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In soybean, only one mitochondrial genome of cultispecies has been completely obtained. To explore the effect of mitochondrial genome on soybean cytoplasmic male sterility (CMS), two CMS lines and three maintainer lines were used for sequencing. Comparative analysis showed that mitochondrial genome of the CMS line was more compact than that of its maintainer line, but genes were highly conserved. Conserved and unique sequence coexisted in the genomes. Mitochondrial genomes contained different sequence lengths and copy numbers of repeats between CMS line and maintainer line. Large and short repeats mediated intramolecular and intermolecular recombination in mitochondria. Unique sequences and genes were also involved in recombination process and constituted a complex network. orf178 and orf261 were identified as CMS-associated candidate genes. They had sequence characteristics of reported CMS genes in other crops and could be transcribed in CMS lines but not in maintainer lines. This report reveals mitochondrial genome of soybean CMS lines and compares complete mitochondrial sequence between CMS lines and their maintainer lines. The information will be helpful in further understanding the characteristics of soybean mitochondrial genome and the mechanism underlying CMS. [ABSTRACT FROM AUTHOR]

Motivated by recent work on rotating black hole shadow (Chang and Zhu in Phys Rev D 101:084029, 2020), we investigate the shadow behaviours of rotating Hayward–de Sitter black hole for static observers at a finite distance in terms of astronomical observables. This paper uses the newly introduced distortion parameter (Chang and Zhu in Phys Rev D 102:044012, 2020) to describe the shadow’s shape quantitatively. We show that the spin parameter would distort shadows and the magnetic monopole charge would increase the degree of deformation. The distortion will increase as the distance between the observer and the black hole increases, and distortion reduces as the cosmological constant increases. Besides, the increase of the spin parameter, magnetic monopole charge and cosmological constant will cause the shadows shrunken. [ABSTRACT FROM AUTHOR]

High purity layered YbB2C2 powder is synthesized by a boro/carbothermic reduction method using YbBO3, B4C and graphite powders as raw materials. Its X-ray diffraction data are presented, and the space group P4/mbm (No. 127) is confirmed. The lattice parameters are a = b = 5.3389 Å and c = 3.5683 Å, and the atom positions are Yb (0.0000, 0.0000, 0.0000), B (0.3621, 0.8621, 0.5000), and C (0.1606, 0.6606, 0.5000). Porous YbB2C2 ceramics have a high porosity in the range of 69.89–58.11% and a high compressive strength in the range of 19.49–63.44 MPa. Furthermore, the as-produced porous YbB2C2 ceramics show unique chemical activity. Porous YbB2C2 ceramic with a porosity of 69.89% emits so much heat that it can burn a piece of paper when this ceramic is wetted by water. The rate of reaction between the porous YbB2C2 ceramic and water can be simply controlled by adjusting the porosity. The solid reaction products are YbB6, C and an unknown amorphous phase. [ABSTRACT FROM AUTHOR]

The zinc transcriptional regulator (ZitR) functions as a metalloregulator that fine tunes transcriptional regulation through zinc-dependent DNA binding. However, the molecular mechanism of zinc-driven allosteric control of the DNA binding to ZitR remains elusive. Here, we performed enhanced sampling accelerated molecular dynamics simulations to figure out the mechanism, revealing the role of protein dynamics in the zinc-induced allosteric control of DNA binding to ZitR. The results suggest that zinc-free ZitR samples distinct conformational states, only a handful of which are compatible with DNA binding. Remarkably, zinc binding reduces the conformational plasticity of the DNA-binding domain of ZitR, promoting the population shift in the ZitR conformational ensemble towards the DNA binding-competent conformation. Further co-binding of DNA to the zinc–ZitR complex stabilizes this competent conformation. These findings suggest that ZitR–DNA interactions are allosterically regulated in a zinc-mediated conformational preselection manner, highlighting the importance of conformational dynamics in the regulation of transcription factor family. [ABSTRACT FROM AUTHOR]

Nucleoporins (NUPs) comprise nuclear pore complexes, gateways for nucleocytoplasmic transport. As primary human keratinocytes switch from the progenitor state towards differentiation, most NUPs are strongly downregulated, with NUP93 being the most downregulated NUP in this process. To determine if this NUP downregulation is accompanied by a reduction in nuclear pore numbers, we leveraged Stochastic Optical Reconstruction Microscopy. No significant changes in nuclear pore numbers were detected using three independent NUP antibodies; however, NUP reduction in other subcellular compartments such as the cytoplasm was identified. To investigate how NUP reduction influences keratinocyte differentiation, we knocked down NUP93 in keratinocytes in the progenitor-state culture condition. NUP93 knockdown diminished keratinocytes' clonogenicity and epidermal regenerative capacity, without drastically affecting nuclear pore numbers or permeability. Using transcriptome profiling, we identified that NUP93 knockdown induces differentiation genes related to both mechanical and immune barrier functions, including the activation of known NF-κB target genes. Consistently, keratinocytes with NUP93 knockdown exhibited increased nuclear localization of the NF-κB p65/p50 transcription factors, and increased NF-κB reporter activity. Taken together, these findings highlight the gene regulatory roles contributed by differential NUP expression levels in keratinocyte differentiation, independent of nuclear pore numbers. Nucleoporins (NUPs) compose the nuclear pores. As skin epidermal cells switch from the progenitor state to differentiation, NUPs are downregulated without changing pore numbers. Downregulation of NUP93 is further connected to NF-kB activation. [ABSTRACT FROM AUTHOR]

