mass, which was identified as a pituitary adenoma upon histological examination. Three months later, the patient experienced significant improvements in subjective and objective visual acuity, with no diplopia or scotomas in the visual field. In conclusion, this case report highlights the importance of considering pituitary adenoma as a potential cause of visual disturbances, even in the absence of bitemporal hemianopsia. Thorough ophthalmological examination, including visual field testing, can aid in the early detection of chiasmal involvement and prompt referral for further investigation. Early intervention, including surgical removal of the tumor, can prevent other complications and significantly improve visual acuity and overall quality of life for patients.
Published: 2023
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30. Enhanced light signal for the suppression of pile-up events in Mo-based bolometers for the 0 $$\nu \beta \beta $$ ν β β decay search.

Author: A. Ahmine, A. Armatol, I. Bandac, L. Bergé, J. M. Calvo-Mozota, P. Carniti, M. Chapellier, T. Dixon, L. Dumoulin, A. Giuliani, Ph. Gras, F. Ferri, L. Imbert, H. Khalife, P. Loaiza, P. de Marcillac, S. Marnieros, C. A. Marrache-Kikuchi, C. Nones, E. Olivieri, A. Ortiz de Solórzano, G. Pessina, D. V. Poda, Th. Redon, J. A. Scarpaci, M. Velázquez, and A. Zolotarova
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Random coincidences of events could be one of the main sources of background in the search for neutrino-less double-beta decay of $$^{100}$$ 100 Mo with macro-bolometers, due to their modest time resolution. Scintillating bolometers as those based on Li $$_2$$ 2 MoO $$_4$$ 4 crystals and employed in the CROSS and CUPID experiments can eventually exploit the coincident fast signal detected in a light detector to reduce this background. However, the scintillation provides a modest signal-to-noise ratio, making difficult a pile-up pulse-shape recognition and rejection at timescales shorter than a few ms. Neganov–Trofimov–Luke assisted light detectors (NTL-LDs) offer the possibility to effectively increase the signal-to-noise ratio, preserving a fast time-response, and enhance the capability of pile-up rejection via pulse shape analysis. In this article we present: (a) an experimental work performed with a Li $$_2$$ 2 MoO $$_4$$ 4 scintillating bolometer, studied in the framework of the CROSS experiment, and utilizing a NTL-LD; (b) a simulation method to reproduce, synthetically, randomly coincident two-neutrino double-beta decay events; (c) a new analysis method based on a pulse-shape discrimination algorithm capable of providing high pile-up rejection efficiencies. We finally show how the NTL-LDs offer a balanced solution between performance and complexity to reach background index $$\sim $$ ∼ $$10^{-4}$$ 10 - 4 counts/keV/kg/year with 280 g Li $$_2$$ 2 MoO $$_4$$ 4 ( $$^{100}$$ 100 Mo enriched) bolometers at 3034 keV, the Q $$_{\beta \beta }$$ β β of the double-beta decay, and target the goal of a next generation experiment like CUPID.
Published: 2023
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31. Single-Pill Combination with Three Antihypertensive Agents to Improve Blood Pressure Control in Hypertension: Focus on Olmesartan-Based Combinations

Author: Burnier, Michel, Redon, Josep, and Volpe, Massimo
Published: 2023
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32. Comprehensive analysis of the effective and intra-particle diffusion of weakly retained compounds in silica hydrophilic interaction liquid chromatography columns

Author: Redón, Lídia, Subirats, Xavier, Chapel, Soraya, Januarius, Timothy, Broeckhoven, Ken, Rosés, Martí, Cabooter, Deirdre, and Desmet, Gert
Published: 2024
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33. Comparison of GLP-1 receptor agonists and other Glucose-Lowering agents on cardiovascular outcomes in individuals with type 2 diabetes and Obesity: A Spanish Real-World Population-Based study

