543 results
Search Results
2. White paper on psychodermatology in Europe: A position paper from the EADV Psychodermatology Task Force and the European Society for Dermatology and Psychiatry (ESDaP).
- Author
-
Misery L, Schut C, Balieva F, Bobko S, Reich A, Sampogna F, Altunay I, Dalgard F, Gieler U, Kupfer J, Lvov A, Poot F, Szepietowski JC, Tomas-Aragones L, Vulink N, Zalewska-Janowska A, and Bewley A
- Subjects
- Child, Humans, Europe, Advisory Committees, Skin Diseases diagnosis, Skin Diseases therapy, Dermatology, Psychiatry
- Abstract
Psychodermatology is a subspecialty of dermatology that is of increasing interest to dermatologists and patients. The case for the provision of at least regional psychodermatology services across Europe is robust. Psychodermatology services have been shown to have better, quicker and more cost-efficient clinical outcomes for patients with psychodermatological conditions. Despite this, psychodermatology services are not uniformly available across Europe. In fact many countries have yet to establish dedicated psychodermatology services. In other countries psychodermatology services are in development. Even in countries where psychodermatolgy units have been established, the services are not available across the whole country. This is especially true for the provision of paediatric psychodermatology services. Also whilst most states across Europe are keen to develop psychodermatology services, the rate at which this development is being implemented is very slow. Our paper maps the current provision of psychodermatology services across Europe and indicates that there is still very much more work to be done in order to develop the comprehensive psychodermatology services across Europe, which are so crucial for our patients., (© 2023 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.)
- Published
- 2023
- Full Text
- View/download PDF
3. Simplifying assessment of dimensions of oral lesions using a syringe and 'impression planimetry' with printer paper.
- Author
-
Vishwanath T, Kumar Bose A, Mahajan S, Chikhalkar S, Gole P, Kharkar V, and Balaji H
- Subjects
- Coloring Agents, Humans, Lichen Planus pathology, Observer Variation, Paper, Pemphigoid, Bullous pathology, Pemphigus pathology, Reproducibility of Results, Syringes, Dermatology methods, Oral Ulcer pathology
- Abstract
Two novel methods of measuring the dimensions of oral lesions are described, which would be of help in deciding relative efficacies of different therapeutic agents when used in clinical trials after larger studies quantitatively assessed for inter/intraobserver variability., (© 2021 British Association of Dermatologists.)
- Published
- 2022
- Full Text
- View/download PDF
4. Simple Paper Tape as a Navigation Guide for Handheld in Vivo Imaging Techniques: Line-field Confocal Optical Coherence Tomography (LC-OCT) and Reflectance Confocal Microscopy (RCM)
- Author
-
Alvaro Abarzúa and Javiera Perez-Anker
- Subjects
Dermatology ,RL1-803 - Published
- 2024
- Full Text
- View/download PDF
5. Paper goniometer for contracture monitoring
- Author
-
Chelsey Kratter
- Subjects
Dermatology ,RL1-803 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Published
- 2021
- Full Text
- View/download PDF
6. Ethical considerations for artificial intelligence in dermatology: a scoping review.
- Author
-
Gordon ER, Trager MH, Kontos D, Weng C, Geskin LJ, Dugdale LS, and Samie FH
- Subjects
- Humans, Telemedicine ethics, Informed Consent ethics, Confidentiality ethics, Diagnostic Errors ethics, Diagnostic Errors prevention & control, Computer Security ethics, Skin Diseases diagnosis, Skin Diseases therapy, Mobile Applications ethics, Artificial Intelligence ethics, Dermatology ethics, Dermatology methods
- Abstract
The field of dermatology is experiencing the rapid deployment of artificial intelligence (AI), from mobile applications (apps) for skin cancer detection to large language models like ChatGPT that can answer generalist or specialist questions about skin diagnoses. With these new applications, ethical concerns have emerged. In this scoping review, we aimed to identify the applications of AI to the field of dermatology and to understand their ethical implications. We used a multifaceted search approach, searching PubMed, MEDLINE, Cochrane Library and Google Scholar for primary literature, following the PRISMA Extension for Scoping Reviews guidance. Our advanced query included terms related to dermatology, AI and ethical considerations. Our search yielded 202 papers. After initial screening, 68 studies were included. Thirty-two were related to clinical image analysis and raised ethical concerns for misdiagnosis, data security, privacy violations and replacement of dermatologist jobs. Seventeen discussed limited skin of colour representation in datasets leading to potential misdiagnosis in the general population. Nine articles about teledermatology raised ethical concerns, including the exacerbation of health disparities, lack of standardized regulations, informed consent for AI use and privacy challenges. Seven addressed inaccuracies in the responses of large language models. Seven examined attitudes toward and trust in AI, with most patients requesting supplemental assessment by a physician to ensure reliability and accountability. Benefits of AI integration into clinical practice include increased patient access, improved clinical decision-making, efficiency and many others. However, safeguards must be put in place to ensure the ethical application of AI., Competing Interests: Conflicts of interest The authors declare no conflicts of interest., (© The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2024
- Full Text
- View/download PDF
7. Hydrocolloid dressing as an alternative anti-fog measure to paper tape
- Author
-
Mohammed Ibrahim AlJasser and Ahmed Al-Issa
- Subjects
Dermatology ,RL1-803 - Published
- 2022
- Full Text
- View/download PDF
8. Multiclass skin lesion classification using image augmentation technique and transfer learning models
- Author
-
NagaSwetha R, Vimal K.Shrivastava, and Parvathi, K.
- Published
- 2024
- Full Text
- View/download PDF
9. Developing electronic monitor adapters for dermatologic medication containers: A methods paper.
- Author
-
Shah, Pooja M., Balogh, Esther A., Van Gorkom, Aaron Ross, Brown, Philip J., and Feldman, Steven R.
- Subjects
- *
ELECTRONIC surveillance , *OINTMENTS , *DRUGS , *CONTAINERS , *PATIENT compliance , *DERMATOLOGIC agents - Abstract
The benefit of using the adapters as opposed to patient self-reporting of medication use is objective monitoring of patient adherence to their assigned medication protocol. Keywords: dermatology; electronic monitoring; medication adherence; topical medication EN dermatology electronic monitoring medication adherence topical medication 371 373 3 03/25/22 20220301 NES 220301 INTRODUCTION Medication nonadherence is associated with increased disease severity and poor disease outcomes. [Extracted from the article]
- Published
- 2022
- Full Text
- View/download PDF
10. Dermatology journals from India: A critical appraisal of the journal metrics.
- Author
-
Mehta H, Bishnoi A, Vinay K, and Dogra S
- Subjects
- Humans, Child, Bibliometrics, Journal Impact Factor, India, Dermatology, Periodicals as Topic
- Abstract
Background Bibliometrics refer to documents and citation-based measures that measure different aspects of performance of a journal, including impact, output and prestige. Objective The aim of this study was to collect bibliometric data of various Indian dermatology journals as well as Indian journals from other disciplines, in order to compare relative performances. Methods Journal metrics pertaining to various Indian journals, both from dermatology [Indian Journal of Dermatology, Venereology and Leprology (IJDVL), Indian Journal of Dermatology (IJD), Indian Dermatology Online Journal, Indian Journal of Pediatric Dermatology and International Journal of Trichology] and other disciplines [Indian Journal of Medical Research (IJMR), Indian Journal of Pediatrics (IJP), Indian Journal of Ophthalmology and Indian Journal of Pharmacology] were sought. Data pertaining to the following 8 metrics during the year 2021 was collected: Journal Impact factor, SCImago Journal Rank, h5-index, Eigenfactor score and normalized Eigenfactor Score, Journal Citation Indicator, Scimago Journal and Country Rank H-index, CiteScore and Source Normalized Impact per Paper. Results Among Indian dermatology journals, for the year 2021, IJDVL had the highest impact factor (2.217) and h-index (48). IJD led in terms of prestige metrics such as SCImago Journal Rank (0.403), Eigenfactor score (0.00231) and Source Normalized Impact per Paper (1.132). IJDVL underperformed with respect to an average dermatology journal on all three prestige metrics. Among selected journals from other disciplines, two (IJMR and IJP) had impact factor exceeding five, despite lagging behind IJDVL two years ago. Most had normalized scores exceeding 1, indicating better performance than an average journal from their respective fields. Limitations Non-inclusion of altmetrics related data Conclusion IJDVL is one of the leading Indian journals in the field of dermatology, followed closely by IJD. A rise in IJDVL influence is evident over the past decade, as evident by various metrics. However, the progress still trails behind the average of global dermatology journals as evident by the field-normalized journal metrics, indicating potential for further growth of journal influence.
- Published
- 2023
- Full Text
- View/download PDF
11. Studies from University of Tennessee Reveal New Findings on Medical Devices and Surgical Technology (American Association of Oral and Maxillofacial Surgeon's Position Paper On Oral Mucosal Dysplasia).
- Abstract
Knoxville, State:Tennessee, United States, North and Central America, Medical Devices and Surgical Technology, Dermatology, Dysplasia, Epidemiology, Health and Medicine Keywords: Knoxville; State:Tennessee; United States; North and Central America; Medical Devices and Surgical Technology; Dermatology; Dysplasia; Epidemiology; Health and Medicine EN Knoxville State:Tennessee United States North and Central America Medical Devices and Surgical Technology Dermatology Dysplasia Epidemiology Health and Medicine 1220 1220 1 09/19/23 20230924 NES 230924 2023 SEP 24 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Investigators publish new report on Medical Devices and Surgical Technology. Keywords for this news article include: Knoxville, Tennessee, United States, North and Central America, Medical Devices and Surgical Technology, Dermatology, Dysplasia, Epidemiology, Health and Medicine, University of Tennessee. [Extracted from the article]
- Published
- 2023
12. Narrative review on the management of moderate-severe atopic dermatitis in pediatric age of the Italian Society of Pediatric Allergology and Immunology (SIAIP), of the Italian Society of Pediatric Dermatology (SIDerP) and of the Italian Society of Pediatrics (SIP).
