17 results on '"Schilder, Anne"'
Search Results
2. Acute middle ear infection (acute otitis media) in children.
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Venekamp, Roderick P., Schilder, Anne G. M., van den Heuvel, Maaike, and Hay, Alastair D.
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ANTIBIOTICS ,OTITIS media diagnosis ,IMMUNE system ,IMMUNIZATION ,MEDICAL referrals ,OTITIS media ,OTITIS media with effusion ,OTOSCOPY ,PARENTS ,RISK assessment ,TYMPANIC membrane ,PAIN management ,ACUTE diseases ,DISEASE complications ,CHILDREN - Published
- 2020
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3. Chronic rhinosinusitis: a qualitative study of patient views and experiences of current management in primary and secondary care.
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Vennik, Jane, Eyles, Caroline, Thomas, Mike, Hopkins, Claire, Little, Paul, Blackshaw, Helen, Schilder, Anne, Savage, Imogen, and Philpott, Carl M.
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Objectives To explore patient views and perspectives of current management of chronic rhinosinusitis (CRS) in primary and secondary care. Design Semistructured qualitative telephone interviews as part of the MACRO programme (Defining best Management for Adults with Chronic RhinOsinusitis). Setting Primary care and secondary care ear, nose and throat outpatient clinics in the UK. Participants Twenty-five patients consented to in-depth telephone interviews. Transcribed recordings were managed using NVivo software and analysed using inductive thematic analysis. Results CRS has a significant impact on patients' quality of life, affecting their ability to work effectively, their social interactions and daily living. Patients seek help when symptoms become unmanageable, but can become frustrated with the primary care system with difficulties obtaining an appointment, and lack of continuity of care. Patients perceive that general practitioners can be dismissive of CRS symptoms, and patients often prioritise other concerns when they consult. Health system barriers and poor communication can result in delays in accessing appropriate treatment and referral. Adherence to intranasal steroids is a problem and patients are uncertain about correct technique. Nasal irrigation can be time-consuming and difficult for patients to use. Secondary care consultations can appear rushed, and patients would like specialists to take a more 'holistic' approach to their management. Surgery is often considered a temporary solution, appropriate when medical options have been explored. Conclusions Patients are frustrated with the management of their CRS, and poor communication can result in delays in receiving appropriate treatment and timely referral. Patients seek better understanding of their condition and guidance to support treatments decisions in light of uncertainties around the different medical and surgical options. Better coordinated care between general practice and specialist settings and consistency of advice has the potential to increase patient satisfaction and improve outcomes. [ABSTRACT FROM AUTHOR]
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- 2019
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4. Evaluation of instructions in patient information leaflets for the use of intranasal corticosteroid sprays: an observational study.
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Rollema, Corine, van Roon, Eric M., Schilder, Anne G. M., and de Vries, Tjalling W.
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Objectives In this study, we analysed patient information leaflets (PILs) of intranasal corticosteroid sprays (INCS) of different manufacturers in the UK to determine if instructions for the use of INCS are complete and uniform. Setting PILs of all INCS of all manufacturers, available for patients in the UK, were collected from the British National Formulary website and the Medicines and Healthcare products Regulatory Agency website. All instructions in these PILs were analysed. Participants We identified PILs of INCS from 21 different manufacturers, available for patients in the UK. Results We analysed the instructions for the use of INCS in 21 different PILs and there is large variation in the PIL instructions for the technique of using INCS across PILs. Conclusion Complete and uniform instructions for the use of INCS are lacking in PILs for registered preparations in the UK. Structured and standardised instructions to be used by both professionals and patients are essential in order to optimise daily use of INCS. [ABSTRACT FROM AUTHOR]
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- 2019
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5. What are the requirements for developing a successful national registry of auditory implants? A qualitative study.
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Mandavia, Rishi, Knight, Alec, Carter, Alexander W., Toal, Connor, Mossialos, Elias, Littlejohns, Peter, and Schilder, Anne G. M.