Author: Palanca, Ana, Ampudia-Blasco, F. Javier, Calderón, José Miguel, Sauri, Inmaculada, Martinez-Hervás, Sergio, Trillo, José Luis, Redón, Josep, and Real, José T.
Published: 2024
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34. Poly(aniline)-based ammonia sensors: Understanding the role of polyurethane on structural/morphological properties and sensing performances

Author: da Silva, Edilene A., Samuel, Cédric, Furini, Leonardo N., Constantino, Carlos José L., Redon, Nathalie, and Duc, Caroline
Published: 2023
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35. Influence of right-angled elbows on the modal response of labyrinthine meta-materials

Author: Cambonie, Tristan, Gourdon, Emmanuel, Redon, Emmanuel, and Leclere, Quentin
Published: 2023
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36. Results from a prototype TES detector for the Ricochet experiment

Author: Augier, C., Baulieu, G., Belov, V., Bergé, L., Billard, J., Bres, G., Bret, J-.L., Broniatowski, A., Calvo, M., Cazes, A., Chaize, D., Chala, M., Chang, C.L., Chapellier, M., Chaplinsky, L., Chemin, G., Chen, R., Colas, J., Cudmore, E., De Jesus, M., de Marcillac, P., Dumoulin, L., Exshaw, O., Ferriol, S., Figueroa-Feliciano, E., Filippini, J.-B., Formaggio, J.A., Fuard, S., Gannon, K., Gascon, J., Giuliani, A., Goupy, J., Goy, C., Guerin, C., Guy, E., Harrington, P., Hertel, S.A., Heusch, M., Hong, Z., Ianigro, J.-C., Jin, Y., Juillard, A., Karaivanov, D., Kazarcev, S., Lamblin, J., Lattaud, H., Li, M., Lisovenko, M., Lubashevskiy, A., Marnieros, S., Martini, N., Mayer, D.W., Minet, J., Monfardini, A., Mounier, F., Novati, V., Olivieri, E., Oriol, C., Ovalle Mateo, L., Palladino, K.J., Patel, P.K., Perbet, E., Pinckney, H.D., Poda, D.V., Ponomarev, D., Rarbi, F., Real, J.-S., Redon, T., Reyes, F.C., Ricol, J.-S., Robert, A., Rozov, S., Rozova, I., Salagnac, T., Schmidt, B., Scorza, S., Shevchik, Ye., Soldner, T., Stachurska, J., Stutz, A., Vagneron, L., Van De Pontseele, W., Veihmeyer, C., Vezzu, F., Wang, G., Winslow, L., Yakushev, E., Yefremenko, V.G., Zhang, J., and Zinatulina, D.
Published: 2023
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37. What clinical analysis of antipsychotic-induced catatonia and neuroleptic malignant syndrome tells us about the links between these two syndromes: A systematic review

Author: Virolle, Jordan, Redon, Maximilien, Montastruc, François, Taïb, Simon, Revet, Alexis, Zivkovic, Vuk, Da Costa, Julien, and Very, Etienne
Published: 2023
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38. An autosomal-dominant childhood-onset disorder associated with pathogenic variants in VCP

Author: Mah-Som, Annelise Y., Daw, Jil, Huynh, Diana, Wu, Mengcheng, Creekmore, Benjamin C., Burns, William, Skinner, Steven A., Holla, Øystein L., Smeland, Marie F., Planes, Marc, Uguen, Kevin, Redon, Sylvia, Bierhals, Tatjana, Scholz, Tasja, Denecke, Jonas, Mensah, Martin A., Sczakiel, Henrike L., Tichy, Heidelis, Verheyen, Sarah, Blatterer, Jasmin, Schreiner, Elisabeth, Thies, Jenny, Lam, Christina, Spaeth, Christine G., Pena, Loren, Ramsey, Keri, Narayanan, Vinodh, Seaver, Laurie H., Rodriguez, Diana, Afenjar, Alexandra, Burglen, Lydie, Lee, Edward B., Chou, Tsui-Fen, Weihl, Conrad C., and Shinawi, Marwan S.
Published: 2023
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39. Study of severe migraine in general medicine

