17 results on '"Shi, Sanjun"'
Search Results
2. Postsurgical wound management and prevention of triple-negative breast cancer recurrence with a pryoptosis-inducing, photopolymerizable hydrogel
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Mi, Dandan, Li, Jiaojiao, Wang, Rujing, Li, Yuke, Zou, Lan, Sun, Chen, Yan, Shenao, Yang, Huan, Zhao, Mengnan, and Shi, Sanjun
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- 2023
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3. Regulation of protein corona on liposomes using albumin-binding peptide for targeted tumor therapy
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Li, Hanmei, Yin, Dan, Liao, Jiaying, Wang, Yao, Gou, Rui, Tang, Chuane, Li, Wei, Liu, Yi, Fu, Jiao, Shi, Sanjun, and Zou, Liang
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- 2023
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4. Albumin-stabilized polydopamine nanoparticles for chemo-photothermal synergistic therapy of melanoma
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Li, Hanmei, He, En, Wang, Yao, Fu, Jiao, Liu, Tianya, Gou, Rui, Shi, Sanjun, and Gu, Chun
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- 2023
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5. Interplay between G protein-coupled receptors and nanotechnology.
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Jiang, Yuhong, Li, Yuke, Fu, Xiujuan, Wu, Yue, Wang, Rujing, Zhao, Mengnan, Mao, Canquan, and Shi, Sanjun
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NANOMEDICINE ,NANOTECHNOLOGY ,DRUG target ,CELL membranes ,DRUG efficacy ,CELLULAR signal transduction ,G protein coupled receptors - Abstract
G protein-coupled receptors (GPCRs), as the largest family of membrane receptors, actively modulate plasma membrane and endosomal signalling. Importantly, GPCRs are naturally nanosized, and spontaneously formed nanoaggregates of GPCRs (natural nano-GPCRs) may enhance GPCR-related signalling and functions. Although GPCRs are the molecular targets of the majority of marketed drugs, the poor pharmacokinetics and physicochemical properties of GPCR ligands greatly limit their clinical applicability. Nanotechnology, as versatile techniques, can encapsulate GPCR ligands to assemble synthetic nano-GPCRs to overcome their obstacles, robustly elevating drug efficacy and safety. Moreover, endosomal delivery of GPCR ligands by nanoparticles can precisely initiate sustained endosomal signal transduction, while nanotechnology has been widely utilized for isolation, diagnosis, and detection of GPCRs. In turn, due to overexpression of GPCRs on the surface of various types of cells, GPCR ligands can endow nanoparticles with active targeting capacity for specific cells via ligand-receptor binding and mediate receptor-dependent endocytosis of nanoparticles. This significantly enhances the potency of nanoparticle delivery systems. Therefore, emerging evidence has revealed the interplay between GPCRs and nanoparticles, although investigations into their relationship have been inadequate. This review aims to summarize the interaction between GPCRs and nanotechnology for understanding their mutual influences and utilizing their interplay for biomedical applications. It will provide a fundamental platform for developing powerful and safe GPCR-targeted drugs and nanoparticle systems. GPCRs as molecular targets for the majority of marketed drugs are naturally nanosized, and even spontaneously form nano aggregations (nano-GPCRs). Nanotechnology has also been applied to construct synthetic nano-GPCRs or detect GPCRs, while endosomal delivery of GPCR ligands by nanoparticles can magnify endosomal signalling. Meanwhile, molecular engineering of nanoparticles with GPCRs or their ligands can modulate membrane binding and endocytosis, powerfully improving the efficacy of nanoparticle system. However, there are rare summaries on the interaction between GPCRs and nanoparticles. This review will not only provide a versatile platform for utilizing nanoparticles to modulate or detect GPCRs, but also facilitate better understanding of the designated value of GPCRs for molecular engineering of biomaterials with GPCRs in therapeutical application. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2023
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6. Synergistic active targeting of dually integrin αvβ3/CD44-targeted nanoparticles to B16F10 tumors located at different sites of mouse bodies
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Shi, Sanjun, Zhou, Min, Li, Xin, Hu, Min, Li, Chenwen, Li, Min, Sheng, Fangfang, Li, Zhuoheng, Wu, Guolin, Luo, Minghe, Cui, Huanhuan, Li, Ziwei, Fu, Ruoqiu, Xiang, Mingfeng, Xu, Jing, Zhang, Qian, and Lu, Laichun
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- 2016
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7. Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression
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Shi, Sanjun, Han, Lu, Deng, Li, Zhang, Yanling, Shen, Hongxin, Gong, Tao, Zhang, Zhirong, and Sun, Xun
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- 2014
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8. Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis.
