19 results on '"Zhang, Tian"'
Search Results
2. Development and validation of a survival nomogram for patients with Siewert type II/III adenocarcinoma of the esophagogastric junction based on real-world data
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Chen, Jian, Xia, Yu-Jian, Liu, Tian-Yu, Lai, Yuan-Hui, Yu, Ji-Shang, Zhang, Tian-Hao, Ooi, Shiyin, and He, Yu-Long
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- 2021
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3. Shear wave elastography parameters adds prognostic value to adverse outcome in kidney transplantation recipients.
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Zhang, Tian-yi, Yan, Jiayi, Wu, Jiajia, Yang, Wenqi, Zhang, Shijun, Xia, Jia, Che, Xiajing, Li, Hongli, Li, Dawei, Ying, Liang, Yuan, Xiaodong, Zhou, Yin, Zhang, Ming, and Mou, Shan
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KIDNEY transplantation , *SHEAR waves , *PROGNOSIS , *ELASTOGRAPHY , *GLOMERULAR filtration rate - Abstract
The tissue stiffness of donor kidneys in transplantation may increase due to pathological changes such as glomerulosclerosis and interstitial fibrosis, and those changes associate worse outcomes in kidney transplantation recipients. Ultrasound elastography is a noninvasive imaging examination with the ability to quantitatively reflect tissue stiffness. Aim of this study was to evaluate the prognostic value of ultrasound elastography for adverse kidney outcome in kidney transplantation recipients. Shear wave elastography (SWE) examinations were performed by two independent operators in kidney transplantation recipients. The primary outcome was a composite of kidney graft deterioration, all-cause re-hospitalization, and all-cause mortality. Survival analysis was calculated by Kaplan-Meier curves with the log-rank test and Cox regression analysis. A total of 161 patients (mean age 46 years, 63.4% men) were followed for a median of 20.1 months. 27 patients (16.77%) reached the primary endpoint. The mean and median tissue stiffness at the medulla (hazard ratio: 1.265 and 1.229, respectively), estimated glomerular filtration rate (eGFR), and serum albumin level were associated with the primary outcome in univariate Cox regression. Adding mean or median medulla SWE to a baseline model containing eGFR and albumin significantly improved its discrimination (C-statistics: 0.736 for the baseline, 0.766 and 0.772 for the model added mean and median medulla SWE, respectively). The medullary tissue stiffness of kidney allograft measured by shear wave elastography may provide incremental prognostic value to adverse outcomes in kidney transplantation recipients. Including SWE parameters in kidney transplantation recipients management could be considered to improve risk stratification. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Prognostic analysis of patients with non-small cell lung cancer harboring exon 19 or 21 mutation in the epidermal growth factor gene and brain metastases
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Wang, Jing, Liu, Zhiyan, Pang, Qingsong, Zhang, Tian, Chen, Xi, Er, Puchun, Wang, Yuwen, Wang, Ping, and Wang, Jun
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- 2020
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5. Predictive and prognostic markers from endoscopic ultrasound with biopsies during definitive chemoradiation therapy in esophageal squamous cell carcinoma.
