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Spinal epidural hematoma is a rare disease and is most commonly idiopathic. Other common causes are vascular malformations, coagulopathy, hypertension, surgery, and trauma. Epidural vascular hamartoma associated with hemorrhage is a less known entity. We report an unusual case of epidural vascular hamartoma associated with hemorrhage resulting in back pain and neurological deficits. A distinctive feature of this case was waxing and waning signs and symptoms with evidence of radiological resolution of the lesion in the phase of remission. [ABSTRACT FROM AUTHOR]

Stable isotopic compositions of carbon and nitrogen (δ13C, δ15N) of archaeological grains/seeds recovered from different cultural layers of an Indus (Harappan) archaeological site 4MSR (29°12'87.2"N; 73°9'421"E; Binjor, western Rajasthan, India) provide insights into the Harappan agriculture between ~2900 to ~1800 BCE. The δ13C values were used to retrieve hydrological status, while δ15N values were used to gauge agricultural intensification. Isotopic data of grains/seeds were generated representing three Indus phases (i) Early phase (~2900−2600 BCE), (ii) Transitional phase (~2600−2500 BCE), and (iii) Mature phase (~2500−1800 BCE). We find δ13C values of barley grains (winter crop) varied in overlapping ranges for all the three phases −21.34‰ ± 1.9; −22.55‰ ± 1.6 and −22.75‰ ± 1.7 respectively (n=10 for each phase) indicating insignificant changes in hydrology for winter crops. For summer crops like cotton, average δ13C values for Transitional phase −23.44‰ ± 1.8 were not significantly different from those of Mature phase −22.55‰ ± 2.5. The δ15Nbarley values varied in wider range, however, intra-phase variability appears to have overlapping values but showing overall increase from Early (7.72‰ ± 1.8) to Mature phase (11.17‰±7.2) indicating a plausible agricultural intensification. We also measured δ13C of host soil organic matter (SOM) and sediment δ15N to assess regional environmental conditions. In contrast to the trends observed for archaeological grains/seeds, δ13CSOM values showed a statistically significant enriching trend from Early (−23.54‰ ± 1.4) to Mature phase (−20.40‰ ± 1.9) hinting a growing aridity in the region. We surmise that Harappan farmers of western Rajasthan region might be managing arable hydrological conditions in their fields through agricultural interventions to continue agriculture practices despite growing aridity in the vicinity. The high proportion of water-demanding crop cotton during the Mature phase despite of changing environmental conditions, also corroborate our interpretation, possibly grown for the trade purposes. [ABSTRACT FROM AUTHOR]

[Display omitted] • UAP56 is a helicase super family 2 member vital for RNA processing. • UAP56 is required in early steps of spliceosome assembly. • Nucleocytoplasmic export of RNA requires UAP56. • Overexpression of UAP56 is linked to cancer pathogenesis. • UAP56 mutations are associated with neurodevelopmental disorders. Posttranscriptional maturation and export from the nucleus to the cytoplasm are essential steps in the normal processing of many cellular RNAs. The RNA helicase UAP56 (U2AF associated protein 56; also known as DDX39B) has emerged as a critical player in facilitating and co-transcriptionally linking these steps. Originally identified as a helicase involved in pre-mRNA splicing, UAP56 has been shown to facilitate formation of the A complex during spliceosome assembly. Additionally, it has been found to be critical for interactions between components of the exon junction and transcription and export complexes to promote the loading of export receptors. Although it appears to be structurally similar to other helicase superfamily 2 members, UAP56′s ability to interact with multiple different protein partners allows it to perform its various cellular functions. Herein, we describe the structure–activity relationship studies that identified protein interactions of UAP56 and its human paralog URH49 (UAP56-related helicase 49; also known as DDX39A) and are beginning to reveal molecular mechanisms by which interacting proteins and substrate RNAs may regulate these helicases. We also provide an overview of reports that have demonstrated less well-characterized roles for UAP56, including R-loop resolution and telomere maintenance. Finally, we discuss studies that indicate a potential pathogenic effect of UAP56 in the development of autoimmune diseases and cancer, and identify the association of somatic and genetic mutations in UAP56 with neurodevelopmental disorders. [ABSTRACT FROM AUTHOR]

Algal polysaccharides, harnessed for their catalytic potential, embody a compelling narrative in sustainable chemistry. This review explores the complex domains of algal carbohydrate-based catalysis, revealing its diverse trajectory. Starting with algal polysaccharide synthesis and characterization methods as catalysts, the investigation includes sophisticated techniques like NMR spectroscopy that provide deep insights into the structural variety of these materials. Algal polysaccharides undergo various preparation and modification techniques to enhance their catalytic activity such as immobilization. Homogeneous catalysis, revealing its significance in practical applications like crafting organic compounds and facilitating chemical transformations. Recent studies showcase how algal-derived catalysts prove to be remarkably versatile, showcasing their ability to customise reactions for specific substances. Heterogeneous catalysis, it highlights the significance of immobilization techniques, playing a central role in ensuring stability and the ability to reuse catalysts. The practical applications of heterogeneous algal catalysts in converting biomass and breaking down contaminants, supported by real-life case studies, emphasize their effectiveness. In sustainable chemistry, algal polysaccharides emerge as compelling catalysts, offering a unique intersection of eco-friendliness, structural diversity, and versatile catalytic properties. Tackling challenges such as dealing with complex structural variations, ensuring the stability of the catalyst, and addressing economic considerations calls for out-of-the-box and inventive solutions. Embracing the circular economy mindset not only assures sustainable catalyst design but also promotes efficient recycling practices. The use of algal carbohydrates in catalysis stands out as a source of optimism, paving the way for a future where chemistry aligns seamlessly with nature, guiding us toward a sustainable, eco-friendly, and thriving tomorrow. This review encapsulates—structural insights, catalytic applications, challenges, and future perspectives—invoking a call for collective commitment to catalyze a sustainable scientific revolution. [Display omitted] [ABSTRACT FROM AUTHOR]

The benefits of Blood Flow Restriction Therapy (BFRT) have gained attention in recent times. This review aimed to evaluate the immediate (up to 24 hours), intermediate (up to 6 weeks), and long term (6–10 weeks) effects of BFRT plus exercises (EX) compared to EX only on athletic performance (sprint and jump performance), muscle strength, and hypertrophy in athletes and physically active population. A literature search was conducted to select randomized controlled trials across four electronic databases from inception till April 2021. The search yielded twenty-seven studies in total. Based on eligibility criteria, twenty-one studies were analyzed. No differences were found between both groups for immediate (standardized mean difference [SMD] −0.02, 95% confidence interval [CI] −0.31, 0.27) and long-term effects (SMD −0.30, 95%CI −0.90, 0.30) on sprint performance. For jump performance, no significant effect was observed immediately (SMD −0.02 (95% CI −1.06, 1.02) and long term (SMD −0.40 (95% CI −1.46, 0.67). Similarly, muscle torque at intermediate (SMD 0.90 (95% CI −1.01, 2.81) and long term (SMD −0.54 (95% CI −1.19, 0.12), muscle strength at intermediate (SMD 1.12 (95% CI 0.20, 2.04), and long term (SMD −0.07 (95% CI −0.56, 0.42) also showed non-significant effects. Muscle hypertrophy at intermediate (SMD 0.16 (95% CI −0.31, 0.63) and long term (SMD −0.20 (95% CI −0.90, 0.50) were not statistically significant. There was no significant difference observed in BFRT plus EX group compared to the EX-group on athletic performance, muscle strength, and muscle hypertrophy. [ABSTRACT FROM AUTHOR]