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K2-19 hosts a planetary system composed of two outer planets, b and c, with size of 7.0 ± 0.2 R⊕ and 4.1 ± 0.2 R⊕, and an inner planet, d, with a radius of 1.11 ± 0.05 R⊕. A recent analysis of Transit-Timing Variations (TTVs) suggested b and c are close to but not in 3:2 mean motion resonance (MMR) because the classical resonant angles circulate. Such an architecture challenges our understanding of planet formation. Indeed, planet migration through the protoplanetary disc should lead to a capture into the MMR. Here, we show that the planets are in fact, locked into the 3:2 resonance despite circulation of the conventional resonant angles and aligned periapses. However, we show that such an orbital configuration cannot be maintained for more than a few hundred million years due to the tidal dissipation experienced by planet d. The tidal dissipation remains efficient because of a secular forcing of the innermost planet eccentricity by planets b and c. While the observations strongly rule out an orbital solution where the three planets are on close to circular orbits, it remains possible that a fourth planet is affecting the TTVs such that the four planet system is consistent with the tidal constraints. [ABSTRACT FROM AUTHOR]

The article discusses a rare genetic condition called acrogeria, which is characterized by the resorption of bones in the distal phalanges. It is caused by a mutation in the LMNA gene and shares similarities with other laminopathies. The article describes a case of acrogeria in a 35-year-old woman from South Korea and highlights the clinical features and diagnostic methods used. Acrogeria is distinguished by its unique distribution of progeroid traits and the absence of widespread osteoporosis. The article emphasizes the importance of considering cardiovascular complications in patients with acrogeria. [Extracted from the article]

Metal production in galaxies traces star formation, and is highly concentrated towards the centres of galactic discs. This suggests that galaxies should have inhomogeneous metal distributions with strong radial gradients, but observations of present-day galaxies show only shallow gradients with little azimuthal variation, implying the existence of a redistribution mechanism. We study the role of gravitational instability-driven turbulence as a mixing mechanism by simulating an isolated galactic disc at high resolution, including metal fields treated as passive scalars. Since any cylindrical field can be decomposed into a sum of Fourier-Bessel basis functions, we set up initial metal fields characterized by these functions and study how different modes mix. We find both shear and turbulence contribute to mixing, but the mixing strongly depends on the symmetries of the mode. Non-axisymmetric modes have decay times smaller than the galactic orbital period because shear winds them up to small spatial scales, where they are erased by turbulence. The decay time-scales for axisymmetric modes are much greater, though for all but the largest scale inhomogeneities the mixing time-scale is still short enough to erase chemical inhomogeneities over cosmological times. These different time-scales provide an explanation for why galaxies retain metallicity gradients while there is almost no variation at a fixed radius. Moreover, the comparatively long time-scales required for mixing axisymmetric modes may explain the greater diversity of metallicity gradients observed in high redshift galaxies as compared to local ones: these systems have not yet reached equilibrium between metal production and diffusion. [ABSTRACT FROM AUTHOR]

Kimura disease (KD) is a rare, chronic angiolymphoproliferative inflammatory disease appearing to be mostly restricted to the skin and soft tissue. Cutaneous involvement of KD includes head and/or neck nodules showing suggestive histological features, frequently associated with an atopic dermatitis-like or prurigo-like presentation. KD is challenging to treat, with high rate of recurrence using current therapeutic strategies. Evidence for involvement of a T-helper type 2 (Th2) immune response in KD pathogenesis has been found in previous studies. Consequently, this study aimed to determine the efficacy and safety of dupilumab, a human monoclonal antibody that inhibits signalling of key Th2 cytokines, interleukin (IL)-4 and IL-13, within a single-centre cohort of patients with cutaneous KD. Two adults with a diagnosis of refractory (failure of at least one treatment line) cutaneous-restricted KD based on clinical, biological, histological, molecular and imaging findings received dupilumab for KD, and showed dramatic response with a good safety profile. [ABSTRACT FROM AUTHOR]

Background: At present there is no standard nomenclature for describing the diversity of human constitutive skin colour. Objectives: To develop a standard nomenclature to describe human constitutive skin colour. Methods: Monthly focus group discussions were carried out among a multidisciplinary group of specialists over a 7‐month period. Topics covered were (i) limitations and unmet needs of current nomenclature(s) pertaining to human cutaneous diversity, (ii) practical considerations about the function and role of any proposed nomenclature pertaining to human cutaneous diversity, (iii) review of the cellular basis and current molecular genetic understanding of variation in human skin pigmentation and (iv) in vivo methods to evaluate human skin pigmentation. In addition, a preliminary review of the published literature was undertaken to collate data on published skin reflectance measurements, notably melanin index values for well‐referenced human populations. Results: We developed a five‐point scale to describe the full spectrum of human constitutive skin colour, termed the Eumelanin Human Skin Colour Scale. The nomenclature of the scale uses eumelanin, the dominant chromophore of human skin, as a central descriptive word. The categories of the scale (nomenclature and melanin index values) are eumelanin low (EML), < 25; eumelanin intermediate low (EMIL), 25 to < 50; eumelanin intermediate (EMI), 50 to < 75; eumelanin intermediate high (EMIH), 75 to < 100; and eumelanin high (EH), ≥ 100. Conclusions: The Eumelanin Human Skin Colour Scale enables the complete range of human constitutive skin colour to be described in an objective, equitable and understandable manner. In future, this scale can be used as the basis for developing other scales that address the specific functional aspects of human skin, such as response to ultraviolet radiation. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 67-year-old man with feeling of malaise and was diagnosed with erythematous papules on the abdomen and limbs. He was given topical steroids and developed asthenia, fever, inflammatory bilateral edema and arthralgia. The patient has a physical examination which shows lesions and vasculitis. The patient receives antihistamines and topical steroids with home decontamination for bed bug.