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Background: Adolescents' mental health literacy is a topic of growing interest and studies have begun to explore the factors that influence adolescents' mental health literacy. This study investigated the relationship between parents' mental health literacy and adolescents' mental health literacy, as well as the mediating roles of parent-child relationship, and the moderating roles of school mental health service. Methods: Questionnaires were distributed to adolescents and their parents at two time points with an interval of one month. In the first survey, 835 parents completed a mental health literacy scale and a parent-child relationship scale. In the second, 841 adolescents completed a school mental health service questionnaire and an adolescent mental health literacy assessment questionnaire. A total of 617 paired data points were matched (parents' age: M = 40.47, SD = 5.10; adolescents' age: M = 13.34, SD = 0.99). Results: Bootstrapping results showed that parents' mental health literacy was positively associated with adolescents' mental health literacy. In addition, parent-child intimacy mediated the relationship between parents' mental health literacy and adolescents' mental health literacy. School mental health service moderated the relationship between parents' mental health literacy and parent-child intimacy and adolescents' mental health literacy. Conclusion: Intergenerational transmission of mental health literacy from parents to adolescents and its conditions were revealed. These findings provide new insights for the intervention of adolescents' mental health literacy, and may lead future research to investigate the role of parents within the family context, as well as the influence of home-school cooperation on adolescents' mental health literacy. [ABSTRACT FROM AUTHOR]

To investigate the status of mental health literacy, overall adaptation, and mental health of university freshers, and to explore the influence of mental health literacy on the overall adaptation and mental health, as well as the mediating role of overall adaptation.Methods: The undergraduate freshers of 2022 from a comprehensive university in Henan Province were selected as the research participants using a cluster sampling method and were investigated by the general information questionnaire, mental health literacy scale (MHLS), the university student overall adaptation questionnaire (CSOAQ) and university personality inventory (UPI).Results: (1) The detection rate of mental health problems among freshers was 22.39%, and the mental health literacy (112.26 ± 9.66), overall adaptation (3.93 ± 0.93), mental health (10.90 ± 10.51) of freshers had significant differences in demographic variables. (2) Mental health literacy was significantly positively correlated with overall adaptation and mental health, and overall adaptation was significantly positively correlated with mental health. (3) Overall adaptation plays a mediating role in the impact of mental health literacy on mental health. (4) Gender plays a moderating role in the effects of overall adaptation on mental health.Conclusion: The mental health literacy of university freshers could not only directly predict their mental health but also indirectly affect their mental health through overall adaptation, which is more significant among women. [ABSTRACT FROM AUTHOR]

Purpose: Based on ego depletion theory and interaction ritual theory, this research explores the impact of compulsory citizenship behavior on new-generation knowledge workers' job performance via the mediating role of ego depletion and the moderating role of relational energy employees experienced in interactions with coworkers. Methods: Two studies were conducted to explore the impact of compulsory citizenship behavior on job performance. Study 1 used a 10-day daily diary Survey (N=112) and Study 2 used a questionnaire survey conducted multiple times (N=356) to test the hypotheses. Results: The results of Study 1 and Study 2 were almost convergent. Compulsory citizenship behavior had a negative effect on job performance through the mediating effect of ego depletion. In addition, relational energy negatively moderated the effect of compulsory citizenship behavior on ego depletion and negatively moderated the mediating effect of ego depletion between compulsory citizenship behavior and job performance. Conclusion: The results deepen our understanding of the mechanism underlying the effect of compulsory citizenship behavior on job performance from the theoretical perspective of psychological energy, and also provide practical implications on how to manage new-generation knowledge employees' work behavior and job performance. [ABSTRACT FROM AUTHOR]

Background: Metabolic reprogramming occurs in the tumor microenvironment and influences the survival and function of tumor and immune cells. Interferon-γ (IFN-γ) produced by T cells up-regulates PD-L1 expression in tumors. However, reports regarding the relationship between nutrient metabolism and the up-regulation of PD-L1 expression are lacking.Materials and methods: In this paper, we analyzed the metabolic changes in T cells and bladder cancer cells in a simulated tumor microenvironment to provide evidence regarding their relevance to PD-L1 up-regulation.Results: The glutaminolysis was increased in both activated T cells and glucose-deprived T cells. IFN-γ production by T cells was decreased in a glucose-free medium and severely decreased when cells were simultaneously deprived of glutamine. Furthermore, the glutaminolysis of the bladder cancer cells under glucose deprivation exhibited a compensatory elevation. The glucose concentration of T cells co-cultured with bladder cancer cells was decreased and T cell proliferation was reduced, but IFN-γ production and glutaminolysis were increased. However, in bladder cancer cells, the elevation in glutaminolysis under co-culture conditions did not compensate for glucose deprivation because the glucose concentration in the culture medium did not significantly differ between the cultures with and without T cells. Our data also show that inhibiting glutamine metabolism in bladder cancer cells could reduce the elevation in PD-L1 expression induced by IFN-γ.Conclusion: In a simulated tumor microenvironment, elevated glutaminolysis may play an essential role in IFN-γ production by T cells, ultimately improving the high PD-L1 expression, and also directly contributing to producing more PD-L1 in bladder cancer cells. [ABSTRACT FROM AUTHOR]