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Delusions of control in schizophrenia are characterized by the striking feeling that one's actions are controlled by external forces. We here tested qualitative predictions inspired by Bayesian causal inference models, which suggest that such misattributions of agency should lead to decreased intentional binding. Intentional binding refers to the phenomenon that subjects perceive a compression of time between their intentional actions and consequent sensory events. We demonstrate that patients with delusions of control perceived less self-agency in our intentional binding task. This effect was accompanied by significant reductions of intentional binding as compared to healthy controls and patients without delusions. Furthermore, the strength of delusions of control tightly correlated with decreases in intentional binding. Our study validated a critical prediction of Bayesian accounts of intentional binding, namely that a pathological reduction of the prior likelihood of a causal relation between one's actions and consequent sensory events--here captured by delusions of control--should lead to lesser intentional binding. Moreover, our study highlights the import of an intact perception of temporal contiguity between actions and their effects for the sense of agency. [ABSTRACT FROM AUTHOR]

While traditional theories of sensorimotor processing have often assumed a serial decision-making pipeline, more recent approaches have suggested that multiple actions may be planned concurrently and vie for execution. Evidence for the latter almost exclusively stems from electrophysiological studies in posterior parietal and premotor cortex of monkeys. Here we study concurrent prospective motor planning in humans by recording functional magnetic resonance imaging (fMRI) during a delayed response task engaging movement sequences towards multiple potential targets. We find that also in human posterior parietal and premotor cortex delay activity modulates both with sequence complexity and the number of potential targets. We tested the hypothesis that this modulation is best explained by concurrent prospective planning as opposed to the mere maintenance of potential targets in memory. We devise a bounded rationality model with information constraints that optimally assigns information resources for planning and memory for this task and determine predicted information profiles according to the two hypotheses. When regressing delay activity on these model predictions, we find that the concurrent prospective planning strategy provides a significantly better explanation of the fMRI-signal modulations. Moreover, we find that concurrent prospective planning is more costly and thus limited for most subjects, as expressed by the best fitting information capacities. We conclude that bounded rational decision-making models allow relating both behavior and neural representations to utilitarian task descriptions based on bounded optimal information-processing assumptions. Author summary: When the future is uncertain, it can be beneficial to concurrently plan several action possibilities in advance. Electrophysiological research found evidence in monkeys that brain regions in posterior parietal and promotor cortex are indeed capable of planning several actions in parallel. We now used fMRI to study brain activity in these brain regions in humans. For our analyses we applied bounded rationality models that optimally assign information resources to fMRI activity in a complex motor planning task. We find that theoretical information costs of concurrent prospective planning explained fMRI activity profiles significantly better than assuming alternative memory-based strategies. Moreover, exploiting the model allowed us to quantify the individual capacity limit for concurrent planning and to relate these individual limits to both subjects' behavior and to their neural representations of planning. [ABSTRACT FROM AUTHOR]

The static magnetic field of MRI scanners can induce a magneto-hydrodynamic stimulation of the vestibular organ (MVS). In common fMRI settings, this MVS effect leads to a vestibular ocular reflex (VOR). We asked whether - beyond inducing a VOR - putting a healthy subject in a 3T MRI scanner would also alter goal-directed spatial behavior, as is known from other types of vestibular stimulation. We investigated 17 healthy volunteers, all of which exhibited a rightward VOR inside the MRI-scanner as compared to outside-MRI conditions. More importantly, when probing the distribution of overt spatial attention inside the MRI using a visual search task, subjects scanned a region of space that was significantly shifted toward the right. An additional estimate of subjective straight-ahead orientation likewise exhibited a rightward shift. Hence, putting subjects in a 3T MRI-scanner elicits MVS-induced horizontal biases of spatial orienting and exploration, which closely mimic that of stroke patients with spatial neglect. [ABSTRACT FROM AUTHOR]

The recruitment of cross-hemispheric counterparts of lateralized prefrontal brain regions with increasing processing demand is thought to increase memory performance despite cognitive aging, but was recently reported to be present also in young adults working at their capacity limit. Here we ask if cross-hemispheric recruitment is a general strategy of the adult brain in that executive task demand would modulate bilateral activation beyond prefrontal cortex and across cognitive tasks. We analyzed data sets from two fMRI experiments investigating retrospective working memory maintenance and prospective action planning. We confirmed a cross-hemispheric recruitment of prefrontal cortex across tasks and experiments. Changes in lateralization due to planning further surfaced in the cerebellum, dorsal premotor and posterior parietal cortex. Parietal cortex thereby exhibited cross-hemispheric recruitment also during spatial but not verbal working memory maintenance. Our results confirm a domain-general role of prefrontal cortex in cross-hemispheric recruitment. They further suggest that other task-specific brain regions also recruit their idling cross-hemispheric counterparts to relocate executive processing power. [ABSTRACT FROM AUTHOR]

The recruitment of cross-hemispheric counterparts of lateralized prefrontal brain regions with increasing processing demand is thought to increase memory performance despite cognitive aging, but was recently reported to be present also in young adults working at their capacity limit. Here we ask if cross-hemispheric recruitment is a general strategy of the adult brain in that executive task demand would modulate bilateral activation beyond prefrontal cortex and across cognitive tasks. We analyzed data sets from two fMRI experiments investigating retrospective working memory maintenance and prospective action planning. We confirmed a cross-hemispheric recruitment of prefrontal cortex across tasks and experiments. Changes in lateralization due to planning further surfaced in the cerebellum, dorsal premotor and posterior parietal cortex. Parietal cortex thereby exhibited cross-hemispheric recruitment also during spatial but not verbal working memory maintenance. Our results confirm a domain-general role of prefrontal cortex in cross-hemispheric recruitment. They further suggest that other task-specific brain regions also recruit their idling cross-hemispheric counterparts to relocate executive processing power. [ABSTRACT FROM AUTHOR]