- Author
-
Galli E, Fortina AB, Ricci G, Maiello N, Neri I, Baldo E, Berti I, Bonamonte D, Capra L, Carboni E, Carello R, Caroppo F, Cavagni G, Chinellato I, Cipriani F, Comberiati P, Diociaiuti A, Di Lernia V, Duse M, Filippeschi C, Giannetti A, Giovannini M, Licari A, Marseglia GL, Pace M, Patrizi A, Pajno GB, Peroni D, Villani A, and Eichenfield L
- Subjects
- Adolescent, Child, Humans, Hyperplasia, Pediatricians, Dermatitis, Atopic therapy, Dermatology, Pediatrics
- Abstract
Currently, there are a few detailed guidelines on the overall management of children and adolescents with moderate-severe atopic dermatitis. AD is a complex disease presenting with different clinical phenotypes, which require an individualized and multidisciplinary approach. Therefore, appropriate interaction between primary care pediatricians, pediatric allergists, and pediatric dermatologists is crucial to finding the best management strategy. In this manuscript, members of the Italian Society of Pediatric Allergology and Immunology (SIAIP), the Italian Society of Pediatric Dermatology (SIDerP), and the Italian Society of Pediatrics (SIP) with expertise in the management of moderate-severe atopic dermatitis have reviewed the latest scientific evidence in the field. This narrative review aims to define a pathway to appropriately managing children and adolescents with moderate-severe atopic dermatitis., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
13. Call for papers: JMIR Dermatology special theme issue on teledermatology.
- Published
- 2023
14. Research from University of Texas Health San Antonio Yields New Study Findings on Bronchopulmonary Dysplasia (Leveraging transcriptomics to develop bronchopulmonary dysplasia endotypes: a concept paper).
- Subjects
BRONCHOPULMONARY dysplasia ,TRANSCRIPTOMES ,T helper cells ,CELL differentiation ,RESPIRATORY diseases - Abstract
A new study from the University of Texas Health San Antonio has explored bronchopulmonary dysplasia (BPD), a common complication of extreme prematurity. The researchers used an unsupervised machine learning approach to identify BPD subclasses, or endotypes, based on gene expression data. They found that T helper 17 cell differentiation was the most significant pathway differentiating the BPD endotypes. The study suggests that bioinformatic analyses can help identify BPD endotypes that are associated with clinical definitions of the disease. [Extracted from the article]
- Published
- 2023
15. University of Giessen Reports Findings in Psychology and Psychiatry [White paper on psychodermatology in Europe: A position paper from the EADV Psychodermatology Task Force and the European Society for Dermatology and Psychiatry (ESDaP)].
- Subjects
TASK forces ,DERMATOLOGY ,PSYCHIATRY - Published
- 2023
16. The Promises and Perils of Foundation Models in Dermatology.
- Author
-
Gui H, Omiye JA, Chang CT, and Daneshjou R
- Subjects
- Humans, Skin Diseases therapy, Delivery of Health Care trends, Dermatology trends, Dermatology organization & administration, Artificial Intelligence
- Abstract
Foundation models (FM), which are large-scale artificial intelligence (AI) models that can complete a range of tasks, represent a paradigm shift in AI. These versatile models encompass large language models, vision-language models, and multimodal models. Although these models are often trained for broad tasks, they have been applied either out of the box or after additional fine tuning to tasks in medicine, including dermatology. From addressing administrative tasks to answering dermatology questions, these models are poised to have an impact on dermatology care delivery. As FMs become more ubiquitous in health care, it is important for clinicians and dermatologists to have a basic understanding of how these models are developed, what they are capable of, and what pitfalls exist. In this paper, we present a comprehensive yet accessible overview of the current state of FMs and summarize their current applications in dermatology, highlight their limitations, and discuss future developments in the field., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
17. Routine dermatology training and tele-expertise for general practitioners.
- Author
-
Senet P
- Subjects
- Humans, General Practitioners education, Dermatology education, Telemedicine
- Abstract
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
- Published
- 2024
- Full Text
- View/download PDF
18. What can we learn about skin of color in dermatopathology?
- Author
-
Wondimu B and Sokumbi O
- Subjects
- Humans, Skin pathology, Skin Neoplasms pathology, Skin Neoplasms diagnosis, Dermatology education, Skin Diseases pathology, Skin Diseases diagnosis, Skin Pigmentation
- Abstract
As the US population becomes increasingly diverse, more patients of color seek dermatologic care and often have concerns that are unique to their skin color. Therefore, it is critically important that the knowledge gap in skin of color dermatology be urgently addressed. In addition to addressing the clinical gap in recognizing dermatologic disease in patients of color, the role of dermatopathology in bridging this gap remains unaddressed. Given the impact that skin color can have on the presentation and subsequent management of dermatologic diseases, understanding the current knowledge of the unique structural and histologic characteristics in skin of color may help give us insight on the role skin color should play in histopathologic diagnosis. In this paper, we bring insights into the role dermatopathology plays in addressing our knowledge of cutaneous disease in patients with skin of color. After we highlight issues to consider, we can begin to identify gaps in knowledge that still exist within dermatopathology that need to be addressed to ensure patients of all backgrounds receive equitable dermatologic care., (© 2024 the International Society of Dermatology.)
- Published
- 2024
- Full Text
- View/download PDF
19. Needs and preferences of patients regarding atopic dermatitis care in the era of new therapeutic options: a qualitative study
- Author
-
Linde E. M. de Wijs, Sven van Egmond, Arjan C. A. Devillers, Tamar Nijsten, DirkJan Hijnen, Marjolein Lugtenberg, and Dermatology
- Subjects
Original Paper ,Patient-centered care ,Qualitative research ,Atopic eczema ,Dermatology ,General Medicine ,Therapy ,Atopic dermatitis - Abstract
To optimally tailor atopic dermatitis (AD) care to patients’ needs, especially considering the many emerging therapeutic options, insight into patients’ needs and preferences regarding AD care is needed. To explore patients’ needs and preferences regarding AD care, a qualitative study consisting of three focus groups with a total of 20 adult AD patients was conducted. All sessions were transcribed verbatim and inductively analyzed using several phases of coding to create an overview of patients’ needs and preferences. AD patients emphasized the need for a patient-tailored approach in all identified aspects of AD care. With regard to consultations, patients stressed the need for a personal approach and increased recognition of the disease impact, which should mainly be determined by patients. With regard to the organization of AD care, the need for psychosocial and medical supportive care as well as quick access to health-care providers during disease flares was emphasized. Within the decision-making process, patients indicated that the provided information, the role of the patient and physician, whether or not treatment goals should be set, and decisive factors for indication and feasibility of novel therapies should be patient dependent. AD care should be patient tailored with increased attention for the psychosocial burden, as well as better access to health care during disease flares. To provide patient-tailored care, the personal situation, needs, and preferences of the patient should be taken into account in the therapeutic decision-making process, with respect for the autonomy of the patient. Supplementary Information The online version contains supplementary material available at 10.1007/s00403-021-02321-z.
- Published
- 2022
20. Complex skin cancer treatment requiring reconstructive plastic surgery
- Author
-
Sven van Egmond, Marlies Wakkee, Marc A.M. Mureau, Ida J. Korfage, M. Lugtenberg, Marit Hoogenraad, Dermatology, Public Health, and Plastic and Reconstructive Surgery and Hand Surgery
- Subjects
Male ,medicine.medical_specialty ,Care process ,Skin Neoplasms ,Patient-centered ,Experiences ,Dermatology ,Lentigo maligna ,Disease ,Social issues ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Patient-Centered Care ,medicine ,Skin cancer ,Humans ,030212 general & internal medicine ,Surgery, Plastic ,Aged ,Aged, 80 and over ,Original Paper ,Physician-Patient Relations ,business.industry ,Communication ,General Medicine ,Continuity of Patient Care ,Middle Aged ,Plastic Surgery Procedures ,medicine.disease ,Plastic surgery ,Family medicine ,Interview study ,Female ,Tumor removal ,Reconstruction ,Needs ,business - Abstract
To provide patient-centered care, it is essential to explore what patients consider important and to adjust care accordingly. This may specifically be relevant for patients with complex skin cancer, for whom the care process is often more complicated and psychological and social problems may play a larger role. The objective was to explore the experiences and needs of patients who had undergone surgical treatment by a dermatologist for a complex skin cancer with a subsequent reconstruction by a plastic surgeon. An interview study was conducted among 16 patients who had undergone surgical treatment by a dermatologist and reconstruction by a plastic surgeon for basal cell carcinoma, cutaneous squamous cell carcinoma, or lentigo maligna. The interviews focused on patients’ experiences and needs regarding care using a predefined topic list. All interviews were audio-taped, transcribed verbatim and inductively analyzed using Atlas.ti. Patients reported a need for a skilled and friendly physician who tailors information and communication to their individual situation. A need for continuity of care and improved collaboration between healthcare providers was also emphasized. Furthermore, patients experienced complications and unmet expectations and expressed a need for shared decision-making at various steps throughout the treatment process (depending on age). Patients also considered completeness of tumor removal, follow-up visits with multiple specialists to be planned the same day and recognition of the psychological impact of the disease on the partner important. To improve patient-centered care for complex skin cancer patients, more efforts should be directed towards improving continuity of care and collaboration. Furthermore, it is advocated for physicians to be sensitive to the individual needs of patients and their partner and adjust information, communication and (supportive) care accordingly.
