24 results on '"Weissman, Irving L."'
Search Results
2. Physiological migration of hematopoietic stem and progenitor cells. (Reports)
- Author
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Wright, Douglas E., Wagers, Amy J., Gulati, Anjali Pathak, Johnson, Frances L., and Weissman, Irving L.
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Cell physiology -- Research ,Hematopoietic stem cells -- Research ,Science and technology ,Research - Abstract
Hematopoietic stem cells (HSCs) reside predominantly in bone marrow, but low numbers of HSCs are also found in peripheral blood. We examined the fate of blood-borne HSCs using genetically marked parabiotic mice, which are surgically conjoined and share a common circulation. Parabionts rapidly established stable, functional cross engraftment of partner-derived HSCs and maintained partner-derived hematopoiesis after surgical separation. Determination of the residence time of injected blood-borne progenitor cells suggests that circulating HSCs/progenitors are cleared quickly from the blood. These data demonstrate that HSCs rapidly and constitutively migrate through the blood and play a physiological role in, at least, the functional reengraftment of unconditioned bone marrow., Bone marrow (BM) transplantation is a common procedure wherein suspensions of cells are harvested from marrow cavities and intravenously injected into patients or animals whose blood-forming system is compromised by [...]
- Published
- 2001
3. Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers.
- Author
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Tsai, Jonathan M., Sinha, Rahul, Seita, Jun, Fernhoff, Nathaniel, Christ, Simon, Koopmans, Tim, Krampitz, Geoffrey W., McKenna, Kelly M., Xing, Liujing, Sandholzer, Michael, Sales, Jennifer Horatia, Shoham, Maia, McCracken, Melissa, Joubert, Lydia-Marie, Gordon, Sydney R., Poux, Nicolas, Wernig, Gerlinde, Norton, Jeffrey A., Weissman, Irving L., and Rinkevich, Yuval
- Subjects
RAT diseases ,VETERINARY diagnosis ,TISSUE adhesions ,CELL proliferation ,TISSUES - Abstract
Surgical adhesions in mice derived from hypoxia-responsive mesothelial cells can be targeted with anti-mesothelial antibodies. Getting adhesions unstuck: Peritoneal adhesions are ectopic fibrotic tissues induced by surgical perturbations that result in postoperative morbidities such as small bowel obstruction. The cellular origin of adhesions remains unclear. Now, Tsai et al. show that mesothelial cells overlying organs and the abdominal wall give rise to adhesions after surgery in mice. The injured mesothelium up-regulated mesothelium-specific genes that were known to be highly expressed during fetal development. Targeting adhesions with antibodies against the mesothelial marker mesothelin eliminated adhesions that had formed after surgery. Injured mesothelium responded to hypoxia, and this was mediated by the HIF1α pathway. Blocking HIF1α with small-molecule inhibitors prevented adhesion formation in mice after surgery. Peritoneal adhesions are fibrous tissues that tether organs to one another or to the peritoneal wall and are a major cause of postsurgical and infectious morbidity. The primary molecular chain of events leading to the initiation of adhesions has been elusive, chiefly due to the lack of an identifiable cell of origin. Using clonal analysis and lineage tracing, we have identified injured surface mesothelium expressing podoplanin (PDPN) and mesothelin (MSLN) as a primary instigator of peritoneal adhesions after surgery in mice. We demonstrate that an anti-MSLN antibody diminished adhesion formation in a mouse model where adhesions were induced by surgical ligation to form ischemic buttons and subsequent surgical abrasion of the peritoneum. RNA sequencing and bioinformatics analyses of mouse mesothelial cells from injured mesothelium revealed aspects of the pathological mechanism of adhesion development and yielded several potential regulators of this process. Specifically, we show that PDPN
+ MSLN+ mesothelium responded to hypoxia by early up-regulation of hypoxia-inducible factor 1 alpha (HIF1α) that preceded adhesion development. Inhibition of HIF1α with small molecules ameliorated the injury program in damaged mesothelium and was sufficient to diminish adhesion severity in a mouse model. Analyses of human adhesion tissue suggested that similar surface markers and signaling pathways may contribute to surgical adhesions in human patients. [ABSTRACT FROM AUTHOR]- Published
- 2018
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4. Disappearing Stem Cells, Disappearing Science
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Weissman, Irving L. and Baltimore, David
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United States -- Laws, regulations and rules ,Stem cells -- Laws, regulations and rules -- Research ,Molecular biology -- Laws, regulations and rules -- Research ,Science and technology ,Government regulation ,Research ,Laws, regulations and rules - Abstract
We need a policy that serves the best interests of society and science. Soon the Bush administration will decide the fate of human embryonic stem cell (ESC) research at U.S. [...]