When lying inside a MRI scanner and even in the absence of any motion, the static magnetic field of MRI scanners induces a magneto-hydrodynamic stimulation of subjects' vestibular organ (MVS). MVS thereby not only causes a horizontal vestibular nystagmus but also induces a horizontal bias in spatial attention. In this study, we aimed to determine the time course of MVS-induced biases in both VOR and spatial attention inside a 3 T MRI-scanner as well as their respective aftereffects after participants left the scanner. Eye movements and overt spatial attention in a visual search task were assessed in healthy volunteers before, during, and after a one-hour MVS period. All participants exhibited a VOR inside the scanner, which declined over time but never vanished completely. Importantly, there was also an MVS-induced horizontal bias in spatial attention and exploration, which persisted throughout the entire hour within the scanner. Upon exiting the scanner, we observed aftereffects in the opposite direction manifested in both the VOR and in spatial attention, which were statistically no longer detectable after 7 min. Sustained MVS effects on spatial attention have important implications for the design and interpretation of fMRI-studies and for the development of therapeutic interventions counteracting spatial neglect. [ABSTRACT FROM AUTHOR]

Axions and axion‐like particles are hypothetical particles predicted in extensions of the standard model and are promising cold dark matter candidates. The Any Light Particle Search (ALPS II) experiment is a light‐shining‐through‐the‐wall experiment that aims to produce these particles from a strong light source and magnetic field and subsequently detect them through a reconversion into photons. With an expected rate ≈1 photon per day, a sensitive detection scheme needs to be employed and characterized. One foreseen detector is based on a transition edge sensor (TES). Here, the machine and deep learning algorithms for the rejection of background events recorded with the TES are investigated. A first application of convolutional neural networks to classify time series data measured with the TES is also presented. [ABSTRACT FROM AUTHOR]

Transition Edge Sensors (TESs) have found widespread application in fundamental studies due to their low background rate, high efficiency, and excellent energy resolution. This makes them suitable candidates for ALPS II, which investigates the existence of new particles (axions and axion-like-particles) which couple very weakly to photons. ALPS II anticipates an extremely low signal rate < 10 - 5 cps (amounting to ∼ 1–2 photons a day). The detection of these low energy (∼ 1 eV, 1064 nm) photons with a high energy resolution is necessary for ALPS II. We show that with our TES setup, we can analyze the TES pulses with different methods such as pulse fitting and Principal Component Analysis (PCA). These achieve (using the standard deviation) an energy resolution ( Δ E / E ) down to ∼ 8 % . The pulse analysis, with a chosen fitting approach, assists also in achieving a very low dark count rate O 10 - 6 cps for 1064 nm photon signal searches in the TES. [ABSTRACT FROM AUTHOR]

A finite axion–nucleon coupling, nearly unavoidable for QCD axions, leads to the production of axions via the thermal excitation and subsequent de-excitation of 57 Fe isotopes in the sun. We revise the solar bound on this flux adopting the up to date emission rate, and investigate the sensitivity of the proposed International Axion Observatory IAXO and its intermediate stage BabyIAXO to detect these axions. We compare different realistic experimental options and discuss the model dependence of the signal. Already BabyIAXO has sensitivity far beyond previous solar axion searches via the nucleon coupling and IAXO can improve on this by more than an order of magnitude. [ABSTRACT FROM AUTHOR]

Recent observations made with advanced LIGO and advanced Virgo have initiated the era of gravitational-wave astronomy. The number of events detected by these '2nd generation' (2G) ground-based observatories is partially limited by noise arising from temperature-induced position fluctuations of the test mass (TM) mirror surfaces used for probing spacetime dynamics. The design of next-generation gravitational-wave observatories addresses this limitation by using cryogenically cooled test masses; current approaches for continuously removing heat (resulting from absorbed laser light) rely on heat extraction via black-body radiation or conduction through suspension fibres. As a complementing approach for extracting heat during observational runs, we investigate cooling via helium gas impinging on the TM in free molecular flow. We establish a relation between cooling power and corresponding displacement noise, based on analytical models, which we compare to numerical simulations. Applying this theoretical framework with regard to the conceptual design of the Einstein telescope (ET), we find a cooling power of 10 mW at 18 K for a gas pressure that exceeds the ET design strain noise goal by at most a factor of ∼3 in the signal frequency band from 3 to 11 Hz. A cooling power of 100 mW at 18 K corresponds to a gas pressure that exceeds the ET design strain noise goal by at most a factor of ∼11 in the band from 1 to 28 Hz. [ABSTRACT FROM AUTHOR]

The Any Light Particle Search II (ALPS II) experiment is a Light-Shining-through-a-Wall experiment under construction at DESY, Hamburg. Its goal is to probe the existence of Axion Like Particles (ALPs), a possible candidate for dark matter. The expected small rate of reconverted photons requires a sensor capable of measuring low-energetic photons (1.165 eV) with high efficiency and a low dark count rate. A first science run in 2022 will be based on a heterodyne detection scheme. For a second run, a Transition Edge Sensor (TES) system is envisioned as a photon-counting detector. The TES reacts to the change in temperature produced by the absorption of a single photon by operating in the transition between the superconducting and normal conducting phases. Due to its high sensitivity, the TES is susceptible to the influence of electronic noise and background events. In this work, we perform analyses in time and frequency domain and compare these results with simulations to understand the detector's energy resolution. The setup of the TES is presented, along with the proposed design to measure its efficiency and linearity. [ABSTRACT FROM AUTHOR]