- Published
- 2022
21. Common variable immunodeficiency: different faces of the same disease
- Author
-
Marlena Ewertowska, Anna Dąbrowska, Sylwia Kołtan, Anna Urbańczyk, Elżbieta Grześk, and Mariusz Wysocki
- Subjects
Pediatrics ,medicine.medical_specialty ,Original Paper ,treatment ,business.industry ,diagnosis ,Common variable immunodeficiency ,clinical course ,immunoglobulins ,Cancer ,Dermatology ,Disease ,medicine.disease ,Pneumonia ,medicine ,Immunology and Allergy ,Medical history ,Differential diagnosis ,Sinusitis ,business ,immunodeficiency ,Immunodeficiency - Abstract
Introduction Common variable immunodeficiency (CVID) is one of the primary humoral immunodeficiencies. Despite the inborn nature, the first symptoms may appear in both children and adults. It is characterized by hypogammaglobulinaemia, severe infections, autoimmunity, allergies, and a predisposition to cancer. A delay in diagnosis is a significant problem: the time from the first symptoms of the disease to diagnosis and the implementation of proper treatment is usually very long. The consequence can be irreversible complications, which is why it is so important to promote knowledge on this immunodeficiency. Aim To present the clinical and laboratory manifestation of primary immunodeficiencies such as common variable immunodeficiency. Material and methods The study presents the clinical and laboratory phenotype of 14 patients diagnosed with CVID, aged 5 to 58 years. A detailed medical history was taken, and clinical symptoms, immunological test results and complications were analysed in each patient. According to the ESID guidelines, in the differential diagnosis process of CVID the secondary hypogammaglobulinaemia was excluded. Results The follow-up period ranged from 39 to 133 months (median: 79 months). The median delay for the entire group was 5 years, which was shorter in children than in adults. In the presented group, the infectious phenotype (pneumonia, sinusitis) was dominant. Autoimmune and allergic diseases, malignant tumours and enteropathies have also been observed. Conclusions The diagnostic delay is still too long, especially in adults, which can lead to serious and irreversible complications. Early diagnosis and appropriate treatment with intravenous and subcutaneous immunoglobulins reduces the frequency of infections and their potential complications.
- Published
- 2021
22. Evaluation of a smartphone application for diagnosis of skin diseases
- Author
-
Mariusz Nieniewski, Sebastian Patrzyk, Maksym Mikołajczyk, and Anna Woźniacka
- Subjects
medicine.medical_specialty ,Original Paper ,skin diseases diagnosis ,Intraclass correlation ,business.industry ,Diagnostic accuracy ,Dermatology ,psoriasis ,Smartphone application ,web application ,artificial intelligence ,medicine ,new technology ,Immunology and Allergy ,Medical physics ,Medical diagnosis ,Skin lesion ,business ,smartphone application ,Reliability (statistics) - Abstract
Introduction Artificial intelligence (AI) could offer equal, or even more accurate, diagnoses of melanoma than most dermatologists. However, the value of popular smartphone applications for diagnosing unpigmented skin lesions remains unclear. Aim To compare the diagnostic accuracy of a popular, free-to-use web application for automatic dermatosis diagnosis against expert diagnosis of selected skin diseases. Material and methods Skin lesion images of patients with verified diagnosis were collected using a smartphone and were diagnosed by the application. The AI provided five diagnoses of varying probability. For each patient, accuracy of the diagnosis was evaluated by three criteria, i.e. whether the expert diagnosis was matched by the most probable automated diagnosis, one of the top three diagnoses or one of the top five diagnoses. Reliability was analysed using intraclass correlation coefficients. Results The chance of a correct diagnosis increased when more outcomes were considered and more samples of a skin condition were included. However, the probability of a diagnosis repeating for the same patient was below 25%. Reliability, sensitivity and specificity were insufficient for clinical purposes. Conclusions Although AI diagnostics are encouraging, there is also a large margin for improvement, and AI is not yet an adequate replacement for medical professionals.
- Published
- 2021
23. Associations between onychomycosis and COVID-19 clinical outcomes: a retrospective cohort study from a US metropolitan center
- Author
-
Brittany Lane, Jaya Manjunath, Brittany Maner, Trisha Kaundinya, Jonathan I. Silverberg, Kamaria Nelson, Gabrielle Schwartzman, Uros Rakita, and Armaan Guraya
- Subjects
Adult ,medicine.medical_specialty ,Epidemiology ,medicine.medical_treatment ,Nail ,Dermatology ,Disease ,Logistic regression ,Internal medicine ,Oxygen therapy ,Onychomycosis ,medicine ,Humans ,Risk factor ,Retrospective Studies ,Original Paper ,Fungus ,business.industry ,SARS-CoV-2 ,COVID-19 ,Retrospective cohort study ,General Medicine ,Odds ratio ,Confidence interval ,Oxygen ,business ,Immunosuppressive Agents - Abstract
Little is known about the relationship of COVID-19 outcomes with onychomycosis. We investigated the relationship of onychomycosis with COVID-19 outcomes. A retrospective cohort study was performed on SARS-CoV-2 positive adult outpatients or inpatients who had onychomycosis and other skin diseases. Overall, 430 adults were identified with SARS-CoV-2 and a skin disease, including 98 with diagnosed onychomycosis. In bivariable logistic regression models, onychomycosis was associated with increased hospitalization {odds ratio(OR) [95% confidence interval (CI)]: 3.56 [2.18-5.80]}, initial inpatient vs. outpatient visits (OR [95% CI]: 2.24 [1.35-3.74]), use of oxygen therapy (OR [95% CI]: 2.77 [1.60-4.79]), severe-critical vs. asymptomatic-mild severity (OR [95% CI]: 2.28 [1.32-3.94]), and death (OR [95% CI]: 7.48 [1.83-30.47]) from COVID-19, but not prolonged hospitalization (OR [95% CI]: 1.03 [0.47-2.25]). In multivariable models adjusting for socio-demographics, comorbidities, and immunosuppressant medication use, the associations with onychomycosis remained significant for hospitalization, inpatient visits, oxygen therapy, severe-critical COVID-19. Onychomycosis was a significant independent risk factor for COVID-19 severity, hospitalization, and receiving supplemental oxygen therapy.
- Published
- 2021
24. Dermatology journals from India: A critical appraisal of the journal metrics.
- Author
-
Mehta, Hitaishi, Bishnoi, Anuradha, Vinay, Keshavamurthy, and Dogra, Sunil
- Subjects
- *
ALTMETRICS , *IMPACT factor (Citation analysis) , *MEDICAL periodicals , *DERMATOLOGY , *BIBLIOTHERAPY , *PEDIATRIC dermatology , *ELECTRONIC journals , *PRESTIGE , *MEDICAL research - Abstract
Background Bibliometrics refer to documents and citation-based measures that measure different aspects of performance of a journal, including impact, output and prestige. Objective The aim of this study was to collect bibliometric data of various Indian dermatology journals as well as Indian journals from other disciplines, in order to compare relative performances. Methods Journal metrics pertaining to various Indian journals, both from dermatology [Indian Journal of Dermatology, Venereology and Leprology (IJDVL), Indian Journal of Dermatology (IJD), Indian Dermatology Online Journal, Indian Journal of Pediatric Dermatology and International Journal of Trichology] and other disciplines [Indian Journal of Medical Research (IJMR), Indian Journal of Pediatrics (IJP), Indian Journal of Ophthalmology and Indian Journal of Pharmacology] were sought. Data pertaining to the following 8 metrics during the year 2021 was collected: Journal Impact factor, SCImago Journal Rank, h5-index, Eigenfactor score and normalized Eigenfactor Score, Journal Citation Indicator, Scimago Journal and Country Rank H-index, CiteScore and Source Normalized Impact per Paper. Results Among Indian dermatology journals, for the year 2021, IJDVL had the highest impact factor (2.217) and h-index (48). IJD led in terms of prestige metrics such as SCImago Journal Rank (0.403), Eigenfactor score (0.00231) and Source Normalized Impact per Paper (1.132). IJDVL underperformed with respect to an average dermatology journal on all three prestige metrics. Among selected journals from other disciplines, two (IJMR and IJP) had impact factor exceeding five, despite lagging behind IJDVL two years ago. Most had normalized scores exceeding 1, indicating better performance than an average journal from their respective fields. Limitations Non-inclusion of altmetrics related data Conclusion IJDVL is one of the leading Indian journals in the field of dermatology, followed closely by IJD. A rise in IJDVL influence is evident over the past decade, as evident by various metrics. However, the progress still trails behind the average of global dermatology journals as evident by the field-normalized journal metrics, indicating potential for further growth of journal influence. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
25. Safety and danger of biologic treatments in psoriasis in context of cutaneous T-cell lymphoma (CTCL)
- Author
-
Małgorzata Sokołowska-Wojdyło and Karol Kołkowski
- Subjects
Mycosis fungoides ,Review Paper ,business.industry ,mycosis fungoides ,interleukin-12 ,Cutaneous T-cell lymphoma ,Context (language use) ,Dermatology ,psoriasis ,Biologic treatment ,medicine.disease ,interleukin-17 ,biologic treatment ,Psoriasis ,hemic and lymphatic diseases ,Immunology ,medicine ,Interleukin 12 ,Immunology and Allergy ,Interleukin 17 ,cutaneous T-cell lymphoma ,tumour necrosis factor-α ,business - Abstract
Microenvironment has a significant impact on the pathogenesis of cutaneous T-cell lymphoma (CTCL), especially in the context of new emerging biologic therapies. Our aim was to review the literature on interleukins 12, 17, 23 and tumour necrosis factor-α in mycosis fungoides in order to clarify the safety of using biologics in the treatment of psoriasis. Our analysis suggests that these drugs may have an impact on the progression of CTCL. Concluding, in case of uncertain psoriatic lesions, a biopsy followed by pathologic examination should exclude the possibility of co-existence of a primary cutaneous lymphoma before administration of therapies affecting cytokine profiles.
