20 results on '"Li, Xuehang"'
Search Results
2. The relationship between sleep status and activity of daily living: based on China Hainan centenarians cohort study
- Author
-
Yang, Shanshan, Wang, Shengshu, Liu, Guangdong, Li, Rongrong, Li, Xuehang, Chen, Shimin, Zhao, Yali, Liu, Miao, Liu, Yunxi, and He, Yao
- Published
- 2023
- Full Text
- View/download PDF
3. Multiple cardiometabolic diseases enhance the adverse effects of hypoalbuminemia on mortality among centenarians in China: a cohort study
- Author
-
Li, Haowei, Wang, Shengshu, Yang, Shanshan, Liu, Shaohua, Song, Yang, Chen, Shimin, Li, Xuehang, Li, Zhiqiang, Li, Rongrong, Zhao, Yali, Zhu, Qiao, Ning, Chaoxue, Liu, Miao, and He, Yao
- Published
- 2023
- Full Text
- View/download PDF
4. Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China
- Author
-
Chen, Shimin, Li, Haowei, Wang, Shengshu, Yang, Shanshan, Liu, Shaohua, Song, Yang, Li, Xuehang, Li, Rongrong, Wang, Jianhua, Liu, Miao, and He, Yao
- Published
- 2023
- Full Text
- View/download PDF
5. Cardiometabolic diseases and early cognitive decline: Mitigated by integrated active lifestyle for brain health
- Author
-
Li, Haowei, Qi, Shige, Wang, Shengshu, Yang, Shanshan, Liu, Shaohua, Chen, Shimin, Li, Xuehang, Li, Rongrong, Yang, Junhan, Li, Huaihao, Bao, Yinghui, Shi, Yueting, Wang, Zhihui, Liu, Miao, and He, Yao
- Published
- 2024
- Full Text
- View/download PDF
6. The secondary orientation effect of single crystal superalloy thin-wall specimens at 850 °C with [001] primary orientation
- Author
-
Wang, Haibo, Li, Xuehang, Shang, Yong, Zhang, Shuangqi, Hu, Bin, Pei, Yanling, Li, Shusuo, and Gong, Shengkai
- Published
- 2024
- Full Text
- View/download PDF
7. Association of sleep status with depressive state in centenarians: Evidence from Hainan centenarian cohort
- Author
-
Yang, Shanshan, Han, Ke, Wang, Shengshu, Li, Rongrong, Li, Xuehang, Chen, Shimin, Zhao, Yali, Liu, Guangdong, Liu, Miao, and He, Yao
- Published
- 2023
- Full Text
- View/download PDF
8. Association between different adiposity measures and all-cause mortality risk among centenarians: A prospective cohort study
- Author
-
Liu, Shaohua, Cao, Wenzhe, Li, Zhiqiang, Wang, Shengshu, Yang, Shanshan, Lu, Mingming, Li, Haowei, Song, Yang, Chen, Shimin, Li, Xuehang, Li, Rongrong, Wang, Jianhua, Yang, Junhan, Liu, Miao, and He, Yao
