1. Difference in the Target Cells for Tolerance Induction in Relation to the Dose of Tolerogen.
- Author
-
Katsura, Y., Kawaguchi, S., and Muramatsu, S.
- Subjects
CYTOLOGICAL research ,BONE marrow cells ,B cells ,T cells ,IMMUNOLOGICAL tolerance ,ANTIGENS ,IMMUNE response ,IMMUNE system - Abstract
Bone marrow cells and thymus cells were observed in cell transfer expehments to collaborate in the production of anti-BSA antibodies. The target cells for tolerance induction either with a 'low dose' of antigen (100 µg of deaggregated BSA once a week × 5) or with a 'high dose' (a single injection of 5000 µg) were identified by the same technique. In 'low dose' tolerance, some indication was obtained that thymus-derived cells in peripheral lymphoid systems were the target cells; bone marrow-derived cells appeared not to be so susceptible, and the cells residing in thymus or bone marrow seemed to remain unimpaired, in contrast, the injection of a 'high dose' of tolerogen rendered both types of cells in spleen, thymus cells and bone marrow cells, unresponsive or hyporesponsive in parallel with one another. [ABSTRACT FROM AUTHOR]
- Published
- 1972