- Published
- 2001
5. The ISSCR guidelines for human embryonic stem cell research: the International Society for Stem Cell Research describes major principles that should guide ethical stem cell research
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Daley, George Q., Ahrlund-Richter, Lars, Auerbach, Jonathan M., Benvenisty, Nissim, Alta Charo, R., Chen, Grace, Deng, Hong-kui, Goldstein, Lawrence S., Hudson, Kathy L., Hyun, Insoo, Chull Junn, Sung, Love, Jane, Hin Lee, Eng, McLaren, Anne, Mummery, Christine L., Nakatsuji, Norio, Racowsky, Catherine, Rooke, Heather, Rossant, Janet, Scholer, Hans R., Helge Solbakk, Jan, Taylor, Patrick, Trounson, Alan O., Weissman, Irving L., Wilmut, Ian, Yu, John, and Zoloth, Laurie
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Embryonic stem cells -- Research ,Embryonic stem cells -- Analysis ,Embryonic stem cells -- Ethical aspects - Published
- 2007
6. Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy.
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Chhabra, Akanksha, Ring, Aaron M., Weiskopf, Kipp, Schnorr, Peter John, Gordon, Sydney, Le, Alan C., Hye-Sook Kwon, Nan Guo Ring, Volkmer, Jens, Po Yi Ho, Serena Tseng, Weissman, Irving L., and Shizuru, Judith A.
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HEMATOPOIETIC stem cells ,IMMUNOGLOBULINS ,CD47 antigen ,BLOOD cells ,HEMATOPOIETIC system - Abstract
The article presents a study which showed that host hematopoietic stem cell (HSC) clearance is dependent on Fc-mediated antibody effector functions, and enhancing effector activity through blockade of CD47, a myeloid-specific immune checkpoint, extends anti-c-Kit (ACK) conditioning to fully immunocompetent mice. Topics discussed include findings showing that CD47 blockade augments the efficacy of ACK2 for transplant conditioning.
- Published
- 2016
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7. Endoscopic molecular imaging of human bladder cancer using a CD47 antibody.
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Ying Pan, Volkmer, Jens-Peter, Mach, Kathleen E., Rouse, Robert V., Jen-Jane Liu, Sahoo, Debashis, Chang, Timothy C., Metzner, Thomas J., Lei Kang, van de Rijn, Matt, Skinner, Eila C., Gambhir, Sanjiv S., Weissman, Irving L., and Liao, Joseph C.
- Published
- 2014
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8. Human Neural Stem Cells Induce Functional Myelination in Mice with Severe Dysmyelination.
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Uchida, Nobuko, Chen, Kevin, Dohse, Monika, Hansen, Kelly D., Dean, Justin, Buser, Joshua R., Riddle, Art, Beardsley, Douglas J., Ying Wan, Xi Gong, Thuan Nguyen, Cummings, Brian J., Anderson, Aileen J., Tamaki, Stanley J., Ann Tsukamoto, Weissman, Irving L., Matsumoto, Steven G., Sherman, Larry S., Kroenke, Christopher D., and Back, Stephen A.
- Published
- 2012
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9. Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia.
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Jan, Max, Snyder, Thomas M., Corces-Zimmerman, M. Ryan, Vyas, Paresh, Weissman, Irving L., Quake, Stephen R., and Majeti, Ravindra
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- 2012
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10. Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47.
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Chao, Mark P., Jaiswal, Siddhartha, Weissman-Tsukamoto, Rachel, Alizadeh, Ash A., Gentles, Andrew J., Volkmer, Jens, Weiskopf, Kipp, Willingham, Stephen B., Raveh, Tal, Park, Christopher Y., Majeti, Ravindra, and Weissman, Irving L.
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- 2010
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11. Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities.
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Weissman, Irving L.
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STEM cell transplantation , *CELL transplantation , *BRAIN diseases - Abstract
Addresses the barriers and opportunities to the application of stem and progenitor cell transplantation. Experiments that proved the existence of stem cells; Biology of hematopoietic stem and progenitor cells; Potential neurological disease targets for stem cell transplantation.