Author: Henri, J., Redon, S., and Donnet, A.
Published: 2023
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40. Cardiovascular risk of metabolically healthy obesity in two european populations: Prevention potential from a metabolomic study

Author: Dongmei Wei, Vannina González-Marrachelli, Jesus D Melgarejo, Chia-Te Liao, Angie Hu, Stefan Janssens, Peter Verhamme, Lucas Van Aelst, Thomas Vanassche, Josep Redon, Maria Tellez-Plaza, Juan C Martin-Escudero, Daniel Monleon, and Zhen-Yu Zhang
Subjects: Cardiovascular risk, Diabetes, Obesity, Metabolically healthy obesity, Metabolomics, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Background A new definition of metabolically healthy obesity (MHO) has recently been proposed to stratify the heterogeneous mortality risk of obesity. Metabolomic profiling provides clues to metabolic alterations beyond clinical definition. We aimed to evaluate the association between MHO and cardiovascular events and assess its metabolomic pattern. Methods This prospective study included Europeans from two population-based studies, the FLEMENGHO and the Hortega study. A total of 2339 participants with follow-up were analyzed, including 2218 with metabolomic profiling. Metabolic health was developed from the third National Health and Nutrition Examination Survey and the UK biobank cohorts and defined as systolic blood pressure
Published: 2023
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41. Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease

Author: Holstege, Henne, Hulsman, Marc, Charbonnier, Camille, Grenier-Boley, Benjamin, Quenez, Olivier, Grozeva, Detelina, van Rooij, Jeroen G. J., Sims, Rebecca, Ahmad, Shahzad, Amin, Najaf, Norsworthy, Penny J., Dols-Icardo, Oriol, Hummerich, Holger, Kawalia, Amit, Amouyel, Philippe, Beecham, Gary W., Berr, Claudine, Bis, Joshua C., Boland, Anne, Bossù, Paola, Bouwman, Femke, Bras, Jose, Campion, Dominique, Cochran, J. Nicholas, Daniele, Antonio, Dartigues, Jean-François, Debette, Stéphanie, Deleuze, Jean-François, Denning, Nicola, DeStefano, Anita L., Farrer, Lindsay A., Fernández, Maria Victoria, Fox, Nick C., Galimberti, Daniela, Genin, Emmanuelle, Gille, Johan J. P., Le Guen, Yann, Guerreiro, Rita, Haines, Jonathan L., Holmes, Clive, Ikram, M. Arfan, Ikram, M. Kamran, Jansen, Iris E., Kraaij, Robert, Lathrop, Marc, Lemstra, Afina W., Lleó, Alberto, Luckcuck, Lauren, Mannens, Marcel M. A. M., Marshall, Rachel, Martin, Eden R., Masullo, Carlo, Mayeux, Richard, Mecocci, Patrizia, Meggy, Alun, Mol, Merel O., Morgan, Kevin, Myers, Richard M., Nacmias, Benedetta, Naj, Adam C., Napolioni, Valerio, Pasquier, Florence, Pastor, Pau, Pericak-Vance, Margaret A., Raybould, Rachel, Redon, Richard, Reinders, Marcel J. T., Richard, Anne-Claire, Riedel-Heller, Steffi G., Rivadeneira, Fernando, Rousseau, Stéphane, Ryan, Natalie S., Saad, Salha, Sanchez-Juan, Pascual, Schellenberg, Gerard D., Scheltens, Philip, Schott, Jonathan M., Seripa, Davide, Seshadri, Sudha, Sie, Daoud, Sistermans, Erik A., Sorbi, Sandro, van Spaendonk, Resie, Spalletta, Gianfranco, Tesi, Niccolo’, Tijms, Betty, Uitterlinden, André G., van der Lee, Sven J., Visser, Pieter Jelle, Wagner, Michael, Wallon, David, Wang, Li-San, Zarea, Aline, Clarimon, Jordi, van Swieten, John C., Greicius, Michael D., Yokoyama, Jennifer S., Cruchaga, Carlos, Hardy, John, Ramirez, Alfredo, Mead, Simon, van der Flier, Wiesje M., van Duijn, Cornelia M., Williams, Julie, Nicolas, Gaël, Bellenguez, Céline, and Lambert, Jean-Charles
Published: 2022
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42. The background model of the CUPID-Mo 0νββ experiment