Knowledge of the raindrop size distribution (DSD) is crucial for disaster prevention and mitigation. The record-breaking rainfall in the summer of 2020 caused some of the worst flooding ever experienced in China. This study uses 96 Parsivel disdrometers and eight-year Global Precipitation Measurement (GPM) satellite observations to reveal the microphysical aspects of the disastrous rainfall during its northward migration over East China. The results show that the nearly twice as heavy rainfall in Jiangsu Province compared to Fujian Province can be attributed to the earlier-than-average northward jump of the summer monsoon rainband to the Yangtze-Huaihe River valley. The persistent heavy monsoon rainfall showed similar near-maritime DSD characteristics, with a higher concentration of small raindrops than the surrounding climatic regimes. During the northward movement of the rainband, the DSD variables and composite spectra between the pre-summer rainfall in Fujian and mei-yu rainfall in Jiangsu exhibited inherent similarities with slight regional variations. These are associated with similar statistical vertical precipitation structures for both convective and stratiform rain in these regions/periods. The vertical profiles of radar reflectivity and DSD parameters are typical of monsoonal rainfall features, implying the competition between coalescence, breakup, and accretion of vital warm rain processes. This study attributes the anomalously long duration of the mei-yu season for the record-breaking rainfall and reveals inherent homogeneous rainfall microphysics during the northward movement of the summer monsoon rainband. The conclusion is statistically robust and would be helpful for accurate precipitation estimation and model parameterization of summer monsoon rainfall over East China. [ABSTRACT FROM AUTHOR]

Reservoir bank collapse is a type of hydrogeological phenomena encountered in hydropower projects, and its prediction remains a challenge. The reservoir bank collapse width in the loess area of China is predicted based on the empirical graphical method established by scholars from the Soviet Union; however, the prediction results are quite different from the actual value. In this study, a field investigation was conducted on the bank slope topography after reservoir bank collapse in a loess area. The results showed that the water bank slope remained vertical after the bank collapse, and the accumulation form of the underwater bank slope followed an exponential curve. When the ratio of the water depth to the bank slope height after bank collapse was less than 0.3, there was an accumulation bank slope above the water. When this ratio was greater than 0.3, the accumulation slope was underwater. Based on the water depth and bank slope height after bank collapse, a formula to predict the topography of the underwater accumulation slope was established. Combined with the characteristics of the post-collapse bank slope, a prediction method for loess bank slope collapse was established. The topography of the bank slope predicted by this method was consistent with the field investigation results. The physical and mechanical properties of the bank slope loess and the characteristics of the bank slope were considered, thus overcoming the shortcomings of the conventional graphical method based on empirical parameters. This study has practical significance for prediction of loess bank collapse. [ABSTRACT FROM AUTHOR]

The deformation characteristics of fractured rock masses and the acoustic emission (microseismic) characteristics of crack propagation can help evaluate and predict the stability of rock masses. Rock-like materials with different strengths were designed using quartz sand, barite powder, and gypsum; models with a single flaw and the same properties were prefabricated to perform uniaxial compression tests. Based on the stress–strain relationship of the models, the deformation process could be divided into four stages: medium compaction stage (I), elastic deformation stage (II), crack propagation stage (III), and model failure stage (IV). The temporal variation trends in the maximum principal strain on both sides of the pre-existing fracture were the same. The range of the local strain deflection angle at the passive loading end increased, and the peak relative displacement rate decreased with the increase of strength of the model. Ring-down count vs time curve could be divided into three stages: initial, growth, and stable stages. The initial stage corresponded to deformation Stage I and II. The high-strength model showed calm ring-down count in this stage. The growth stage corresponded to Stage III, where the higher the model strength, the higher the growth rate of the cumulative ring-down counts. The stable stage corresponded to Stage IV, where the cumulative ring-down counts were either stable or increased steadily. Overall, the peak frequency distribution tended to widen with the decrease in the model strength. The results can serve as an experimental basis to understand the deformation and damage mechanisms of rock masses. [ABSTRACT FROM AUTHOR]

A correction to the article "Supply-Based Optimal Scheduling of Oil Product Pipelines," that was pulished in the previous issue is presented.

Machining-induced residual stress plays a significant role in the corrosion resistance and fatigue life of the manufacturing end product. In the current study, milling experiments were performed to investigate the influence of pre-stress on the surface residual stresses. For this purpose, finite element (FE) simulations of the orthogonal cutting based on arbitrary Lagrangian-Eulerian approach were performed. To validate the simulation results, a device was designed to stretch the workpiece with pre-stresses before the machining process. The residual stresses obtained under different pre-stresses were measured based on the varied bending deflection of the workpiece after each material layer removal. As a result, the general variation trend of residual stress profiles that obtained under different pre-stresses was found well consistent with the finite element simulation results, indicating that the proposed residual stress measuring principle is reliable. Furthermore, the pre-stress loaded on the Ti6Al4V part can significantly affect the distribution of machining-induced residual stresses, implying that surface residual stresses can be adjusted by employing appropriate values of pre-stresses during the machining process. [ABSTRACT FROM AUTHOR]

Combining analyses of spatial and temporal characteristics of the ionosphere is of great significance for scientific research and engineering applications. Tensor decomposition is performed to explore the temporal-longitudinal-latitudinal characteristics in the ionosphere. Three-dimensional tensors are established based on the time series of ionospheric vertical total electron content maps obtained from the Centre for Orbit Determination in Europe. To obtain large-scale characteristics of the ionosphere, rank-1 decomposition is used to obtain U(1), U(2), and U(3), which are the resulting vectors for the time, longitude, and latitude modes, respectively. Our initial finding is that the correspondence between the frequency spectrum of U(1) and solar variation indicates that rank-1 decomposition primarily describes large-scale temporal variations in the global ionosphere caused by the Sun. Furthermore, the time lags between the maxima of the ionospheric U(2) and solar irradiation range from 1 to 3.7 h without seasonal dependence. The differences in time lags may indicate different interactions between processes in the magnetosphere-ionosphere-thermosphere system. Based on the dataset displayed in the geomagnetic coordinates, the position of the barycenter of U(3) provides evidence for north-south asymmetry (NSA) in the large-scale ionospheric variations. The daily variation in such asymmetry indicates the influences of solar ionization. The diurnal geomagnetic coordinate variations in U(3) show that the large-scale EIA (equatorial ionization anomaly) variations during the day and night have similar characteristics. Considering the influences of geomagnetic disturbance on ionospheric behavior, we select the geomagnetic quiet GIMs to construct the ionospheric tensor. The results indicate that the geomagnetic disturbances have little effect on large-scale ionospheric characteristics. [ABSTRACT FROM AUTHOR]