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Objectives Hearing loss is an area of unmet need, and industry is targeting this field with a growing range of surgically implanted hearing devices. Currently, there is no comprehensive UK registry capturing data on these devices; in its absence, it is difficult to monitor clinical and cost-effectiveness and develop national policy. Recognising that developing such a registry faces considerable challenges, it is important to gather opinions from stakeholders and patients. This paper builds on our systematic review on surgical registry development and aims to identify the specific requirements for developing a successful national registry of auditory implants. Design Qualitative study. Participants Data were collected in two ways: (1) semistructured interviews with UK professional stakeholders; and (2) focus groups with patients with hearing loss. The interview and focus group schedules were informed by our systematic review on registry development. Data were analysed using directed content analysis. Judges mapped the themes obtained against a conceptual framework developed from our systematic review on registry development. The conceptual framework consisted of five categories for successful registry development: (1) planning, (2) registry governance, (3) registry dataset, (4) anticipating challenges, (5) implementing solutions. results Twenty-seven themes emerged from 40 semistructured interviews with professional stakeholders and 18 themes emerged from three patient focus groups. The most important factor for registry success was high rates of data completion. Benefits of developing a successful registry of auditory implants include: strengthening the evidence base and regulation of auditory implants, driving quality and safety improvements, increased transparency, facilitating patient decision-making and informing policy and guidelines development. Conclusions This study identifies the requirements for developing a successful national registry of auditory implants, benefiting from the involvement of numerous professional stakeholder groups and patients with hearing loss. Our approach may be used internationally to inform successful registry development. [ABSTRACT FROM AUTHOR]
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- 2018
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6. Impact of acute otitis media clinical practice guidelines on antibiotic and analgesic prescriptions: a systematic review.
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Deniz, Yelin, van Uum, Rick T., de Hoog, Marieke L. A., Schilder, Anne G. M., Damoiseaux, Roger A. M. J., and Venekamp, Roderick P.
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ACUTE otitis media ,ANTIBIOTICS ,ANALGESICS ,JUVENILE diseases ,SCIENTIFIC observation - Abstract
Background: Clinical practice guidelines focusing on judicious use of antibiotics for childhood acute otitis media (AOM) have been introduced in many countries around the world.Objective: To systematically review the effects of these guidelines on the prescription of antibiotics and analgesics for children with AOM.Methods: Systematic searches of PubMed, Embase and Cochrane Library from inception to 6 June 2017 using broad search terms. Studies specifically aimed at evaluating the effects of introduction of national AOM practice guidelines on type of antibiotic and/or analgesic prescriptions were included, irrespective of design, setting or language. The Risk Of Bias In Non-randomized Studies of Interventions tool was used to assess risk of bias.Results: Of 411 unique records retrieved, seven studies conducted in six different countries (France, Italy, Spain, Sweden, UK and USA (twice)) compared data before and after guideline introduction. All studies had an observational design, using longitudinal data of children aged under 15 years (n=200-4.6 million) from either routine care, insurance databases or electronic surveys. Risk of bias of all studies was judged serious to critical.Of the five studies reporting on antibiotic prescription rates, three showed a decline of 5%-12% up to 3 years after guideline introduction and two found no or negligible effect. In one US study, the initial 9% decline decreased to 5% after 4-6 years. The recommended first choice antibiotic was prescribed more frequently (9%-58% increase) after guideline introduction in four out of five studies reporting on this outcome. Analgesic prescription rates for AOM were reported in one US study and increased from 14% to 24% after guideline introduction.Conclusion: Based upon what is published, the effects of introduction of national clinical practice guidelines on antibiotic and analgesic prescribing for children with AOM seem modest at the most.Registration: PROSPERO: CRD42016050976. [ABSTRACT FROM AUTHOR]- Published
- 2018
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7. Outpatient antibiotic use in Dutch infants after 10-valent pneumococcal vaccine introduction: a time-series analysis.
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Fortanier, Alexandre C., Venekamp, Roderick P., Stellato, Rebecca K., Sanders, Elisabeth A. M., Damoiseaux, Roger A. M. J., Hoes, Arno W., and Schilder, Anne M.
