10 results on '"Hammad, Tarek A."'
Search Results
2. Medication Exposure in Pregnancy Risk Evaluation Program: The Prevalence of Asthma Medication Use During Pregnancy
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Hansen, Craig, Joski, Peter, Freiman, Heather, Andrade, Susan, Toh, Sengwee, Dublin, Sascha, Cheetham, Craig, Cooper, William, Pawloski, Pamala, Li, De-Kun, Beaton, Sarah, Kaplan, Sigal, Scott, Pamela, Hammad, Tarek, and Davis, Robert
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- 2013
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3. Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001–2007: a population-based study of 585,615 deliveries
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Toh, Sengwee, Li, Qian, Cheetham, T. Craig, Cooper, William O., Davis, Robert L., Dublin, Sascha, Hammad, Tarek A., Li, De-Kun, Pawloski, Pamala A., Pinheiro, Simone P., Raebel, Marsha A., Scott, Pamela E., Smith, David H., Bobo, William V., Lawrence, Jean M., Dashevsky, Inna, Haffenreffer, Katherine, Avalos, Lyndsay A., and Andrade, Susan E.
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- 2013
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4. Medication Exposure in Pregnancy Risk Evaluation Program
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Andrade, Susan E., Davis, Robert L., Cheetham, T. Craig, Cooper, William O., Li, De-Kun, Amini, Thushi, Beaton, Sarah J., Dublin, Sascha, Hammad, Tarek A., Pawloski, Pamala A., Raebel, Marsha A., Smith, David H., Staffa, Judy A., Toh, Sengwee, Dashevsky, Inna, Haffenreffer, Katherine, Lane, Kimberly, Platt, Richard, and Scott, Pamela E.
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- 2012
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5. Validation of an Algorithm to Estimate Gestational Age in Electronic Health Plan Databases
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Li, Qian, Andrade, Susan E., Cooper, William O., Davis, Robert L., Dublin, Sascha, Hammad, Tarek A., Pawloski, Pamala A., Pinheiro, Simone P., Raebel, Marsha A., Scott, Pamela E., Smith, David H., Dashevsky, Inna, Haffenreffer, Katie, Johnson, Karin E., and Toh, Sengwee
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Adult ,Adolescent ,Databases, Factual ,Pharmacoepidemiology ,Infant, Newborn ,Gestational Age ,Middle Aged ,Delivery, Obstetric ,Sensitivity and Specificity ,Article ,Antidepressive Agents ,Anti-Bacterial Agents ,Young Adult ,International Classification of Diseases ,Predictive Value of Tests ,Pregnancy ,Birth Certificates ,Humans ,Female ,Pregnancy, Multiple ,Algorithms - Abstract
To validate an algorithm that uses delivery date and diagnosis codes to define gestational age at birth in electronic health plan databases.Using data from 225,384 live born deliveries to women aged 15-45 years in 2001-2007 within eight of the 11 health plans participating in the Medication Exposure in Pregnancy Risk Evaluation Program, we compared (1) the algorithm-derived gestational age versus the "gold-standard" gestational age obtained from the infant birth certificate file and (2) the prenatal exposure status of two antidepressants (fluoxetine and sertraline) and two antibiotics (amoxicillin and azithromycin) as determined by the algorithm-derived versus the gold-standard gestational age.The mean algorithm-derived gestational age at birth was lower than the mean obtained from the birth certificate file among singleton deliveries (267.9 vs 273.5 days) but not among multiple-gestation deliveries (253.9 vs 252.6 days). The algorithm-derived prenatal exposure to the antidepressants had a sensitivity and a positive predictive value of ≥95%, and a specificity and a negative predictive value of almost 100%. Sensitivity and positive predictive value were both ≥90%, and specificity and negative predictive value were both99% for the antibiotics.A gestational age algorithm based upon electronic health plan data correctly classified medication exposure status in most live born deliveries, but trimester-specific misclassification may be higher for drugs typically used for short durations.
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- 2013
6. The Prevalence and Trends of Antiviral Medication Use During Pregnancy in the US: A Population-Based Study of 664,297 Deliveries in 2001-2007.