Multi-layer perceptron (MLP) is a class of Artificial Neural Networks widely used in regression, classification, and prediction. To accelerate the training of MLP, more cores can be used for parallel computing on many-core systems. However, with the increasing number of cores integrated into the chip, the communication bottleneck in the training of MLP on electrical network-on-chip (ENoC) becomes severe, degrading MLP training performance. Replacing ENoC with optical network-on-chip (ONoC) can break the communication bottleneck in MLP training. To facilitate the development of ONoC for MLP training, it is necessary to compare and model the MLP training performance of ONoC and ENoC in advance. This paper first analyzes and compares the differences between ONoC and ENoC. Then, we formulate the performance and energy model of MLP training on ONoC and ENoC by analyzing the communication and computation time, static energy, and dynamic energy consumption, respectively. Furthermore, we conduct extensive simulations to compare their MLP training performance and energy consumption with our simulation infrastructure. The experimental results show the MLP training time of ONoC has been reduced by 65.16% and 52.51% on average in different numbers of cores and batch sizes compared with ENoC. The results also exhibit that ONoC overall has 54.86% and 43.13% on average energy reduction in different numbers of cores and batch sizes compared with ENoC. However, with a small number of cores (e.g., less than 50) in MLP training, ENoC consumes less energy than ONoC. These experiments confirm that generally ONoC is a good replacement for ENoC when using a large number of cores in terms of performance and energy consumption for MLP training. [ABSTRACT FROM AUTHOR]

The genetic base of soybean cultivars (Glycine max (L.) Merr.) has been narrowed through selective domestication and specific breeding improvement, similar to other crops. This presents challenges in breeding new cultivars with improved yield and quality, reduced adaptability to climate change, and increased susceptibility to diseases. On the other hand, the vast collection of soybean germplasms offers a potential source of genetic variations to address those challenges, but it has yet to be fully leveraged. In recent decades, rapidly improved high-throughput genotyping technologies have accelerated the harness of elite variations in soybean germplasm and provided the important information for solving the problem of a narrowed genetic base in breeding. In this review, we will overview the situation of maintenance and utilization of soybean germplasms, various solutions provided for different needs in terms of the number of molecular markers, and the omics-based high-throughput strategies that have been used or can be used to identify elite alleles. We will also provide an overall genetic information generated from soybean germplasms in yield, quality traits, and pest resistance for molecular breeding. [ABSTRACT FROM AUTHOR]

Fish muscle growth is important for the rapidly developing global aquaculture industry, particularly with respect to production and quality. Changes in muscle fibre size are accomplished by altering the balance between protein synthesis and proteolysis. However, our understanding regarding the effects of different protein sources on fish muscle proteins is still limited. Here we report on the proteomic profile of muscle fibre hyperplasia in grass carp fed only with whole faba bean. From the results, a total of 99 significantly changed proteins after muscle hyperplasia increase were identified (p < 0.05, ratio <0.5 or >2). Protein-protein interaction analysis demonstrated the presence of a network containing 56 differentially expressed proteins, and muscle fibre hyperplasia was closely related to a protein-protein network of 12 muscle component proteins. Muscle fibre hyperplasia was also accompanied by decreased abundance in the fatty acid degradation and calcium signalling pathways. In addition, metabolism via the pentose phosphate pathway decreased in grass carp after ingestion of faba bean, leading to haemolysis. These findings could provide a reference for the prevention and treatment of human glucose-6-phosphate dehydrogenase deficiency ('favism'). [ABSTRACT FROM AUTHOR]

Endothelial mesenchymal transition (EndMT) plays a critical role in the pathogenesis and progression of interstitial and perivascular fibrosis after acute myocardial infarction (AMI). Pigment epithelium-derived factor (PEDF) is shown to be a new therapeutic target owing to its protective role in cardiovascular disease. In this study, we tested the hypothesis that PEDF is an endogenous inhibitor of EndMT and represented a novel mechanism for its protective effects against overactive cardiac fibrosis after AMI. Masson's trichrome (MTC) staining and picrosirius red staining revealed decreased interstitial and perivascular fibrosis in rats overexpressing PEDF. The protective effect of PEDF against EndMT was confirmed by co-labeling of cells with the myofibroblast and endothelial cell markers. In the endothelial cells of microvessels in the ischemic myocardium, the inhibitory effect of PEDF against nuclear translocation of β-catenin was observed through confocal microscopic imaging. The correlation between antifibrotic effect of PEDF and inactivation of β-catenin was confirmed by co-transfecting cells with lentivirus carrying PEDF or PEDF RNAi and plasmids harboring β-catenin siRNA(r) or constitutive activation of mutant β-catenin. Taken together, these results establish a novel finding that PEDF could inhibit EndMT related cardiac fibrosis after AMI by a mechanism dependent on disruption of β-catenin activation and translocation. [ABSTRACT FROM AUTHOR]

