1. Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy.
- Author
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Rideout, Todd C., Harding, Scott V., and Mackay, Dylan S.
- Subjects
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LOW density lipoproteins , *METABOLISM , *STEROLS , *CHOLESTEROL , *HUMAN genetic variation , *HETEROGENEITY , *CARDIOVASCULAR diseases - Abstract
Reducing intestinal cholesterol absorption with plant sterol consumption is a well-characterized strategy to lower LDL-C and potentially reduce cardiovascular disease risk. However, over 50 years of clinical research demonstrate that there is significant heterogeneity in the individual LDL-C lowering response to plant sterol therapy. A clear understanding of why plant sterols work effectively in some individuals but not in others will ensure optimal integration of plant sterols in future personalized nutritional lipid-lowering strategies. This review will examine the current knowledge base surrounding the metabolic and genetic determinants of LDL-C lowering in response to plant sterol consumption. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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