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Du, Qingwu, Wu, Xiaoyue, Zhang, Kunning, Cao, Fuliang, Zhao, Gang, Wei, Xiaoying, Guo, Zhoubo, Li, Yang, Dong, Jie, Zhang, Tian, Zhang, Wencheng, Wang, Ping, Chen, Xi, and Pang, Qingsong
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ENDOSCOPIC ultrasonography ,ESOPHAGEAL cancer ,PROGNOSIS ,SQUAMOUS cell carcinoma ,CHEMORADIOTHERAPY ,RECEIVER operating characteristic curves - Abstract
Introduction: Endoscopic ultrasound (EUS) may play a role in evaluating treatment response after definitive chemoradiation therapy (dCRT) for esophageal squamous cell carcinoma (ESCC). This study explored the prognostic markers of EUS with biopsies and developed two nomograms for survival prediction. Methods: A total of 821 patients newly diagnosed with ESCC between January 2015 and December 2019 were reviewed. We investigated the prognostic value of the changes in tumor imaging characteristics and histopathological markers by an interim response evaluation, including presence of stenosis, ulceration, tumor length, tumor thickness, lumen involvement, and tumor remission. Independent prognostic factors of progression-free survival (PFS) and overall survival (OS) were determined using Cox regression analysis and further selected to build two nomogram models for survival prediction. The receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA) were used to respectively assess its discriminatory capacity, predictive accuracy, and clinical usefulness. Results: A total of 155 patients were enrolled in this study and divided into the training (109 cases) and testing (46 cases) cohorts. Tumor length, residual tumor thickness, reduction in tumor thickness, lumen involvement, and excellent remission (ER) of spatial luminal involvement in ESCC (ER/SLI) differed significantly between responders and non-responders. For patients undergoing dCRT, tumor stage (P = 0.001, 0.002), tumor length (P = 0.013, 0.008), > 0.36 reduction in tumor thickness (P = 0.004, 0.004) and ER/SLI (P = 0.041, 0.031) were independent prognostic markers for both PFS and OS. Time-dependent ROC curves, calibration curves, and DCA indicated that the predicted survival rates of our two established nomogram models were highly accurate. Conclusion: Our nomogram showed high accuracy in predicting PFS and OS for ESCC after dCRT. External validation and complementation of other biomarkers are needed in further studies. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Lower neutrophil-to-lymphocyte ratio predicts high risk of multidrug-resistant Pseudomonas aeruginosa infection in patients with hospital-acquired pneumonia
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Zhou,Yu-Qi, Feng,Ding-Yun, Li,Wen-Juan, Yang,Hai-Ling, Wang,Zhao-Ni, Zhang,Tian-Tuo, and Chen,Zhuang-Gui
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Therapeutics and Clinical Risk Management ,hospital-acquired pneumonia ,risk factors ,prognosis ,multidrug-resistant Pseudomonas aeruginosa ,Original Research - Abstract
Yu-Qi Zhou,1,2,* Ding-Yun Feng,1,2,* Wen-Juan Li,1,2 Hai-Ling Yang,1,2 Zhao-Ni Wang,3 Tian-Tuo Zhang,1,2 Zhuang-Gui Chen1,3 1Institute of Respiratory Diseases of Sun Yat-Sen University, Guangzhou, Guangdong, China; 2Department of Internal Medicine, Division of Respiratory Diseases, Guangzhou, Guangdong, China; 3Department of Pediatrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China *These authors contributed equally to this work Background and purpose: Hospital-acquired pneumonia (HAP) remains an important cause of morbidity and mortality despite advances in antimicrobial therapy. The emergence of multidrug resistant (MDR) Pseudomonas aeruginosa (PA) is of major concern. Our aim was to evaluate the risk factors and prognosis of HAP due to MDR-PA infection.Patients and methods: In a retrospective observational study, we collected data on all episodes of HAP caused by PA (PA-HAP) occurring from January 2013 to December 2016. Characteristics of patients with drug-sensitive PA were compared with those with MDR-PA. Data of demographic, underlying conditions, peripheral neutrophil-to-lymphocyte ratio (NLR), and clinical outcomes were collected and analyzed.Results: One hundred fifty-seven patients with PA-HAP were included, of which 69 (43.9%) patients were diagnosed with MDR-PA infection. There were significant differences between MDR-PA group and non-MDR-PA group on the following variables: initial inappropriate antibiotic therapy (P
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- 2018
7. A Clinical Scoring Model to Predict the Effect of Induction Chemotherapy With Definitive Concurrent Chemoradiotherapy on Esophageal Squamous Cell Carcinoma Prognosis.
