12 results on '"Tugal-Tutkun, Ilknur"'
Search Results
2. The Potential Role of Large Language Models in Uveitis Care: Perspectives After ChatGPT and Bard Launch.
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Tan Yip Ming, Collin, Rojas-Carabali, William, Cifuentes-González, Carlos, Agrawal, Rajdeep, Thorne, Jennifer E., Tugal-Tutkun, Ilknur, Nguyen, Quan Dong, Gupta, Vishali, de-la-Torre, Alejandra, and Agrawal, Rupesh
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LANGUAGE models ,INFLAMMATORY bowel diseases ,MEDICAL personnel ,KNOWLEDGE representation (Information theory) ,EYE inflammation ,IRIDOCYCLITIS ,ALLERGIC conjunctivitis - Abstract
Large language models (LLMs) like ChatGPT and Bard have the potential to greatly benefit healthcare, including the field of uveitis care. LLMs can provide accessible advice for patients, helping them make decisions about when to seek medical attention or escalate their treatment. They can also assist in the diagnosis of uveitis, although more research specific to uveitis is needed. LLMs can improve the consultation experience by engaging with patients and providing empathetic responses. Additionally, they can aid in medication management and streamline administrative processes. LLMs have the potential to accelerate research in uveitis by automating tasks such as data analysis and identifying potential drug targets. However, there are ethical considerations to address, including patient autonomy, bias, transparency, and accountability. Efforts should be made to ensure equity and accessibility in the implementation of LLMs, and regulatory frameworks should be developed to ensure responsible use. The future directions of LLMs in uveitis care include integrating them with visual and auditory processing and training them in real-time. While LLMs show promise, more research is needed to develop them with reliability and replicability. [Extracted from the article]
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- 2024
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3. The Relevance of Bacillary Layer Detachment and Choroidal flow Insufficiency in Unilateral Acute Idiopathic Maculopathy Associated with Hand, Foot, and Mouth Disease: A Case Report.
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Thakur, Rashim, Guleser, Umit Yasar, Kesim, Cem, Kapran, Ziya, Tugal-Tutkun, Ilknur, and Hasanreisoglu, Murat
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RETINAL detachment ,MACULAR degeneration ,HAND, foot & mouth disease ,INFLAMMATION ,OPTICAL coherence tomography - Abstract
In a case of unilateral acute idiopathic maculopathy (UAIM) following hand, foot, and mouth disease, we aim to discuss the decreased perfusion of choriocapillaris secondary to systemic inflammation as shown by optical coherence tomography angiography (OCTA) and to assess the prognostic significance of bacillary layer detachment (BALAD). A 33-year-old male presented with a decrease of vision in the right eye (OD) for 5 days preceding viral prodromal symptoms and vesicular lesions on bilateral palms and soles along with vesicles and ulcers on the oral mucosa. The best-corrected visual acuity was finger counting at 1 meter distance in OD and 20/20 in his left eye (OS). Dilated fundus examination revealed a circular white-grey dome-shaped elevated lesion at the macula indicative of serous retinal detachment in OD. Spectral-domain optical coherence tomography demonstrated BALAD associated with adjacent subretinal and intraretinal fluid along with pigment epithelium detachment and disruption of ellipsoid and interdigitation zones. OCTA showed decreased choriocapillaris perfusion. All the investigations were normal in OS. The resolution of BALAD occurred during the first 2 days, which was followed by gradual improvement of choriocapillaris flow that lasted 2 months. UAIM is associated with hand, foot, and mouth disease. OCTA demonstrates both qualitative and quantitative data by detecting alterations in the choriocapillaris flow, which could be monitored during the disease course. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Vogt-Koyanagi-Harada Disease.
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Tugal-Tutkun, Ilknur, Smit, Derrick P., El-Asrar, Ahmed M. Abu, Herbort Jr., Carl P., and Thorne, Jennifer E.
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IRIDOCYCLITIS , *DIAGNOSIS , *LATENT tuberculosis , *THERAPEUTICS , *EYE diseases - Abstract
This article provides an overview of Vogt-Koyanagi-Harada (VKH) disease, an autoimmune disorder that affects multiple systems in the body. It discusses the four clinical phases of the disease and emphasizes the importance of early diagnosis and treatment. The article also explores recent studies on diagnostic criteria, imaging features, and treatment options for VKH disease. It includes brief reports on atypical cases of the disease and discusses the use of OCT angiography and adalimumab therapy in monitoring and treating VKH disease. The article highlights the need for prompt diagnosis and early intervention to prevent complications and visual impairment. It also mentions a rare case of a 2-year-old girl with VKH disease and autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome, a rare genetic disease. The authors encourage further research on VKH disease. [Extracted from the article]
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- 2024
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5. The Multifaceted Landscape of Endophthalmitis: Insights and Implications.
