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1. MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways.

Author

Bao, Longlong, Yan, Yan, Xu, Can, Ji, Weidan, Shen, Shuwen, Xu, Gaoya, Zeng, Yong, Sun, Bin, Qian, Haihua, Chen, Lei, Wu, Mengchao, Su, Changqing, and Chen, Jie

Subjects
*MICRORNA, *LIVER cancer, *CANCER invasiveness, *PROTEIN kinase B, *GENE expression, *CANCER cell proliferation, *CELLULAR signal transduction
Abstract

Highlights: [•] miR-21 suppresses the expression of hSulf-1 and PTEN in HCC cells. [•] Suppression of hSulf-1 or PTEN by miR-21 can activate AKT/ERK1/2 signaling. [•] Activation of AKT/ERK1/2 pathways induces EMT in HCC cells. [•] miR-21 functions to promote cancer cell proliferation and movement. [Copyright &y& Elsevier]

Published
2013
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