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Li, Yang, Du, Qingwu, Wei, Xiaoying, Guo, Zhoubo, Lei, Tongda, Li, Yanqi, Han, Dong, Wu, Xiaoyue, Zhang, Kunning, Zhang, Tian, Chen, Xi, Dong, Jie, Zhang, Baozhong, Wei, Hui, Zhang, Wencheng, Pang, Qingsong, and Wang, Ping
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SQUAMOUS cell carcinoma ,ESOPHAGEAL cancer ,CHEMORADIOTHERAPY ,PROGNOSIS ,TREATMENT effectiveness ,REFERENCE values - Abstract
Purpose: The aim of the study was to compare the clinical outcomes of induction chemotherapy (IC) followed by definitive concurrent chemoradiotherapy (dCCRT) versus chemoradiotherapy alone in patients with esophageal squamous cell carcinoma (ESCC) on the basis of a clinical scoring model. Methods: A retrospective review of 599 patients with ESCC treated with dCCRT at our institution from 2010 to 2019 was conducted. The patients were divided into two groups based on whether they received IC. A clinical scoring model was performed using the significant variables obtained from the multivariate analysis. The PFS and OS rates were estimated using the Kaplan–Meier method. Results: During the study period, 182 patients receiving IC followed by dCCRT and 417 dCCRT alone were identified. No significant differences in the PFS and OS rates were observed between the IC group (P=0.532) and the non-IC group (P=0.078). A clinical scoring model was constructed based on independent prognostic factors with scores ranging from 0 to 10.4. The patients were divided into high- and low-risk groups by using the median score as the cutoff value. The PFS rate of patients receiving IC was higher than that of patients treated without IC (P=0.034), while there was no improvement in the OS rate (P=0.794) in the high-risk group. No significant differences in the PFS (P=0.207) or OS (P=0.997) rate were found between the two treatment groups in the low-risk group. Conclusions: The addition of IC followed by dCCRT for patients with ESCC might be associated with better PFS rates based on a clinical scoring model but has no impact on OS rates. Further prospective studies are warranted for the validation of this model. [ABSTRACT FROM AUTHOR]
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- 2021
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8. The lncRNA ALMS1‐IT1 may promote malignant progression of lung adenocarcinoma via AVL9‐mediated activation of the cyclin‐dependent kinase pathway.
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Luan, Tian, Zhang, Tian‐Ye, Lv, Zhong‐Hua, Guan, Bi‐Xi, Xu, Jian‐Yu, Li, Jian, Li, Ming‐Xu, and Hu, Song‐Liu
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LINCRNA ,ADENOCARCINOMA ,PROGNOSIS ,LUNGS ,CYCLIN-dependent kinases ,SQUAMOUS cell carcinoma - Abstract
Lung adenocarcinoma (LUAD) is the primary epithelial tumor of the lung. The lack of clinical symptoms and specific molecular diagnostic indicators during the early stages of LUAD mean that the disease may not be detected until late stages, and the 5‐year survival rate is only approximately 15%. Long non‐coding RNA ALMS1 intronic script 1 (ALMS1‐IT1) was previously reported to be correlated with the poor prognosis of head and neck squamous cell carcinoma patients. Here, we investigated whether ALMS1‐IT1 has prognostic potential for LUAD. Bioinformatics analyses were performed to examine the expression and prognostic value of ALMS1 and AVL9 (for which gene expression is positively correlated with ALMS1‐IT1 expression in LUAD) in LUAD based on TCGA and Oncomine databases. We report that ALMS1‐IT1 and AVL9 were both highly expressed in LUAD and correlated with poor outcomes in LUAD patients. Of note, the prognosis of LUAD patients with low expression of both ALMS1‐IT1 and AVL9 was superior to that of other patients. Furthermore, the proliferation, migration and invasion of LUAD cells were decreased in cells lacking ALMS1‐IT1, and this decrease could be almost completely reversed through overexpression of AVL9. Gene set enrichment analysis revealed that expression of genes related to the cell cycle pathway is closely related to both the high expression of ALMS1‐IT1 and AVL9 in LUAD. Finally, up‐regulation of ALMS1‐IT1 can activate the cyclin‐dependent kinase pathway, whereas absence of AVL9 can reverse this activation, as shown by western blotting. In summary, ALMS1‐IT1/AVL9 may promote the malignant progression of LUAD, at least in part by regulating the cyclin‐dependent kinase pathway. [ABSTRACT FROM AUTHOR]
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- 2021
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9. Correction: Predictive and prognostic markers from endoscopic ultrasound with biopsies during definitive chemoradiation therapy in esophageal squamous cell carcinoma.
