19 results on '"Liu, Wen-Ming"'
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2. Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells
- Author
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Li, Zi-bo, Jiang, Lin, Ni, Jia-dong, Xu, Yuan-hang, Liu, Fang, Liu, Wen-ming, Wang, Shao-gui, Liu, Zhong-qiu, and Wang, Cai-yan
- Published
- 2023
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3. Research on Creative Product Design of Jewelry Design
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Liu Wen Ming and Pu Yu
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Environmental sciences ,GE1-350 - Abstract
With the development of the times and the promotion of technology, people’s living standards and aesthetic requirements have also been continuously improved. Intelligent design enables jewelry to break through its position in the traditional sense It is no longer limited to the handmade production of precious metals. Intelligent design can also be applied to jewelry design. The unlimited choice of materials allows designers to have greater design space and imagination. With the development of fashion trends, jewelry as a kind of decoration, in another way shows the personal quality of life and life attitude. Therefore, the more diversified forms of jewelry design are eclectic, and the pursuit of higher levels and more comprehensive forms to create fashionable and personalized products.
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- 2021
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4. Interaction Design Research Of Suitable For Student Travel APP
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Liu Wen Ming and Zhang Pei Lei
- Subjects
Environmental sciences ,GE1-350 - Abstract
In recent years, with the use of mobile phone APPs, more and more people like to use tourism APPs when traveling, and the tourism industry also enters a new era of wireless tourism. College students are a huge tourist group. This paper will summarize an APP suitable for students’ tourism through the analysis of tourism APPs and tourist groups. This APP will make travel plans based on the student’s time, including travel time, travel residence, travel strategy, travel expenses, tour groups, etc. It also includes working with schools and local police to keep students safe. There should be such an APP for student travel to make it convenient for students to travel, enrich their university experience, and make student travel safer and more convenient.
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- 2021
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5. CD24+LCN2+ liver progenitor cells in ductular reaction contributed to macrophage inflammatory responses in chronic liver injury.
- Author
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Huang, Wei-Jian, Qiu, Bi-Jun, Qi, Xiao-Shu, Chen, Cai-Yang, Liu, Wen-Ming, Zhou, Shen-ao, Ding, Min, Lu, Feng-Feng, Zhao, Jie, Tang, Dan, Zhou, Xu, Fu, Gong-Bo, Wang, Zhen-Yu, Ma, Hong-Qian, Wu, Yu-Ling, Wu, Hong-ping, Chen, Xiao-Song, Yu, Wei-Feng, and Yan, He-Xin
- Subjects
LIVER cells ,INTRAHEPATIC bile ducts ,PROGENITOR cells ,INFLAMMATION ,LIVER injuries ,MACROPHAGES - Abstract
Background: CD24
+ CK19+ /CD24+ SOX9+ resident liver cells are activated and expanded after chronic liver injury in a ductular reaction. However, the sources and functions of these cells in liver damage remain disputed. Results: The current study combined genetic lineage tracing with in vitro small-molecule-based reprogramming to define liver progenitor cells (LPCs) derived from hepatic parenchymal and non-parenchymal tissues. tdTom+ hepatocytes were isolated from ROSA26tdTomato mice following AAV8-Tbg-Cre-mediated recombination, EpCAM+ biliary epithelial cells (BECs) from wild-type intrahepatic bile ducts and ALB/GFP− EpCAM− cells were isolated from AlbCreERT /R26GFP mice. A cocktail of small molecules was used to convert the isolated cells into LPCs. These in vitro cultured LPCs with CD24 and SOX9 expression regained the ability to proliferate. Transcriptional profiling showed that the in-vitro cultured LPCs derived from the resident LPCs in non-parenchymal tissues expressed Lipocalin-2 (Lcn2) at high levels. Accordingly, endogenous Cd24a+ Lcn2+ LPCs were identified by integration of sc-RNA-sequencing and pathological datasets of liver dysfunction which indicates that LPCs produced by ductular reactions might also originate from the resident LPCs. Transplantation of in-vitro cultured Cd24a+ Lcn2+ LPCs into CCl4 -induced fibrotic livers exacerbated liver damage and dysfunction, possibly due to LCN2-dependent macrophage inflammatory response. Conclusions: CD24+ LCN2+ LPCs constituted the expanding ductular reaction and contributed to macrophage-mediated inflammation in chronic liver damage. The current findings highlight the roles of LPCs from distinct origins and expose the possibility of targeting LPCs in the treatment of chronic hepatic diseases. [ABSTRACT FROM AUTHOR]- Published
- 2023
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6. Interaction Design Research Of Suitable For Student Travel APP.