- Published
- 2023
- Full Text
- View/download PDF
9. Association of Sleep Status With Cognitive Functions in Centenarians: Evidence From Hainan Centenarian Cohort.
- Author
-
Yang, Shanshan, Wang, Shengshu, Liu, Guangdong, Li, Rongrong, Li, Xuehang, Chen, Shimin, Wang, Jianhua, Zhao, Yali, Liu, Miao, and He, Yao
- Subjects
COGNITION disorder risk factors ,SLEEP quality ,RESEARCH ,MEMORY ,CENTENARIANS ,CONFIDENCE intervals ,SLEEP latency ,MENTAL orientation ,SLEEP duration ,PATIENT monitoring ,ATTENTION ,COGNITIVE testing ,LOGISTIC regression analysis ,ODDS ratio ,OLD age - Abstract
Objectives This study aimed to analyze the association between sleep quality, sleep duration, and cognitive functions among centenarians. Methods The baseline data of the China Hainan Centenarians Cohort Study served as the foundation for this study. Logistic regression was utilized to demonstrate the relationship between sleep status and cognitive impairment. Moreover, a canonical correlation analysis was performed to analyze the correlation between these variables. Results A total of 994 centenarians were included. After adjustment, poor sleep quality centenarians had an odds ratio of 1.77 (95% confidence interval [CI]: 1.00–3.09) for cognitive impairment when compared to centenarians with normal sleep quality. Centenarians who slept for more than 9 hr had a stronger association with severe cognitive impairment, indicated by an odds ratio of 1.41 (95% CI: 1.02–1.96), compared to those who slept for 7–9 hr. Additionally, the canonical correlation analysis results revealed that the linear combination of sleep quality V1, primarily determined by sleep latency, daytime dysfunction, and subjective sleep quality, was associated with cognitive function; the linear combination of cognitive function W1, mainly determined by orientation, attention and calculation, and memory. Discussion There exists a correlation between poor sleep quality and cognitive impairment in centenarians, as well as a correlation between sleep duration >9 hr at night and severe cognitive impairment. The primary cognitive domains associated with sleep quality are orientation, calculation, and memory. It is imperative to monitor and safeguard the cognitive functions linked to poor sleep quality in the older individuals, with attention to orientation, calculation, and memory. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
10. Effect of the Online Mindfulness-Based Stress Reduction on Anxiety and Depression Status of COVID-19 Patients Treated in Fangcang Hospitals: A Randomized Controlled Trial
- Author
-
Li,Haowei, Chen,Hao, Ye,Zifeng, Li,Xuehang, Yang,Lei, Wang,Shengshu, Yang,Shanshan, Liu,Shaohua, Chen,Shimin, Li,Rongrong, Yang,Junhan, Li,Huaihao, Bao,Yinghui, Shi,Yueting, Wang,Jianhua, He,Yao, and Liu,Miao
- Subjects
Psychology Research and Behavior Management - Abstract
Haowei Li,1,* Hao Chen,2,3,* Zifeng Ye,4 Xuehang Li,1 Lei Yang,1,5 Shengshu Wang,1 Shanshan Yang,6 Shaohua Liu,1 Shimin Chen,1 Rongrong Li,1 Junhan Yang,1,3 Huaihao Li,1 Yinghui Bao,1 Yueting Shi,1,3 Jianhua Wang,1 Yao He,1,7 Miao Liu3 1Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing, Peopleâs Republic of China; 2Healthcare Office of Medical Service Department, Hainan Hospital, Chinese PLA General Hospital, Sanya, Hainan, Peopleâs Republic of China; 3Department of Statistics and Epidemiology, Graduate School of PLA General Hospital, Beijing, Peopleâs Republic of China; 4Department of Medical Psychology of Hainan Hospital, Chinese PLA General Hospital, Sanya, Hainan, Peopleâs Republic of China; 5Healthcare Office of Chinese PLA General Hospital, Beijing, 100853, Peopleâs Republic of China; 6Department of Disease Prevention and Control, First Medical Center of PLA General Hospital, Beijing, Peopleâs Republic of China; 7State Key Laboratory of Kidney Diseases, Beijing, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Yao He, Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National clinical research center for geriatrics diseases, State Key Laboratory of Kidney Diseases, Second Medical Center of Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, Peopleâs Republic of China, Tel +86-10-66876411, Email yhe301@x263.net Miao Liu, Department of statistics and epidemiology, Graduate School of PLA General Hospital, 28 Fuxing Road, Beijing, 100853, Peopleâs Republic of China, Tel +86-10-66937715, Email liumiaolmbxb@163.comBackground: As the focal point of epidemic prevention and control, the mental health of COVID-19 patients cannot be ignored. Online Mindfulness-Based Stress Reduction (MBSR) allows for the provision of conveniently accessible, effective and low-cost interventions on a large scale. We aim to evaluate the effectiveness of an online MBSR intervention in alleviating anxiety and depression among asymptomatic/mild patients limited by COVID-19-related restrictions.Methods: Fifty-eight patients treated in Sanya Fangcang hospital were randomly allocated to either to the experimental group (n = 29) following daily, for 5 days, an online-based mindfulness intervention or to the control group (n = 29). Patients from both groups underwent online questionnaires including assessment of anxiety and depression status at pre- and post-tests using Self-rating Anxiety Scale and Self-Rating Depression Scale.Results: After the online-based MBSR program, the anxiety and depression scores of the patients in the MBSR group decreased significantly in comparison to the scores of those in the control group (respectively η2 = 0.175, η2 = 0.215, p < 0.001). And the proportion of severe anxiety and depression patients in the MBSR group decreased to 0% which lower than the control group, and the proportion of light anxiety and depression patients was significantly more than that in the control group after the MBSR intervention.Conclusion: The online-based MBSR intervention appears to be an effective way of alleviating anxiety and depression symptoms among COVID-19 patients with associated quarantine in Fangcang hospital. Given the seriousness of mental health threat that could be posed by this ongoing pandemic, our study provides a new idea and method for cost-effective and time-efficient interventions in the future of epidemic prevention and control.Keywords: COVID-19 patients, online mindfulness, psychological intervention, anxiety, depression
- Published
- 2023
11. The Preventive Effect of Distal Perfusion Catheters on Vascular Complications in Patients Undergoing Venous Artery Extracorporeal Membrane Oxygenation.
