1. Differences in Depressive Patterns According to Disease Severityin Early-Onset Alzheimer's Disease.
- Author
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Bora Yoon, Dong Won Yang, Yun Jeong Hong, Seong Hye Choi, Sun Ah Park, Hee Kyung Park, Yong Duk Kim, Shim, Yong S., Yoon, Bora, Yang, Dong Won, Hong, Yun Jeong, Choi, Seong Hye, Park, Sun Ah, Park, Hee Kyung, and Kim, Yong Duk
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ALZHEIMER'S disease , *DEMENTIA , *GERIATRIC Depression Scale , *SEVERITY of illness index , *DISEASE progression , *ALZHEIMER'S disease diagnosis , *DIAGNOSIS of mental depression , *AGE factors in disease , *COMPARATIVE studies , *MENTAL depression , *FACTOR analysis , *RESEARCH methodology , *MEDICAL cooperation , *PSYCHOLOGICAL tests , *RESEARCH , *LOGISTIC regression analysis , *EVALUATION research , *DISEASE prevalence , *DISEASE complications , *PSYCHOLOGY - Abstract
Background& Objective: Depression frequently combines with dementia, including early-onset Alzheimer's disease (EOAD). We investigated differences in prevalence and characteristics of depressive symptoms according to dementia severity in EOAD patients.Methods: The 15-item Korean version of the Geriatric Depression Scale (GDS-15) was administered to 412 EOAD patients. Factor analysis was used to assess GDS-15 factor structure. We subdivided participants into three groups by disease severity, then compared the frequencies and scores of individual GDS-15 items and performed logistic regression analysis to assess associations between depressive symptoms and EOAD stage.Results: Factor analysis yielded three factor categories: 1) "hopelessness and ominousness" (symptoms no. 6, 8, 12, 14, 15); 2) "unhappiness and dissatisfaction" (no. 1, 3, 5, 7, 11); and 3) "monotony and lack of energy" (no. 2, 4, 9, 10, 13). Factor 2 depressive symptoms (no. 1, 5, 11) were less common in moderate EOAD. The risk of Factor 1 symptoms: no. 12 (OR, 2.04; 95% CI, 1.19-3.50; p = 0.010) and 14 (OR, 1.84; 95% CI, 1.07-3.16; p = 0.028) was higher in mild than very mild EOAD. The risk of Factor 2 symptoms: no. 9 (OR, 2.69; 95% CI, 1.08-6.71; p = 0.033) and 13 (OR, 2.12; 95% CI, 1.02-4.40; p = 0.043) was higher in moderate than mild EOAD.Conclusion: We confirmed that depressive symptoms differ according to EOAD severity. When assessing depressive symptoms related to dementia progression, we recommend focusing on "hopelessness and ominousness" in very mild EOAD and "unhappiness and dissatisfaction" in mild EOAD. [ABSTRACT FROM AUTHOR]- Published
- 2016
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