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Du, Qingwu, Wu, Xiaoyue, Zhang, Kunning, Cao, Fuliang, Zhao, Gang, Wei, Xiaoying, Guo, Zhoubo, Li, Yang, Dong, Jie, Zhang, Tian, Zhang, Wencheng, Wang, Ping, Chen, Xi, and Pang, Qingsong
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ENDOSCOPIC ultrasonography ,ESOPHAGEAL cancer ,PROGNOSIS ,SQUAMOUS cell carcinoma ,CHEMORADIOTHERAPY - Abstract
Qingwu Du and Xiaoyue Wu contributed equally to this work. 2Distributions of tumor remission (A), tumor thickness (B) and lumen involvement (C) at baseline and during treatment between responders and non-responders Graph: Fig. [Extracted from the article]
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- 2023
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10. Low- and intermediate-risk myelodysplastic syndrome with pure red cell aplasia.
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Wang, Huaquan, Niu, Haiyue, Zhang, Tian, Xing, Limin, Shao, Zonghong, and Fu, Rong
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PURE red cell aplasia ,MYELODYSPLASTIC syndromes ,RECOMBINANT erythropoietin - Abstract
Our aim is to investigate the clinical characteristics of low- and intermediate-risk myelodysplastic syndrome (MDS) with pure red cell aplasia (PRCA). We retrospectively reviewed the patients of low- and intermediate-risk MDS patients who had been diagnosed with PRCA in our hospital between January 2010 and December 2019. There were 6 low- and intermediate-risk MDS patients with PRCA in our study, 1 male and 5 females, with a median age of 63.5 (50-75) years. It accounted for 7.7% (6/78) of all diagnosed PRCA cases and 1.67% (6/359) of diagnosed MDS cases during the same period. All patients were treated with multiple drugs, including recombinant human erythropoietin, cyclosporine, glucocorticoids, androgen, sirolimus, intravenous immunoglobulin and decitabine. Two patients achieved complete remission, two patients achieved partial remission and became blood transfusion independent. Two patients had no response and one patient died. Low- and intermediate-risk MDS with PRCA was difficult to treat, but the prognosis was good. [ABSTRACT FROM AUTHOR]
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- 2021
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11. Prognostic value of the combination of GRACE risk score and mean platelet volume to lymphocyte count ratio in patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention.
