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Purpose: The rising incidence and mortality associated with cutaneous malignant tumours highlight the importance of early diagnosis of these tumors. In clinical practice, these tumors are often misdiagnosed as benign skin lesions such as melanocytic nevi (MN) and seborrheic keratosis (SK) because of their similar morphologic features. The incidence and clinicopathological subtypes of cutaneous malignancies in East Asia populations significantly differ from those in fair-skinned groups. However, studies on misdiagnoses in Eastern countries are lacking. Therefore, this study focused on the clinical and pathological features of cutaneous malignant tumors misdiagnosed as MN or SK in a Chinese population. Patients and Methods: A total of 4592 samples clinically diagnosed as MN (n = 3503) or SK (n = 1089) from July 2014 to June 2022 were collected and evaluated retrospectively. The clinical and pathological data were analyzed to identify associated factors. Results: Pathological assessments showed that 2.5% (86/3503) of the specimens clinically diagnosed as MN were malignancies, predominantly basal cell carcinoma (BCC, 84.9%, 73/86), followed by malignant melanoma (MM, 8.1%, 7/86) and squamous cell carcinoma (SCC, 7.0%, 6/86). Similarly, 5.7% (62/1089) of the specimens clinically diagnosed as SK were malignant tumors, of which BCC (50.0%, 31/62) was the most common, followed by SCC (41.9%, 26/62) and MM (8.1%, 5/62). In both types of specimens, advanced age and facial lesions were risk factors for malignancy misdiagnosis. The malignancy rate, mean age, and proportion of SCC in the specimens clinically diagnosed as SK were higher than those in the specimens clinically diagnosed as MN. Dermoscopy significantly reduced the rate of misdiagnosis of these tumors as MN or SK. Conclusion: In China, cutaneous malignant tumors misdiagnosed as MN or SK are not uncommon in clinical practice, and active introduction of noninvasive diagnostic techniques is essential to distinguish them. [ABSTRACT FROM AUTHOR]

The Tanlu Fault Zone in eastern China stretches more than 2,400 km and is a significant, active, feature in the tectonics of East Asia. Here, we show the results of local earthquake travel‐time tomographical approach based on a comprehensive and systematic set of seismic data collected from 2008 to 2018 along the Central South Segment of the Tanlu Fault Zone. According to the model, the uppermost 0–10 km of the crust shows a close relationship between seismic velocity and the lithological properties of surface geological units. The middle crust at 10–20 km depths exhibits a strong connection between its high‐low velocity transitions and sites of augmented seismic activity. The top mantle at 34 km depths has lower velocities in the western region in comparison to the east, implying that the seismic Moho is deeper in the western area. These characteristics may reflect spatial variations in the destruction of the North China Craton. [ABSTRACT FROM AUTHOR]