Molecular dynamics simulations of ubiquitin in water/glycerol solutions are used to test the suggestion by Karplus and coworkers that proteins in their biologically active state should exhibit a dynamics similar to 'surface-melted' inorganic nanoparticles (NPs). Motivated by recent studies indicating that surface-melted inorganic NPs are in a 'glassy' state that is an intermediate dynamical state between a solid and liquid, we probe the validity and significance of this proposed analogy. In particular, atomistic simulations of ubiquitin in solution based on CHARMM36 force field and pre-melted Ni NPs (Voter-Chen Embedded Atom Method potential) indicate a common dynamic heterogeneity, along with other features of glass-forming (GF) liquids such as collective atomic motion in the form of string-like atomic displacements, potential energy fluctuations and particle displacements with long range correlations ('colored' or 'pink' noise), and particle displacement events having a power law scaling in magnitude, as found in earthquakes. On the other hand, we find the dynamics of ubiquitin to be even more like a polycrystalline material in which the α-helix and β-sheet regions of the protein are similar to crystal grains so that the string-like collective atomic motion is concentrated in regions between the α-helix and β-sheet domains. [ABSTRACT FROM AUTHOR]

Spoof surface plasmon polariton (SPP) has been realized at low frequencies through corrugated metallic structures. As two-dimensional application, the ultrathin SPP transmission lines (TLs) have been proposed with great potentials for microwave compact circuits due to the strong field confinement and enhancement, as well as controllable dispersive properties. In this paper, we examine the radiation loss at small-radius bend, which may cause severe crosstalk in highly-integrated circuits or systems, for the SPP TLs. We theoretically analyze that the SPP TL has essential merit of low radiation loss, and show better performance of SPP TL than the conventional microstrip line through numerical simulations and experiments. Both simulated and measured results demonstrate that the new type of transmission line can efficiently suppress the radiation loss at small-radius bend, and hence reduce the crosstalk in circuits and systems. [ABSTRACT FROM AUTHOR]

Novel ultra-wideband filtering of spoof surface plasmon polaritons (SPPs) is proposed in the microwave frequency using deep subwavelength planar structures printed on thin and flexible dielectric substrate. The proposed planar SPPs waveguide is composed of two mirror-oriented metallic corrugated strips, which are further decorated with parallel-arranged slots in the main corrugated strips. This compound structure provides deep subwavelength field confinement as well as flexible parameters when employed as a plasmonic waveguide, which is potential to construct miniaturization. Using momentum and impedance matching technology, we achieve a smooth conversion between the proposed SPPs waveguide and the conventional transmission line. To verify the validity of the design, we fabricate a spoof SPPs filter, and the measured results illustrate excellent performance, in which the reflection coefficient is less than −10 dB within the −3 dB passband from 1.21 GHz to 7.21 GHz with the smallest insertion loss of 1.23 dB at 2.21 GHz, having very good agreements with numerical simulations. The ultra-wideband filter with low insertion loss and high transmission efficiency possesses great potential in modern communication systems. [ABSTRACT FROM AUTHOR]

Sedimentation is recognized as a major factor determining the ecosystem processes of lake beaches; however, the underlying mechanisms, especially in freshwater sand dunes, have been insufficiently studied. To this end, nine belt transects from nine freshwater sand dunes, classified into low (<23.7 m), medium (25.4-26.0 m), and high-elevation groups (>28.1 m) based on their elevations in 1972, were sampled to investigate differences in sedimentation rate and soil and vegetation characteristics in Southern Dongting Lake, China. Sedimentation rate, soil sand content, and soil pH increased, whereas soil clay, fine silt, moisture (MC), organic matter (OM), total N, and total K content, in addition to the growth and biodiversity of sand dune plants generally decreased with decreasing belt transect elevation. Regression analyses revealed that the negative effects of sedimentation on the ecosystem functions of sand dunes could be attributed to higher fine sand content in deposited sediments and stronger inhibition of plant growth. These results are consistent with previous studies performed in coastal sand dunes, which highlights the importance of sedimentation in determining ecological processes. [ABSTRACT FROM AUTHOR]

Participation of the wind turbine generators (WTGs) in the frequency regulation service is an appealing issue in order to consider the safe increasing of the wind power generation. The droop and virtual inertia control are the most popular approaches that facilitate the WTGs to provide frequency regulation. However, the intermittent nature of the wind complicates the implementation of these methods and has impacts on the wind turbine stability and may cause violation of the allowed power reserve and minimum turbine rotor speed. Therefore, in this paper, a control approach based on the dynamic de-loading technique is proposed, where the wind turbine operating curve is dynamically adjusted in the response of the frequency deviation throughout controlling the turbine tip-speed ratio which helps the turbine provide steady-state power sharing within the reserved power as well as the transient response within its stability criteria. In addition, the inertial response based on a dynamic gain is suggested. The inertial weighting gain has been formulated where it is continuously regulated in the response of rotor speed and reflects the amount of available kinetic energy in the rotating mass. The effectiveness of the proposed control approaches is verified throughout the comparisons of the results with the fixed inertial gain control and the droop control. The simulation results confirm that the combined control of the proposed tip-speed ratio and dynamic inertia control improve the overall system dynamic behavior in terms of frequency response and turbine stability. [ABSTRACT FROM AUTHOR]

Due to its relatively high gravity material removal, the thin-walled part machining would go through a complex process, from stable to unstable and/or reverse repeatedly. As a result, the monitored signals generally exhibit full-oscillatory behaviors, which require that the chatter indicators should meet the dynamic conditions. However, the conventional indicators, including time domain indicators and time-frequency domain indicators, could only capture the state mutation point in the continuous process. In this paper, a novel chatter indicator, Q-factors, is proposed for chatter detection. The relationship between Q-factor and signal oscillatory behavior is illustrated from the perspective of signal’s frequency characteristics and tool-workpiece system’s response. Chatter indicator’s identification ability for thin-walled part flank and mirror milling is analyzed, i.e., its ability to express characteristics of machining state, sensibility to change machining state, and its chatter-related information inclusion. It can be indicated that as a multi-dimensional indicator, Q-factor can be used to identify chatter-related signal component and quantify the level of chatter simultaneously. The value of Q-factor exhibits obvious difference between stable state and chatter state. The obvious mutation at the place where the machining state changes will supply more useful and effective information for the following chatter prediction and suppression before the chatter is completely developed. [ABSTRACT FROM AUTHOR]