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Chen, Xinsen, Shao, Meng, Zhang, Tian, Zhang, Wei, Meng, Youbao, Zhang, Hongyan, Hai, Hua, and Li, Guihua
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MEAN platelet volume ,PERCUTANEOUS coronary intervention ,LYMPHOCYTE count ,MYOCARDIAL infarction ,ACUTE coronary syndrome - Abstract
The Global Registry of Acute Coronary Events (GRACE) risk score and the mean platelet volume to lymphocyte count ratio (MPVLR) can be used independently to predict adverse outcomes in patients with acute coronary syndromes. However, the level of MPVLR in relation to the GRACE score, and whether a combination of these methods can better predict the clinical adverse outcome of patients with ST-segment elevation myocardial infarction (STEMI), have not been previously examined. Therefore, the aim of the present study was to investigate whether the combination of GRACE risk score and MPVLR is a good predictor of a 30-day major adverse cardiovascular events (MACE) in patients with STEMI. A total of 464 patients with STEMI undergoing percutaneous coronary intervention (PCI) were enrolled, and divided into four groups based on the optimal cut-off values for GRACE score and MPVLR. GRACE score and MPVLR levels were separately recorded during admission. Spearman's rank correlation analysis showed a positive correlation between GRACE score and MPVLR (ρ=0.304; P<0.001). Both GRACE score [hazard ratio (HR), 1.706; 95% CI, 1.435-3.058; P<0.001] and MPVLR level (HR, 1.668; 95% CI, 1.202-2.170; P<0.001) were found to be independent predictors of a 30-day MACE. Additionally, the high MPVLR + high GRACE score group of patients had an HR of 2.455 (95% CI, 1.736-3.188) for a 30-day MACE, when using the low MPVLR + low GRACE score group as a reference. Based on the area under the curve, MPVLR combined with GRACE scores achieved an improved performance in differentiating angiographic no-reflow during a 30-day MACE, compared with individual MPVLR and GRACE scores. Therefore, the present results suggested that the GRACE score may be positively correlated with MPVLR and that their combination accurately predicted the occurrence of short-term MACE in patients with STEMI after PCI. [ABSTRACT FROM AUTHOR]
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- 2020
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12. The Efficacy and Safety of Chemotherapy in Patients With Nonsmall Cell Lung Cancer and Interstitial Lung Disease
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Chen, Yu Jie, Chen, Ling Xiao, Han, Mei Xiang, Zhang, Tian Song, Zhou, Zhi Rui, and Zhong, Dian Sheng
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Lung Neoplasms ,Prognosis ,Disease-Free Survival ,Survival Rate ,Treatment Outcome ,Carcinoma, Non-Small-Cell Lung ,Antineoplastic Combined Chemotherapy Protocols ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Disease Progression ,Humans ,Lung Diseases, Interstitial ,Systematic Review and Meta-Analysis ,Research Article - Abstract
Supplemental Digital Content is available in the text, Chemotherapy plays a critical and venturous role against the co-morbidity of nonsmall cell lung cancer and interstitial lung disease (NSCLC–ILD). We performed a Bayesian meta-analysis and systematic review to evaluate the safety and efficacy of the chemotherapy in NSCLC–ILD patients. EMBASE, PubMed, the Cochrane Central Register of Controlled Trials, and clinicaltrials.gov (up to January 2015). We included all study designs except case reports, all studies with NSCLC–ILD patients and all the possible chemotherapy regimens. Quality was assessed by a components approach. We derived summary estimates using Bayesian method through WinBUGS (version 1.4.3, MRC Biostatistics Unit, Cambridge, UK). Seven studies involving 251 patients with NSCLC–ILD were included in the meta-analysis. The treatment response (complete remission, 0; [partial remission, 39.1%; 95% credible interval [CrI], 32.6–45.7]; [stable disease, 36%; 95% CrI, 29.6–42.2]; [PD, 15.4%; 95% CrI, 11.3–19.8]; [nonevaluable, 6.4%; 95% CrI, 2.7–10.1]; [overall response rate, 41.3%; 95% CrI, 35.3–47.4]; [disease control rate, 77.7%; 95% CrI, 72.2–82.7]) were comparable to that of patients with NSCLC alone; the survival outcomes (median overall survival, median progression-free survival, and 1-year survival rate) were slightly worse, especially the lower 1-year survival rate. Platinum-based doublets as first-line chemotherapy may be related to higher incidence of acute exacerbation-ILD in first line chemotherapy (AE, 8.47%; 95% CrI, 5.04–12.6). The data selection bias and small patient number make the meta-analysis of treatment response and conclusions generated from these data inaccurate. The present meta-analysis suggests that chemotherapy might be an effective therapy for patients with NSCLC–ILD, but it might be associated with higher incidence of acute exacerbation.
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- 2015
13. Comparison of albumin-bilirubin grade, platelet-albumin-bilirubin grade and Child-Turcotte-Pugh class for prediction of survival in patients with large hepatocellular carcinoma after transarterial chemoembolization combined with microwave ablation.