- Published
- 2021
26. IFNG, FCER1A, PCDHB10 expression as a new potential marker of efficacy in grass pollen allergen-specific immunotherapy
- Author
-
Marek Niedoszytko, Ewa Jassem, Agnieszka Maciejewska, Eliza Wasilewska, Jan Romantowski, Marta Chełmińska, Krzysztof Specjalski, and Joanna Polanska
- Subjects
Oncology ,medicine.medical_specialty ,Allergy ,mRNA ,Dermatology ,medicine.disease_cause ,Allergen ,allergen ,Internal medicine ,Clinical endpoint ,Immunology and Allergy ,Medicine ,Asthma ,Whole blood ,Univariate analysis ,Original Paper ,allergic rhinitis ,business.industry ,Maintenance dose ,asthma ,medicine.disease ,FCER1A ,RC31-1245 ,RL1-803 ,business - Abstract
Introduction Allergen-specific immunotherapy (AIT) is the core treatment in allergic rhinitis and asthma. Although widely used, some patients do not benefit from treatment and there is no efficacy objective marker. Aim To define the profile of gene transcripts during the build-up phase of AIT and their comparison to the control group and then search for a viable efficacy marker in relation to patient symptoms. Material and methods AIT was administered in 22 patients allergic to grass pollen. Analysis of 15 selected transcript expression was performed in whole blood samples taken before AIT (sample A) and after reaching the maintenance dose (sample B). The control group included 25 healthy volunteers (sample C). The primary endpoint was Relative Quantification. The gene expression analysis was followed by clinical evaluation with the use of Allergy Control Score (ACS). Results Comparison between samples A and B of gene expression showed a significant increase in IFNG expression (p = 0.03). In relation to the control group, pretreatment samples from patients showed higher levels of AFAP1L1 (p = 0.006), COMMD8 (p = 0.001), PIK3CD (p = 0.027) and TWIST2 (p = 0.0003) in univariate analysis. A generalized linear regression model was built according to the Bayesian Information Criterion based on the IFNG, FCER1A and PCDHB10 expression pattern for prediction of the AIT outcome. The model showed a correlation in predicted and observed changes in ACS. Conclusions There is a significant change in the expression of IFNG during the build-up phase of AIT. The authors propose an in vitro model of AIT efficacy prediction for further validation.
- Published
- 2021
27. Significance of interleukin-31 (IL-31) gene polymorphisms and IL-31 serum level in psoriasis in correlation with pruritus
- Author
-
Jolanta Gleń, Krzysztof Rębała, Monika Zabłotna, Bogusław Nedoszytko, Aneta Szczerkowska-Dobosz, Małgorzata Sokołowska-Wojdyło, Roman Nowicki, and Dorota Purzycka-Bohdan
- Subjects
gene polymorphism ,Population ,interleukin-31 ,Dermatology ,law.invention ,law ,Psoriasis ,Genotype ,Immunology and Allergy ,Medicine ,Allele ,education ,Internal medicine ,Polymerase chain reaction ,education.field_of_study ,Original Paper ,business.industry ,Promoter ,psoriasis ,pruritus ,medicine.disease ,RC31-1245 ,Interleukin 31 ,RL1-803 ,Immunology ,Gene polymorphism ,business - Abstract
Introduction Interleukin-31 (IL-31) impact on the development and clinical presentation of psoriasis as well as pruritus has not been widely investigated so far. Aim To analyse IL-31 -1066G/A and -2057G/A promoter gene polymorphisms as well as serum IL-31 level and their correlation with severity of psoriasis and pruritus in the population of northern Poland. Material and methods The study included 300 psoriasis patients and 186 healthy volunteers. The polymorphisms were analysed using amplified refractory mutation system – polymerase chain reaction (ARMS-PCR) method. Serum levels of IL-31 were measured using the enzyme-linked immunosorbent assay (ELISA) test. Results The -1066 AA genotype of the IL-31 gene was statistically more frequent in patients and it increased the risk of psoriasis (OR = 1.80; p = 0.04). The GG genotype as well as G allele of the IL-31 -2057 gene polymorphism were rarely observed in psoriasis and were associated with a decreased risk of the disease (OR = 0.6, p = 0.007 and OR = 0.7, p = 0.01, respectively). Serum levels of IL-31 were significantly elevated in psoriasis patients (p < 0.000001), however, they did not correlate with the studied polymorphic variants of the IL-31 gene, severity of psoriasis, disease onset, presence of psoriatic arthritis and pruritus intensity. Conclusions Distinct IL-31 promoter gene polymorphisms may be involved in psoriasis development. It seems that serum concentration of IL-31 may not be a reliable marker of psoriatic pruritus.
- Published
- 2021
28. Skin oxygenation impairment is associated with increased total cholesterol level in children with short-lasting type 1 diabetes mellitus
- Author
-
Leszek Bieniaszewski, Małgorzata Myśliwiec, Anna Wołoszyn-Durkiewicz, Grzegorz Kozera, Agnieszka Brandt-Varma, Jolanta Neubauer-Geryk, and Melanie Wielicka
- Subjects
medicine.medical_specialty ,Ischemia ,Late onset ,Dermatology ,Gastroenterology ,lipids ,Hyperaemia ,chemistry.chemical_compound ,children ,Diabetes mellitus ,Internal medicine ,medicine ,Immunology and Allergy ,post occlusive reactive hyperaemia ,Type 1 diabetes ,Original Paper ,integumentary system ,business.industry ,Cholesterol ,Microangiopathy ,Oxygenation ,transcutaneous oxygen pressure ,medicine.disease ,RC31-1245 ,skin microangiopathy ,chemistry ,RL1-803 ,diabetes mellitus ,medicine.symptom ,business - Abstract
Introduction Transcutaneous oxygen pressure (tcPO2) is a non-invasive method of measuring skin oxygenation that may reflect its superficial perfusion. Skin microvasculature may be impaired in patients with late onset of type 1 diabetes (DM1). However, its condition in children has not been fully determined. Aim To compare tcPO2 in children with short-lasting non-complicated DM1 and age-matched healthy controls with regard to concomitant vascular risk factors. Material and methods The study group consisted of 51 paediatric patients aged 14.9 (8.4-18.0) years with short-lasting DM1 without clinical evidence of diabetic micro- or macroangiopathy and 28 control subjects aged 14.8 (11.3-17.7) years. TcPO2 was tested prior, during and after applying post-occlusive reactive hyperaemia (PORH) test in standardized conditions. Biochemical parameters were assessed and then compared between the groups. Results TcPO2 at maximal ischemia during PORH was higher in the DM1 patients than in healthy controls (2.4 (0.7-18.8) vs. 1.6 (0.4-12.0), p = 0.002). No differences were found regarding the tcPO2 measurements recorded prior to ischemia or after recovery. In DM1, concentrations of total cholesterol, triglycerides, HbA1c and TSH were significantly higher than in healthy controls. The fT4 levels were significantly lower in the DM1 group. After adjusting for lipid levels, no differences in tcPO2 were found, and a multivariate analysis showed the cholesterol levels have a significant impact on tcPO2 response to maximal ischemia. Conclusions Our results indicate that increased lipid levels are responsible for the impaired skin response to ischemic stimuli in short-lasting DM1. This supports the importance of aggressive lipid control in prevention of early onset microangiopathy in those patients.
- Published
- 2021
29. Assessment of the anxiety and depression among patients with idiopathic pruritus ani
- Author
-
Ligia Brzezińska-Wcisło, Karolina Hadasik, and Hubert Arasiewicz
- Subjects
medicine.medical_specialty ,Dermatology ,pruritus ani ,psychogenic pruritus ,Quality of life ,Pruritus Ani ,anxiety-depressive disorders ,Immunology and Allergy ,Medicine ,skin and connective tissue diseases ,Internal medicine ,Depression (differential diagnoses) ,Original Paper ,integumentary system ,business.industry ,Psychogenic pruritus ,medicine.disease ,Anus ,Personality disorders ,RC31-1245 ,body regions ,Mood ,medicine.anatomical_structure ,RL1-803 ,Anxiety ,medicine.symptom ,business - Abstract
Introduction Pruritus ani is an unpleasant sensation that leads to scratching of the skin around the anus. It is a common symptom due to many systemic, dermatological, and proctological conditions. In the absence of evident organic origin of a disease, pruritus may be related to mental disorders as well as personality disorders. Aim To assess the influence of pruritus on anxiety and depression in these patients. Material and methods The study involved 60 patients complaining of persistent pruritus ani. The study included people in which pruritus for organic reasons was ruled out. Tests were carried out to assess the level of depression and anxiety disorders. In addition, patients were asked to fill in the Questionnaire for the Descriptive Assessment of Pruritus and the 4-Item Itch Questionnaire by prof. Jacek Szepietowski. Results The cause of pruritus ani in the study groups has been shown to have a significant influence on the level of depressive symptoms. There was no such relationship for anxiety disorders. In the study group, there was no correlation of depressive-anxiety symptoms with the level of pruritus intensity and the frequency of pruritus. Conclusions The presented data reveal the negative effect of pruritus ani on the psychological functioning of patients. Pruritus ani is characterized by moderate intensity of pruritus, but has a significant influence on the aggravation of depressive symptoms. It is important to look for the causes of this symptom, which can help to eliminate its intensity, improve the patients' mood, and thus improve their quality of life.