- Author
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Wen, F., Ziaei, S.M., Liu, Wen Ming, and Zhang, Pei Lei
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- 2021
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7. Research on Creative Product Design of Jewelry Design.
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Anpo, M., Song, F., Liu, Wen Ming, and Pu, Yu
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- 2021
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8. Research on the application of color semantics in the human-computer interaction design of smartphones
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Liu Wen-ming and Bao Xiaoxiao
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Semantics (computer science) ,business.industry ,media_common.quotation_subject ,0211 other engineering and technologies ,Product semantics ,02 engineering and technology ,Interaction design ,020303 mechanical engineering & transports ,0203 mechanical engineering ,User experience design ,Human–computer interaction ,lcsh:TA1-2040 ,Factor (programming language) ,021105 building & construction ,Key (cryptography) ,Quality (business) ,Smart products ,business ,lcsh:Engineering (General). Civil engineering (General) ,computer ,computer.programming_language ,media_common - Abstract
To evaluate the user experience in the human-computer interaction design of intelligent products, the quality of color design is a key factor. The purpose of this article is to design the human-computer interaction in smart phones through the study of color semantics, which is one of the branches of product semantics. In particular, the application of color semantics in UI design would help designers better meet user’s needs and improve user’s experience in the human-computer interaction design of smart products.
- Published
- 2018
9. N-3 Polyunsaturated Fatty Acids Protect Esophageal Epithelial Cell From Acid Exposure
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Chen, Yue-hang, Jiang, Ying, Wei, Jing-Jing, Liu, Wen-Ming, and Zhuang, Ze-Hao
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- 2021
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10. On the existence of (10, 2, 7, 488) resilient functions
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Liu, Wen Ming and Youssef, Amr
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Heuristic programming -- Usage ,Algebra, Boolean -- Analysis - Abstract
Using a heuristic search combined with some algebraic techniques, several examples for 10-variable Boolean functions with nonlinearity 488, algebraic degree 7, and resiliency degree 2, were constructed. This construction affirmatively answers the open problem about the existence of such functions. Index Terms--Boolean functions, cryptography, resilient functions.
- Published
- 2009
11. Microfluidics-based assay on the effects of microenvironmental geometry and aqueous flow on bacterial adhesion behaviors.
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Liu, Yang, Wang, Jian-Chun, Ren, Li, Tu, Qin, Liu, Wen-Ming, Wang, Xue-Qin, Liu, Rui, Zhang, Yan-Rong, and Wang, Jin-Yi
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MICROFLUIDICS ,BIOLOGICAL assay ,BACTERIAL adhesion ,GREEN fluorescent protein ,POLYDIMETHYLSILOXANE ,ESCHERICHIA coli ,BACTERIAL disease prevention ,BIOFILMS - Abstract
Abstract: A new microfluidic system with four different microchambers (a circle and three equilateral concave polygons) was designed and fabricated using poly(dimethylsiloxane) (PDMS) and the soft lithography method. Using this microfluidic device at six flow rates (5, 10, 20, 30, 40, and 50μL/h), the effects of microenvironmental geometry and aqueous flow on bacterial adhesion behaviors were investigated. Escherichia coli HB101 pGLO, which could produce a green fluorescent protein induced by l-arabinose, was utilized as the model bacteria. The results demonstrated that bacterial adhesion was significantly related to culture time, microenvironment geometry, and aqueous flow rates. Adhered bacterial density increased with the culture time. Initially, the adhesion occurred at the microchamber sides, and then the entire chamber was gradually covered with increased culture time. Adhesion densities in the side zones were larger than those in the center zones because of the lower shearing force in the side zone. Also, the adhesion densities in the complex chambers were larger than those in the simple chambers. At low flow rates, the orientation of adhered bacteria was random and disorderly. At high flow rates, bacterial orientation became close to the streamline and oriented toward the flow direction. All these results implied that bacterial adhesion tended to occur in complicated aqueous flow areas. The present study provided an on-chip flow system for physiological behavior of biological cells, as well as provided a strategic cue for the prevention of bacterial infection and biofilm formation. [Copyright &y& Elsevier]
- Published
- 2011
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12. Predictors of difficult endoscopic resection of submucosal tumors originating from the muscularis propria layer at the esophagogastric junction.