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Smit, Derrick P., Tugal-Tutkun, Ilknur, and Thorne, Jennifer E.
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EYE infections , *COVID-19 pandemic , *AQUEOUS humor , *PARS plana , *LIVER abscesses , *VITRECTOMY - Abstract
The article discusses the multifaceted nature of endophthalmitis, which is inflammation of the intraocular fluids that can lead to vision loss or loss of an eye. The article covers various topics related to endophthalmitis, including prophylactic measures to reduce postoperative infections, the challenges of endogenous endophthalmitis, differences in incidence and microbiological profile across different age groups, and the management of fungal endophthalmitis. The article also includes case reports and case series that highlight different aspects of endophthalmitis. The authors emphasize the need for tailored management strategies, early diagnosis, and personalized therapies to improve patient outcomes. [Extracted from the article]
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- 2024
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6. Optical Coherence Tomography Angiographic Follow-Up in a Case of Subacute Sclerosing Panencephalitis and Unilateral Necrotising Retinitis.
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Köksaldı, Seher, Ala, Rahmi Tumay, Oztura, Ibrahim, Emirbayer, Emre, Akdal, Gulden, Emre, Sinan, Tugal-Tutkun, Ilknur, and Saatci, Ali Osman
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OPTICAL coherence tomography ,ANGIOGRAPHY ,MAGNETIC resonance imaging ,ANTIBODY titer ,CEREBROSPINAL fluid ,MYOCLONUS - Abstract
We present a 20-year-old woman who was diagnosed with subacute sclerosing panencephalitis (SSPE) 20 months after presenting with unilateral retinitis. At presentation, the patient had two inferotemporal macular lesions in her left eye. Corresponding to these areas, optical coherence tomography (OCT) showed hyporeflective spaces with loss of nearly all of the retinal layers. OCT-angiography (OCTA) demonstrated some flow deficit areas with a reduction in the vessel density. Her serum measles antibody titre was high (IgG >5000.0 mIU/ml). Twenty months later the macular lesions had diminished in size, and there was some focal retinal thinning with interruption of the ellipsoid zone. OCTA showed that the flow deficit areas were diminished in size together with the relatively improved perfusion density. Neurological examination disclosed myoclonic jerks. Neuropsychological assessment demonstrated impaired executive function, attention, and narrowed lexical fluency. Measles IgG antibody was high in the cerebrospinal fluid (>230.0 U/ml). Brain magnetic resonance imaging demonstrated bilateral, non-specific, small foci of T2 hyperintensity in the frontoparietal subcortical white matter and centrum semiovale. The present case is the first where OCTA findings of SSPE-related retinal lesions have been described. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Correlation between Widefield Fundus Fluorescein Angiography Leakage Score and Anterior Chamber Flare in Behçet Uveitis.
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Kabaalioglu Guner, Melis, Guner, Mehmet Eren, Oray, Merih, and Tugal-Tutkun, Ilknur
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FLUORESCENCE angiography ,UVEITIS ,LEAKAGE ,ANGIOGRAPHY ,ANTERIOR chamber (Eye) ,PHOTOMETRY - Abstract
To investigate the correlation between widefield fundus fluorescein angiography (WF-FA) and anterior chamber laser flare photometry (LFP-flare) in Behçet uveitis (BU). Patients with BU who underwent Heidelberg WF-FA between March 2016 and March 2018 were included. Demographics, ocular findings, LFP-flare, central macular thickness were retrospectively analyzed. Eighty-six patients (162 eyes) were included. There was a high correlation between WF-FA leakage score and LFP-flare (rho: 0.691, p <.001). For a flare value of 5.75 ph/ms or higher, the sensitivity for predicting angiographic leakage was 70% and the specificity was 94% (AUC: 0.897, p <.001). Flare values that were equal or above 7.6 ph/ms were found to be 100% specific for leakage in the WF-FA. A strong correlation was found between WF-FA leakage and LFP-flare in patients with BU. High LFP-flare levels indicate subclinical posterior segment inflammation in clinically inactive BU. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Cytomegalovirus and the Eye.
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Smit, Derrick P., Tugal-Tutkun, Ilknur, and Thorne, Jennifer E.
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CYTOMEGALOVIRUSES , *AIDS , *IRIDOCYCLITIS , *MACULAR degeneration , *HIV-positive persons , *MONOCULAR vision - Abstract
This article discusses the impact of cytomegalovirus (CMV) on the eye, specifically CMV retinitis (CMVR) in immunocompromised patients. While CMVR is commonly associated with acquired immunodeficiency syndrome (AIDS), the proportion of HIV-negative patients with CMVR has been increasing due to factors such as immunosuppressive therapies, old age, diabetes, autoimmune conditions, and hematological abnormalities. The article highlights various reports on CMV and the eye, including cases of panretinal occlusive vasculitis, retinal neovascularization after resolution of CMVR, predictors for CMVR recurrence, risk factors for delayed diagnosis, and the impact of CMVR on quality of life. The authors also discuss the potential use of 2% ganciclovir drops in preventing relapses of Posner-Schlossman syndrome. Overall, the article aims to provide valuable insights for healthcare professionals in their daily practice. [Extracted from the article]
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- 2024
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9. Monkeypox.
