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Various methods of genetic modification have been applied to plant breeding as an integral part of agriculture. This article examines a method of targeted mutagenesis -- CRISPR-Cas9 -- and its dysregulation in the European Union (EU). It provides clarity for food business operators relating to the traceability and labelling of food products induced using this biotechnology. In addition, it outlines policy recommendations to improve the regulation of such food products in the EU. [ABSTRACT FROM AUTHOR]

We present a case of kidney transplantation in a 28-year-old patient who received a heart transplant at 7 weeks of age due to hypoplastic left heart syndrome. The patient's renal insufficiency was the result of chronic immunosuppression and hypertension. The almost 28-year-old graft demonstrated very good function. This patient represents as one of the longest pediatric cardiac graft recipients living without any significant functional limitations. [ABSTRACT FROM AUTHOR]

There is interest in stock enhancement to support fisheries for California halibut Paralichthys californicus , a regionally important yet depleted species in the Southern California Bight (SCB), U.S. A quantitative model was developed to assess the cost of increasing harvestable California halibut in the SCB via releases of cultured juveniles. Reduced post-release survival of cultured juveniles was incorporated into the model, as was sex-specific lifetime survival, growth, and maturity. Simulations examined how adult California halibut population metrics were influenced by key release-strategy variables (i.e., size, number, survival, and sex ratio of released juveniles). A target increase in abundance of harvestable (≥ 559 mm total length; TL) California halibut by 5% in the entire SCB could likely be achieved by releasing large numbers (0.1–1.6 million per year) of larger-sized juveniles (40–200 mm TL). However, this was strongly mediated by their survival and sex ratio; fewer and smaller juveniles were required when releases comprised better surviving and / or more female individuals. Depending on the survival and sex ratio of released juveniles, increasing harvestable abundance in the SCB to achieve this 5% target was estimated to cost US$ 0.2–2.9 million annually, or US$ 14–219 per additional harvestable California halibut in the wild. This exploratory modeling study demonstrates that releasing juvenile California halibut could be a feasible management tool in the SCB, and provides a theoretical basis for field experiments. More broadly, it suggests that the allocation of resources to the production of larger and / or better surviving juveniles, in addition to optimizing release sex ratios, should be explored in stock enhancement programs. • Stock enhancement of California halibut was simulated by quantitative modeling. • Pre-defined target was achieved by releasing 0.1–1.6 million larger-sized (40–200 mm) juveniles. • Outcomes were strongly mediated by survival and sex ratio of released fish. • Annual costs to achieve the target were US$ 0.2–2.9 million. • Provides guidance for the allocation of resources in stock enhancement programs. [ABSTRACT FROM AUTHOR]