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- 2000
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12. Reactivation of the pluripotency program precedes formation of the cranial neural crest.
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Zalc, Antoine, Sinha, Rahul, Gulati, Gunsagar S., Wesche, Daniel J., Daszczuk, Patrycja, Swigut, Tomek, Weissman, Irving L., and Wysocka, Joanna
- Published
- 2021
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13. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2.
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Vaux, David L. and Weissman, Irving L.
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CYTOLOGICAL research - Abstract
Examines the role of the bcl-2 gene in the regulation of programmed cell death in mammalian cells. Expression of the human bcl-2 gene in the nematode Caenorhabditis elegans reducing the number of programmed cell deaths; Similar mechanisms of programmed cell death controlled by bcl-2 in humans and nematodes; More.
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- 1992
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14. Evolution of a Protochordate Allorecognition Locus.
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De Tomaso, Anthony W. and Weissman, Irving L.
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GENES , *POLYMORPHISM (Zoology) , *GENETICS , *PARABIOSIS , *ALLELES , *PROTOCHORDATES - Abstract
Specificity ultimately depends on highly polymorphic genes, with populations often containing hundreds of alleles. Emergence and maintenance of this extraordinary polymorphism are unresolved issues in population genetics. Contact between adjacent colonies initiates an allorecognition reaction at juxtaposed extracorporeal blood vessels, resulting in either vascular fusion, forming a natural parabiosis, or in rejection, which prevents blood transfer between the two individuals. During positional cloning of the Fu/HC, we created F2 mapping populations using five independently isolated alleles.
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- 2004
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15. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential.
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Rinkevich, Yuval, Walmsley, Graham G., Hu, Michael S., Maan, Zeshaan N., Newman, Aaron M., Drukker, Micha, Januszyk, Michael, Krampitz, Geoffrey W., Gurtner, Geoffrey C., Lorenz, H. Peter, Weissman, Irving L., and Longaker, Michael T.
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FIBROBLASTS , *SKIN , *CONNECTIVE tissue cells , *EMBRYOLOGY , *SCARS , *TRANSLATIONAL research , *MELANOMA , *INHIBITION (Chemistry) , *GENETICS - Abstract
Dermal fibroblasts represent a heterogeneous population of cells with diverse features that remain largely undefined. We reveal the presence of at least two fibroblast lineages in murine dorsal skin. Lineage tracing and transplantation assays demonstrate that a single fibroblast lineage is responsible for the bulk of connective tissue deposition during embryonic development, cutaneous wound healing, radiation fibrosis, and cancer stroma formation. Lineage-specific cell ablation leads to diminished connective tissue deposition in wounds and reduces melanoma growth. Using flow cytometry, we identify CD26/DPP4 as a surface marker that allows isolation of this lineage. Small molecule-based inhibition of CD26/DPP4 enzymatic activity during wound healing results in diminished cutaneous scarring. Identification and isolation of these lineages hold promise for translational medicine aimed at in vivo modulation of fibrogenic behavior. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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16. Engineered SIRPα Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies.
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Weiskopf, Kipp, Ring, Aaron M., Ho, Chia Chi M., Volkmer, Jens-Peter, Levin, Aron M., Volkmer, Anne Kathrin, Ozkan, Engin, Fernhoff, Nathaniel B., van de Rijn, Matt, Weissman, Irving L., and Garcia, K. Christopher
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CD47 antigen , *PROTEIN engineering , *IMMUNOLOGICAL adjuvants , *THERAPEUTIC use of monoclonal antibodies , *CANCER immunotherapy , *PHAGOCYTOSIS , *MACROPHAGE activation , *CHEMICAL antagonism , *THERAPEUTICS - Abstract
CD47 is an antiphagocytic signal that cancer cells employ to inhibit macrophage-mediated destruction. Here, we modified the binding domain of human SIRPα, the receptor for CD47, for use as a CD47 antagonist. We engineered high-affinity SIRPα variants with about a 50,000-fold increased affinity for human CD47 relative to wild-type SIRPα. As high-affinity SIRPα monomers, they potently antagonized CD47 on cancer cells but did not induce macrophage phagocytosis on their own. Instead, they exhibited remarkable synergy with all tumor-specific monoclonal antibodies tested by increasing phagocytosis in vitro and enhancing antitumor responses in vivo. This "one-two punch" directs immune responses against tumor cells while lowering the threshold for macrophage activation, thereby providing a universal method for augmenting the efficacy of therapeutic anticancer antibodies. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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17. Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells.