- Author
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Wang YP, Xu H, Shen JX, Liu WM, Chu Y, Duan BS, Lian JJ, Zhang HB, Zhang L, Xu MD, and Cao J
- Abstract
Background: Endoscopic resection approaches, including endoscopic submucosal dissection (ESD), submucosal tunneling endoscopic resection (STER) and endoscopic full-thickness resection (EFTR), have been widely used for the treatment of submucosal tumors (SMTs) located in the upper gastrointestinal tract. However, compared to SMTs located in the esophagus or stomach, endoscopic resection of SMTs from the esophagogastric junction (EGJ) is much more difficult because of the sharp angle and narrow lumen of the EGJ. SMTs originating from the muscularis propria (MP) in the EGJ, especially those that grow extraluminally and adhere closely to the serosa, make endoscopic resection even more difficult., Aim: To investigate the predictors of difficult endoscopic resection for SMTs from the MP layer at the EGJ., Methods: A total of 90 patients with SMTs from the MP layer at the EGJ were included in the present study. The difficulty of endoscopic resection was defined as a long procedure time, failure of en bloc resection and intraoperative bleeding. Clinicopathological, endoscopic and follow-up data were collected and analyzed. Statistical analysis of independent risks for piecemeal resection, long operative time, and intraoperative bleeding were assessed using univariate and multivariate analyses., Results: According to the location and growth pattern of the tumor, 44 patients underwent STER, 14 patients underwent EFTR, and the remaining 32 patients received a standard ESD procedure. The tumor size was 20.0 mm (range 5.0-100.0 mm). Fourty-seven out of 90 lesions (52.2%) were regularly shaped. The overall en bloc resection rate was 84.4%. The operation time was 43 min (range 16-126 min). The intraoperative bleeding rate was 18.9%. There were no adverse events that required therapeutic intervention during or after the procedures. The surgical approach had no significant correlation with en bloc resection, long operative time or intraoperative bleeding. Large tumor size (≥ 30 mm) and irregular tumor shape were independent predictors for piecemeal resection (OR: 7.346, P = 0.032 and OR: 18.004, P = 0.029, respectively), long operative time (≥ 60 min) (OR: 47.330, P = 0.000 and OR: 6.863, P = 0.034, respectively) and intraoperative bleeding (OR: 20.631, P = 0.002 and OR: 19.020, P = 0.021, respectively)., Conclusion: Endoscopic resection is an effective treatment for SMTs in the MP layer at the EGJ. Tumors with large size and irregular shape were independent predictors for difficult endoscopic resection., Competing Interests: Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article., (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.)
- Published
- 2022
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13. Establishment of Functional Liver Spheroids From Human Hepatocyte-Derived Liver Progenitor-Like Cells for Cell Therapy.
- Author
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Liu WM, Zhou X, Chen CY, Lv DD, Huang WJ, Peng Y, Wu HP, Chen Y, Tang D, Guo LN, Wang XL, Zhang HD, Liu XH, Yang LQ, Yu WF, and Yan HX
- Abstract
Globally, about two million people die from liver diseases every year. Liver transplantation is the only reliable therapy for severe end-stage liver disease, however, the shortage of organ donors is a huge limitation. Human hepatocytes derived liver progenitor-like cells (HepLPCs) have been reported as a novel source of liver cells for development of in vitro models, cell therapies, and tissue-engineering applications, but their functionality as transplantation donors is unclear. Here, a 3-dimensional (3D) co-culture system using HepLPCs and human umbilical vein endothelial cells (HUVECs) was developed. These HepLPC spheroids mimicked the cellular interactions and architecture of mature hepatocytes, as confirmed through ultrastructure morphology, gene expression profile and functional assays. HepLPCs encapsulated in alginate beads are able to mitigate liver injury in mice treated with carbon tetrachloride (CCL4), while alginate coating protects the cells from immune attack. We confirmed these phenomena due to HUVECs producing glial cell line-derived neurotrophic factor (GDNF) to promote HepLPCs maturation and enhance HepLPCs tight junction through MET phosphorylation. Our results display the efficacy and safety of the alginate microencapsulated spheroids in animal model with acute liver injury (ALF), which may suggest a new strategy for cell therapy., Competing Interests: H-DZ was employed by the company Shanghai Celliver Biotechnology Co. Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Liu, Zhou, Chen, Lv, Huang, Peng, Wu, Chen, Tang, Guo, Wang, Zhang, Liu, Yang, Yu and Yan.)