Author: Augier, C., Barabash, A. S., Bellini, F., Benato, G., Beretta, M., Bergé, L., Billard, J., Borovlev, Yu. A., Cardani, L., Casali, N., Cazes, A., Celi, E., Chapellier, M., Chiesa, D., Dafinei, I., Danevich, F. A., De Jesus, M., de Marcillac, P., Dixon, T., Dumoulin, L., Eitel, K., Ferri, F., Fujikawa, B. K., Gascon, J., Gironi, L., Giuliani, A., Grigorieva, V. D., Gros, M., Helis, D. L., Huang, H. Z., Huang, R., Imbert, L., Johnston, J., Juillard, A., Khalife, H., Kleifges, M., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kotila, J., Loaiza, P., Ma, L., Makarov, E. P., Mariam, R., Marini, L., Marnieros, S., Navick, X.-F., Nones, C., Norman, E. B., Olivieri, E., Ouellet, J. L., Pagnanini, L., Pattavina, L., Paul, B., Pavan, M., Peng, H., Pessina, G., Pirro, S., Poda, D. V., Polischuk, O. G., Pozzi, S., Previtali, E., Redon, Th., Rojas, A., Rozov, S., Sanglard, V., Scarpaci, J. A., Schmidt, B., Shen, Y., Shlegel, V. N., Singh, V., Tomei, C., Tretyak, V. I., Umatov, V. I., Vagneron, L., Velázquez, M., Welliver, B., Winslow, L., Xue, M., Yakushev, E., Zarytskyy, M., and Zolotarova, A. S.
Published: 2023
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43. Enhanced light signal for the suppression of pile-up events in Mo-based bolometers for the 0νββ decay search.

Author: Ahmine, A., Armatol, A., Bandac, I., Bergé, L., Calvo-Mozota, J. M., Carniti, P., Chapellier, M., Dixon, T., Dumoulin, L., Giuliani, A., Gras, Ph., Ferri, F., Imbert, L., Khalife, H., Loaiza, P., de Marcillac, P., Marnieros, S., Marrache-Kikuchi, C. A., Nones, C., Olivieri, E., de Solórzano, A. Ortiz, Pessina, G., Poda, D. V., Redon, Th., Scarpaci, J. A., Velázquez, M., and Zolotarova, A.
Published: 2023
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44. Diethyl (5-Benzyl-2-(4-(N′-hydroxycarbamimidoyl)phenyl)-5-methyl-4,5-dihydrofuran-3-yl)phosphonate

Author: Oscar Leonardo Avendaño Leon, Christophe Curti, Fabiana Maia Santos Urbancg Moncorvo, Youssef Kabri, Sébastien Redon, Eduardo Caio Torres-Santos, Romain Paoli-Lombardo, and Patrice Vanelle
Subjects: amidoxime, 4,5-dihydrofuran-phosphonyl derivative, leishmaniasis, microwave irradiation, Inorganic chemistry, QD146-197
Abstract: As part of our ongoing research into the antileishmanial properties of amidoxime derivatives, we report a preliminary assessment of the antiparasitic properties of a novel compound, diethyl (5-benzyl-2-(4-(N′-hydroxycarbamimidoyl)phenyl)-5-methyl-4,5-dihydrofuran-3-yl)phosphonate. This compound was evaluated in vitro for the first time against the promastigote form of Leishmania amazonensis. Compounds containing both amidoxime and phosphonyl functional groups in dihydrofuran scaffolds are relatively rare, despite the extensive study of this heterocycle in various biological applications. Therefore, this work makes a valuable contribution to the fight against Leishmania spp. as a neglected disease. The cyclized 4,5-dihydrofuran intermediate scaffold was obtained via a three-step synthetic route that had previously been developed for accessing other derivatives, including the sulfone moiety. This synthesis was performed using a manganese-based free radical oxidative method under microwave irradiation. The intermediary 4,5-dihydrofuran, which included a nitrile group, tolerated the subsequent reaction with hydroxylamine hydrochloride, resulting in the formation of the target product. The target compound showed moderate activity in vitro against the promastigote form of L. amazonensis (IC50 = 91.1 µM).
Published: 2023
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45. Presentation of Myopericytoma in the Lower Leg: A Case Report with a Brief Review of the Literature