- Author
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Wagers, Amy J., Sherwood, Richard I., Christensen, Julie L., and Weissman, Irving L.
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HEMATOPOIETIC stem cells , *GREEN fluorescent protein , *FLUORESCENCE microscopy - Abstract
To rigorously test the in vivo cell fate specificity of bone marrow (BM) hematopoietic stem cells (HSCs), we generated chimeric animals by transplantation of a single green fluorescent protein (GFP)—marked HSC into lethally irradiated nontransgenic recipients. Single HSCs robustly reconstituted peripheral blood leukocytes in these animals, but did not contribute appreciably to nonhematopoietic tissues, including brain, kidney, gut, liver, and muscle. Similarly, in GFP[sup +]:GFP[sup −] parabiotic mice, we found substantial chimerisrn of hernatopoietic but not nonhematopoietic cells. These data indicate that “transdifferentiation” of circulating HSCs and/or their progeny is an extremely rare event, if it occurs at all. [ABSTRACT FROM AUTHOR]
- Published
- 2002
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18. Lift NIH restrictions on chimera research.
- Author
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Sharma, Arun, Sebastiano, Vittorio, Scott, Christopher T., Magnus, David, Koyano-Nakagawa, Naoko, Garry, Daniel J., Witte, Owen N., Nakauchi, Hiromitsu, Wu, Joseph C., Weissman, Irving L., and Wu, Sean M.
- Subjects
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CHIMERISM , *GOVERNMENT policy - Abstract
A letter to the editor is presented on the subject of the U.S. National Institutes of Health's (NIH's) policy on research on chimerism with topics, including the ethics of biomedical research, the NIH's research funding and human pluripotent stem cells (hPSCs).
- Published
- 2015
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19. Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.
- Author
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Gholamin S, Mitra SS, Feroze AH, Liu J, Kahn SA, Zhang M, Esparza R, Richard C, Ramaswamy V, Remke M, Volkmer AK, Willingham S, Ponnuswami A, McCarty A, Lovelace P, Storm TA, Schubert S, Hutter G, Narayanan C, Chu P, Raabe EH, Harsh G 4th, Taylor MD, Monje M, Cho YJ, Majeti R, Volkmer JP, Fisher PG, Grant G, Steinberg GK, Vogel H, Edwards M, Weissman IL, and Cheshier SH
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- Animals, Antibodies pharmacology, Brain Neoplasms pathology, Cell Proliferation drug effects, Child, Disease Models, Animal, Humans, Immunocompetence, Injections, Intraventricular, Medulloblastoma drug therapy, Medulloblastoma pathology, Meningeal Neoplasms pathology, Meningeal Neoplasms secondary, Mice, Inbred C57BL, Models, Biological, Neoplasm Metastasis, Survival Analysis, Xenograft Model Antitumor Assays, Antibodies therapeutic use, Antigens, Differentiation metabolism, Brain Neoplasms drug therapy, CD47 Antigen immunology, Phagocytosis drug effects, Receptors, Immunologic metabolism
- Abstract
Morbidity and mortality associated with pediatric malignant primary brain tumors remain high in the absence of effective therapies. Macrophage-mediated phagocytosis of tumor cells via blockade of the anti-phagocytic CD47-SIRPα interaction using anti-CD47 antibodies has shown promise in preclinical xenografts of various human malignancies. We demonstrate the effect of a humanized anti-CD47 antibody, Hu5F9-G4, on five aggressive and etiologically distinct pediatric brain tumors: group 3 medulloblastoma (primary and metastatic), atypical teratoid rhabdoid tumor, primitive neuroectodermal tumor, pediatric glioblastoma, and diffuse intrinsic pontine glioma. Hu5F9-G4 demonstrated therapeutic efficacy in vitro and in vivo in patient-derived orthotopic xenograft models. Intraventricular administration of Hu5F9-G4 further enhanced its activity against disseminated medulloblastoma leptomeningeal disease. Notably, Hu5F9-G4 showed minimal activity against normal human neural cells in vitro and in vivo, a phenomenon reiterated in an immunocompetent allograft glioma model. Thus, Hu5F9-G4 is a potentially safe and effective therapeutic agent for managing multiple pediatric central nervous system malignancies., (Copyright © 2017, American Association for the Advancement of Science.)