In this study, we propose an integrated particle approach based on the coupling of smoothed particle hydrodynamics (SPH) and discrete element method (DEM) to predict the injection molding process of discrete short fibers. The fibers in the coupled SPH-DEM model are treated as non-rigid bodies to allow deformation and fracture. The interaction between resin and fibers is solved by a physical model to take into consideration of drag forces. Two cases of injection molding process with different volume fractions of short fibers are studied to predict the flow behaviors of fibers and resin. The numerical results qualitatively agree with previous experimental studies. It is found that the velocity contour of resin flow is parabolic in shape due to the velocity gradient near the wall boundaries and consequently the moving direction of fibers is in parallel with the flow direction of resin. Fiber accumulation is found in the case with higher content of short fibers. [ABSTRACT FROM AUTHOR]

Retinopathy of prematurity (ROP) represents a major cause of childhood vision loss worldwide. The 50/10 oxygen-induced retinopathy (OIR) model mimics the findings of ROP, including peripheral vascular attenuation and neovascularization. The oxygen metabolism of the inner retina has not been previously explored in this model. Using visible-light optical coherence tomography (vis-OCT), we measured the oxygen saturation of hemoglobin and blood flow within inner retinal vessels, enabling us to compute the inner retinal oxygen delivery (irDO2) and metabolic rate of oxygen (irMRO2). We compared these measurements between age-matched room-air controls and rats with 50/10 OIR on postnatal day 18. To account for a 61% decrease in the irDO2 in the OIR group, we found an overall statistically significant decrease in retinal vascular density affecting the superficial and deep retinal vascular capillary networks in rats with OIR compared to controls. Furthermore, matching the reduced irDO2, we found a 59% decrease in irMRO2, which we correlated with a statistically significant reduction in retinal thickness in the OIR group, suggesting that the decreased irMRO2 was due to decreased neuronal oxygen utilization. By exploring these biological and metabolic changes in great detail, our study provides an improved understanding of the pathophysiology of OIR model. [ABSTRACT FROM AUTHOR]

We propose a hybrid circuit for spoof surface plasmon polaritons (SPPs) and spatial waveguide modes to develop new microwave devices. The hybrid circuit includes a spoof SPP waveguide made of two anti-symmetric corrugated metallic strips and a traditional substrate integrated waveguide (SIW). From dispersion relations, we show that the electromagnetic waves only can propagate through the hybrid circuit when the operating frequency is less than the cut-off frequency of the SPP waveguide and greater than the cut-off frequency of SIW, generating efficient band-pass filters. We demonstrate that the pass band is controllable in a large range by designing the geometrical parameters of SPP waveguide and SIW. Full-wave simulations are provided to show the large adjustability of filters, including ultra wideband and narrowband filters. We fabricate a sample of the new hybrid device in the microwave frequencies, and measurement results have excellent agreements to numerical simulations, demonstrating excellent filtering characteristics such as low loss, high efficiency, and good square ratio. The proposed hybrid circuit gives important potential to accelerate the development of plasmonic integrated functional devices and circuits in both microwave and terahertz frequencies. [ABSTRACT FROM AUTHOR]

To test whether there are general patterns in biomass partitioning in relation to environmental variation when stand biomass is considered, we investigated biomass allocation in leaves, stems, and roots in China's forests using both the national forest inventory data (2004-2008) and our field measurements (2011-2012). Distribution patterns of leaf, stem, and root biomass showed significantly different trends according to latitude, longitude, and altitude, and were positively and significantly correlated with stand age and mean annual precipitation. Trade-offs among leaves, stems, and roots varied with forest type and origin and were mainly explained by stand biomass. Based on the constraints of stand biomass, biomass allocation was also influenced by forest type, origin, stand age, stand density, mean annual temperature, precipitation, and maximum temperature in the growing season. Therefore, after stand biomass was accounted for, the residual variation in biomass allocation could be partially explained by stand characteristics and environmental factors, which may aid in quantifying carbon cycling in forest ecosystems and assessing the impacts of climate change on forest carbon dynamics in China. [ABSTRACT FROM AUTHOR]

Chronic kidney disease (CKD) is associated with osteosarcopenia, and because a physical decline in patients correlates with an increased risk of morbidity, an improvement of the musculoskeletal system is expected to improve morbi-mortality. We recently uncovered that the intestinal hormone Fibroblast Growth Factor 19 (FGF19) is able to promote skeletal muscle mass and strength in rodent models, in addition to its capacity to improve glucose homeostasis. Here, we tested the effects of a treatment with recombinant human FGF19 in a CKD mouse model, which associates sarcopenia and metabolic disorders. In 5/6 nephrectomized (5/6Nx) mice, subcutaneous FGF19 injection (0.1 mg/kg) during 18 days increased skeletal muscle fiber size independently of food intake and weight gain, associated with decreased gene expression of myostatin. Furthermore, FGF19 treatment attenuated glucose intolerance and reduced hepatic expression of gluconeogenic genes in uremic mice. Importantly, the treatment also decreased gene expression of liver inflammatory markers in CKD mice. Therefore, our results suggest that FGF19 may represent a novel interesting therapeutic strategy for a global improvement of sarcopenia and metabolic complications in CKD. [ABSTRACT FROM AUTHOR]

