1. The people behind the papers - Eduardo Leyva-Díaz and Oliver Hobert.
- Subjects
- Animals, Caenorhabditis elegans embryology, Gene Editing history, History, 20th Century, History, 21st Century, Humans, New York, Organ Specificity genetics, CRISPR-Cas Systems physiology, Caenorhabditis elegans genetics, Central Nervous System embryology, Developmental Biology history, Developmental Biology trends, Gene Editing methods, Laboratory Personnel history
- Abstract
Transcriptional autoregulation occurs when transcription factors bind their own cis -regulatory sequences, ensuring their own continuous expression along with expression of other targets. During development, continued expression of identity-specifying transcription factors can be achieved by autoregulation, but until now formal evidence for a developmental requirement of autoregulation has been lacking. A new paper in Development provides this proof with the help of CRISPR/Cas9 gene editing in the C. elegans nervous system . We caught up with the paper's two authors: postdoc Eduardo Leyva-Díaz and his supervisor Oliver Hobert, Professor of Biological Sciences and HHMI Investigator at Columbia University, New York, to find out more about the work., (© 2019. Published by The Company of Biologists Ltd.)
- Published
- 2019
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