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Ni, Jia-Yan, Fang, Zhu-Ting, An, Chao, Sun, Hong-Liang, Huang, Zhi-Mei, Zhang, Tian-Qi, Jiang, Xiong-Ying, Chen, Yao-Ting, Xu, Lin-Feng, and Huang, Jin-Hua
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- 2019
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14. Predictive value of the albumin-bilirubin grade on long-term outcomes of CT-guided percutaneous microwave ablation in intrahepatic cholangiocarcinoma.
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Ni, Jia-Yan, An, Chao, Zhang, Tian-Qi, Huang, Zhi-Mei, Jiang, Xiong-Ying, and Huang, Jin-Hua
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- 2019
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15. Lower neutrophil-to-lymphocyte ratio predicts high risk of multidrug-resistant infection in patients with hospital-acquired pneumonia.
- Author
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Zhou, Yu-Qi, Feng, Ding-Yun, Li, Wen-Juan, Yang, Hai-Ling, Wang, Zhao-Ni, Zhang, Tian-Tuo, and Chen, Zhuang-Gui
- Subjects
NOSOCOMIAL infections ,PSEUDOMONAS aeruginosa infections ,ANTIBIOTICS ,MULTIDRUG resistance in bacteria ,PNEUMONIA-related mortality - Abstract
Background and Purpose: Hospital-acquired pneumonia (HAP) remains an important cause of morbidity and mortality despite advances in antimicrobial therapy. The emergence of multidrug resistant (MDR) Pseudomonas aeruginosa (PA) is of major concern. Our aim was to evaluate the risk factors and prognosis of HAP due to MDR-PA infection.Patients and Methods: In a retrospective observational study, we collected data on all episodes of HAP caused by PA (PA-HAP) occurring from January 2013 to December 2016. Characteristics of patients with drug-sensitive PA were compared with those with MDR-PA. Data of demographic, underlying conditions, peripheral neutrophil-to-lymphocyte ratio (NLR), and clinical outcomes were collected and analyzed.Results: One hundred fifty-seven patients with PA-HAP were included, of which 69 (43.9%) patients were diagnosed with MDR-PA infection. There were significant differences between MDR-PA group and non-MDR-PA group on the following variables: initial inappropriate antibiotic therapy (P<0.001, OR 0.103, 95% CI 0.044-0.244), admission in more than two departments in previous 30 days (P<0.001, OR 0.186, 95% CI 0.072-0.476), and NLR level (P=0.020, OR 0.911, 95% CI 0.843-0.985). The effect of antibiotic treatment was significantly different (P<0.001, OR 4.263, 95% CI 2.142-8.483). The 30-day mortality was higher in MDR-PA group than that in non-MDR-PA group (P<0.001).Conclusion: We have shown that lower NLR level was identified as a clinical predictor of MDR-PA infection in HAP patients. Even with goal-directed therapy, MDR-PA infection implicates poor outcomes in patients with HPA. [ABSTRACT FROM AUTHOR]- Published
- 2018
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16. Expression of proteins associated with epithelial‑mesenchymal transition in esophageal squamous cell carcinoma.
