1. Cancer immunology: Cat and mouse games.
- Author
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Melief, Cornelis J. M.
- Subjects
- *
TUMORS , *CANCER invasiveness , *IMMUNE system , *IMMUNE response , *T cells , *CARCINOGENESIS , *DENDRITIC cells , *ONCOLOGY - Abstract
Discusses a paper by G. Willimsky and T. Blankenstein which showed that sporadic tumors in mice, against which the immune system initially reacts, nevertheless manage to spread by molding the killer T cells into a state that tolerates them. Implications for the debate on whether the development of sporadic, nonviral tumors is really affected by so-called immunoediting; Concurrence of both sides of the controversy that both virus-induced and sporadic tumors do elicit immune responses, and that T-cell responses protect against viral carcinogenesis; Variation in the natural ability of tumors to activate dendritic cells; Need for tumors to be sensed by an exquisitely sensitive sentinel system, the dendritic cell network.
- Published
- 2005
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