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Understanding of the geodynamic evolution of the Tethyan realm cannot be complete without paleogeographical reconstructions of the North Qiangtang Block (NQB) that occupies a central position in Tibet. However, the reliability of such a reconstruction for the Paleozoic still requires substantial improvement. In this paper, we present paleomagnetic results obtained from the Middle Permian limestones and Upper Permian volcanic rocks in the Tanggula area, aiming to provide precise constraints on the NQB kinematics during the geodynamic evolution of the Tethys realm. Combined with other available paleomagnetic data from the NQB, our results suggest that the block was stably located at ~24°S for a long time before the Middle Permian, started to drift rapidly northward in the Middle Permian, and reached ~8.4°S in the Late Permian. The NQB continued drifting rapidly northward during the Triassic until merging with the southern margin of Eurasia in the Late Triassic. We reviewed new and available paleomagnetic and geological data and proposed a revised model for the tectonic evolution of the eastern Tethys realm. The NQB likely belonged to a ribbon-like separate continental archipelago in the middle of the Paleo-Tethys Ocean during the early--late Paleozoic. The Cimmerian continent, including the South Qiangtang Block (SQB), rifted away from the northern margin of Gondwana and drifted northward to ~22°S in the Middle Permian. The continent approached or partially collided with the NQB, resulting in the rapid northward movement of the NQB and the formation of the Longmuco--Shuanghu suture between the NQB and SQB. [ABSTRACT FROM AUTHOR]