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Objective This population-based cohort study assesses the impact of switching from a 7-valent pneumococcal conjugate vaccine (PCV) to a 10-valent PCV on outpatient antibiotic use in Dutch infants, and whether geographical vaccination coverage modifies this association. Setting and participants We extracted 2006-2013 anonymised antibiotic purchase data of 255 154 Dutch infants aged below 2 years from Achmea Health, a health insurance fund covering 28% of the national population. Design and main outcome measure Changes in monthly antibiotic use from 2006-2011 (PCV7) to 2011-2013 (PCV10) were estimated using time-series analysis accounting for seasonality and autocorrelation. Interaction terms for vaccination coverage (categorised into seven groups) and period were added to the model to test whether this association was vaccination coverage-dependent. Results 275 337 antibiotic courses were used by 119 078 infants (461 352 person-years). PCV10 introduction was associated with a modest 1.6% overall reduction in antibiotic use (purchase rate ratio: 0.98, 95% CI: 0.98 to 0.99). Our model showed a significant difference in time trend in antibiotic use after PCV10 introduction (p=0.0084) with an increase in prescriptions in the PCV7 period (slope: 0.0023/month, 95% CI: -0.0001 to 0.0047) versus a decline in the PCV10 period (slope: -0.0089/month, 95% CI: -0.0150 to -0.0029). There was no evidence that PCV vaccination coverage affected this association, but since the largest rate ratios were observed in municipalities with the lowest vaccine coverage and had very wide accompanying CIs, our study might have insufficient power to detect such an association. Conclusions Switching from PCV7 to PCV10 was associated with a modest decline in outpatient antibiotic use in Dutch infants. [ABSTRACT FROM AUTHOR]
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- 2018
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8. What are the essential features of a successful surgical registry? a systematic review.
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Mandavia, Rishi, Knight, Alec, Phillips, John, Mossialos, Elias, Littlejohns, Peter, and Schilder, Anne
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Objective The regulation of surgical implants is vital to patient safety, and there is an international drive to establish registries for all implants. Hearing loss is an area of unmet need, and industry is targeting this field with a growing range of surgically implanted hearing devices. Currently, there is no comprehensive UK registry capturing data on these devices; in its absence, it is difficult to monitor safety, practices and effectiveness. A solution is developing a national registry of all auditory implants. However, developing and maintaining a registry faces considerable challenges. In this systematic review, we aimed to identify the essential features of a successful surgical registry. Methods A systematic literature review was performed adhering to Preferred Reporting Items for Systematic Review and Meta-Analysis recommendations. A comprehensive search of the Medline and Embase databases was conducted in November 2016 using the Ovid Portal. Inclusion criteria were: publications describing the design, development, critical analysis or current status of a national surgical registry. All registry names identified in the screening process were noted and searched in the grey literature. Available national registry reports were reviewed from registry websites. Data were extracted using a data extraction table developed by thematic analysis. Extracted data were synthesised into a structured narrative. Results Sixty-nine publications were included. The fundamentals to successful registry development include: steering committee to lead and oversee the registry; clear registry objectives; planning for initial and long-term funding; strategic national collaborations among key stakeholders; dedicated registry management team; consensus meetings to agree registry dataset; established data processing systems; anticipating challenges; and implementing strategies to increase data completion. Patient involvement and awareness of legal factors should occur throughout the development process. Conclusions This systematic review provides robust knowledge that can be used to inform the successful development of any UK surgical registry. It also provides a methodological framework for international surgical registry development. [ABSTRACT FROM AUTHOR]
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- 2017
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9. Does laryngeal reinnervation or type I thyroplasty give better voice results for patients with unilateral vocal fold paralysis (VOCALIST): study protocol for a feasibility randomised controlled trial.