- Author
-
Wang, Jianwei, Wang, Shengshu, Song, Yang, Huang, MingJun, Cao, Wenzhe, Liu, Shaohua, Chen, Shimin, Li, Xuehang, Liu, Miao, and He, Yao
- Subjects
EXTRACORPOREAL membrane oxygenation ,VASCULAR catheters ,PULMONARY veins ,HEART assist devices ,TIBIAL arteries - Abstract
In fact, DPCs are often used in several ECMO facilities.[4] Those patients with a higher risk of developing limb ischemia (eg female patients, younger patients and patients taking high doses of vasopressors) may benefit most from the prophylactic use of a DPC. In the early phases of ECMO, it has been clinically shown that the initial ischemia status of the lower extremities on the side of femoral artery cannulation naturally improves without DPC intervention.9-11 Due to their condition not rapidly improving following an ECMO procedure, some patients can progressively acquire severe limb ischemia.12-14 Therefore, it is crucial to assess whether DPC implantation is successful in treating or preventing limb ischemia in addition to its efficacy.[12],15-18 It seems that the DPC cannulation approach must be changed, and the DPC time must be adjusted. Although the use of a DPC is a widespread strategy for the prevention and treatment of limb ischemia, the number of patients with limb ischemia and its aftereffects is rising as more adult patients are obtaining femoral VA-ECMO cannulation. [Extracted from the article]
- Published
- 2023
- Full Text
- View/download PDF
12. Topologically Closed Packed Phase and Its Interaction with Dislocation Movement in Ni–Based Superalloy during High–Temperature Creep.
- Author
-
Guo, Wenqi, Zhao, Haigen, Ru, Yi, Pei, Yanling, Wang, Junwu, Liu, Qiaomu, Li, Xuehang, Wang, Haibo, Zhang, Shuangqi, Gong, Shengkai, and Li, Shusuo
- Subjects
HEAT resistant alloys ,SINGLE crystals ,DISLOCATIONS in crystals ,LATTICE constants ,CRACK propagation (Fracture mechanics) - Abstract
In superalloys, topologically close–packed (TCP) phases, which contain refractory elements, usually significantly influence the mechanical properties. The current work investigates the structure and composition of the TCP phase in an Al–Mo–rich Ni–based single crystal superalloy. It is shown that after 40 h of thermal exposure, a large number of strip–like TCP phases are formed, which are enriched in Mo and Re. The structure of the TCP phase is identified as the tetragonal σ phase with the lattice parameter a being 0.93 nm and c being 0.50 nm. During the creep process, the single crystal tilts obviously and leads to orientation variation from <1 1 0> direction. Two groups of dislocations are observed in the deformed sample. One group contains straight dislocation lines and another group contains dislocation networks. The interaction between TCP phase and dislocation in the single crystal superalloy is studied to reveal the effect of the TCP phase on the deformation behavior. During creep, the σ phase hinders the dislocation movement, which may contribute to the propagation of the cracks and the final fracture. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
13. Current status, trends, and predictions in the burden of gallbladder and biliary tract cancer in China from 1990 to 2019.