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Zhang, Tian, Li, Hao, Zhang, Yang, Wang, Pei, Bian, Huijie, and ChEN, Zhi-Nan
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TREATMENT of esophageal cancer , *ESOPHAGEAL cancer , *LYMPH node diseases , *SQUAMOUS cell carcinoma , *GENE expression , *IMMUNOHISTOCHEMISTRY , *GENETICS - Abstract
Cluster of differentiation 147 (CD147), pituitary tumor transforming gene (PTTG) and CD44v6 are proteins involved in the epithelial‑mesenchymal transition (EMT). To investigate the prognostic value of CD147 and PTTG, and CD44v6 expression in esophageal squamous cell carcinoma (ESCC), tissue microarray specimens from 76 patients with ESCC were evaluated by immunohistochemistry staining and scored by intensity and proportion of positive areas. Expression levels of CD147, PTTG and CD44v6 were higher in tumor tissues than in matched adjacent tissues. CD147 expression was positively associated with lymph node metastasis (P=0.025) and American Joint Committee on Cancer (AJCC) system clinical grades (P=0.037). CD147 expression was positively correlated with the expression levels of PTTG (R=0.369; P=0.001) and CD44v6 (R=0.320; P=0.005). In addition, Kaplan‑Meier analysis indicated that positive expression of CD147, PTTG and CD44v6 was significantly associated with poor overall survival times (P=0.045, P=0.014 and P=0.027, respectively). Patients exhibiting CD147‑PTTG co‑expression, CD147‑CD44v6 co‑expression and CD147‑PTTG‑CD44v6 triple‑positive expression had the poorest overall survival rates. In conclusion, the expression of EMT‑associated proteins, including CD147, PTTG and CD44v6, was significantly associated with poor survival in ESCC and these novel targets may serve as potential biomarkers for anticancer therapies. [ABSTRACT FROM AUTHOR]
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- 2018
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17. A microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinoma
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Gao, Ge, Gay, Hiram A., Chernock, Rebecca D., Zhang, Tian R., Luo, Jingqin, Thorstad, Wade L., Lewis, James S., and Wang, Xiaowei
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Male ,Gene Expression Profiling ,Papillomavirus Infections ,Middle Aged ,Prognosis ,Article ,MicroRNAs ,Oropharyngeal Neoplasms ,Biomarkers, Tumor ,Carcinoma, Squamous Cell ,Humans ,RNA, Viral ,Female ,Papillomaviridae ,Aged - Abstract
Oropharyngeal squamous cell carcinoma (SCC) rates have been increasing significantly in recent years, despite a decreasing incidence of head and neck cancer in general. Oropharyngeal SCC has many characteristics that are distinct from other head and neck cancers, and thus it is important to focus specifically on cancers arising in this region, with the goal of improving patient outcomes. One important goal is to identify those patients who are likely to fail standard therapy and who could potentially benefit from alternative or targeted treatments.In the current study, the prognostic value of microRNAs (miRNAs) was evaluated in patients with oropharyngeal SCC. miRNAs are small, noncoding RNAs that are master regulators of many important biological processes. In total, 150 oropharyngeal tumors were analyzed using the recently developed quantitative polymerase chain reaction-based method for miRNA expression profiling. In addition, the expression of miRNAs was also compared with human papillomavirus (HPV) transcriptional activities.The current study identified 6 miRNAs that were found to be significantly associated with cancer survival. A combined expression signature of these miRNAs was prognostic of oropharyngeal SCC, independent of common clinical features or HPV status.This new miRNA signature was experimentally validated in an independent oropharyngeal SCC cohort. Furthermore, 5 HPV-related miRNAs were identified, which may help to characterize HPV-induced cancers including both oropharyngeal and cervical SCC.