We present a study of top quark mass measurements at the t t ¯ threshold based on CEPC. A centre-of-mass energy scan near two times of the top quark mass is performed and the measurement precision of top quark mass, width and α S are evaluated using the t t ¯ production rates. Realistic scan strategies at the threshold are discussed to maximise the sensitivity to the measurements individually and simultaneously in the CEPC scenarios assuming a total luminosity limited to 100 fb - 1 . With the optimal scan for individual property measurements, the top quark mass precision is expected to be 9 MeV, the top quark width precision is expected to be 26 MeV, and α S can be measured at a precision of 0.00039, considering only the statistical uncertainty. Taking into account the systematic uncertainties from theory, width, α S , experimental efficiency, background subtraction, beam energy and luminosity spectrum, the top quark mass can be measured at a precision of 25 MeV optimistically and 59 MeV conservatively at CEPC. [ABSTRACT FROM AUTHOR]

Rice is the primary staple food for more than 50% of the world's population. Narrowing the gap between the maximum potential food crop yield and actual yield is critical for improving the current yield, resource use efficiency, and global food security. Here, we examined the fertilizer use efficiency (FUE), radiation use efficiency (RUE), and temperature production efficiency (TPE) of four management treatments (super high yield [SH], high yield and high efficiency [HH], farmer level [FP], and basic production level [CK]). SH and HH treatments significantly reduced the yield gap by 22.4 and 9.5%, respectively. The large yield gap between HH and FP was mainly attributed to high specific leaf weight at the jointing stage (7.5–7.7 mg·cm−2), and the high leaf area maintained during tillering–jointing stages (35.4–37.6 m2·m−2·per day). Compared with FP, HH increased the specific leaf weight in the heading stage (8.2–8.4 mg·cm−2), relative crop growth rate, net assimilation rate (NAR), and mean leaf area index (> 2.6). Moreover, compared with FP, HH significantly increased partial factor productivity (PFP) of nitrogen, FUE, TPE, and RUE owing to greater yield and NAR after the full heading stage. Although the HH yield was 93.32% that of SH, HH increased PFP of fertilizer (12.5%), fertilizer nitrogen (9.07%), and fertilizer K2O (36.34%), and required 26% less fertilizer than SH. The findings of this study could facilitate high-efficiency rice production and bridging of yield gaps. [ABSTRACT FROM AUTHOR]

Background: Inflammatory biomarkers in the peripheral blood have been established as predictors for immunotherapeutic efficacy in advanced non-small cell lung cancer (NSCLC). Whether they can also predict major pathological response (MPR) in neoadjuvant setting remains unclear. Methods: In this multi-center retrospective study, 122 and 92 stage I-IIIB NSCLC patients from six hospitals who received neoadjuvant chemoimmunotherapy followed by surgery were included in the discovery and external validation cohort, respectively. Baseline and on-treatment neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII) were calculated and associated with MPR. Furthermore, resected tumor samples from 37 patients were collected for RNA-sequencing to investigate the immune-related tumor microenvironment. Results: In both the discovery and validation cohorts, the on-treatment NLR, dNLR, PLR, and SII levels were significantly lower in the patients with MPR versus non-MPR. On-treatment SII remained an independent predictor of MPR in multivariate logistic regression analysis. The area under the curve (AUC) of on-treatment SII for predicting MPR was 0.75 (95%CI, 0.67–0.84) in the discovery cohort. Moreover, the predictive value was further improved by combining the on-treatment SII and radiological tumor regression data, demonstrating an AUC of 0.82 (95%CI, 0.74–0.90). The predictive accuracy was validated in the external cohort. Compared with the SII-high group, patients with SII-Low were associated with the activated B cell receptor signaling pathway and a higher intratumoral immune cell infiltration level. Conclusions: On-treatment SII was independently associated with MPR in NSCLC patients receiving neoadjuvant chemoimmunotherapy. Further prospective studies are warranted. [ABSTRACT FROM AUTHOR]

Although lithium-sulfur (Li-S) batteries are an advanced energy storage system, their development has been impeded due to poor cycling stability and low sulfur utilization. Hollow TiN microspheres with a porous shell were prepared to host sulfur (TiN-S) for use as a Li-S battery cathode. The TiN-S electrode delivered a high capacity of 1206.1 mA h/g at 0.1 C, and a narrow value domain of 1218.2 ± 17.7 mA h/g was obtained from initial discharge capacities of 9 cells. Furthermore, a capacity of 623.3 mA h/g (with a retention of 67.5%) was maintained after 300 progressive cycles at 1 C. The superior cycling performance of the TiN-based cathode can be ascribed to the following: (1) TiN improved the electrical conductivity of the cathode, effectively increasing the active sulfur utilization; (2) the hollow TiN microspheres with pores restricted the soluble polysulfides by both chemical and physical interactions; (3) the large void of the spherical cavity in TiN could accommodate the change in volume of the cathode during the discharge-charge processes. [ABSTRACT FROM AUTHOR]

Proteins are carriers of biological functions and the effects of atmospheric-pressure non-thermal plasmas on proteins are important to applications such as sterilization and plasma-induced apoptosis of cancer cells. Herein, we report our detailed investigation of the effects of helium-oxygen non-thermal dielectric barrier discharge (DBD) plasmas on the inactivation of lactate dehydrogenase (LDH) enzyme solutions. Circular dichroism (CD) and dynamic light scattering (DLS) indicate that the loss of activity stems from plasma-induced modification of the secondary molecular structure as well as polymerization of the peptide chains. Raising the treatment intensity leads to a reduced alpha-helix content, increase in the percentage of the beta-sheet regions and random sequence, as well as gradually decreasing LDH activity. However, the structure of the LDH plasma-treated for 300 seconds exhibits a recovery trend after storage for 24 h and its activity also increases slightly. By comparing direct and indirect plasma treatments, plasma-induced LDH inactivation can be attributed to reactive species (RS) in the plasma, especially ones with a long lifetime including hydrogen peroxide, ozone, and nitrate ion which play the major role in the alteration of the macromolecular structure and molecular diameter in lieu of heat, UV radiation, and charged particles. [ABSTRACT FROM AUTHOR]

A correction to the article "Entanglement with negative Wigner function of almost 3,000 atoms heralded by one photon" which was published in issue #519 of the journal is presented.