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Avalos, Lyndsay, Chen, Hong, Yang, Chunmei, Andrade, Susan, Cooper, William, Cheetham, Craig, Davis, Robert, Dublin, Sascha, Hammad, Tarek, Kaplan, Sigal, Pawloski, Pamala, Raebel, Marsha, Scott, Pamela, Smith, David, Toh, Sengwee, and Li, De-Kun
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VIRUS disease drug therapy ,VIRAL disease diagnosis ,ANTIVIRAL agents ,EVALUATION of medical care ,RESEARCH funding ,VIRUS diseases ,DISEASE prevalence ,TREATMENT duration ,PREGNANCY - Abstract
To evaluate the prevalence, trends, timing and duration of exposure to antiviral medications during pregnancy within a US cohort of pregnant women and to evaluate the proportion of deliveries with a viral infection diagnosis among women given antiviral medication during pregnancy. Live-born deliveries between 2001 and 2007, to women aged 15-45 years, were included from the Medication Exposure in Pregnancy Risk Evaluation Program, a collaborative research program between the U.S. Food and Drug Administration and eleven health plans. They were evaluated for prevalence, timing, duration, and temporal trends of exposure to antiviral medications during pregnancy. We also calculated the proportion of deliveries with a viral infection diagnosis among those exposed to antiviral medications. Among 664,297 live births, the overall prevalence of antiviral exposure during pregnancy was 4 % (n = 25,155). Between 2001 and 2007, antiviral medication exposure during pregnancy doubled from 2.5 to 5 %. The most commonly used antiviral medication was acyclovir, with 3 % of the deliveries being exposed and most of the exposure occurring after the 1st trimester. Most deliveries exposed to antiviral medications were exposed for less than 30 days (2 % of all live births). Forty percent of the women delivering an infant exposed to antiviral medications had a herpes diagnosis. Our findings highlight the increased prevalence of women delivering an infant exposed to antiviral medications over time. These findings support the need for large, well-designed studies to assess the safety and effectiveness of these medications during pregnancy. [ABSTRACT FROM AUTHOR]
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- 2014
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7. Validation of an algorithm to estimate gestational age in electronic health plan databases Validation of an algorithm to estimate gestational age in electronic health plan databases.
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Li, Qian, Andrade, Susan E., Cooper, William O., Davis, Robert L., Dublin, Sascha, Hammad, Tarek A., Pawloski, Pamala A., Pinheiro, Simone P., Raebel, Marsha A., Scott, Pamela E., Smith, David H., Dashevsky, Inna, Haffenreffer, Katherine, Johnson, Karin E., and Toh, Sengwee
- Abstract
ABSTRACT Purpose To validate an algorithm that uses delivery date and diagnosis codes to define gestational age at birth in electronic health plan databases. Methods Using data from 225 384 live born deliveries to women aged 15-45 years in 2001-2007 within eight of the 11 health plans participating in the Medication Exposure in Pregnancy Risk Evaluation Program, we compared (1) the algorithm-derived gestational age versus the 'gold-standard' gestational age obtained from the infant birth certificate file and (2) the prenatal exposure status of two antidepressants (fluoxetine and sertraline) and two antibiotics (amoxicillin and azithromycin) as determined by the algorithm-derived versus the gold-standard gestational age. Results The mean algorithm-derived gestational age at birth was lower than the mean obtained from the birth certificate file among singleton deliveries (267.9 vs 273.5 days) but not among multiple-gestation deliveries (253.9 vs 252.6 days). The algorithm-derived prenatal exposure to the antidepressants had a sensitivity and a positive predictive value of ≥95%, and a specificity and a negative predictive value of almost 100%. Sensitivity and positive predictive value were both ≥90%, and specificity and negative predictive value were both >99% for the antibiotics. Conclusions A gestational age algorithm based upon electronic health plan data correctly classified medication exposure status in most live born deliveries, but trimester-specific misclassification may be higher for drugs typically used for short durations. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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- 2013
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8. Validity of health plan and birth certificate data for pregnancy research.
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Andrade, Susan E., Scott, Pamela E., Davis, Robert L., Li, De‐Kun, Getahun, Darios, Cheetham, T. Craig, Raebel, Marsha A., Toh, Sengwee, Dublin, Sascha, Pawloski, Pamala A., Hammad, Tarek A., Beaton, Sarah J., Smith, David H., Dashevsky, Inna, Haffenreffer, Katherine, and Cooper, William O.