- Published
- 2017
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20. Pharmacological rescue of diabetic skeletal stem cell niches.
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Tevlin R, Seo EY, Marecic O, McArdle A, Tong X, Zimdahl B, Malkovskiy A, Sinha R, Gulati G, Li X, Wearda T, Morganti R, Lopez M, Ransom RC, Duldulao CR, Rodrigues M, Nguyen A, Januszyk M, Maan Z, Paik K, Yapa KS, Rajadas J, Wan DC, Gurtner GC, Snyder M, Beachy PA, Yang F, Goodman SB, Weissman IL, Chan CK, and Longaker MT
- Subjects
- Animals, Bone and Bones pathology, Cell Proliferation, Cell Separation, Diabetes Mellitus, Experimental pathology, Female, Flow Cytometry, Hedgehog Proteins metabolism, Humans, Mice, Mice, Inbred C57BL, Osteogenesis, Signal Transduction, Femoral Fractures drug therapy, Fracture Healing drug effects, Hedgehog Proteins pharmacology, Mesenchymal Stem Cells cytology, Stem Cell Niche
- Abstract
Diabetes mellitus (DM) is a metabolic disease frequently associated with impaired bone healing. Despite its increasing prevalence worldwide, the molecular etiology of DM-linked skeletal complications remains poorly defined. Using advanced stem cell characterization techniques, we analyzed intrinsic and extrinsic determinants of mouse skeletal stem cell (mSSC) function to identify specific mSSC niche-related abnormalities that could impair skeletal repair in diabetic (Db) mice. We discovered that high serum concentrations of tumor necrosis factor-α directly repressed the expression of Indian hedgehog (Ihh) in mSSCs and in their downstream skeletogenic progenitors in Db mice. When hedgehog signaling was inhibited during fracture repair, injury-induced mSSC expansion was suppressed, resulting in impaired healing. We reversed this deficiency by precise delivery of purified Ihh to the fracture site via a specially formulated, slow-release hydrogel. In the presence of exogenous Ihh, the injury-induced expansion and osteogenic potential of mSSCs were restored, culminating in the rescue of Db bone healing. Our results present a feasible strategy for precise treatment of molecular aberrations in stem and progenitor cell populations to correct skeletal manifestations of systemic disease., (Copyright © 2017, American Association for the Advancement of Science.)
- Published
- 2017
- Full Text
- View/download PDF
21. Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential.
- Author
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Rinkevich Y, Walmsley GG, Hu MS, Maan ZN, Newman AM, Drukker M, Januszyk M, Krampitz GW, Gurtner GC, Lorenz HP, Weissman IL, and Longaker MT
- Subjects
- Animals, Cell Lineage genetics, Cicatrix metabolism, Disease Models, Animal, Embryonic Development, Embryonic Stem Cells cytology, Fibroblasts cytology, Fibroblasts pathology, Gene Expression, Homeodomain Proteins genetics, Mice, Mouth injuries, Mouth pathology, Mouth surgery, Skin injuries, Translational Research, Biomedical, Cell Separation methods, Cicatrix pathology, Fibroblasts physiology, Skin pathology, Wound Healing
- Abstract
Dermal fibroblasts represent a heterogeneous population of cells with diverse features that remain largely undefined. We reveal the presence of at least two fibroblast lineages in murine dorsal skin. Lineage tracing and transplantation assays demonstrate that a single fibroblast lineage is responsible for the bulk of connective tissue deposition during embryonic development, cutaneous wound healing, radiation fibrosis, and cancer stroma formation. Lineage-specific cell ablation leads to diminished connective tissue deposition in wounds and reduces melanoma growth. Using flow cytometry, we identify CD26/DPP4 as a surface marker that allows isolation of this lineage. Small molecule-based inhibition of CD26/DPP4 enzymatic activity during wound healing results in diminished cutaneous scarring. Identification and isolation of these lineages hold promise for translational medicine aimed at in vivo modulation of fibrogenic behavior., (Copyright © 2015, American Association for the Advancement of Science.)