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Blackshaw, Helen, Carding, Paul, Jepson, Marcus, Baki, Marina Mat, Ambler, Gareth, Schilder, Anne, Morris, Stephen, Degun, Aneeka, Yu, Rosamund, Husbands, Samantha, Knowles, Helen, Walton, Chloe, Yakubu Karagama, Heathcote, Kate, and Birchall, Martin
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Introduction A functioning voice is essential for normal human communication. A good voice requires two moving vocal folds; if one fold is paralysed (unilateral vocal fold paralysis (UVFP)) people suffer from a breathy, weak voice that tires easily and is unable to function normally. UVFP can also result in choking and breathlessness. Current treatment for adults with UVFP is speech therapy to stimulate recovery of vocal fold (VF) motion or function and/or injection of the paralysed VF with a material to move it into a more favourable position for the functioning VF to close against. When these therapies are unsuccessful, or only provide temporary relief, surgery is offered. Two available surgical techniques are: (1) surgical medialisation; placing an implant near the paralysed VF to move it to the middle (thyroplasty) and/or repositioning the cartilage (arytenoid adduction) or (2) restoring the nerve supply to the VF (laryngeal reinnervation). Currently there is limited evidence to determine which surgery should be offered to adults with UVFP. Methods and analysis A feasibility study to test the practicality of running a multicentre, randomised clinical trial of surgery for UVFP, including: (1) a qualitative study to understand the recruitment process and how it operates in clinical centres and (2) a small randomised trial of 30 participants recruited at 3 UK sites comparing non-selective laryngeal reinnervation to type I thyroplasty. Participants will be followed up for 12 months. The primary outcome focuses on recruitment and retention, with secondary outcomes covering voice, swallowing and quality of life. Ethics and dissemination Ethical approval was received from National Research Ethics Service--Committee Bromley (reference 11/LO/0583). In addition to dissemination of results through presentation and publication of peer-reviewed articles, results will be shared with key clinician and patient groups required to develop the future large-scale randomised controlled trial. Trial registration number ISRCTN90201732; 16 December 2015. [ABSTRACT FROM AUTHOR]
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- 2017
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10. Neonatal total IgE and respiratory tract infections in children with intrauterine smoke exposure.
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Ruskamp, Jopje, Smit, Henriette, Rovers, Maroeska, Hoekstra, Maarten, Schilder, Anne, Brunekreef, Bert, Wijga, Alet, Kerkhof, Marjan, de Jongste, Johan, and Sanders, Elisabeth
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IMMUNOGLOBULIN E ,TOBACCO smoke pollution ,RESPIRATORY infections in children ,ASTHMA in children ,ALLERGIES ,DISEASE incidence ,POSTNATAL care ,PREVENTION - Abstract
Background Exposure to environmental tobacco smoke (ETS) is known to increase the risk of respiratory tract infections (RTI). Some children, however, may be more susceptible to the harmful effects of ETS than others. We examined whether early atopic status (defined by elevated neonatal total IgE (tIgE) or symptoms of atopic dermatitis) modified the association between ETS exposure and RTI. Methods The data of 2863 children from the Prevention and Incidence of Asthma and Mite Allergy birth cohort were collected to the age of 4 years. Neonatal tIgE was collected from a subset of 914 children, and clinical information by yearly parental questionnaires. The effect of pre- and/or postnatal ETS exposure, early atopic status and interaction between these factors was studied for various RTI. Results Children with elevated tIgE or atopic dermatitis and prenatal ETS exposure have a strongly increased risk of frequent RTI (aOR 6.18 (95% CI 1.45 to 26.34) and 5.69 (2.01 to 16.04), respectively; interaction p=0.006 and p=0.14, respectively) compared to non-atopic children without prenatal ETS exposure. Similar results were seen for lower RTI and otitis. This effect was less evident for postnatal ETS. Conclusion Early atopic status enhances the risk of RTI in children with prenatal ETS exposure. This suggests that host factors modify the association between ETS and RTI. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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11. Effectiveness of adenotonsillectomy in children with mild symptoms of throat infections or adenotonsillar hypertrophy: open, randomised controlled trial.
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Van Staaij, Birgit K., Van den Akker, Emma H., Rovers, Maroeska M., Hordijk, Gerrit Jan, Hoes, Arno W., and Schilder, Anne G. M.
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THROAT diseases ,HEALTH outcome assessment ,TONSILLECTOMY ,ADENOIDECTOMY ,PEDIATRIC surgery ,PEDIATRIC research ,THERAPEUTICS - Abstract
Presents a study evaluating the effectiveness of adenotonsillectomy in children with mild throat infections or adenotonsillar hypertrophy. Design, setting in the Netherlands, participants, intervention, main outcome measures, and results; Conclusion that adenotonsillectomy has no major clinical benefits over watchful waiting.
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- 2004
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12. Recurrence up to 3.5 years after antibiotic treatment of acute otitis media in very young Dutch children: survey of trial participants.
