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This paper examines the relationship between science and religion in the education system of Roman-Catholic Portuguese society. In particular, we explored perceptions of the relationship between science and religion for religious education teachers. We surveyed 198 Portuguese religious education teachers about how they view science and religion. The questionnaires' results revealed a number of similarities: religious education teachers are highly involved in religious practices and exposed to science; they perceived a compatibility between science and religion; and they have an openness to dialogue between both. They do not adhere to anti-scientific perspectives, but they simultaneously try to limit what can be explained by science. Thus, an interpretative view of dialogue and/or integration seems to best explain the perceptions of religious education teachers of the relationship between science and religion. These findings allow a space of discussion, enabling teachers to possibly foster the science-religion dialogue in their contexts of pedagogical activity.

Incidental visualizations are meant to be perceived at-a-glance, on-the-go, and during short exposure times, but are not seen on demand. Instead, they appear in people's fields of view during an ongoing primary task. They differ from glanceable visualizations because the information is not received on demand, and they differ from ambient visualizations because the information is not continuously embedded in the environment. However, current graphical perception guidelines do not consider situations where information is presented at specific moments during brief exposure times without being the user's primary focus. Therefore, we conducted a crowdsourced user study with 99 participants to understand how accurate people's incidental graphical perception is. Each participant was tested on one of the three conditions: position of dots, length of lines, and angle of lines. We varied the number of elements for each combination and the display time. During the study, participants were asked to perform reproduction tasks, where they had to recreate a previously shown stimulus in each. Our results indicate that incidental graphical perception can be accurate when using position, length, and angles. Furthermore, we argue that incidental visualizations should be designed for low exposure times (between 300 and 1000 ms). [ABSTRACT FROM AUTHOR]

This document provides insights into lipid-based nanosystems and their potential therapeutic applications. Lipid-based nanosystems, such as solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), liposomes, and others, have been extensively studied for their ability to improve drug transport and efficacy through various routes of administration. The document highlights 16 research articles published in a special issue on lipid-based nanosystems, covering topics such as breast cancer treatment, anti-tumor efficacy, antidepressant activity, and ocular drug delivery. The most investigated diseases include cancer, brain diseases, ocular diseases, skin diseases, microbial infections, and metabolic diseases. The authors express their gratitude to the contributors and reviewers of the special issue for their valuable contributions. [Extracted from the article]

We tested the hypothesis that milk proteins, through microencapsulation, guarantee protection against bioactive substances in coffee silverskin extracts. Therefore, the aim of this study was to carry out technological, nutritional and physicochemical characterisation of a coffee silverskin extract microencapsulated using instant skim milk powder and whey protein concentrate as wall materials. The aqueous extract of coffee silverskin was spray-dried using 10% (w/v) skim milk powder and whey protein concentrate. The samples were characterised by determining the water content, water activity, particle size distribution, colour analysis and total phenolic compound content as well as antioxidant activity using 2,2-diphenyl-radical 1-picrylhydrazyl scavenging methods, nitric oxide radical inhibition and morphological analysis. The product showed water activity within a range that ensured greater stability, and the reduced degradation of the dried coffee silverskin extract with whey protein concentrate resulted in better rehydration ability. The luminosity parameter was higher and the browning index was lower for the encapsulated samples than for the pure coffee silverskin extract. The phenolic compound content (29.23 ± 8.39 and 34.00 ± 8.38 mg gallic acid equivalents/g for the coffee silverskin extract using skimmed milk powder and whey protein concentrate, respectively) and the antioxidant activity of the new product confirmed its potential as a natural source of antioxidant phenolic compounds. We conclude that the dairy matrices associated with spray drying preserved the bioactive and antioxidant activities of coffee silverskin extracts. [ABSTRACT FROM AUTHOR]

Early caregiving adversity (ECA) is associated with elevated psychological symptomatology. While neurobehavioral ECA research has focused on socioemotional and cognitive development, ECA may also increase risk for "low-level" sensory processing challenges. However, no prior work has compared how diverse ECA exposures differentially relate to sensory processing, or, critically, how this might influence psychological outcomes. We examined sensory processing challenges in 183 8-17-year-old youth with and without histories of institutional (orphanage) or foster caregiving, with a particular focus on sensory over-responsivity (SOR), a pattern of intensified responses to sensory stimuli that may negatively impact mental health. We further tested whether sensory processing challenges are linked to elevated internalizing and externalizing symptoms common in ECA-exposed youth. Relative to nonadopted comparison youth, both groups of ECA-exposed youth had elevated sensory processing challenges, including SOR, and also had heightened internalizing and externalizing symptoms. Additionally, we found significant indirect effects of ECA on internalizing and externalizing symptoms through both general sensory processing challenges and SOR, covarying for age and sex assigned at birth. These findings suggest multiple forms of ECA confer risk for sensory processing challenges that may contribute to mental health outcomes, and motivate continuing examination of these symptoms, with possible long-term implications for screening and treatment following ECA. [ABSTRACT FROM AUTHOR]

Incidental visualizations are meant to be seen at-a-glance, on-the-go, and during short exposure times. They will always appear side-by-side with an ongoing primary task while providing ancillary information relevant to those tasks. They differ from glanceable visualizations because looking at them is never their major focus, and they differ from ambient visualizations because they are not embedded in the environment, but appear when needed. However, unlike glanceable and ambient visualizations that have been studied in the past, incidental visualizations have yet to be explored in-depth. In particular, it is still not clear what is their impact on the users' performance of primary tasks. Therefore, we conducted an empirical online between-subjects user study where participants had to play a maze game as their primary task. Their goal was to complete several mazes as quickly as possible to maximize their score. This game was chosen to be a cognitively demanding task, bound to be significantly affected if incidental visualizations have a meaningful impact. At the same time, they had to answer a question that appeared while playing, regarding the path followed so far. Then, for half the participants, an incidental visualization was shown for a short period while playing, containing information useful for answering the question. We analyzed various metrics to understand how the maze performance was impacted by the incidental visualization. Additionally, we aimed to understand if working memory would influence how the maze was played and how visualizations were perceived. We concluded that incidental visualizations of the type used in this study do not disrupt people while they played the maze as their primary task. Furthermore, our results strongly suggested that the information conveyed by the visualization improved their performance in answering the question. Finally, working memory had no impact on the participants' results. [ABSTRACT FROM AUTHOR]

Hereditary Transthyretin Amyloidosis is a rare, progressive and life-threatening systemic disease with predominant peripheral and autonomic nervous system involvement caused by mutation of the transthyretin protein. The most common TTR mutation regarding to ATTRv is a substitution of a Methionine for a Valine at position 30 that predisposes TTR to form aggregates and fibrils. S100A8 protein levels were measured in plasma samples from ATTRV30M patients and healthy donors. Additionally, S100A8/9 levels were measured in Schwann cells after incubation with human WT or V30M TTR. Moreover, bone marrow derived macrophages of either genetic background were generated and the expression of S100A8/9 was measured in response to toll like receptors agonists. S100A8/A9 mRNA levels are decreased in HSF V30M mice as compared with the WT. Moreover, S100A8 protein levels were found downregulated in plasma samples from ATTRV30M patients. Furthermore, we provide evidence for a dysregulated S100 expression by Schwann cells in response to TTRV30M and by mutated macrophages in response to toll like receptors agonists. The presence of TTRV30M impacts S100 expression, possibly contributing to the impaired immune activation of Schwann cells in nerves from ATTRV30M patients. This may be linked to the diminished immune cellular infiltration in these nerves, contributing in this way for the neuronal dysfunction present in the disease. [ABSTRACT FROM AUTHOR]