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- 2012
18. Interventional treatment experience in multiple injury with major abdominal or pelvic injuries: 160 cases analysis.
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Zhang, Tian-Xi, Han, Mei, Ye, Peng, Hu, Quan, Li, Jia-Lin, Yin, Ling, and Yu, An-Yong
- Abstract
Purpose: To observe the therapeutic effect of interventional embolization and haemorrhage control in multiple trauma patients with a major abdominal or pelvic injury.Methods: Data of 160 multiple trauma patients with a major abdominal or pelvic injury were retrospectively analyzed. They were admitted into the Department of Emergency of the First Affiliated Hospital of Zunyi Medical College from October 2013 to April 2016. Eighty-seven patients who received emergent intervention for embolization and haemorrhage control were set as group A, including 72 males and 15 females, with an average age of (39.32 ± 14.0) years. Patients underwent emergent intervention for embolization and hemostasis. The other 73 patients who received traditional surgeries were set as group B, including 62 males and 11 females, with an average age of (38.48 ± 13.12) years. The time from admission to emergency intervention, the time of interventional embolization, transfusion during hospitalization, length of stay and prognosis were observed. The whole treatment and prognosis were compared between group A and group B.Results: In group A, the average time from admission to intervention exploration was (132.05 ± 86.80) min, the average operation time was (149 ± 49.69) min, the average hospitalization time was (18.37 ± 4.71) days, the average amount of RBC transfusion during hospitalization was (7.2 ± 4.33) units, and the mortality was 4.60% (4 patients died). The corresponding data in group B were respectively (138.95 ± 82.49) min, (183 ± 52.39) min, (22.72 ± 6.63) days, (12.23 ± 5.43) units, and 9.59% (7 cases died). There was no statistical difference in the time from admission to operation between the two groups (p > 0.05), but there was statistical difference in operation time, RBC transfusion, hospitalization time, prognosis, and mortality between the two groups (all p < 0.05).Conclusion: The emergent intervention for embolization and haemorrhage control of multiple trauma patients with a major abdominal or pelvic injury and visceral organ haemorrhage has the advantages of less trauma, shorter operation time, shorter hospital stay, less blood transfusion in comparison to the traditional emergency surgeries. [ABSTRACT FROM AUTHOR]- Published
- 2018
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19. Downregulation of 14-3-3σ Correlates with Multistage Carcinogenesis and Poor Prognosis of Esophageal Squamous Cell Carcinoma.
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Qi, Yi-Jun, Wang, Ming, Liu, Rui-Min, Wei, Hua, Chao, Wei-Xia, Zhang, Tian, Lou, Qiang, Li, Xiu-Min, Ma, Jin, Zhu, Han, Yang, Zhen-Hua, Liu, Hai-Qing, and Ma, Yuan-Fang
- Subjects
SQUAMOUS cell carcinoma ,ESOPHAGEAL cancer ,EARLY detection of cancer ,CARCINOGENESIS ,TUMOR growth ,EPITHELIAL cells ,CANCER cell culture ,DIAGNOSIS ,PROGNOSIS - Abstract
Aims: The asymptomatic nature of early-stage esophageal squamous cell carcinoma (ESCC) results in late presentation and consequent dismal prognosis This study characterized 14-3-3σ protein expression in the multi-stage development of ESCC and determined its correlation with clinical features and prognosis. Materials and Methods: Western blot was used to examine 14-3-3σ protein expression in normal esophageal epithelium (NEE), low grade intraepithelial neoplasia (LGIN), high grade intraepithelial neoplasia (HGIN), ESCC of TNM I to IV stage and various esophageal epithelial cell lines with different biological behavior. Immunohistochemistry was used to estimate 14-3-3σ protein in 110 biopsy samples of NEE, LGIN or HGIN and in 168 ESCC samples all of whom had follow-up data. Support vector machine (SVM) was used to develop a classifier for prognosis. Results: 14-3-3σ decreased progressively from NEE to LGIN, to HGIN, and to ESCC. Chemoresistant sub-lines of EC9706/PTX and EC9706/CDDP showed high expression of 14-3-3σ protein compared with non-chemoresistant ESCC cell lines and immortalized NEC. Furthermore, the downregulation of 14-3-3σ correlated significantly with histological grade (P = 0.000) and worse prognosis (P = 0.004). Multivariate Cox regression analysis indicated that 14-3-3σ protein (P = 0.016) and T stage (P = 0.000) were independent prognostic factors for ESCC. The SVM ESCC classifier comprising sex, age, T stage, histological grade, lymph node metastasis, clinical stage and 14-3-3σ, distinguished significantly lower- and higher-risk ESCC patients (91.67% vs. 3.62%, P = 0.000). Conclusions: Downregulation of 14-3-3σ arises early in the development of ESCC and predicts poor survival, suggesting that 14-3-3σ may be a biomarker for early detection of high-risk subjects and diagnosis of ESCC. Our seven-feature SVM classifier for ESCC prognosis may help to inform clinical decisions and tailor individual therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
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