1. Cutting Edge: Allergen-Specific CD4 T Cells Respond Indirectly to Thymic Stromal Lymphopoietin To Promote Allergic Responses in the Skin.
- Author
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Larson, Ryan P., Comeau, Michael R., and Ziegler, Steven F.
- Subjects
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SKIN inflammation , *T cells , *CD4 antigen , *ALLERGENS , *THYMUS , *LYMPH nodes , *DENDRITIC cells , *DISEASE risk factors , *PHYSIOLOGY - Abstract
Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine that has been implicated in the initiation of allergic responses. CD4 T cells and dendritic cells are able to respond to TSLP in vitro; however, there has not been a careful dissection of the spatiotemporal response to TSLP by CD4 T cells in vivo during an allergic response. Previous work has suggested a requirement for TSLP in amplifying Th2 responses during allergen challenge by direct action on CD4 T cells; however, these studies did not determine whether there is an effect of TSLP on CD4 T cells during allergen sensitization. In this study we demonstrate an indirect role for TSLP on CD4 T cells during sensitization and challenge phases of an allergic response. This indirect effect of TSLP on CD4 T cells is due in part to the presence of TSLP exclusively in the allergen-sensitized and -challenged skin, rather than the draining lymph nodes. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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