- Author
-
Chen, Shimin, Han, Ke, Song, Yang, Liu, Shaohua, Li, Xuehang, Wang, Shengshu, Li, Haowei, Li, Rongrong, Wang, Jianhua, He, Yao, and Liu, Miao
- Published
- 2022
- Full Text
- View/download PDF
14. Elevated D-dimer and Adverse In-hospital Outcomes in COVID-19 Patients and Synergism with Hyperglycemia.
- Author
-
Li, Haowei, Chen, Shimin, Wang, Shengshu, Yang, Shanshan, Cao, Wenzhe, Liu, Shaohua, Song, Yang, Li, Xuehang, Li, Zhiqiang, Li, Rongrong, Liu, Xiong, Wang, Changjun, Chen, Yong, Xie, Fei, He, Yao, and Liu, Miao
- Subjects
HYPERGLYCEMIA ,COVID-19 ,FIBRIN fragment D ,BLOOD sugar ,TREATMENT effectiveness ,CONFIDENCE intervals - Abstract
Aim: One of the most common laboratory findings in COVID-19 patients has been observed to be hypercoagulability with elevated D-dimer levels. An activation of thrombosis may be generated by hyperglycemia. We aimed to explore the association between D-dimer and in-hospital outcomes, and evaluate the synergistic effect between elevated D-dimer and hyperglycemia on COVID-19 prognosis. Methods: A retrospective cohort study was undertaken with 2467 COVID-19 inpatients. D-dimer and fasting blood glucose (FBG) on admission and adverse in-hospital outcomes (events of death and aggravated severity) were collected. Cox proportional risk model was performed to assess the association of D-dimer and adverse in-hospital outcomes, and the combined effects of D-dimer and FBG. Results: Among these COVID-19 patients, 1100 (44.6%) patients had high D-dimer (≥ 0.50 mg/L). Patients with high D-dimer were older, with higher FBG (≥ 7.00 mmol/L), and had significantly higher adjusted risk of adverse in-hospital outcomes when comparing with those who with D-dimer< 0.50 mg/L (hazard ratio, 2.73; 95% confidence interval, 1.46– 5.11). Moreover, patients with high FBG and D-dimer levels had an increasing risk (hazard ratio, 5.72; 95% confidence interval: 2.65– 12.34) than those with normal FBG and D-dimer. Conclusion: Risk of adverse in-hospital outcomes is higher among patients with high D-dimer levels. Additionally, this study found for the first time that elevated D-dimer and hyperglycemia had a synergistic effect on COVID-19 prognosis, and this risk was independent of diabetes history. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
15. A Novel Technique for Full-Field Deformation and Temperature Measurement by Ultraviolet Imaging: Experimental Design and Preliminary Results.
- Author
-
Zhang, Jingqing, Shang, Yong, Li, Xuehang, Dong, Yali, and Pei, Yanling
- Subjects
TEMPERATURE measurements ,COMPLEMENTARY metal oxide semiconductors ,DIGITAL image correlation ,IMAGING systems ,HIGH temperatures - Abstract
Synchronous measurement of full-field temperature and deformation at high temperature especially more than 1273 K is of much significance especially for part applications of turbine structures and materials. Non-contact optical methods attract more and more attention, however, current methods all face different challenges, such as strong light reflection on the surface of the specimen, disturbing radiation from environment, complex equipment setup, limited measured temperature not higher than 900 °C and so on. In this work, we develop an innovative technique to overcome some current problems. The measurement system employing an ultraviolet (UV) imaging system is composed of a scientific complementary metal oxide semiconductor (sCMOS) camera, a lens and a UV bandpass filter. The UV bandpass filter was used for thermal radiation elimination to acquire high quality images at elevated temperatures for deformation field calculation suitable for digital image correlation (DIC) method. The UV sensitive sCMOS camera without using active illumination was employed to collect enough UV radiation energy and eliminate the interference of the external ambient light, which is applicable for high accuracy temperature field measurement. Our system can realize the synchronous capture of image and temperature acquisition with passive UV imaging system at temperature not lower than 1473 K. The feasibility of the method was verified through heating molybdenum (Mo) and Ni-based superalloy IC21 materials. The temperature fields of Mo measured by the established imaging system up to 1835 K with error less than 0.25% showed the effectiveness for temperature measurement. The estimated deformation and temperature field of Ni-based superalloy IC21 up to 1473 K with measured temperature error less than 0.5% demonstrated well the great potential of the UV imaging system in simultaneous measurement of temperature and deformation fields at elevated temperatures. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
16. Analysis of 24-hour Death Risk Factors in Circulatory Failure Patients Treated with Venoarterial Extracorporeal Membrane Oxygenation.