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Bezáková, Natália, Damoiseaux, Roger A. M. J., Hoes, Arno W., Schilder, Anne G. M., and Rovers, Maroeska M.
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ANTIBIOTICS ,OTITIS media in children ,ACUTE otitis media ,AMOXICILLIN ,PLACEBOS ,THERAPEUTICS - Abstract
Objective To determine the long term effects of antibiotic treatment for acute otitis media in young children. Design Prospective three year follow-up study within the framework of a primary care based, double blind, randomised, placebo controlled trial. Setting 53 general practices in the Netherlands. Participants 168 children aged 6 months to 2 years with acute otitis media. Interventions Amoxicillin 40 mg/kg/day in three doses compared with placebo. Main outcome measures Recurrence of acute otitis media; referral to secondary care; ear, nose, and throat surgery. Results Acute otitis media recurred in 63% (47/75) of children in the amoxicillin group and in 43% (37/86) of the placebo group (risk difference 20%,95% confidence interval 5% to 35%); 30% (24/78 amoxicillin; 27/89 placebo) of children in both groups were referred to secondary care, and 21% (16/78) of the amoxicillin group compared with 30% (27/90) of the placebo group had ear, nose, and throat surgery (risk difference -9%, -23% to 4%). Conclusion Recurrent acute otitis media occurred more often in the children originally treated with amoxicillin. This is another argument for judicious use of antibiotics in children with acute otitis media. Trial registration Netherlands Trial Register NTR1426. [ABSTRACT FROM AUTHOR]
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- 2009
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13. Clinical failure is more common in young children with acute otitis media who receive a short course of antibiotics compared with standard duration.
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Venekamp, Roderick P. and Schilder, Anne G. M.
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ANTIBIOTICS ,DRUG resistance in microorganisms ,OTITIS media ,PEDIATRICS ,TREATMENT effectiveness ,TREATMENT duration - Published
- 2017
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14. Early adenotonsillectomy for obstructive sleep apnoea improved quality of life and symptoms but not attention or executive function.
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Schilder, Anne G. M.
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ADENOTONSILLECTOMY , *SLEEP apnea syndromes - Abstract
An abstract of the "A Randomized Trial of Adenotonsillectomy for Childhood Sleep Apnea," by C. L. Marcus et al. in the 2013 issue of the "New England Journal of Medicine" is presented.
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- 2014
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15. Identifying streptococcal throat infections in primary care: more guidance but uncertainty remains.
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Schilder, Anne G. M. and Venekamp, Roderick P.
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PHARYNGITIS diagnosis , *STREPTOCOCCAL disease diagnosis , *ACUTE diseases , *MEDICAL protocols , *PRIMARY health care , *DIAGNOSIS - Abstract
The authors reflect on the study titled "Incidence and clinical variables associated with streptococcal throat infections: a prospective diagnostic cohort study" by P. Little and colleagues published in a 2012 issue of the "British Journal of General Practice." Topics include diagnosis of group A β-haemolytic streptococcal (GABHS) infections in primary medical care, risks factors associated with acute sore throat patients, and limitations in diagnosing streptococcal pharyngitis.
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- 2013
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16. Authors' reply.
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Schilder, Anne G. M., Rovers, Maroeska M., van den Akker, E. Henriette, van Staaij, Birgit K., and Hoes, Arno W.
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LETTERS to the editor , *TONSILLECTOMY - Abstract
Presents a response by Anne G. M. Schilder, Maroeska M. Rovers, E. Henriette van den Akker, Birgit K. van Staaij, and Arno W. Hoes, to letters to the editor about their article, "Effectiveness of adenotonsillectomy in children with mild symptoms of throat infections or adenotonsillar hypertrophy: open, randomized controlled trial," in the September 18, 2004 issue.
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- 2004
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17. Clinical failure is more common in young children with acute otitis media who receive a short course of antibiotics compared with standard duration.
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Venekamp RP and Schilder AGM
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- Acute Disease, Azithromycin, Child, Humans, Infant, Anti-Bacterial Agents, Otitis Media
- Abstract
Competing Interests: Competing interests: None declared.
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- 2017
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