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Zhao, Mengnan, Wang, Rujing, Yang, Kunmeng, Jiang, Yuhong, Peng, Yachen, Li, Yuke, Zhang, Zhen, Ding, Jianxun, and Shi, Sanjun
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NUCLEIC acids ,RNA ,DNA nanotechnology ,GENE silencing ,GENOME editing - Abstract
RNAs are involved in the crucial processes of disease progression and have emerged as powerful therapeutic targets and diagnostic biomarkers. However, efficient delivery of therapeutic RNA to the targeted location and precise detection of RNA markers remains challenging. Recently, more and more attention has been paid to applying nucleic acid nanoassemblies in diagnosing and treating. Due to the flexibility and deformability of nucleic acids, the nanoassemblies could be fabricated with different shapes and structures. With hybridization, nucleic acid nanoassemblies, including DNA and RNA nanostructures, can be applied to enhance RNA therapeutics and diagnosis. This review briefly introduces the construction and properties of different nucleic acid nanoassemblies and their applications for RNA therapy and diagnosis and makes further prospects for their development. Nucleic acid nanoassemblies with different shapes and structures are fabricated for enhanced RNA-based gene silencing, gene expression, gene editing, gene detection, and imaging strategies. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2023
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9. Local delivery of deep marine fungus-derived equisetin from polyvinylpyrrolidone (PVP) nanofibers for anti-MRSA activity
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Luo, Minghe, Ming, Yue, Wang, Linli, Li, Yuanyuan, Li, Bin, Chen, Jianhong, and Shi, Sanjun
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- 2018
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10. An in situ-forming phospholipid-based phase transition gel prolongs the duration of local anesthesia for ropivacaine with minimal toxicity.
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Li, Hanmei, Liu, Tao, Zhu, Yuxuan, Fu, Qiang, Wu, Wanxia, Deng, Jie, Lan, Li, and Shi, Sanjun
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IN situ microanalysis ,ROPIVACAINE ,LOCAL anesthesia ,PHOSPHOLIPIDS ,TRIGLYCERIDES ,SURGICAL therapeutics ,THERAPEUTICS - Abstract
An injectable, phospholipid-based phase transition gel (PPTG) has been developed for prolonging the release of ropivacaine (RO) for local anesthesia. PPTG was prepared by mixing phospholipids, medium-chain triglyceride and ethanol. Prior to injection, the PPTG is in a sol state with low viscosity. After subcutaneous injection, the PPTG rapidly forms a gel in situ, which acts as a drug release depot as verified by in vitro release profiles and in vivo pharmacokinetics. Administering RO-PPTG to rats led to a significantly smaller initial burst release than administering RO solution or RO base suspension. Nerve blockade in guinea pigs lasted 3-fold longer after injection of RO-PPTG than after injection of RO solution. RO-PPTG showed good biocompatibility and excellent degradability in vivo . These results suggest that this PPTG-based depot system may be useful for sustained release of local anesthetics to prolong analgesia without causing systemic toxicity. Statement of Significance The sustained release of local anesthetics at the surgical site after a single injection is the optimal method to control post-surgical pain. In situ forming implant is an attractive alternative for the sustained release of local anesthetics. However, its practical use is highly limited by certain drawbacks including high viscosity, involved toxic organic solvents and fast drug release. To date, phospholipids-based phase transition gel (PPTG) is emerging for clinical development because of the non-toxicity, biocompatibility and ready availability of phospholipids in body. Thus, we present a novel strategy for sustained release of local anesthetics to control post-surgical pain based on PPTG, which showed a prolonged duration of nerve blockade and excellent biocompatibility. [ABSTRACT FROM AUTHOR]
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- 2017
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11. State-of-the-art nanotechnologies for the detection, recovery, analysis and elimination of liquid biopsy components in cancer.
