1. Impact of Sarcopenia on Clinical Course of Inflammatory Bowel Disease in Korea.
- Author
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Nam, Kwangwoo, Lee, Jae Yong, Ko, Yousun, Kim, Kyung Won, Lee, Ho-Su, Hong, Seung Wook, Park, Jin Hwa, Hwang, Sung Wook, Yang, Dong-Hoon, Ye, Byong Duk, Byoun, Jeong-Sik, Myung, Seung-Jae, Yang, Suk-Kyun, and Park, Sang Hyoung
- Subjects
INFLAMMATORY bowel diseases ,SARCOPENIA ,CROHN'S disease ,COLECTOMY ,ULCERATIVE colitis ,MUSCLE mass ,ANAL diseases ,CELIAC disease - Abstract
Background and Aims: Reduced body muscle mass is a poor prognostic factor for inflammatory bowel disease (IBD). In this study, we investigated the prevalence of sarcopenia at diagnosis and its clinical significance in Korean patients with IBD. Methods: The prevalence of sarcopenia in IBD patients between June 1989 and December 2016 was investigated using a well-characterized referral center-based cohort. Abdominopelvic computed tomography within six months from IBD diagnosis was used for the evaluation. Sarcopenia was defined as an L3 skeletal muscle index of < 49 cm
2 /m2 for male and < 31 cm2 /m2 for female. The clinical characteristics and outcomes were evaluated with respect to sarcopenia. Results: A total of 1,027 patients (854 Crohn's disease [CD]; 173 ulcerative colitis [UC]) were evaluated. Sarcopenia was found in 56.8% of the population (CD, 57.5%; UC, 53.2%), and male were more likely to be sarcopenic (CD, 94.3%; UC, 91.6%). There were no significant differences in the cumulative risk of using steroids, immunomodulators, biologics, and bowel resections (or colectomy) with or without sarcopenia during follow-up (median: CD, 5.8 years; UC, 3.7 years). In sarcopenic patients with CD, there was a significantly higher cumulative risk of perianal surgeries than in non-sarcopenic patients with CD (Log-rank test; P = 0.001). However, the risk of perianal surgeries was not significant in multivariate analysis (Odds ratio 1.368; 95% confidence interval 0.782–2.391; P = 0.272). Conclusion: Sarcopenia at diagnosis may have no significant prognostic value for medical treatment and bowel resection, but it may be associated with perianal CD. [ABSTRACT FROM AUTHOR]- Published
- 2023
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