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The Yellow River Basin (YRB) is an important ecological defense and economic zone in China and occupies a very important position in the economy and society of China. Premise condition of ecological protection and development of high quality in YRB is the greening of the industry. Based on the data of 35 cities in YRB in 2012, 2015, and 2018, this paper constructs an evaluation index system for the industrial green development (IGD) and explores spatial differentiation characteristics of the IGD by the exploratory spatial data analysis (ESDA) method. On this basis, this paper uses the geographical weighted regression (GWR) model to analyze the influencing factors. The results indicate the following: (1) in general, IGD in YRB shows an upward trend. (2) The Global Moran's I index of IGD shows a small increase; the distribution of local spatial correlation is basically unchanged. (3) There are obvious regional differences in the influencing factors of IGD. The degree of influence of each factor on IGD is openness > industrial upgrading index > urbanization rate > science and technology expenditures > reduction rate of energy consumption. [ABSTRACT FROM AUTHOR]