- Published
- 2015
- Full Text
- View/download PDF
22. Endoscopic molecular imaging of human bladder cancer using a CD47 antibody.
- Author
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Pan Y, Volkmer JP, Mach KE, Rouse RV, Liu JJ, Sahoo D, Chang TC, Metzner TJ, Kang L, van de Rijn M, Skinner EC, Gambhir SS, Weissman IL, and Liao JC
- Subjects
- CD47 Antigen genetics, Humans, RNA, Messenger genetics, Urinary Bladder Neoplasms immunology, Urinary Bladder Neoplasms surgery, CD47 Antigen immunology, Endoscopy, Urinary Bladder Neoplasms diagnosis
- Abstract
A combination of optical imaging technologies with cancer-specific molecular imaging agents is a potentially powerful strategy to improve cancer detection and enable image-guided surgery. Bladder cancer is primarily managed endoscopically by white light cystoscopy with suboptimal diagnostic accuracy. Emerging optical imaging technologies hold great potential for improved diagnostic accuracy but lack imaging agents for molecular specificity. Using fluorescently labeled CD47 antibody (anti-CD47) as molecular imaging agent, we demonstrated consistent identification of bladder cancer with clinical grade fluorescence imaging systems, confocal endomicroscopy, and blue light cystoscopy in fresh surgically removed human bladders. With blue light cystoscopy, the sensitivity and specificity for CD47-targeted imaging were 82.9 and 90.5%, respectively. We detected variants of bladder cancers, which are diagnostic challenges, including carcinoma in situ, residual carcinoma in tumor resection bed, recurrent carcinoma following prior intravesical immunotherapy with Bacillus Calmette-Guérin (BCG), and excluded cancer from benign but suspicious-appearing mucosa. CD47-targeted molecular imaging could improve diagnosis and resection thoroughness for bladder cancer., (Copyright © 2014, American Association for the Advancement of Science.)
- Published
- 2014
- Full Text
- View/download PDF
23. Identification of a colonial chordate histocompatibility gene.
- Author
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Voskoboynik A, Newman AM, Corey DM, Sahoo D, Pushkarev D, Neff NF, Passarelli B, Koh W, Ishizuka KJ, Palmeri KJ, Dimov IK, Keasar C, Fan HC, Mantalas GL, Sinha R, Penland L, Quake SR, and Weissman IL
- Subjects
- Alleles, Animals, Genome, Genotype, Immune Tolerance, Molecular Sequence Data, Sequence Analysis, DNA, Transcriptome, Up-Regulation, Urochordata physiology, Genes, Histocompatibility genetics, Urochordata genetics, Urochordata immunology
- Abstract
Histocompatibility is the basis by which multicellular organisms of the same species distinguish self from nonself. Relatively little is known about the mechanisms underlying histocompatibility reactions in lower organisms. Botryllus schlosseri is a colonial urochordate, a sister group of vertebrates, that exhibits a genetically determined natural transplantation reaction, whereby self-recognition between colonies leads to formation of parabionts with a common vasculature, whereas rejection occurs between incompatible colonies. Using genetically defined lines, whole-transcriptome sequencing, and genomics, we identified a single gene that encodes self-nonself and determines "graft" outcomes in this organism. This gene is significantly up-regulated in colonies poised to undergo fusion and/or rejection, is highly expressed in the vasculature, and is functionally linked to histocompatibility outcomes. These findings establish a platform for advancing the science of allorecognition.
- Published
- 2013
- Full Text
- View/download PDF
24. Ethics. The ISSCR guidelines for human embryonic stem cell research.
- Author
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Daley GQ, Ahrlund Richter L, Auerbach JM, Benvenisty N, Charo RA, Chen G, Deng HK, Goldstein LS, Hudson KL, Hyun I, Junn SC, Love J, Lee EH, McLaren A, Mummery CL, Nakatsuji N, Racowsky C, Rooke H, Rossant J, Schöler HR, Solbakk JH, Taylor P, Trounson AO, Weissman IL, Wilmut I, Yu J, and Zoloth L
- Subjects
- Animals, Cell Line, Chimera, Embryonic Development, Humans, Informed Consent, International Cooperation, Oocyte Donation economics, Oocyte Donation ethics, Pluripotent Stem Cells, Societies, Scientific, Tissue Donors ethics, Embryo Research ethics, Embryo Research legislation & jurisprudence, Embryonic Stem Cells, Guidelines as Topic
- Published
- 2007
- Full Text
- View/download PDF
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