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Zhao, Mengnan, Mi, Dandan, Ferdows, Bijan Emiliano, Li, Yuke, Wang, Rujing, Li, Jiaojiao, Patel, Dylan, Kong, Na, Shi, Sanjun, and Tao, Wei
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LIQUID analysis ,NANOMEDICINE ,BIOPSY ,CIRCULATING tumor DNA ,DISEASE relapse ,EXTRACELLULAR vesicles ,NUCLEIC acids - Abstract
• Potential blood-based biosources in cancer liquid biopsy were introduced. • We reviewed nanoparticle-labeled with targeting-moieties, nanostructured substrates and nanobiosensors in liquid biopsy. • The mechanisms and methods of using functional nanoparticles to capture and recover CTCs were summarized. • Nanotechnology-mediated downstream analysis and elimination of CTCs were also discussed. • We offered an outlook on the challenges and suggestions for nanotechnology-based cancer liquid biopsy. The applications of nanotechnology on the detection, recovery, analysis, and elimination of liquid biopsy components in cancer. [Display omitted] Liquid biopsy allows for the quick and noninvasive detection of tumor-associated components. Various liquid biopsy components, which include circulating tumor cells, tumor-derived extracellular vesicles, circulating tumor nucleic acids, and tumor-educated platelets, can be analyzed. These components hold great potential for tracking the evolutionary dynamics of tumors and detecting the early emergence of therapeutic resistance and tumor recurrence. In recent decades, significant advances in nanotechnology have contributed to the development of blood-based liquid biopsy with higher sensitivity and specificity. This review discusses the key nanotechnologies that can be used to detect, isolate, and recover tumor-associated components, providing a brief overview of the downstream analysis of these components and then focusing on the different types of nanomaterials that can be applied for the treatment of circulating tumor cells to prevent metastasis. Taken together, these noninvasive nanotechnology-mediated diagnostic approaches can aid precise cancer assessment and guide modifications to current treatment strategies. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Cancer stem cells: therapeutic implications and perspectives in cancer therapy.
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Han, Lu, Shi, Sanjun, Gong, Tao, Zhang, Zhirong, and Sun, Xun
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CANCER stem cells ,CANCER treatment ,CANCER research ,CANCER diagnosis ,CANCER chemotherapy ,FLUOROURACIL ,ATP-binding cassette transporters - Abstract
Abstract: The cancer stem cell (CSC) theory is gaining increasing attention from researchers and has become an important focus of cancer research. According to the theory, a minority population of cancer cells is capable of self-renewal and generation of differentiated progeny, termed cancer stem cells (CSCs). Understanding the properties and characteristics of CSCs is key to future study on cancer research, such as the isolation and identification of CSCs, the cancer diagnosis, and the cancer therapy. Standard oncology treatments, such as chemotherapy, radiotherapy and surgical resection, can only shrink the bulk tumor and the tumor tends to relapse. Thus, therapeutic strategies that focus on targeting CSCs and their microenvironmental niche address the ineffectiveness of traditional cancer therapies to eradicate the CSCs that otherwise result in therapy resistance. The combined use of traditional therapies with targeted CSC-specific agents may target the whole cancer and offer a promising strategy for lasting treatment and even cure. [Copyright &y& Elsevier]
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- 2013
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13. Chemical constituents from Valeriana jatamansi.
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Wang, Rujing, Shi, Sanjun, Tan, Yuzhu, Yao, Lincai, and Zhu, Lixia
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VALERIANA , *IRIDOIDS , *SESQUITERPENES , *LIGNINS , *STEROIDS - Abstract
Phytochemical study of Valeriana jatamansi Jones afforded 45 compounds, including twenty-three iridoids (1 – 23), five sesquiterpenes (24 – 28), three steroids (29 – 31) and fourteen lignins (32 – 45). The structures of these compounds were assigned by detailed interpretation of spectroscopic data (1D and 2D NMR, HRESIMS) and comparisons with the published data. This is the first report of isolation of compounds (1 – 6 , 10 , 21 , 25 , 41 , 43 , 44 , 45) from Valerianaceae , compounds (13 , 27 , 39) within the genus Valeriana and compound 30 from V. jatamans. The chemotaxonomic data can support the genus Valeriana being accepted as a member of transitional taxa between the family Valerianaceae and Caprifoliaceae. Image 1 • This is the first report of isolation of compounds (1–6, 10, 21, 25, 41, 43, 44, 45) from Valerianaceae , compounds (13, 27, 39) within the genus Valeriana and compound 30 from V. jatamans. • The chemotaxonomic data can support the genus Valeriana being accepted as a member of transitional taxa between the family Valerianaceae and Caprifoliaceae. All the isolates were evaluated for cytotoxicity effect. [ABSTRACT FROM AUTHOR]
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- 2021
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14. Magnesium oxide-crosslinked low-swelling citrate-based mussel-inspired tissue adhesives.