Claims are often found in the literature that metallic materials can be nanocrystallized by severe plastic deformation (SPD). However, SPD does not generate a well-defined nanocrystalline (NC) material, which can be achieved by subsequent annealing/recovery treatment. In this study, molecular dynamics (MD) simulation is employed to study the effect of annealing on structure and mechanical properties of cyclic deformed NC α-iron, which simulates SPD-processed α-iron. It is demonstrated that grain boundaries in the deformed NC α-iron evolve to a more equilibrium state during annealing, eliminating or minimizing the residual stress. The annealing treatment increases the system's strength by reducing dislocation emission sources, and improves material ductility through strengthening grain boundaries' resistance to intergranular cracks. The results indicate that the annealing treatment is an essential process for obtaining a well-defined NC structure with superior mechanical properties. [ABSTRACT FROM AUTHOR]

The solution-aging behavior and properties of spray-formed 7055 aluminum alloy TIG weld metal (WM) reinforced by TiC–TiB2 (BC) ceramic particles are investigated, in detail. Weld joints were subjected to solution at 475 °C for 1, 2.5, and 5 h, followed by the aging process at 120 °C for 0–24 h. The results show that ceramic particles not only restrict the grain coarsening of WM during the heat treatment but also accelerate the solution and age-precipitation behavior. The optimum solution time of ceramic particle-reinforced WM is 2.5 h, which has superior aging kinetics due to the completely dissolved eutectic phases. More importantly, during the aging process, ceramic particles decrease the width of the precipitate free zone and modify the size and distribution of precipitates. With the 475 °C/2.5 h + 120 °C/15 h treatment, the tensile strength (530 ± 15 MPa) and elongation (3.9 ± 0.29%) of BC weld joints are higher than 7055 weld joints (358 ± 20 MPa, 2.38 ± 0.42%). Grain refinement, Zener pinning strengthening, coefficients of thermal expansion mismatch strengthening, and precipitation strengthening are the dominant strengthening mechanisms of ceramic particle-reinforced WM. [ABSTRACT FROM AUTHOR]

Introduction: Recently, large channel endoscopic systems and full endoscopic visualization technique have been used to perform unilateral laminotomy for bilateral decompression (ULBD) treatment for lumbar central spinal stenosis (LCSS). However, various endoscopic systems possess different design parameters, which may affect the technical points and treatment outcomes. The object of this retrospective study was to compare the efficiency, safety, and effectiveness of ULBD under the iLESSYS Delta system versus the Endo-Surgi Plus system. Methods: In the period from October 2020 to April 2021, ULBD was performed using the iLESSYS Delta system or Endo-Surgi Plus system to treat LCSS. Patients were classified into two groups based on the endoscopy system employed. Patient demographics, perioperative indexes, complications, and imaging characteristics were reviewed. Clinical outcomes were quantified using back and leg visual analog scale (VAS) scores and Oswestry Disability Index (ODI) at the time points of follow-up. Results: Thirty-two patients were assigned to the iLESSYS Delta system group and 37 to the Endo-Surgi Plus system group. In the comparison between the two groups, the Endo-Surgi Plus system possessed a shorter incision length and operation time (p < 0.005), and no statistical differences in other aspects were observed. The dural sacs of both groups were significantly expanded postoperatively compared to preoperatively (p < 0.001). Both groups experienced improvements in VAS and ODI scores at all time points (p < 0.001) and equally low frequency of complications. Conclusions: Current research suggests that both the Endo-Surgi Plus system and iLESSYS Delta system achieved favorable high safety and clinical outcomes in ULBD for treatment of LCSS. The use of a fully visualized trephine may have increased the efficiency of the Endo-Surgi Plus system. Moreover, the Endo-Surgi Plus system may be associated with a wider decompression range and indications. [ABSTRACT FROM AUTHOR]

Although the smoking rate of human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV) infected people was much higher than that of the general population, smoking cessation interventions have long been ineffective. We aimed to examine the estimates of prevalence, time-trend, and association of smoking among people living with HIV, HBV, or HCV. This cohort was composed of 32,115 individuals from the NHANES database (1999–2018) and they were collected in the US. The time trend analysis of smoking and quitting rates was conducted using different years of survey follow-up and different infected groups. Multivariable logistic regression analysis was used to identify the risk factors related to smoking behavior of these infected people. Compared to non-infected smokers, infected smokers were more likely to be older (aged 30–39, OR = 9.92, CI 6.07–16.21; aged 40–49,OR = 3.51, CI 2.49–4.94), males (1.99, 1.54–2.55), lower education and economic level (1.78, 1.39–2.29; 2.05, 1.59–2.65), unemployed (1.63, 1.21–2.20), suffering depression (1.35, 1.05–1.72), and drug users (7.65, 5.04–11.59). Taken together, our study showed that these complex psychosocial characteristics and unhealthy behavioral factors might be major independent risk factors for increasing smoking rate and decreasing smoking cessation rate among these infected people. [ABSTRACT FROM AUTHOR]