- Author
-
Wang J, Wang S, Song Y, Huang M, Cao W, Liu S, Chen S, Li X, Liu M, and He Y
- Subjects
- Humans, Adult, Middle Aged, Hospital Mortality, Retrospective Studies, Risk Factors, Extracorporeal Membrane Oxygenation adverse effects, Shock
- Abstract
Objective: To explore the factors affecting short-term prognosis of circulatory failure patients undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO) treatment., Methods: A total of 136 patients undergoing VA-ECMO were enrolled in this study and subsequently divided into the death group (n=35) and the survival group (n=101) based on whether death occurred during hospitalisation. Extracorporeal membrane oxygenation (ECMO) running time, length of intensive care unit stay, length of hospital stay, costs, and ECMO complications were then compared between the two groups., Results: The average age of all patients undergoing ECMO was 47.64±16.78 years (53.2±16.20 years in the death group and 45.713±16.62 years in the survival group) (P=0.022). Patients in the survival group exhibited a clear downward trend in lactic acid value following ECMO treatment compared to those in the death group. Total hospitalisation stay was longer in the survival group (35 days) than in the death group (15.5 days) (P<0.001). In the analysis of ECMO complications, the incidence of neurological complications, renal failure, limb complications, and infection were higher in the death group than in the survival group (P<0.05 for all). Specifically, as a risk factor for patient survival and discharge, the occurrence of infection will lead to increased hospitalisation stays and costs (P<0.05 for both)., Conclusion: Complications such as kidney failure and infection are associated with in-hospital death, and ECMO-related complications should be actively prevented to improve the survival rate of VA-ECMO treatment.
- Published
- 2023
- Full Text
- View/download PDF
17. Cognitive impairment assessed by Mini-Mental State Examination predicts all-cause and CVD mortality in Chinese older adults: A 10-year follow-up study.
- Author
-
Li Z, Gong X, Wang S, Liu M, Liu S, Wang Y, Wu D, Yang M, Li R, Li H, Li X, Chen S, Zhang X, Jia R, Guo J, He Y, and Wang Y
- Subjects
- Humans, Aged, Follow-Up Studies, East Asian People, Prospective Studies, Cardiovascular Diseases complications, Cognitive Dysfunction epidemiology, Cognitive Dysfunction complications
- Abstract
Objective: Cognitive impairment (CI) has been demonstrated as a useful proxy measure of mortality in Western populations. However, the predictive value of CI in Chinese populations is unknown. We aimed to explore whether CI is independently associated with increased long-term all-cause and cardiovascular disease (CVD) mortality in Chinese older adults and the association of performance in specific MMSE sub-domains to subsequent mortality., Methods and Results: A total of 4,499 older adults [mean (SD) age, 70.3(6.7) years] who received a sample investigation from 2011 to 2014 were followed up till 2021 for mortality. The Mini-Mental State Examination was used to assess cognitive function, and Cox's proportional hazard models were used to evaluate the effects of cognitive function on the risk of all-cause and CVD mortality. Demographic characteristics, lifestyle, and health status were included as covariates. During a 10-year follow-up, a total of 667 (14.8%) died. In the fully adjusted model, compared with cognitively normal participants with CI had a 1.33-fold [HR, 1.33; (95% CI, 1.10-1.61)] greater risk of all-cause mortality and a 1.45-fold [HR, 1.45; (95% CIs, 1.11-1.92)] greater risk of CVD mortality. After a similar multivariable adjustment, a per-SD increase in MMSE scores was associated with a reduced risk of all-cause mortality [HR, 0.85; (95% CI, 0.78-0.93)] and CVD mortality [HR, 0.74; (95% CI, 0.65-0.84)]. In the unadjusted model, MMSE sub-domains (apart from immediate recall) were associated with mortality. But only orientation and calculation and attention were still independently associated with all-cause and CVD mortality in a multivariable model., Conclusion: These findings confirmed that CI is a marker of all-cause and CVD mortality risk in Chinese older adults, independently of other commonly assessed risk factors, and some sub-domains of the MMSE may have stronger associations with mortality. Further research is needed to identify the mechanisms underlying the observed associations., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Li, Gong, Wang, Liu, Liu, Wang, Wu, Yang, Li, Li, Li, Chen, Zhang, Jia, Guo, He and Wang.)