Author: Redon Jashari, Afrim Shabani, Dijon Musliu, Donjet Bislimi, and Ardita Kafexholli
Subjects: myopericitoma, myoid cells, lower extremities, Medicine
Abstract: Myopericitoma is a rare benign tumor of soft tissue that emerges from perivascular smooth tissue. Myopericitoma primarily derives from soft tissue and skin of the inferior extremities and is rarely found in internal organs. Considering the rare encounter with this neoplasia, it is often misdiagnosed as lipoma or atheroma. Our patient presents with a lump in the lateral region of the Achilles tendon on the right side. On inspection, a small, painful lump of approximately 5 mm×5 mm is noticed without cutaneous changes. In histopathologic examination, branched blood vessels are detected with a characteristic “hemangiopericytoma look-alike” appearance surrounded by prolonged myoid cells.
Published: 2023
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46. Characterization of solute-solvent interactions in liquid chromatography systems: A fast method based on Abraham's linear solvation energy relationships

Author: Redón, Lídia, Safar Beiranvand, Mahmoud, Subirats, Xavier, and Rosés, Martí
Published: 2023
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47. Left Ventricular Abnormal Substrate in Brugada Syndrome

Author: Cheniti, Ghassen, Haissaguerre, Michel, Dina, Christian, Kamakura, Tsukasa, Duchateau, Josselin, Sacher, Frederic, Racine, Hugo-Pierre, Surget, Elodie, Simonet, Floriane, Gourraud, Jean-Baptiste, Sridi, Soumaya, Cochet, Hubert, Andre, Clementine, Bouyer, Benjamin, Chauvel, Remi, Tixier, Romain, Derval, Nicolas, Pambrun, Thomas, Dubois, Remi, Jais, Pierre, Nademanee, Koonlawee, Redon, Richard, Schott, Jean-Jacques, Probst, Vincent, Hocini, Meleze, Barc, Julien, and Bernus, Olivier
Published: 2023
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48. Genetic interaction in the association between oxidative stress and diabetes in the Spanish population

Author: Melero, Rebeca, Quiroz-Rodríguez, Maria Elena, Lara-Hernández, Francisco, Redón, Josep, Sáez, Guillermo, Briongos-Figuero, Laisa S., Abadía-Otero, Jessica, Martín-Escudero, Juan Carlos, Chaves, F. Javier, Ayala, Guillermo, and García-García, Ana-Bárbara
Published: 2023
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49. Uric acid relationships with lipid profile and adiposity indices: Impact of different hyperuricemic thresholds

Author: Alessandro Maloberti, Jennifer Vanoli, Alessandra Finotto, Michele Bombelli, Rita Facchetti, Pau Redon, Giuseppe Mancia, and Guido Grassi
Subjects: adiposity indices, cardiometabolic index, lipid accumulation product, lipids, uric acid, visceral adiposity index, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Previous studies focused on the relationships between Serum Uric Acid (SUA) and lipids have found an association mainly with triglycerides. Furthermore, previous studies on adiposity indices have been focused on the evaluation of the Visceral Adiposity Index (VAI). The present study was aimed at providing within the same population a systematic evaluation of lipids and adiposity indices with SUA, employing both the classic cutoff for hyperuricemia and the newly one identified by the Uric Acid Right for Heart Health (URRAH) study. We analyzed data collected in 1892 subjects of the Pressioni Arteriose Monitorate E loro Associazioni (PAMELA) study with available SUA, lipid profile and variables necessary to calculate VAI, Cardio‐Metabolic Index (CMI) and Lipid Accumulation Product (LAP). At linear regression model (corrected for confounders) SUA correlated with all the lipids values (with the strongest β for triglycerides) and adiposity indices. When the two different cutoffs were compared, the URRAH one was significantly related to atherogenic lipids profile (OR 1.207 for LDL and 1.33 for non‐HDL, P
Published: 2023
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50. Fast neutron background characterization of the future Ricochet experiment at the ILL research nuclear reactor