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Lu, Xili, Shi, Sanjun, Li, Hanmei, Gerhard, Ethan, Lu, Zhihui, Tan, Xinyu, Li, Wenliang, Rahn, Kevin M., Xie, Denghui, Xu, Guodong, Zou, Fang, Bai, Xiaochun, Guo, Jinshan, and Yang, Jian
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POLYIMIDES , *ADHESIVES , *FIBRIN tissue adhesive , *BIOMEDICAL adhesives , *TISSUE wounds , *DENTIN , *MAGNESIUM , *GRANULATION tissue - Abstract
Tissue adhesives are commonly used in surgeries and regenerative engineering for the repair and regeneration of topical and internal wounds on tissues and organs such as skin, heart, blood vessels, and bone. However, achieving rapid crosslinking, strong wet adhesion and cohesion strengths, and minimal cytotoxicity remains a critical roadblock for clinical translation. Herein, in contrast to harsh and cytotoxic oxidants, magnesium oxide (MgO) particles were found to facilitate rapid crosslinking for injectable citrate-based mussel-inspired tissue bioadhesives synthesized by reacting citric acid, PEG-PPG-PEG diol and dopamine (iC-EPE). Our results confirmed the role of MgO particles as both crosslinkers and composite fillers to concurrently enhance bioadhesive cohesion and adhesion. iC-EPE crosslinked by MgO with/without sodium periodate (PI) exhibit enhanced mechanical strengths (1.0 Mpa < tensile strength ≤ 4.5 MPa) compared to that of iC-EPE crosslinked only by PI (~0.75 MPa), high adhesion strength (up to 125 kPa, 8 fold that of fibrin glue (~15 kPa)), tunable degradability (full degradation from <1 week to > 1 month), excellent in vitro and in vivo biocompatibility, encouraging anti-bacterial performance, and favorable wound closure efficacy. Thus, MgO crosslinked bioadhesives possess great potential for a wide range of applications in surgery and regenerative engineering. [ABSTRACT FROM AUTHOR]
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- 2020
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15. Development of a pulmonary peptide delivery system using porous nanoparticle-aggregate particles for systemic application.
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Yang, Likai, Luo, Jing, Shi, Sanjun, Zhang, Qiang, Sun, Xun, Zhang, Zhirong, and Gong, Tao
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DRUG delivery systems , *PULMONARY artery , *PEPTIDE drugs , *DRUG development , *NANOMEDICINE , *DRUG efficacy - Abstract
Highlights: [•] The entrapment efficiency of peptide loaded nanostructured lipid carriers (NLCs) could reach to 95%. [•] The porous nanoparticle-aggregate particles (PNAPs) powders could remain in lungs for a longer time than octreotide acetate (OA) solution and reach a sustained release. [•] The bioavailability was markedly enhanced by pulmonary deliver PNAPs compared with pulmonary deliver OA solutions and subcutaneous inject OA solution. [•] As far as we know, this is the first report on the anti-hepatic ischemia–reperfusion injury (HIRI) effects through intrapulmonary administration. [Copyright &y& Elsevier]
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- 2013
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16. PLGA nanoparticles loaded with curcumin produced luminescence for cell bioimaging.