- Published
- 2022
- Full Text
- View/download PDF
18. Synergistic impact of diabetes and cognitive impairment on all-cause and cause-specific mortality in Chinese older adults: A prospective population-based cohort study.
- Author
-
Li Z, Wang S, Liu S, Gong X, Wang Y, Wu D, Yang M, Li R, Li H, Li X, Chen S, Jia R, Guo J, Wang J, Liu M, He Y, and Wang Y
- Subjects
- Aged, Humans, Cohort Studies, Cause of Death, Prospective Studies, China epidemiology, Cognitive Dysfunction epidemiology, Diabetes Mellitus epidemiology, Cardiovascular Diseases complications
- Abstract
Background: Diabetes mellitus (DM) or cognitive impairment (CI) is known to be strongly associated with mortality. DM commonly coexists with CI and proportionally increases with age. However, little is known about the combined effect of cognitive function and diabetes on mortality. This study aimed to evaluate the combined effects of DM and CI on all-cause and cause-specific mortality in Chinese older adults., Methods: This prospective population-based cohort study was based on the Beijing Elderly Comprehensive Health Cohort Study. A total of 4,499 older adults were included. Cox's proportional hazard models were utilized to calculate the effect of DM and CI on all-cause, cardiovascular disease (CVD) mortality and cancer mortality, and a multiplicative term was introduced to study a potential interaction between DM and CI on outcomes., Results: During a median follow-up of 6.8 years (ranging from 6.6 to 11.7 years), 667 (14.8%) participants died from all causes, 292 from CVD, and 215 from cancer. In the fully adjusted model, participants with coexisting DM and CI had the highest risk of all-cause mortality [hazard ratios (HRs), 3.08; 95% confidence intervals (CIs), 2.30,4.11] and CVD mortality (HRs, 3.85; 95% CIs, 2.60,5.71) compared with individuals with normal cognition and non-DM. We also found a multiplicative interaction between DM and CI in respect to all-cause (HRs, 2.46; 95% CI, 1.87,3.22) and CVD mortality (HRs, 3.15 95% CI, 2.19,4.55). In the diabetic population, CI was associated with an increased risk of all-cause mortality (HRs, 2.09; 95% CIs, 1.51,2.89) and CVD mortality (HRs, 3.16; 95% CIs, 2.02,5.05) compared with the normal cognition group. Restricted cubic spline revealed a linear inverse association between Mini-Mental State Examination (MMSE) score and all-cause, CVD mortality in the total sample and participants without diabetes. However, a nearly reverse J association was observed between MMSE and mortality from all causes and CVD in the diabetes group., Conclusion: The findings highlighted that cognitive impairment concomitant with diabetes further increases the risk of mortality. In addition to strengthening routine screening of cognitive functioning in older adults with early-stage diabetes, more extensive assessment of prognostic risks has high clinical value for developing comprehensive treatment plans., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Li, Wang, Liu, Gong, Wang, Wu, Yang, Li, Li, Li, Chen, Jia, Guo, Wang, Liu, He and Wang.)
