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Groundwater is a primary freshwater resource for human consumption and an essential source for industry and agriculture. Therefore, understanding its spatial and temporal trends and drivers is crucial for governments to take appropriate measures to manage water resources. This paper uses Gravity Recovery and Climate Experiment (GRACE) satellite data and the Global Land Data Assimilation System (GLDAS) to derive groundwater storage anomalies (GWSAs) and to analyze the spatial and temporal trends of GWSA in different regions of China (Xinjiang, Tibet, Inner Mongolia, North China Plain, South China, and Northeast China). It used groundwater-level observation data to verify the accuracy of GWSA estimates and analyzed the drivers of regional GWSA changes. The results showed that: (1) GWSA in South China increased at a rate of 4.79 mm/a from 2003 to 2016, and GWSA in other regions in China showed a decreasing trend. Among them, the decline rates of GWSA in Xinjiang, Tibet, Inner Mongolia, North China Plain, and Northeast China were −6.24 mm/a, −3.33 mm/a, −3.17 mm/a, −7.35 mm/a, and −0.75 mm/a, respectively. (2) The accuracy of the annual-scale GWSA estimates was improved after deducting gravity losses due to raw coal quality, and the correlation coefficient between GWSA and groundwater levels monitored by observation wells increased. (3) In Xinjiang, the annual water consumed by raw coal mining, industrial, and agricultural activities had a greater impact on GWSA than rainfall and temperature, so these human activities might be the main drivers of the continued GWSA decline in Xinjiang. Water consumption by raw coal mining and industry might be the main drivers of the continued decline in GWSA in Inner Mongolia and the North China Plain. The increase in groundwater storage in South China was mainly due to the recharge of rainfall. [ABSTRACT FROM AUTHOR]