- Published
- 2021
30. Atherosclerosis attacks in patients with psoriasis vulgaris but without a relationship with the severity and course of the disease
- Author
-
Agnieszka Białecka, Rafał Czajkowski, Marcin Białecki, and Zbigniew Serafin
- Subjects
medicine.medical_specialty ,Inflammation ,Disease ,Dermatology ,Psoriasis ,Internal medicine ,medicine.artery ,Immunology and Allergy ,Medicine ,In patient ,intima media thickness ,Common carotid artery ,Original Paper ,business.industry ,calcium score ,psoriasis ,medicine.disease ,RC31-1245 ,Increased risk ,Intima-media thickness ,Coronary artery calcification ,RL1-803 ,medicine.symptom ,atherosclerosis ,business - Abstract
Introduction In recent years numerous research studies have indicated that chronic inflammation in psoriasis can be associated with an increased risk of developing atherosclerosis. Aim The presented study was aimed at demonstrating whether patients suffering from psoriasis vulgaris are at a greater risk of developing atherosclerosis depending on the presence of selected cardiovascular risk factors and the course and severity of the disease. Material and methods Sixty-two patients with diagnosed psoriasis vulgaris and 42 healthy volunteers were included in the study. All the patients underwent carotid ultrasound with the assessment of the common carotid artery intima-media thickness (IMT) and the computed tomography with determination of coronary artery calcification (CAC). Results The IMT was significantly higher in the study group (1.030 ±0.303 mm vs. 0.838 ±0.151 mm, p < 0.0001). We also found a significantly increased severity of Calcium Score (CS) in Agatston units (168.20 ±309.63 vs. 24.52 ±43.21, p = 0.0207) of CAC in patients with psoriasis. There was no significant correlation between the degree of atherosclerosis and psoriasis severity determined in the PASI (Psoriasis Area and Severity Index) scale, duration of the disease, number of exacerbations per year or C-reactive protein values. Conclusions The study showed an increased risk of developing atherosclerosis in patients diagnosed with psoriasis vulgaris, but no correlation was found between the degree of atherosclerosis and the severity of the disease.
- Published
- 2021
31. A comparative analysis of tuberculosis in vitro screening in pemphigus patients selected for treatment with rituximab
- Author
-
Elżbieta Kaczmarek, Magdalena Jałowska, Marian Dmochowski, Agnieszka Seraszek-Jaros, Justyna Gornowicz-Porowska, Monika Bowszyc-Dmochowska, and Paweł Bartkiewicz
- Subjects
medicine.medical_specialty ,Tuberculosis ,medicine.medical_treatment ,Mucocutaneous zone ,Dermatology ,rituximab ,tuberculosis screening ,Internal medicine ,medicine ,Immunology and Allergy ,Original Paper ,medicine.diagnostic_test ,business.industry ,Pemphigus vulgaris ,pemphigus ,Immunosuppression ,medicine.disease ,bacterial infections and mycoses ,RC31-1245 ,Exact test ,Pemphigus ,RL1-803 ,Rituximab ,Chest radiograph ,business ,medicine.drug - Abstract
Introduction Patients qualified for the Polish government programme of treating severe pemphigus diseases with rituximab (RTX) available in 2018-2019 had to meet numerous criteria, including no active infectious disease. Aim The clinical usefulness of tuberculosis screening with the QuantiFERON-TB Gold Plus (QFT-Plus) in native pemphigus patients selected for RTX treatment was statistically evaluated. Material and methods Eighteen pemphigus patients were examined with QFT-Plus prior to the intended RTX therapy. Ninety hospital employees examined with QFT-Plus due to contact with a cleaning worker who was diagnosed with active pulmonary tuberculosis were the control group. Results Six of 18 pemphigus patients had a positive QFT-Plus test result, one indefinite result and one initially indefinite and then negative. In the control group, 26 of 90 employees had a positive test result and none had an indefinite result. Statistical analysis by Fisher's exact test showed no statistically significant difference in QFT-Plus positive results between the groups (p = 0.5577). Only in 1 patient with recurrent mucocutaneous pemphigus vulgaris previously treated with traditional immunosuppression, lung changes were detected by computed tomography. No employee had any changes in the chest radiograph. Conclusions Prior immunosuppression and autoimmunity might be the cause of indefinite test results, but they do not seem to increase positive results. In the native population, the QFT-Plus screening reveals a significant population exposure to M. tuberculosis infection independent of pemphigus autoimmunity, and such screening can be a starting point for identifying patients requiring anti-tuberculosis drug prophylaxis before combined RTX-glucocorticosteroid treatment.
- Published
- 2021
32. Use of tape for the management of hypertrophic scar development: A comprehensive review
- Author
-
Jason Brown, Sarah O'Reilly, E. Crofton, Jennifer Strong, and Jenny Ziviani
- Subjects
RD1-811 ,medicine.medical_treatment ,education ,Energy Engineering and Power Technology ,Dentistry ,Scars ,Review ,cicatrix ,Dermatology ,Management Science and Operations Research ,scar ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Hypertrophic scar ,0302 clinical medicine ,medicine ,Reduction (orthopedic surgery) ,tape ,business.industry ,Paper tape ,Mechanical Engineering ,030208 emergency & critical care medicine ,medicine.disease ,Hypertrophic scarring ,RL1-803 ,Wound closure ,Surgery ,Hypertrophic scars ,medicine.symptom ,business ,Wound healing - Abstract
Introduction: Tapes have been used to aid fresh wound closure. For hypertrophic scars, the use of tapes as a therapy to reduce the mechanical forces that stimulate excessive and long-term scarring is yet to be evaluated. The aim of this comprehensive review was to explore the current clinical application of tapes, as a minimally invasive option, as purposed specifically for the management of hypertrophic scarring, regardless of scar causation. Method: Databases were searched using MeSH terms including one identifier for hypertrophic scar and one for the intervention of taping. Studies included the following: patients who received tape for a minimum of 12 weeks as a method of wound closure specifically for the purpose of scar prevention; those who received tape as a method of scar management after scar formation; reported outcomes addressing subjective and/or objective scar appearance; and were available in English. Results: With respect to non-stretch tapes, their use for the prevention of linear surgical scarring is evident in reducing scar characteristics of height, colour and itch. Statistically significant results were found in median scar width, reduction in procedure times and overall scar rating. Tapes were predominately applied by participants themselves, and incidence of irritation was infrequently reported. After 12 months, significance with respect to scar pain, itch, thickness and overall scar elevation was reported in one study investigating paper tape. Two papers reported the use of high stretch tapes; however, subjective results limited formal analysis. Although the use of taping for abnormal hypertrophic scar management is in its infancy, emerging research indicates tapes with an element of stretch may have a positive impact. Conclusions: Non-stretch tapes, for the prevention of linear surgical scarring, are effective in reducing scar characteristics of height, colour and itch. Paper tapes have shown effectiveness when applied during wound remodelling or even on mature scarring, with reported subjective changes in scar colour, thickness and pliability. Preliminary evidence of the benefits of high-stretch, elasticised tapes for scar management in the remodelling phase of wound healing have also been reported. Lay Summary Patients are often concerned about unsightly scars that form on their bodies after trauma, especially burn injuries. These scars can be thick, red and raised on the skin, and can impact on the patient’s quality of life. For some scars, the process of skin thickening continues for up to two years after an injury. Unfortunately, scar formation is a part of the body’s healing process, whereby there is a constant pull or tension under and along the skin’s surface. The use of simple tapes, such as microporetm, to help with wound closure are sometimes used as a therapy to reduce the tension on the skin’s surface when a wound is healing to minimise scar formation. However, the effectiveness of taping has not been proven. This paper looks at the available evidence to support the use of taping to reduce scar features of height, thickness and colour. Initial evidence of mixed levels, suggests some benefits of tapes for scar management and show preliminary efficacy for reduction of scar height, thickness and colour. More research is required to determine the direct impact, comparison to other treatments available and patient viewpoint for this therapy.
- Published
- 2021
33. Quality of life measurement in teledermatology. Position statement of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Teledermatology.
- Author
-
Chernyshov PV, Finlay AY, Tomas-Aragones L, Tognetti L, Moscarella E, Pasquali P, Manolache L, Pustisek N, Svensson A, Marron SE, Bewley A, Salavastru C, Suru A, Koumaki D, Linder D, Abeni D, Augustin M, Blome C, Salek SS, Evers AWM, Poot F, Sampogna F, and Szepietowski JС
- Subjects
- Child, Humans, Quality of Life, Pandemics, Venereology, Dermatology methods, Skin Diseases diagnosis, Skin Diseases therapy
- Abstract
Many events, including the COVID-19 pandemic, have accelerated the implementation of teledermatology pathways within dermatology departments and across healthcare organizations. Quality of Life (QoL) assessment in dermatology is also a rapidly developing field with a gradual shift from theory to practice. The purpose of this paper organized jointly by the European Academy of Dermatology and Venereology (EADV) Task Force (TF) on QoL and patient-oriented outcomes and the EADV TF on teledermatology is to present current knowledge about QoL assessment during the use of teledermatology approaches, including data on health-related (HR) QoL instruments used in teledermatology, comparison of influence of different treatment methods on HRQoL after face-to-face and teledermatology consultations and to make practical recommendations concerning the assessment of QoL in teledermatology. The EADV TFs made the following position statements: HRQoL assessment may be an important part in most of teledermatology activities; HRQoL assessment may be easily and effectively performed during teledermatology consultations. It is especially important to monitor HRQoL of patients with chronic skin diseases during lockdowns or in areas where it is difficult to reach a hospital for face-to-face consultation; regular assessment of HRQoL of patients with skin diseases during teledermatology consultations may help to monitor therapy efficacy and visualize individual patient's needs; we recommend the use of the DLQI in teledermatology, including the use of the DLQI app which is available in seven languages; it is important to develop apps for dermatology-specific HRQoL instruments for use in children (for example the CDLQI and InToDermQoL) and for disease-specific instruments., (© 2023 European Academy of Dermatology and Venereology.)