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- 2021
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14. Clinical features and mortality-related factors of extensive burns among young adults: the Kunshan disaster experience.
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Huang YZ, Lu GZ, Zhao HS, Liu LJ, Jin J, Wu YF, Wu J, Zhao FL, Liu N, Liu WM, Liu L, Zhu TJ, Chen EZ, Gu Q, Ye HW, Xi XM, Du B, Yi Y, and Qiu HB
- Abstract
Background: The aim of the study was to identify the clinical features and the factors associated with burn induced mortality among young adults after exposure to indoor explosion and fire., Methods: This is an observational study which included burn patients who were admitted to eighteen ICUs after a fire disaster. Epidemiologic and clinical characteristics, as well as therapy were recorded. The primary outcome was 90-day mortality. The mortality-related factors were also analyzed., Results: There were 167 burn patients enrolled in the study, the median age was 38 years, 62 (37.1%) patients died within 90 days. Seventy-one percent of patients had a burn size ≥90% TBSA, and 73.7% of patients had a full-thickness burn area above 50% TBSA. The survivors had lower Baux scores, and received earlier escharectomy and autologous skin grafts. The 50% mortality rates (LA50s) for burn size and full-thickness burn area were 95.8% and 88.6% TBSA, respectively. The multivariate analysis showed that full-thickness burn area over 50% TBSA and residual burned surface area (RBSA)/TBSA at 28 days were strong predictors of mortality among burn patients (odds ratio 2.55; 95% CI, 1.01 to 6.44, P=0.047; odds ratio 1.07; 95% CI, 1.04 to 1.09, P<0.001). The ROC curve-based cut-off values of RBSA/TBSA at 28 days for predicting 90-day mortality were 62.5%., Conclusions: Burn size and full-thickness burn area were the main risk factors for poor outcome in patients with extensive burns. Earlier escharectomy and autologous skin grafts may improve outcomes., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-288). All authors have no conflicts of interest to declare., (2020 Annals of Translational Medicine. All rights reserved.)
- Published
- 2020
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15. Minimally invasive thalamic hematoma drainage can improve the six-month outcome of thalamic hemorrhage.
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Liu WM, Zhang XG, Zhang ZL, Li G, and Huang QB
- Abstract
Objective: To explore predictors of the 6-month clinical outcome of thalamic hemorrhage, and evaluate if minimally invasive thalamic hematoma drainage (THD) could improve its prognosis., Methods: A total of 54 patients with spontaneous thalamic hemorrhage were evaluated retrospectively. Clinical data, including demographics, stroke risk factors, neuroimaging variables, Glasgow Coma Score (GCS) on admission, surgical strategy, and outcome, were collected. Clinical outcome was assessed using a modified Rankin Scale, six months after onset. Univariate analysis and multivariate logistic regression analysis were performed to determine predictors of a poor outcome., Results: Conservative treatment was performed for five patients (9.3%), external ventricular drainage (EVD) for 20 patients (37.0%), THD for four patients (7.4%), and EVD combined with THD for 25 patients (46.3%). At six months after onset, 21 (38.9%) patients achieved a favorable outcome, while 33 (61.1%) had a poor outcome. In the univariate analysis, predictors of poor 6-month outcome were lower GCS on admission ( P = 0.001), larger hematoma volume ( P < 0.001), midline shift ( P = 0.035), acute hydrocephalus ( P = 0.039), and no THD ( P = 0.037). The independent predictors of poor outcome, according to the multivariate logistic regression analysis, were no THD and larger hematoma volume., Conclusions: Minimally invasive THD, which removes most of the hematoma within a few days, with limited damage to perihematomal brain tissue, improved the 6-month outcome of thalamic hemorrhage. Thus, THD can be widely applied to treat patients with thalamic hemorrhage.
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- 2017
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16. Positive feedback loop of IL-1β/Akt/RARα/Akt signaling mediates oncogenic property of RARα in gastric carcinoma.