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Smit, Derrick P., Tugal-Tutkun, Ilknur, and Thorne, Jennifer E.
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MONKEYPOX , *SYPHILIS - Abstract
Monkeypox is a virus that belongs to the same genus as smallpox and is transmitted through animal-to-human and human-to-human contact. The first case was detected in the Democratic Republic of the Congo in 1970 and subsequent cases have mainly occurred in Western and Central Africa. The discontinuation of smallpox vaccination in 1980 has been attributed to the rise in cases. In 2022, the World Health Organization declared Monkeypox a Public Health Emergency of International Concern. Ocular manifestations of Monkeypox, known as Monkeypox-related ophthalmic disease, have been reported but are rare and typically resolve with conservative management. [Extracted from the article]
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- 2024
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10. Sarcoid Uveitis.
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Tugal-Tutkun, Ilknur, Thorne, Jennifer E., and Smit, Derrick P.
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SARCOIDOSIS , *IRIDOCYCLITIS , *UVEITIS , *ARRHYTHMIA , *COMPUTED tomography - Abstract
Sarcoidosis is a common cause of uveitis worldwide, but diagnosing it can be challenging due to overlapping symptoms with other inflammatory diseases. Diagnostic criteria have been developed to standardize the approach to diagnosing sarcoid uveitis. Recent research has focused on the performance of diagnostic tools, presentation patterns, screening for cardiac involvement, and the use of hydroxychloroquine therapy. Other studies have explored the presence of anti-retinal antibodies in sarcoidosis patients, the response to therapy, and the coexistence of other autoimmune conditions. Hydroxychloroquine has shown promise as a treatment option for sarcoid uveitis. [Extracted from the article]
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- 2024
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11. Editorial 2024.
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Tugal-Tutkun, Ilknur, Thorne, Jennifer E., and Smit, Derrick P.
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EYE inflammation , *IMMUNOLOGY of inflammation , *UVEITIS - Abstract
The first edition of Ocular Immunology and Inflammation for 2024 has been released, featuring 338 manuscripts that have been processed for publication out of over 700 submissions in 2023. The previous volume of the journal included special topics, such as COVID-19-related articles, infectious uveitis articles, and pediatric uveitis articles. The upcoming volume will focus on "Intermediate Uveitis" as the disease of the year, with experts reviewing epidemiologic, clinical, and imaging features, as well as differential diagnosis and treatment. The editors express gratitude to contributors, reviewing editors, and reviewers for their support and encourage continued submissions to improve knowledge in the field of ocular immunology and inflammation. [Extracted from the article]
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- 2024
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12. The Role of Corticosteroids and Immunomodulatory Therapy in the Management of Infectious Uveitis.
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Akhavanrezayat A, Uludag Kirimli G, Matsumiya W, Khojasteh H, Or C, Karaca I, Pham B, Ongpalakorn P, Lajevardi S, Lam B, Hwang JJ, Than NTT, Park S, Yavari N, Bazojoo V, Mobasserian A, Khatri A, Halim MS, Thng ZX, Ghoraba H, Do DV, Tugal-Tutkun I, Gupta V, de Smet M, and Nguyen QD
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- Humans, Immunomodulation, Immunomodulating Agents therapeutic use, Eye Infections drug therapy, Eye Infections microbiology, Immunologic Factors therapeutic use, Uveitis drug therapy, Glucocorticoids therapeutic use
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Purpose: The index review aims to provide an update on the role of corticosteroids and steroid-sparing immunomodulatory therapy (IMT) in managing patients with infectious uveitis., Method: Narrative literature review., Results: Corticosteroids and immunomodulatory therapy (IMT) focus on the host defense system instead of the pathogen, adjusting exaggerated inflammatory reactions to reduce potential harm to ocular tissues. Systemic or local corticosteroids are primarily selected as adjunctive medication for infectious uveitis. Concomitant corticosteroids have also been used in cases of paradoxical worsening in ocular tuberculosis and immune recovery uveitis in cytomegalovirus (CMV) retinitis. While there is no well-established evidence to support the use of IMT in infectious uveitis, it is occasionally used in clinical settings to treat persistent inflammation following resolution of infection such as cases of ocular tuberculosis and ocular syphilis where an insufficient response is observed with corticosteroids., Conclusion: There is no consensus on the position of immunomodulatory therapy in the management of infectious uveitis with different etiologies. The index review provides an overview of available adjunctive corticosteroids and IMT options to assist clinicians in managing such disease entities more efficiently.
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- 2024
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