1. Cilostazol as an add-on therapy for patients with Alzheimer's disease in Taiwan: a case control study.
- Author
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Shu-Yu Tai, Chun-Hung Chen, Chen-Yu Chien, Yuan-Han Yang, Tai, Shu-Yu, Chen, Chun-Hung, Chien, Chen-Yu, and Yang, Yuan-Han
- Subjects
ALZHEIMER'S disease treatment ,ALZHEIMER'S disease diagnosis ,ACETYLCHOLINESTERASE inhibitors ,COMBINATION drug therapy ,NEUROPSYCHOLOGICAL tests ,COGNITIVE ability ,LOGISTIC regression analysis ,CHOLINESTERASE inhibitors ,HETEROCYCLIC compounds ,NEUROPROTECTIVE agents ,ALZHEIMER'S disease ,APOLIPOPROTEINS ,COGNITION ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,EVALUATION research ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,CASE-control method ,ODDS ratio ,GENOTYPES ,THERAPEUTICS - Abstract
Background: Combination therapy using acetylcholinesterase inhibitors (AChEIs) and cilostazol is of unknown efficacy for patients with Alzheimer's disease (AD).Methods: We explored the therapeutic responses by using a case-control study, which was conducted in Taiwan. We enrolled 30 participants with stable AD who were receiving cilostazol (50 mg) twice per day as an add-on therapy combined with AChEIs, and 30 participants as controls who were not receiving cilostazol as an add-on therapy. The therapeutic responses were measured using neuropsychological assessments and analyzed in relation to cilostazol use, apolipoprotein E genotype, and demographic characteristics. Mini-mental state examination (MMSE) and clinical dementia rating sum of boxes (CDR-SB) were administered at the outset of the study and 12 months later. Multiple logistic regression analysis was used to estimate the association between the therapeutic response and cilostazol use.Results: For the therapeutic indicator of cognition, Cilostazol use (adjusted odds ratio (aOR) = 0.17, 95% confidence interval (CI) = 0.03-0.80), initial CDR-SB score (aOR = 2.06, 95% CI = 1.31-3.72), and initial MMSE score (aOR = 1.41, 95% CI = 1.11-1.90), but not age, sex, education, or ApoE ε4 status, were significantly associated with poor therapeutic outcomes. For the therapeutic indicator of global status, no significant association was observed between the covariates and poor therapeutic outcomes.Conclusions: Cilostazol may reduce the decline of cognitive function in stable AD patients when applied as an add-on therapy. [ABSTRACT FROM AUTHOR]- Published
- 2017
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