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This document provides a summary of a special issue on the use of magnetic nanoparticles (MNPs) in nanomedicine. MNPs have shown promise in medical imaging, anemia treatments, and cancer therapeutics. The document highlights ongoing clinical trials exploring the potential of MNPs in treating prostate and pancreatic cancers. MNPs are also being utilized in drug delivery systems, offering targeted and controlled release of therapeutic agents. The special issue covers a range of topics related to the use of MNPs in medicine, including studies on drug delivery, hyperthermia-based therapy, and cancer treatment. The document acknowledges the authors and editorial staff for their contributions to the special issue. [Extracted from the article]

As presented in our Special Issue, oleic acid and the impregnation of NPs with iron or nitrogen atoms have been demonstrated to significantly mitigate side effects inflicted by various types of NPs. 10.3390/ijms22073510 21 Lojk J., Bregar V.B., Strojan K., Hudoklin S., Veranic P., Pavlin M., Kreft M.E. Increased endocytosis of magnetic nanoparticles into cancerous urothelial cells versus normal urothelial cells. Due to potentially toxic side effects of NPs, it is necessary to consider the protection of cells and tissues upon administering the NP-drug conjugate therapy. For example, TiO SB 2 sb nanoparticles (NPs) can induce inflammation by increasing levels of NF- B, IFN- , TNF- , NO, and many other signalling molecules [[1]]. [Extracted from the article]

The original research articles regarding environmental nanotoxicology address aspects that have been less explored in the nanotoxicology studies so far, such as combination toxicity and long-term toxicity of NPs. Nanotoxicology, a discipline transpired by the need to assess the human and environmental safety of nanoscale materials, has evolved over the past 15 years into a mature area of toxicology. Early on, nanotoxicology studies established a necessary understanding of dose-response relationships of nanomaterials using typical in vitro toxicology models, provided crucial information on interferences induced by nanoparticles (NPs) in the conventional toxicity assays and how to overcome these, and demonstrated that due to their unique physical-chemical properties, nanomaterials act via different toxicological mechanisms than the bulk counterparts of the same materials. The topics of the research articles and review papers address both environmental nanotoxicity as well as human health and nanomedicine safety aspects, providing an excellent overview of the current status of these important sub-areas of nanotoxicology. [Extracted from the article]

Cancer is one of the major health issues with increasing incidence worldwide. In spite of the existing conventional cancer treatment techniques, the cases of cancer diagnosis and death rates are rising year by year. Thus, new approaches are required to advance the traditional ways of cancer therapy. Currently, nanomedicine, employing nanoparticles and nanocomposites, offers great promise and new opportunities to increase the efficacy of cancer treatment in combination with thermal therapy. Nanomaterials can generate and specifically enhance the heating capacity at the tumor region due to optical and magnetic properties. The mentioned unique properties of nanomaterials allow inducing the heat and destroying the cancerous cells. This paper provides an overview of the utilization of nanoparticles and nanomaterials such as magnetic iron oxide nanoparticles, nanorods, nanoshells, nanocomposites, carbon nanotubes, and other nanoparticles in the thermal ablation of tumors, demonstrating their advantages over the conventional heating methods. [ABSTRACT FROM AUTHOR]