1. Complete Remission of Lupus Nephritis Following Chemoradiotherapy of Carcinoma Cervix: An Association.
- Author
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Girimaji, Niveditha, Nada, Ritambhra, Sharma, Aman, Bharati, Joyita, and Rathi, Manish
- Subjects
LUPUS nephritis ,BIOPSY ,STEROIDS ,MYCOPHENOLIC acid ,CHEMORADIOTHERAPY ,CISPLATIN ,SYSTEMIC lupus erythematosus ,CERVIX uteri tumors ,IMMUNOSUPPRESSIVE agents ,DISEASE remission ,DISEASE complications ,THERAPEUTICS - Abstract
Systemic lupus erythematosus (SLE) is associated with a higher incidence of solid organ malignancies, including cervical carcinoma, creating a paradox in their management in the context of autoimmunity. We present a case of 45-year-old female presented with mucocutaneous, musculoskeletal symptoms of SLE. Renal biopsy showed class IV lupus nephritis (LN); modified NIH activity score: 8/24, chronicity score: 6/12. Post NIH regimen induction, she achieved partial remission; further developed proteinuric relapse which was re-induced with mycophenolate mofetil (MMF) to which she failed to respond. Subsequently diagnosed with carcinoma cervix stage IIB, she received four cycles of concurrent cisplatin-based chemoradiotherapy. MMF was stopped; low dose steroids continued. Following this, the patient achieved complete remission (CR) of LN and is in remission for 5 years. This is an unexpected association between chemoradiotherapy of cervical carcinoma and CR of class IV LN, allowing long-term discontinuation of immunosuppression. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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