- Author
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Ren HY, Liu F, Huang GL, Liu Y, Shen JX, Zhou P, Liu WM, and Shen DY
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- Animals, Antimetabolites, Antineoplastic pharmacology, Carcinoma drug therapy, Carcinoma genetics, Carcinoma secondary, Cell Cycle, Cell Cycle Proteins genetics, Cell Cycle Proteins metabolism, Cell Line, Tumor, Cell Movement, Cell Proliferation, Feedback, Physiological, Female, Fluorouracil pharmacology, Gene Expression Regulation, Neoplastic, Humans, Lymphatic Metastasis, Male, Mice, Inbred BALB C, Mice, Nude, Middle Aged, Neoplasm Staging, RNA Interference, Retinoic Acid Receptor alpha genetics, Signal Transduction, Stomach Neoplasms drug therapy, Stomach Neoplasms genetics, Stomach Neoplasms pathology, Time Factors, Transfection, Tumor Burden, Up-Regulation, Xenograft Model Antitumor Assays, Carcinoma enzymology, Interleukin-1beta metabolism, Proto-Oncogene Proteins c-akt metabolism, Retinoic Acid Receptor alpha metabolism, Stomach Neoplasms enzymology
- Abstract
Abnormal expression and function of retinoic acid receptor α (RARα) have been reported to be associated with various cancers including acute promyelocytic leukemia and hepatocellular carcinoma. However, the role and the mechanism of RARα in gastric carcinoma (GC) were unknown. Here, the expression of RARα was frequently elevated in human GC tissues and cell lines, and its overexpression was closely correlated with tumor size, lymph node metastasis and clinical stages in GC patients. Moreover, RARα overexpression was related with pathological differentiation. Functionally, RARα knockdown inhibited the proliferation and metastasis of GC cells, as well as enhanced drug susceptibility both in vitro and in vivo. Additionally, RARα knockdown suppressed GC progression through regulating the expression of cell proliferation, cell cycle, invasion and drug resistance associated proteins, such as PCNA, CyclinB1, CyclinD2, CyclinE, p21, MMP9 and MDR1. Mechanistically, the above oncogenic properties of RARα in GC were closely associated with Akt signaling activation. Moreover, overexpression of RARα was induced by IL-1β/Akt signaling activation, which suggested a positive feedback loop of IL-1β/Akt/RARα/Akt signaling in GC. Taken together, we demonstrated that RARα was frequently elevated in GC and exerted oncogenic properties. It might be a potential molecular target for GC treatment.
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- 2017
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17. Impact of the number of resected lymph nodes on survival after preoperative radiotherapy for esophageal cancer.
- Author
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Wu SG, Zhang ZQ, Liu WM, He ZY, Li FY, Lin HX, Sun JY, Lin H, and Li Q
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- Adult, Aged, Aged, 80 and over, Esophageal Neoplasms radiotherapy, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Neoadjuvant Therapy, Prognosis, Proportional Hazards Models, Radiotherapy, Adjuvant, SEER Program, Survival Rate, Treatment Outcome, Young Adult, Esophageal Neoplasms mortality, Esophageal Neoplasms surgery, Lymph Node Excision
- Abstract
To assess the impact of the number of resected lymph nodes (RLNs) for survival in esophageal cancer (EC) patients treated with preoperative radiotherapy and cancer-directed surgery. The Surveillance Epidemiology and End Results (SEER) database was queried to identify EC patients treated from 1988 to 2012 who had complete data on the number of positive lymph nodes and number of RLNs. Kaplan-Meier survival analysis and Cox regression proportional hazard methods were used to determine factors that significantly impact cause-specific survival (CSS) and overall survival (OS). There were a total of 3,159 patients who received preoperative radiotherapy and cancer-directed surgery. The median number of RLNs was 10 in both patients who received and did not receive preoperative radiotherapy (P = 0.332). Cox regression univariate and multivariate analysis showed that RLN count was a significant prognostic factor for CSS and OS. Patients with 11-71 RLNs had better CSS (hazard ratio [HR] = 0.694, 95% confidence interval [CI]: 0.603-0.799, P < 0.001) and OS (HR = 0.724, 95% CI: 0.636-0.824, P < 0.001) than patients with 1-10 RLNs. The 5-year CSS rates were 39.1% and 44.8% in patients with 1-10 RLNs and 11-71 RLNs, respectively (P < 0.001). The 5-year OS rates were 33.7% and 39.9% in patients with 1-10 RLNs and 11-71 RLNs, respectively (P < 0.001). A higher number of RLNs was associated with better survival by tumor stage and nodal stage (all P < 0.05). RLN count is an independent prognostic factor in EC patients who undergo preoperative radiotherapy and cancer-directed surgery., Competing Interests: No any actual or potential conflicts of interest exist.