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Wang, Rujing, Zou, Lan, Yi, Zhiwen, Zhang, Zhen, Zhao, Mengnan, and Shi, Sanjun
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CURCUMIN , *LUMINESCENCE , *BIO-imaging sensors , *SOLVATOCHROMISM , *NANOPARTICLES , *HYDROPHOBIC interactions , *ELECTROSTATIC interaction - Abstract
[Display omitted] • Cur@PLGA-NPs are a novel AIE formulation capable of providing rich optical properties. • Hydrophobic interaction, electrostatic interaction, and π-π conjugation are responsible for the AIE properties. • The curcumin-based nano-AIE formulation could be successful used to image live cells. To revise the emission of curcumin (Cur) from "off" to "on", poly (D, L-lactide-co-glycolide) acid (PLGA) nanoparticles loaded with Cur were embedded in a polyvinyl alcohol (PVA) emulsifier (named Cur@PLGA-NPs). First, the emission intensities of different nanoformulations, including liposomes, bovine serum albumin (BSA) nanoparticles, and PLGA nanoparticles, were examined to discover the most effective carriers for Cur luminescence. As a result, Cur@PLGA-NPs exhibited the highest fluorescence intensity due to aggregation-induced emission (AIE), with quantum yields of 23.78% in aqueous solution and 21.52% in the solid state. According to X-ray diffraction (XRD) data, Cur@PLGA-NPs existed in the amorphous state, with a size of 217.2 ± 5.2 nm, an encapsulation efficiency (EE) of 69.98%, and a drug loading efficiency (LE) of 1.37%. The intramolecular interactions, which included hydrophobic interactions, electrostatic interactions, π-π interactions and solvatochromic effects, stabilized the chromophore cluster of Cur@PLGA-NPs in terms of nanoparticle formulation. Compared with free Cur, Cur@PLGA-NPs sensitized CT26 cells more efficiently with an IC 50 value of 16.9 μmol/L and an apoptotic rate of 17.20% at 10 μmol/L Cur. Because of the robust fluorescence emission based on AIE, Cur@PLGA-NPs were utilized as a nano-AIE probe for cell bioimaging, and many red fluorescent signals were observed in CT26 cells after treatment. These results suggest that Cur@PLGA-NPs provide a novel amorphous AIE formulation with imaging and bioactive capabilities. [ABSTRACT FROM AUTHOR]
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- 2023
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17. Injectable thermosensitive lipo-hydrogels loaded with ropivacaine for prolonging local anesthesia.
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Li, Hanmei, Tang, Qi, Wang, Yao, Li, Mao, Wang, Yannan, Zhu, Hong, Geng, Fang, Wu, Di, Peng, Lianxin, Zhao, Gang, Zou, Liang, and Shi, Sanjun
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LOCAL anesthesia , *NERVE block , *ROPIVACAINE , *HYDROGELS , *SUBCUTANEOUS injections , *PAIN management , *LIPOSOMES - Abstract
[Display omitted] • Sustained local anesthetics system can improve the satisfaction of patient. • Poloxamer 407 can release drugs sustained but with higher initial burst release. • Ropivacaine loaded injectable liposome-in-gel had low initial burst release. • Ropivacaine loaded gel was useful for local anesthesia without systemic toxicity. Reducing post-surgical pain can promote recovery of mobility, improve patient satisfaction, and reduce the risk of chronic pain syndrome. When managing post-surgical pain, single-injection local anesthesia is more convenient and involves lower risk to the patient than multi-injection regimes, but the effects are not long-lasting. Here we developed a system that can prolong local anesthesia after a single injection. In this system, ropivacaine (Ro) is encapsulated into liposomes, which are then loaded into Poloxamer 407-based thermosensitive hydrogels. The Ro-loaded liposome-in-gel system (Ro-Lip-Gel) is in a sol state before injection, and immediately after subcutaneous injection, it forms a gel in situ. We show through in vitro release and in vivo pharmacokinetics studies that this gel acts as a drug release depot. In rats, the initial burst release of Ro was smaller from Ro-Lip-Gel than from Ro solution or Ro-Gel, and Ro-Lip-Gel caused nerve blockade lasting four times longer than Ro solution. Ro-Lip-Gel degraded in vivo and showed good biocompatibility. Our results suggest that a liposome-in-gel system can show small initial burst release, long-term nerve blockade and good biocompatibility in vitro and in vivo. Therefore, such a system may be useful for sustained local anesthesia without systemic toxicity. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
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