This study aimed to improve microbial flocculant production by optimizing the components of a Bacillus subtilis CZ1003 culture medium. Using the flocculation rate as the dependent variable, single-factor experiments were performed and beef extract at a concentration of 9 g/L was found to be the optimal nitrogen source, while glucose at a concentration of 20 g/L was the optimal carbon source. KCl, MgCl, NaCl, and CaCl at concentrations of 0.75, 2.5, 0.5, and 5.0 g/L, respectively, were the optimum inorganic salts, in order of flocculant production activity. Orthogonal experimental demonstrated that KCl played a dominant role for Bacillus subtilis production of bioflocculants, followed by NaCl and CaCl. Optimization experiments demonstrated that the optimal combination of the two salts was 0.75 g/L KCl and 0.5 g/L NaCl, resulting in a flocculation rate of 36.2% when included together at these concentrations. The final optimized medium consisted of 20 g/L glucose, 9 g/L beef extract, 0.75 g/L KCl, and 0.5 g/L NaCl. Compared with the initial medium, the optimized medium enhanced the flocculation activity from 12.1 to 36.2%, which equates to an increase of 199.17%. Meanwhile, the flocculant yield was increased from 0.058 g/L to 0.134/L, an increase of 131.03%. The optimized medium could be used to improve microbial flocculant production and provides a basis for further exploration. [ABSTRACT FROM AUTHOR]

Immune checkpoint inhibitors (ICIs) are standard-of-care as first-line (1L) therapy for advanced non-small cell lung cancer (aNSCLC) without actionable oncogenic driver mutations. While clinical trials demonstrated benefits of ICIs over chemotherapy, variation in outcomes across patients has been observed and trial populations may not be representative of clinical practice. Predictive models can help understand heterogeneity of treatment effects, identify predictors of meaningful clinical outcomes, and may inform treatment decisions. We applied machine learning (ML)-based survival models to a real-world cohort of patients with aNSCLC who received 1L ICI therapy extracted from a US-based electronic health record database. Model performance was evaluated using metrics including concordance index (c-index), and we used explainability techniques to identify significant predictors of overall survival (OS) and progression-free survival (PFS). The ML model achieved c-indices of 0.672 and 0.612 for OS and PFS, respectively, and Kaplan–Meier survival curves showed significant differences between low- and high-risk groups for OS and PFS (both log-rank test p < 0.0001). Identified predictors were mostly consistent with the published literature and/or clinical expectations and largely overlapped for OS and PFS; Eastern Cooperative Oncology Group performance status, programmed cell death-ligand 1 expression levels, and serum albumin were among the top 5 predictors for both outcomes. Prospective and independent data set evaluation is required to confirm these results. [ABSTRACT FROM AUTHOR]

Immune checkpoint inhibitors (ICIs) are standard-of-care as first-line (1L) therapy for advanced non-small cell lung cancer (aNSCLC) without actionable oncogenic driver mutations. While clinical trials demonstrated benefits of ICIs over chemotherapy, variation in outcomes across patients has been observed and trial populations may not be representative of clinical practice. Predictive models can help understand heterogeneity of treatment effects, identify predictors of meaningful clinical outcomes, and may inform treatment decisions. We applied machine learning (ML)-based survival models to a real-world cohort of patients with aNSCLC who received 1L ICI therapy extracted from a US-based electronic health record database. Model performance was evaluated using metrics including concordance index (c-index), and we used explainability techniques to identify significant predictors of overall survival (OS) and progression-free survival (PFS). The ML model achieved c-indices of 0.672 and 0.612 for OS and PFS, respectively, and Kaplan–Meier survival curves showed significant differences between low- and high-risk groups for OS and PFS (both log-rank test p < 0.0001). Identified predictors were mostly consistent with the published literature and/or clinical expectations and largely overlapped for OS and PFS; Eastern Cooperative Oncology Group performance status, programmed cell death-ligand 1 expression levels, and serum albumin were among the top 5 predictors for both outcomes. Prospective and independent data set evaluation is required to confirm these results. [ABSTRACT FROM AUTHOR]

The work prepared in situ synthesis VC particle-reinforced Ni-based coating using laser cladding. A 3-kW fiber laser was applied with a coupled coaxial nozzle head. The response surface methodology was applied to establish mathematical models of coating hardnesses, aspect ratios, and cladding areas at the laser power of 1200–2000 W, a scanning speed of 3–5 mm/s, and a powder ratio of 30–70% as input variables. The influences of process parameters on coating performance and geometries were explored hereafter. The feasibility of in situ synthesis of VC was analyzed by thermodynamics. The XRD test showed that coatings consisted of FeNi3, VC, V8C7, and Cr23C6 phases, with internal VC compounds of round and petal shapes. The response surface analysis showed that coating hardness increased with increased LP and PRs and decreased with increased SSs. The aspect ratio of coatings increased with increased LP and decreased with the increased SSs and PRs. Besides, the cladding area increased with increased LP and decreased with increased SSs and PRs. Sensitivity analysis indicated that the PR was included in the sensitive items of coating hardness, aspect ratios, and cladding area models. Coating hardness, aspect ratios, and cladding areas were not sensitive to LP. The accuracy of the sensitivity analysis was verified with 7 mm/s SS, while adjusting one factor between LP and PR. This research results provide a theoretical reference and basis for controlling coating properties and geometries in the industrial application of laser cladding. [ABSTRACT FROM AUTHOR]

Research on the influence of gut microbiota on systemic inflammatory arthritis has exploded in the past decade. Gut microbiota changes may be a crucial regulatory component in systemic inflammatory arthritis. As a result of advancements in the field, microbiota-assisted therapy has evolved, but this discipline is still in its infancy. Consequently, we review the limitations of current systemic inflammatory arthritis treatment, analyze the connection between the microbiota and arthritis, and summarize the research progress of microbiota regulating systemic inflammatory arthritis and the further development aspects of microbiota-assisted therapy. Finally, the partial mechanisms of microbiota-assisted therapy of systemic inflammatory arthritis are being discussed. In general, this review summarizes the current progress, challenges, and prospects of microbiota-assisted therapy for systemic inflammatory arthritis and points out the direction for the development of microbiota-assisted therapy in the future. [ABSTRACT FROM AUTHOR]