Author: C. Augier, G. Baulieu, V. Belov, L. Berge, J. Billard, G. Bres, J-. L. Bret, A. Broniatowski, M. Calvo, A. Cazes, D. Chaize, M. Chapellier, L. Chaplinsky, G. Chemin, R. Chen, J. Colas, M. De Jesus, P. de Marcillac, L. Dumoulin, O. Exshaw, S. Ferriol, E. Figueroa-Feliciano, J. -B. Filippini, J. A. Formaggio, S. Fuard, J. Gascon, A. Giuliani, J. Goupy, C. Goy, C. Guerin, E. Guy, P. Harrington, S. T. Heine, S. A. Hertel, M. Heusch, C. F. Hirjibehedin, Z. Hong, J.-C. Ianigro, Y. Jin, J. P. Johnston, A. Juillard, D. Karaivanov, S. Kazarcev, J. Lamblin, H. Lattaud, M. Li, A. Lubashevskiy, S. Marnieros, D. W. Mayer, J. Minet, D. Misiak, J-.L. Mocellin, A. Monfardini, F. Mounier, W. D. Oliver, E. Olivieri, C. Oriol, P. K. Patel, E. Perbet, H. D. Pinckney, D. Poda, D. Ponomarev, F. Rarbi, J.-S. Real, T. Redon, A. Robert, S. Rozov, I. Rozova, T. Salagnac, V. Sanglard, B. Schmidt, Ye. Shevchik, V. Sibille, T. Soldner, J. Stachurska, A. Stutz, L. Vagneron, W. Van De Pontseele, F. Vezzu, S. Weber, L. Winslow, E. Yakushev, D. Zinatulina, and the Ricochet Collaboration
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The future Ricochet experiment aims at searching for new physics in the electroweak sector by providing a high precision measurement of the Coherent Elastic Neutrino-Nucleus Scattering (CENNS) process down to the sub-100 eV nuclear recoil energy range. The experiment will deploy a kg-scale low-energy-threshold detector array combining Ge and Zn target crystals 8.8 m away from the 58 MW research nuclear reactor core of the Institut Laue Langevin (ILL) in Grenoble, France. Currently, the Ricochet Collaboration is characterizing the backgrounds at its future experimental site in order to optimize the experiment’s shielding design. The most threatening background component, which cannot be actively rejected by particle identification, consists of keV-scale neutron-induced nuclear recoils. These initial fast neutrons are generated by the reactor core and surrounding experiments (reactogenics), and by the cosmic rays producing primary neutrons and muon-induced neutrons in the surrounding materials. In this paper, we present the Ricochet neutron background characterization using $$^3$$ 3 He proportional counters which exhibit a high sensitivity to thermal, epithermal and fast neutrons. We compare these measurements to the Ricochet Geant4 simulations to validate our reactogenic and cosmogenic neutron background estimations. Eventually, we present our estimated neutron background for the future Ricochet experiment and the resulting CENNS detection significance. Our results show that depending on the effectiveness of the muon veto, we expect a total nuclear recoil background rate between 44 ± 3 and 9 ± 2 events/day/kg in the CENNS region of interest, i.e. between 50 eV and 1 keV. We therefore found that the Ricochet experiment should reach a statistical significance of 4.6 to 13.6 $$\sigma $$ σ for the detection of CENNS after one reactor cycle, when only the limiting neutron background is considered.
Published: 2023
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