- Published
- 2024
- Full Text
- View/download PDF
34. Effectiveness of omalizumab in children and adolescents with uncontrolled allergic asthma: a case series from Poland
- Author
-
Mikołaj Gwardys, Ewa Mospinek, Anna Sztafińska, Iwona Stelmach, and Daniela Podlecka
- Subjects
Budesonide ,Pediatrics ,medicine.medical_specialty ,Exacerbation ,Dermatology ,Omalizumab ,Quality of life ,children ,medicine ,Immunology and Allergy ,Internal medicine ,Asthma ,Original Paper ,business.industry ,anti-IgE therapy ,asthma ,medicine.disease ,RC31-1245 ,Discontinuation ,Asthma Control Questionnaire ,RL1-803 ,omalizumab ,Observational study ,business ,medicine.drug - Abstract
Introduction Omalizumab has been successfully used as a supplementary therapy to improve asthma control in children aged ≥ 6 years with moderate or severe persistent allergic asthma. Aim To evaluate effectiveness ofomalizumab in children and adolescents with uncontrolled allergic asthma. Material and methods Seventeen children and adolescents aged 8-16, treated with omalizumab from 2011 until now, were enrolled into the retrospective, open, uncontrolled, observational study. The effectiveness of therapy, asthma control, quality of life, exacerbation rate, corticosteroid use, were assessed after 16, 52 and 104 weeks of treatment and after omalizumab cessation. Results The response to treatment was assessed as excellent (9 patients) and good (6 patients), according to global evaluation of treatment effectiveness (GETE). A statistically significant decrease in use of oral corticosteroids (OCS) and leukotriene receptor antagonists (LTRAs) was observed. The doses of inhaled corticosteroids (ICS) decreased significantly (the mean dose of ICS converted to a dose of budesonide before treatment was 1503.53 μg/day versus 903.53 μg after discontinuation). The mean asthma control questionnaire (ACQ) value decreased from 2.10 to 0.84 points and the mean mini asthma quality of life questionnaire (miniAQLQ) outcome increased from 4.37 to 6.1 points. The mean number of exacerbations decreased from 5.59 to 0.53 per year. Conclusions Our results are supportive of the existing evidence that omalizumab therapy improves asthma control, reduces OCS and ICS use, decreases exacerbations in children and adolescents with severe/moderate uncontrolled allergic asthma.
- Published
- 2021
35. Convolutional neural networks for the detection of malignant melanoma in dermoscopy images
- Author
-
Dominika Kwiatkowska, Piotr Kluska, and Adam Reich
- Subjects
Original Paper ,Artificial neural network ,Receiver operating characteristic ,business.industry ,Deep learning ,Melanoma ,deep learning ,Pattern recognition ,Dermatology ,medicine.disease ,neural networks ,Convolutional neural network ,RC31-1245 ,Melanoma detection ,Open source ,RL1-803 ,melanoma ,Immunology and Allergy ,Medicine ,Artificial intelligence ,dermoscopy ,business ,F1 score ,Internal medicine - Abstract
Introduction Convolutional neural networks gained popularity due to their ability to detect and classify objects in images and videos. It gives also an opportunity to use them for medical tasks in such specialties like dermatology, radiology or ophthalmology. The aim of this study was to investigate the ability of convolutional neural networks to classify malignant melanoma in dermoscopy images. Aim To examine the usefulness of deep learning models in malignant melanoma detection based on dermoscopy images. Material and methods Four convolutional neural networks were trained on open source dataset containing dermoscopy images of seven types of skin lesions. To evaluate the performance of artificial neural networks, the precision, sensitivity, F1 score, specificity and area under the receiver operating curve were calculated. In addition, an ensemble of all neural networks' ability of proper malignant melanoma classification was compared with the results achieved by every single network. Results The best convolutional neural network achieved on average 0.88 precision, 0.83 sensitivity, 0.85 F1 score and 0.99 specificity in the classification of all skin lesion types. Conclusions Artificial neural networks might be helpful in malignant melanoma detection in dermoscopy images.
- Published
- 2021
36. Vulvar cancer in a patient with long-lasting premalignant lesions in the genital area: easily overlooked and difficult to diagnose – a case report and literature review
- Author
-
Paweł Bartnik, Paweł Derlatka, Hanna Marczuk, Alicja Szatko, Agnieszka Dobrowolska-Redo, Ewa Romejko-Wolniewicz, Joanna Kacperczyk-Bartnik, and Monika Kalinowska
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Dermatology ,Lichen sclerosus ,Lesion ,vulvar diseases ,medicine ,Immunology and Allergy ,Internal medicine ,Vulvar Diseases ,Vulvar neoplasm ,papillomaviridae ,Vulvar Lichen Sclerosus ,Review Paper ,integumentary system ,business.industry ,urogenital system ,vulvar lichen sclerosus ,Vulvar cancer ,medicine.disease ,Vulvar intraepithelial neoplasia ,RC31-1245 ,female genital diseases and pregnancy complications ,RL1-803 ,Lymphadenectomy ,vulvar neoplasms ,medicine.symptom ,business - Abstract
Vulvar intraepithelial lesions are a heterogenic group of diseases, which can be easily misdiagnosed. The case of a 61-year-old woman with a history of genital intraepithelial lesions and infection with HPV is presented. Her main complaint was vulvar pruritus. Vulvoscopy revealed the presence of two skin lesions: the first one had the morphology of lichen sclerosus, and the second of a Bowenoid lesion. The biopsy of the first lesion revealed vulvar intraepithelial neoplasia, whereas cells of squamous vulvar cancer were identified in the second lesion. After staging, the patient was advised to undergo hemivulvectomy and lymphadenectomy. The coexistence of morphologically diverse vulvar skin lesions may cause difficulties with diagnosis and the selection of an adequate treatment. Long-term follow-up and regular examination are essential for diagnosis of vulvar malignancies in the early stage.
- Published
- 2021
37. Evaluation of serum omentin-1 and apelin concentrations in patients with hidradenitis suppurativa
- Author
-
Cristina Mata, Ricardo Blanco, Sandra Guiral, Miguel A. González-Gay, Marcos A. González-López, José L. Hernández, J. Gonzalo Ocejo-Viñals, Alfonso Corrales, Virginia Portilla, Diego Díaz, M. Carmen González-Vela, and Universidad de Cantabria
- Subjects
medicine.medical_specialty ,Omentin ,Adipokine ,Dermatology ,Pathogenesis ,Insulin resistance ,Adipokines ,Internal medicine ,Immunology and Allergy ,Medicine ,Hidradenitis suppurativa ,Risk factor ,adipokines ,omentin ,Original Paper ,business.industry ,hidradenitis suppurativa ,medicine.disease ,RC31-1245 ,Hidradenitis Suppurativa ,Apelin ,Endocrinology ,apelin ,RL1-803 ,business ,Body mass index ,Homeostasis - Abstract
Introduction: Recent studies suggest a role of adipokines in the pathogenesis of hidradenitis suppurativa (HS). Omentin-1 and apelin are two recently identified adipokines that have been involved in the regulation of metabolic and inflammatory responses. Aim: To investigate serum omentin-1 and apelin levels in patients with HS and to assess their associations with metabolic parameters, disease severity and HS risk. Material and methods: This case-control study included 139 non-diabetic individuals (78 HS patients and 61 ageand sex-matched controls). Serum concentrations of omentin-1 and apelin and the homeostasis model assessment of insulin resistance (HOMA-IR) were measured in all participants. Results: Serum omentin-1 concentrations were significantly higher in HS patients compared to controls, whereas apelin serum levels did not significantly differ between both groups. These differences in omentin-1 concentrations remained significant even after adjusting for age, sex, and body mass index (BMI). The results of logistic regression analysis showed that increased omentin-1 plasma levels were an independent risk factor for HS. However, we found no association between serum levels of both omentin-1 and apelin with HS severity. Conclusions: Our results show that patients with HS have raised omentin-1 serum levels, which are associated with HS risk.
- Published
- 2021
38. Leukaemia cutis for clinicians, a literature review
- Author
-
Agata Kłosowicz, Wiesław Wiktor Jędrzejczak, Małgorzata Osmola, Artur Jurczyszyn, Beata Gierej, Grzegorz W. Basak, Bogna Ziarkiewicz-Wróblewska, and Anna Waszczuk-Gajda
- Subjects
medicine.medical_specialty ,clinical presentation ,Dermatology ,Mini review ,leukaemia cutis ,Leukaemia cutis ,hemic and lymphatic diseases ,Immunology and Allergy ,Medicine ,In patient ,acute myeloid leukaemia ,Internal medicine ,Multiple myeloma ,Review Paper ,multiple myeloma ,medicine.diagnostic_test ,integumentary system ,business.industry ,medicine.disease ,RC31-1245 ,RL1-803 ,Skin biopsy ,business ,chronic lymphocytic leukaemia - Abstract
Leukaemia cutis (LC) describes infiltration of the skin by leukaemia cells, resulting in clinically identifiable cutaneous lesions. LC has a wide range of clinical manifestations, which can make it difficult to distinguish LC from other skin changes. In a group of patients, LC can be the first manifestation of leukaemia, therefore skin biopsy is crucial for the diagnosis. In this mini review, we discuss various types of leukaemia most frequently represented in leukaemia cutis, in both children and adults and skin changes in multiple myeloma, focusing on the clinical presentation of LC and prognosis in patients.