- Published
- 2022
- Full Text
- View/download PDF
19. Spatiotemporal Analysis of the Prevalence and Pattern of Multimorbidity in Older Chinese Adults.
- Author
-
Chen S, Wang S, Jia W, Han K, Song Y, Liu S, Li X, Liu M, and He Y
- Abstract
Background: Multimorbidity presents an enormous problem to societal and healthcare utilization under the context of aging population in low- and middle-income countries (LMICs). Currently, systematic studies on the profile of multimorbidity and its characteristics among Chinese elderly are lacking. We described the temporal and spatial trends in the prevalence of multimorbidity and explored chronological changes of comorbidity patterns in a large elderly population survey., Methods: Data were extracted from the Chinese Longitudinal Healthy Longevity Study (CLHLS) conducted between 1998 and 2018 in a random selection of half of the counties and city districts. All the elderly aged 65 and older were included in the survey of eight waves. We used 13 investigated chronic diseases to measure the prevalence of multimorbidity by means of geography, subpopulation, and chronological changes. The patterns of multimorbidity were assessed by computing the value of relative risk (RR indicates the likelihood of certain diseases to be associated with multimorbidity) and the observed-to-expected ratio (O/E indicates the likelihood of the coexistence of a multimorbidity combination)., Results: From 1998 to 2018, the prevalence of multimorbidity went from 15.60 to 30.76%, increasing in the fluctuation across the survey of eight waves ( p
for trend = 0.020). Increasing trends were observed similarly in a different gender group ( pmale = 0.009; pfemale = 0.004) and age groups among female participants ( p~80 = 0.009; p81-90 = 0.004; p91-100 = 0.035; p101~ = 0.018). The gap in the prevalence of multimorbidity between the north and the south was getting narrow across the survey of eight waves. Hypertension was the highest prevalent chronic condition while diabetes was most likely to coexist with other chronic conditions in the CLHLS survey. The most frequently occurring clusters were hypertension and heart disease, hypertension and cataract, and hypertension and chronic lung disease. And, the cancer, TB, and Parkinson's disease cluster took the domination of O/E rankings over time, which had a higher probability of coexistence in all the multimorbidity combinations., Conclusions: The prevalence of multimorbidity has been increasing nationwide, and more attention should be paid to a rapid growth in the southern part of China. It demands the effective diagnosis and treatment adopted to the highly prevalent comorbidities, and strategies and measures were adjusted to strongly relevant clusters., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Chen, Wang, Jia, Han, Song, Liu, Li, Liu and He.)- Published
- 2022
- Full Text
- View/download PDF
20. Role of blood pressure on stroke-related mortality: a 45-year follow-up study in China.
- Author
-
Wang S, Yang S, Jia W, Han K, Song Y, Zeng J, Cao W, Liu S, Chen S, Li Z, Li X, Tai P, Kou F, He Y, and Liu M
- Subjects
- Adult, Blood Pressure physiology, China epidemiology, Follow-Up Studies, Humans, Male, Middle Aged, Risk Factors, Hypertension, Stroke
- Abstract
Background: Hypertension is associated with stroke-related mortality. However, the long-term association of blood pressure (BP) and the risk of stroke-related mortality and the influence path of BP on stroke-related death remain unknown. The current study aimed to estimate the long-term causal associations between BP and stroke-related mortality and the potential mediating and moderated mediating model of the associations., Methods: This is a 45-year follow-up cohort study and a total of 1696 subjects were enrolled in 1976 and 1081 participants died by the latest follow-up in 2020. COX proportional hazard model was used to explore the associations of stroke-related death with baseline systolic blood pressure (SBP)/diastolic blood pressure (DBP) categories and BP changes from 1976 to 1994. The mediating and moderated mediating effects were performed to detect the possible influencing path from BP to stroke-related deaths. E value was calculated in the sensitivity analysis., Results: Among 1696 participants, the average age was 44.38 ± 6.10 years, and 1124 were men (66.3%). After a 45-year follow-up, a total of 201 (11.9%) stroke-related deaths occurred. After the adjustment, the COX proportional hazard model showed that among the participants with SBP ≥ 160 mmHg or DBP ≥ 100 mmHg in 1976, the risk of stroke-related death increased by 217.5% (hazard ratio [HR] = 3.175, 95% confidence interval [CI]: 2.297-4.388), and the adjusted HRs were higher in male participants. Among the participants with hypertension in 1976 and 1994, the risk of stroke-related death increased by 110.4% (HR = 2.104, 95% CI: 1.632-2.713), and the adjusted HRs of the BP changes were higher in male participants. Body mass index (BMI) significantly mediated the association of SBP and stroke-related deaths and this mediating effect was moderated by gender., Conclusions: In a 45-year follow-up, high BP and persistent hypertension are associated with stroke-related death, and these associations were even more pronounced in male participants. The paths of association are mediated by BMI and moderated by gender., (Copyright © 2022 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.)
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.