- Abstract
ABSTRACT Purpose To evaluate the validity of health plan and birth certificate data for pregnancy research. Methods A retrospective study was conducted using administrative and claims data from 11 U.S. health plans and corresponding birth certificate data from state health departments. Diagnoses, drug dispensings, and procedure codes were used to identify infant outcomes (cardiac defects, anencephaly, preterm birth, and neonatal intensive care unit [NICU] admission) and maternal diagnoses (asthma and systemic lupus erythematosus [SLE]) recorded in the health plan data for live born deliveries between January 2001 and December 2007. A random sample of medical charts ( n = 802) was abstracted for infants and mothers identified with the specified outcomes. Information on newborn, maternal, and paternal characteristics (gestational age at birth, birth weight, previous pregnancies and live births, race/ethnicity) was also abstracted and compared to birth certificate data. Positive predictive values (PPVs) were calculated with documentation in the medical chart serving as the gold standard. Results PPVs were 71% for cardiac defects, 37% for anencephaly, 87% for preterm birth, and 92% for NICU admission. PPVs for algorithms to identify maternal diagnoses of asthma and SLE were ≥ 93%. Our findings indicated considerable agreement (PPVs > 90%) between birth certificate and medical record data for measures related to birth weight, gestational age, prior obstetrical history, and race/ethnicity. Conclusions Health plan and birth certificate data can be useful to accurately identify some infant outcomes, maternal diagnoses, and newborn, maternal, and paternal characteristics. Other outcomes and variables may require medical record review for validation. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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- 2013
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9. Trends in the Use of Antiepileptic Drugs among Pregnant Women in the US, 2001-2007: A Medication Exposure in Pregnancy Risk Evaluation Program Study.
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Bobo, William V., Davis, Robert L., Toh, Sengwee, Li, De-Kun, Andrade, Susan E., Cheetham, T. Craig, Pawloski, Pamala, Dublin, Sascha, Pinheiro, Simone, Hammad, Tarek, Scott, Pamela E., Epstein, Jr., Richard A., Arbogast, Patrick G., Morrow, James A., Dudley, Judith A., Lawrence, Jean M., Avalos, Lyndsay A., and Cooper, William O.
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ANTICONVULSANTS ,PREGNANT women ,HEALTH risk assessment ,DRUG utilization ,DRUG prescribing ,PREGNANCY - Abstract
Background: Little is known about the extent of antiepileptic drug (AED) use in pregnancy, particularly for newer agents. Our objective was to assess whether AED use has increased among pregnant women in the US, 2001-2007. Methods: We analysed data from the Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP) database, 1 January 2001 to 31 December 2007. We identified liveborn deliveries among women, aged 15-45 years on delivery date, who were members of MEPREP health plans ( n = 585 615 deliveries). Pregnancy exposure to AEDs, determined through outpatient pharmacy dispensing files. Older AEDs were available for clinical use before 1993; other agents were considered newer AEDs. Information on sociodemographic and medical/reproductive factors was obtained from linked birth certificate files. Maternal diagnoses were identified based on ICD-9 codes. Results: Prevalence of AED use during pregnancy increased between 2001 (15.7 per 1000 deliveries) and 2007 (21.9 per 1000 deliveries), driven primarily by a fivefold increase in the use of newer AEDs. Thirteen per cent of AED-exposed deliveries involved a combination of two or more AEDs. Psychiatric disorders were the most prevalent diagnoses, followed by epileptic and pain disorders, among AED users regardless of AED type, year of conception or gestational period. Conclusions: AED use during pregnancy increased between 2001 and 2007, driven by a fivefold increase in the use of newer AEDs. Nearly one in eight AED-exposed deliveries involved the concomitant use of more than one AED. Additional investigations of the reproductive safety of newer AEDs may be needed. [ABSTRACT FROM AUTHOR]
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- 2012
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10. Prevalence, Trends, and Patterns of Use of Antidiabetic Medications Among Pregnant Women, 2001-2007.
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Lawrence, Jean M., Andrade, Susan E., Avalos, Lyndsay A., Beaton, Sarah J., Chiu, Vicki Y., Davis, Robert L., Dublin, Sascha, Pawloski, Pamala A., Raebel, Marsha A., Smith, David H., Toh, Sengwee, Wang, Jean Q., Kaplan, Sigal, Amini, Thushi, Hampp, Christian, Hammad, Tarek A., Scott, Pamela E., and Cheetham, T. Craig
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HYPOGLYCEMIC agents , *PREGNANT women , *HYPERGLYCEMIA , *INSULIN resistance , *PREGNANCY , *GESTATIONAL diabetes - Abstract
The article discusses the results of a study that examines the use of antidiabetic medicines by pregnant women to treat hyperglycemia and insulin resistance from 2001-2007. The study shows an increased in the use of antidiabetic drugs before pregnancy from 0.66 percent of deliveries to 1.66 percent of deliveries. It concludes that the increased in the prevalence of gestational diabetes mellitus and type 1 and type 2 diabetes contributed to the increase in the use of antidiabetic medications.
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- 2013
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