- Published
- 2021
39. Position statement on the role of nurses in therapeutic patient education in atopic dermatitis
- Author
-
M El-Hachem, K Thormann, A Britsch-Yilmaz, Hélène Aubert, Annice Heratizadeh, Dagmar Simon, J.J.M.C. de Groot, M. Deleuran, A. Wollenberg, F Raymakers, Pavel V Chernyshov, J. F. Stalder, and Sébastien Barbarot
- Subjects
Position statement ,medicine.medical_specialty ,Dieticians ,Modalities ,atopic dermatitis ,business.industry ,Eczema ,nurse ,Nurses ,Dermatology ,Atopic dermatitis ,medicine.disease ,therapeutic patient education ,Dermatitis, Atopic ,Infectious Diseases ,Quality of life (healthcare) ,Patient Education as Topic ,Therapeutic patient education ,Quality of Life ,medicine ,Humans ,Position paper ,Disease management (health) ,Intensive care medicine ,business - Abstract
In chronic skin diseases such as atopic dermatitis (AD), therapeutic failure due to poor patient adherence to treatment is commonly reported. Therapeutic patient education (TPE) is an approach to improve self-management and adherence. Several studies demonstrated that TPE programmes have positive effects on disease management resulting in decreased disease severity and improved quality of life in AD patients. Various healthcare professionals (dermatologists, nurses, psychologists, dieticians) have been involved. TPE performed by trained dermatology nurses are highly efficient and improve various health-related outcomes. The aim of this position paper is to analyse the aims, modalities and efficacy of TPE in AD, to identify specific roles of dermatology nurses, to assess qualification requirements, and to propose practical recommendations. Potential activities of nurses in ongoing and future TPE programmes for AD patients will be discussed.
- Published
- 2021
40. Quality of life assessment in core outcome sets:: a position statement of the EADV Task Force on Quality of Life and Patient Oriented Outcomes
- Author
-
Anthony Bewley, Francesca Sampogna, L. Manolache, Andrea W M Evers, L. Tomas-Aragones, Jacek C Szepietowski, Servando E Marron, M.D. Linder, Pavel V Chernyshov, N. Pustišek, Damiano Abeni, and Mir-saeed Salek
- Subjects
medicine.medical_specialty ,Venereology ,Task force ,business.industry ,Advisory Committees ,Dermatology ,Outcome (game theory) ,Clinical trial ,Core (game theory) ,Infectious Diseases ,Quality of life (healthcare) ,Outcome Assessment, Health Care ,Quality of Life ,Medicine ,Position paper ,Humans ,Medical physics ,Location ,business - Abstract
Core outcome sets (COSs) are an agreed standardized collection of outcomes that should be measured and reported in all clinical trials for a specific clinical condition. Tsekhe aim of our position paper by the European Academy of Dermatology and Venereology (EADV) Task Force on Quality of Life and Patient Oriented Outcomes was to identify the challenges and Patient Oriented Outcomes advantages in the development of COSs within dermatological QoL research. Twelve EADV Task Force multidisciplinary team members presented a total of 101 items (51 advantages and 50 disadvantages). All participants considered that COS are beneficial for comparison between different studies, treatments, dermatological diseases, geographical location and ethnicities. In conclusion, the EADV Task Force on Quality of Life and Patient Oriented Outcomes has recognized the primacy of advantages of COS and deliberated that the disadvantages in COS are related to development process and use of COS.
- Published
- 2021
41. Valorization of Wine-Making By-Products’ Extracts in Cosmetics
- Author
-
Maria Letizia Manca, Richard G. Maroun, Rindala El Khoury, Israa Hoss, Maria Manconi, Hiba N. Rajha, Nicolas Louka, and Sahar Youssef
- Subjects
Wine ,Active ingredient ,Aging ,extracts ,cosmetics ,Bioactive molecules ,media_common.quotation_subject ,Pomace ,grape pomace ,natural active ingredient ,Pharmaceutical Science ,Dermatology ,phenolic compounds ,Pulp and paper industry ,Cosmetics ,Chemistry ,antioxidants ,Chemical Engineering (miscellaneous) ,Surgery ,Business ,QD1-999 ,media_common ,Winemaking - Abstract
The increased demand for conscious, sustainable and beneficial products by the consumers has pushed researchers from both industries and universities worldwide to search for smart strategies capable of reducing the environmental footprint, especially the ones connected with industrial wastes. Among various by-products, generally considered as waste, those obtained by winemaking industries have attracted the attention of a wide variety of companies, other than the vineries. In particular, grape pomaces are considered of interest due to their high content in bioactive molecules, especially phenolic compounds. The latter can be recovered from grape pomace and used as active ingredients in easily marketable cosmetic products. Indeed, phenolic compounds are well known for their remarkable beneficial properties at the skin level, such as antioxidant, antiaging, anti-hyperpigmentation and photoprotective effects. The exploitation of the bioactives contained in grape pomaces to obtain high value cosmetics may support the growing of innovative start-ups and expand the value chain of grapes. This review aims to describe the strategies for recovery of polyphenols from grape pomace, to highlight the beneficial potential of these extracts, both in vitro and in vivo, and their potential utilization as active ingredients in cosmetic products.
- Published
- 2021
42. The Classification of Six Common Skin Diseases Based on Xiangya-Derm: Development of a Chinese Database for Artificial Intelligence
- Author
-
Xiang Chen, Zixi Jiang, Yu Zhang, Xian Wu, Shuang Zhao, Yixin Li, Mingzhu Yin, Siliang Liu, Nianzhou Yu, Juan Su, Yi Li, Zhe Wu, Buyue Qian, Ke Zuo, Kai Huang, Zhu Wu, Mingliang Chen, Xianggui Wang, and Xing Huang
- Subjects
skin ,China ,Skin Neoplasms ,convolutional neural network ,Health Informatics ,Dermoscopy ,Disease ,Primary care ,computer.software_genre ,Convolutional neural network ,medical image processing ,Skin Diseases ,Medicine ,Humans ,Melanoma ,Disease burden ,automatic auxiliary diagnoses ,Chinese population ,Original Paper ,skin disease ,Database ,business.industry ,artificial intelligence ,Data set ,dermatology ,Information fusion ,classification ,Artificial intelligence ,Skin lesion ,business ,computer - Abstract
Background Skin and subcutaneous disease is the fourth-leading cause of the nonfatal disease burden worldwide and constitutes one of the most common burdens in primary care. However, there is a severe lack of dermatologists, particularly in rural Chinese areas. Furthermore, although artificial intelligence (AI) tools can assist in diagnosing skin disorders from images, the database for the Chinese population is limited. Objective This study aims to establish a database for AI based on the Chinese population and presents an initial study on six common skin diseases. Methods Each image was captured with either a digital camera or a smartphone, verified by at least three experienced dermatologists and corresponding pathology information, and finally added to the Xiangya-Derm database. Based on this database, we conducted AI-assisted classification research on six common skin diseases and then proposed a network called Xy-SkinNet. Xy-SkinNet applies a two-step strategy to identify skin diseases. First, given an input image, we segmented the regions of the skin lesion. Second, we introduced an information fusion block to combine the output of all segmented regions. We compared the performance with 31 dermatologists of varied experiences. Results Xiangya-Derm, as a new database that consists of over 150,000 clinical images of 571 different skin diseases in the Chinese population, is the largest and most diverse dermatological data set of the Chinese population. The AI-based six-category classification achieved a top 3 accuracy of 84.77%, which exceeded the average accuracy of dermatologists (78.15%). Conclusions Xiangya-Derm, the largest database for the Chinese population, was created. The classification of six common skin conditions was conducted based on Xiangya-Derm to lay a foundation for product research.
- Published
- 2021
43. Why Are Wet Wipes So Difficult to Preserve? Understanding the Intrinsic Causes
- Author
-
Paul Salama, Inbal Tzafrir, Noa Ziklo, Ariel Gliksberg, and Matan Cohen
- Subjects
Aging ,Preservative ,Nonwoven fabric ,preservation ,technology, industry, and agriculture ,Pharmaceutical Science ,Dermatology ,Contamination ,Pulp and paper industry ,hydrophilic–lipophilic balance ,Phenoxyethanol ,biofilm ,wet wipes ,Chemistry ,chemistry.chemical_compound ,chemistry ,Chemical Engineering (miscellaneous) ,Surgery ,QD1-999 - Abstract
Over the last two decades, significant advances have been made in developing disposable baby wet wipes. Wet wipes consist of two main components: nonwoven fabric and liquid. Being more than 90% water, wet wipes are more susceptible to microbial growth than typical personal care products, hence, high concentrations of preservative compounds are often used to ensure extended protection against contamination. However, there is an obvious tendency to minimize the concentration of irritating actives. Baby wet wipes should contain particularly mild surfactants, well-tolerated preservatives, and a buffer system maintaining the formulation pH at a suitable level for the infant’s skin. Efforts have been centered on removing ingredients with irritation potential, such as phenoxyethanol. In addition, a move towards more natural fabrics is occurring. However, these modifications provoke new challenges in preserving the final products. The nature and composition of the fiber can influence the interactions between the preservative and the wipe, subsequently affecting the performance of the preservative system. In this study, we analyzed the causes of the challenge in preserving wet wipes. We found that fabrics containing natural fibers are the main source of contamination, promoting the generation of biofilms on their surfaces. Moreover, the hydrophilic–lipophilic balance (HLB) was utilized to rationalize the physicochemical interactions between the fabric and the preservatives.
