1. Mesoporous Fe3O4/hydroxyapatite composite for targeted drug delivery.
- Author
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Gu, Lina, He, Xiaomei, and Wu, Zhenyu
- Subjects
- *
IRON oxides , *MESOPOROUS materials , *COMPOSITE materials , *DRUG delivery systems , *HYDROXYAPATITE , *DOXORUBICIN , *PH effect - Abstract
In this contribution, we introduced a simple, efficient, and green method of preparing a mesoporous Fe 3 O 4 /hydroxyapatite (HA) composite. The as-prepared material had a large surface area, high pore volume, and good magnetic separability, which made it suitable for targeted drug delivery systems. The chemotherapeutic agent doxorubicin (DOX) was used to investigate the drug release behavior of Fe 3 O 4 /HA composite. The drug release profiles displayed a little burst effect and pH-dependent behavior. The release rate of DOX at pH 5.8 was larger than that at pH 7.4, which could be attributed to DOX protonation in acid medium. In addition, the released DOX concentrations remained at 0.83 and 1.39 μg/ml at pH 7.4 and 5.8, respectively, which indicated slow, steady, and safe release rates. Therefore, the as-prepared Fe 3 O 4 /hydroxyapatite composite could be an efficient platform for targeted anticancer drug delivery. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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