- Published
- 2016
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18. Effect of postoperative radiotherapy for squamous cell cancer of the breast in a surveillance epidemiology and end results population-based study.
- Author
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Wu SG, Sun JY, Liu WM, Li FY, Lin HX, and He ZY
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- Adult, Aged, Aged, 80 and over, Female, Humans, Kaplan-Meier Estimate, Middle Aged, Multivariate Analysis, Neoplasm Staging, Prognosis, Radiotherapy, Adjuvant, Retrospective Studies, SEER Program, Survival Rate, Young Adult, Breast Neoplasms mortality, Breast Neoplasms radiotherapy, Breast Neoplasms surgery, Neoplasms, Squamous Cell mortality, Neoplasms, Squamous Cell radiotherapy, Neoplasms, Squamous Cell surgery
- Abstract
The therapeutic value of postoperative radiotherapy (RT) for squamous cell cancer of the breast (SCCB) is unclear. This retrospective study used a population-based national registry to determine the impact of postoperative RT on survival of women with SCCB. The Surveillance Epidemiology and End Results (SEER) database was used to identify females with SCCB who underwent primary surgical resection from 1973 to 2012. Kaplan-Meier survival analysis and Cox regression proportional hazard methods were used to determine the impact of RT following resection associated with cause-specific survival (CSS) and overall survival (OS). A total of 523 patients met the eligibility criteria. The median follow-up time was 55 months, the 10-year CSS and OS rates were 65.6%, and 46.0%, respectively. A total of 167 patients (31.9%) received postoperative RT. Multivariate analysis indicated that advanced pT and pN stage, and no postoperative RT were independently associated with poor OS; advanced pT and pN stage were independently associated with poor CSS. Postoperative RT was significantly associated with improved 10-year OS (54.5% vs. 42.0%, P =.001), but had no effect on CSS (P =.217). Analysis of patients with different stages of SCCB indicated that RT was associated with improved CSS (P =.047) and OS (P <.001) in those with stage II cancer and improved OS in patients with stage pN0 cancer (P <.001). Postoperative RT improved the survival of SCCB patients, especially in those with stage II and stage pN0 cancer.
- Published
- 2016
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19. Anterior cingulate cortex-related connectivity in first-episode schizophrenia: a spectral dynamic causal modeling study with functional magnetic resonance imaging.
- Author
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Cui LB, Liu J, Wang LX, Li C, Xi YB, Guo F, Wang HN, Zhang LC, Liu WM, He H, Tian P, Yin H, and Lu H
- Abstract
Understanding the neural basis of schizophrenia (SZ) is important for shedding light on the neurobiological mechanisms underlying this mental disorder. Structural and functional alterations in the anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), hippocampus, and medial prefrontal cortex (MPFC) have been implicated in the neurobiology of SZ. However, the effective connectivity among them in SZ remains unclear. The current study investigated how neuronal pathways involving these regions were affected in first-episode SZ using functional magnetic resonance imaging (fMRI). Forty-nine patients with a first-episode of psychosis and diagnosis of SZ-according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision-were studied. Fifty healthy controls (HCs) were included for comparison. All subjects underwent resting state fMRI. We used spectral dynamic causal modeling (DCM) to estimate directed connections among the bilateral ACC, DLPFC, hippocampus, and MPFC. We characterized the differences using Bayesian parameter averaging (BPA) in addition to classical inference (t-test). In addition to common effective connectivity in these two groups, HCs displayed widespread significant connections predominantly involved in ACC not detected in SZ patients, but SZ showed few connections. Based on BPA results, SZ patients exhibited anterior cingulate cortico-prefrontal-hippocampal hyperconnectivity, as well as ACC-related and hippocampal-dorsolateral prefrontal-medial prefrontal hypoconnectivity. In summary, spectral DCM revealed the pattern of effective connectivity involving ACC in patients with first-episode SZ. This study provides a potential link between SZ and dysfunction of ACC, creating an ideal situation to associate mechanisms behind SZ with aberrant connectivity among these cognition and emotion-related regions.
- Published
- 2015
- Full Text
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