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Abstract: Chickens fed 200ppb aflatoxin from 10 days of age were evaluated for their immune response to a modified live infectious laryngotracheitis vaccine. Vaccination was administered at age 4 and 12 weeks. Antibody titers to the vaccine were reduced in chickens given dietary aflatoxin. After 7 weeks, aflatoxin feeding was continued for one month in a treated group and was withdrawn in another. Serology indicated significant differences between the two treated groups relative to whether aflatoxin was fed or not. Significant reduction in body weights, antibody titers and elevated SGOT and SGPT levels were found in chickens treated with aflatoxin. The impact of aflatoxin on reduced body weight, decreased SGOT and SGPT levels and lower antibody titers was shown to be significant in the treated group fed on a ration of aflatoxin until throughout the experiment. [Copyright &y& Elsevier]