- Published
- 2021
- Full Text
- View/download PDF
44. From good to bad fibroblasts: New promising targets to cure Chron's disease
- Author
-
Cipriani Gianluca
- Subjects
TAZ ,Crohn's disease ,medicine.medical_specialty ,Medicine (General) ,Research paper ,business.industry ,MEDLINE ,General Medicine ,Fibroblasts ,medicine.disease ,Dermatology ,General Biochemistry, Genetics and Molecular Biology ,R5-920 ,Crohn Disease ,ROCK1 ,medicine ,Humans ,Medicine ,intestinal fibroblasts ,YAP ,business - Abstract
Background Intestinal obstruction caused by intestinal fibrosis is a common and serious complication of Crohn's disease (CD). Intestinal fibroblasts, the main effector cells mediating gastrointestinal fibrosis, are activated during chronic inflammation. However, the mechanism of fibroblast activation in CD has not been well elucidated. Methods Fibroblasts isolated from stenotic and nonstenotic intestines of CD patients were used for RNA sequencing. Immunohistochemical and immunofluorescent staining was performed to evaluate the correlation between intestinal fibrosis and YAP/TAZ expression in our CD cohort and a DSS-induced chronic colitis murine model. A Rho-associated coiled-coil-containing protein kinase 1 (ROCK1) inhibitor was used to explore the ROCK1-YAP/TAZ axis in intestinal fibroblasts in vitro and DSS-induced chronic colitis murine model in vivo. Findings The expression of YAP/TAZ was significantly upregulated in stenotic fibroblasts, which was associated with the YAP/TAZ target gene signature. YAP/TAZ knockdown suppressed the activation of intestinal fibroblasts. In intestinal fibroblasts, YAP/TAZ were activated by the Rho-ROCK1 signalling pathway. High YAP/TAZ expression was positively correlated with ROCK1 expression, which is a prognostic marker for intestinal obstruction in CD patients. Interpretation YAP/TAZ activation can lead to fibroblast activation and intestinal obstruction in CD. The effect of ROCK1 inhibitor on alleviating intestinal fibrosis is associated with YAP/TAZ inhibition. Targeted inhibition of YAP/TAZ in fibroblasts may be a potential therapeutic strategy to suppress intestinal fibrosis in CD. Funding This work was supported by the National Key R&D Program of China (2019YFC1316002), the NSFC (81873547, 82073201, 81874177, 82000481) and the Shanghai Sailing Program (20YF1429400).
- Published
- 2021
45. Evidence-based management of cutaneous scarring in dermatology part 2: atrophic acne scarring.
- Author
-
Kim EY, Wong JH, Hussain A, and Khachemoune A
- Subjects
- Humans, Cicatrix etiology, Cicatrix therapy, Cicatrix pathology, Combined Modality Therapy, Atrophy therapy, Treatment Outcome, Dermatology, Acne Vulgaris complications, Acne Vulgaris therapy, Chemexfoliation methods
- Abstract
Atrophic acne scars are the most common type of acne scars and are classified into three main types: icepick, boxcar, and rolling scars. Various procedures and techniques for atrophic acne scarring are discussed in detail, with stronger evidence-based support for lasers (non-fractional, fractional, ablative, and non-ablative), platelet-rich plasma as adjunctive treatment, chemical peels (glycolic acid, trichloroacetic acid, and Jessner's solution), dermal fillers such as hyaluronic acid, and microneedling, and lesser quality evidence for microdermabrasion, subcision, and lipoaspirate grafting. Further research is needed to optimize treatment protocols, assess the efficacy of monotherapies, and establish standardized guidelines for clinicians. This paper will provide a comprehensive review of the evidence-based management of atrophic acne scars, including currently commonly utilized therapies as well as more innovative treatment options., (© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
- Published
- 2023
- Full Text
- View/download PDF
46. Improved polarimetric analysis of human skin through stitching: advantages, limitations, and applications in dermatology.
- Author
-
Jütte L, Patel H, and Roth B
- Subjects
- Animals, Swine, Humans, Skin, Spectrum Analysis, Dermatology
- Abstract
Polarimetry is a powerful tool for the analysis of the optical properties of materials and systems, such as human skin. However, in many polarimetric setups, the field of view is limited to a few square centimeters. In these cases, it is possible to resort to stitching techniques, which involve combining multiple Mueller matrix measurements obtained from different overlapping regions of the sample. In this paper, we propose a stitching technique for polarimetric data and discuss its advantages and limitations. We also describe the potential of image stitching for improving the accuracy and robustness of in vivo polarimetry in the presence of random patient movement. We conducted our research using a diverse set of samples which included porcine skin, human skin from arms and fingers, cold cuts of chicken and gelatine, alongside synthetically created sample data. Our results demonstrate the effectiveness of this technique for the application in dermatology. Each additional in vivo measurement enhances the field of view by approximately one third, thereby considerably augmenting the total observation area. We show that stitching enables for the polarimetric assessment of large skin patches which is useful for the diagnosis of inflammatory skin diseases., (Creative Commons Attribution license.)
- Published
- 2023
- Full Text
- View/download PDF
47. Past, present, and future of global research on artificial intelligence applications in dermatology: A bibliometric analysis.
- Author
-
Wang G, Meng X, and Zhang F
- Subjects
- Humans, Prospective Studies, Algorithms, Bibliometrics, Artificial Intelligence, Dermatology
- Abstract
In recent decades, artificial intelligence (AI) has played an increasingly important role in medicine, including dermatology. Worldwide, numerous studies have reported on AI applications in dermatology, rapidly increasing interest in this field. However, no bibliometric studies have been conducted to evaluate the past, present, or future of this topic. This study aimed to illustrate past and present research and outline future directions for global research on AI applications in dermatology using bibliometric analysis. We conducted an online search of the Web of Science Core Collection database to identify scientific papers on AI applications in dermatology. The bibliometric metadata of each selected paper were extracted, analyzed, and visualized using VOS viewer and Cite Space. A total of 406 papers, comprising 8 randomized controlled trials and 20 prospective studies, were deemed eligible for inclusion. The United States had the highest number of papers (n = 166). The University of California System (n = 24) and Allan C. Halpern (n = 11) were the institution and author with the highest number of papers, respectively. Based on keyword co-occurrence analysis, the studies were categorized into 9 distinct clusters, with clusters 2, 3, and 7 containing keywords with the latest average publication year. Wound progression prediction using machine learning, the integration of AI into teledermatology, and applications of the algorithms in skin diseases, are the current research priorities and will remain future research aims in this field., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2023
- Full Text
- View/download PDF
48. Stefania Jabłońska (1920-2017): A giant in 20 th century dermatology.
- Author
-
Grzybowski A and Pawlikowska-Łagód K
- Subjects
- Humans, Poland, Schools, Medical, Dermatology history, Physicians, Skin Neoplasms
- Abstract
Stefania Jabłońska (1920-2017) is remembered as a physician extraordinaire, outstanding medical scientist, and superb professor of dermatology. She served as Professor and Chairman of Dermatology at the Warsaw Medical School. Not only is she one of the most cited of Polish physicians, she also was world renowned, being elected to honorary membership in innumerable dermatology societies. Jabłońska in 1972 was the first to describe the relationship between the human papillomavirus and skin cancer in epidermodysplasia verruciformis. She collaborated with Professor Gérard Charles Jacques Orth (1936-), with whom she characterized the molecular structure of the oncogenic virus to be the first to be discovered in dermatologic diseases. They also showed that a viral infection could not spread to people with different genetic patterns. For this discovery, Jabłońska and Orth in 1985 were awarded the Robert Koch Medal, which was presented to them by the President of the Federal Republic of Germany, Richard Karl Freiherr von Weizsäcker (1920-2015). Jabłońska is the only Polish scientist to be so honored., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
49. Celebrating the 40th anniversary of Clinics in Dermatology.
- Subjects
- Humans, Anniversaries and Special Events, Dermatology
- Abstract
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
- Published
- 2023
- Full Text
- View/download PDF
50. Early detection of skin cancer using AI: Deciphering dermatology images for melanoma detection.
- Author
-
Deepa, R., ALMahadin, Ghayth, C, Prashant G, and Sivasamy, A.
- Subjects
- *
EARLY detection of cancer , *DEEP learning , *ARTIFICIAL intelligence , *MELANOMA , *MACHINE learning , *DERMATOLOGY - Abstract
This Review explores the transformative impact of artificial intelligence (AI) on the early detection of skin cancer, with a specific focus on melanoma, a potentially lethal form of the disease. Beginning with an overview of traditional diagnostic methods and their limitations, this paper delves into the evolution of AI within dermatology, emphasizing its application in image analysis and pattern recognition. A comprehensive examination of AI algorithms for melanoma detection, including machine learning and deep learning models, is provided. This Review critically assesses the performance metrics, training datasets, and comparative analyses with traditional methods. Addressing challenges such as data quality, interpretability, and ethical considerations, this paper outlines future directions, emphasizing ongoing research, algorithm improvements, and integration with clinical practices. Case studies and success stories highlight the real-world impact of AI in dermatology. This Review concludes by summarizing key findings and underlining the pivotal role of AI in revolutionizing early melanoma detection, with implications for personalized medicine and enhanced patient outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.