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A crucial step in an epidemiological study of the effects of air pollution is to accurately quantify exposure of the population. In this paper, we investigate the sensitivity of the health effects estimates associated with short-term exposure to fine particulate matter with respect to three potential metrics for daily exposure: ambient monitor data, estimated values from a deterministic atmospheric chemistry model, and stochastic daily average human exposure simulation output. Each of these metrics has strengths and weaknesses when estimating the association between daily changes in ambient exposure to fine particulate matter and daily emergency hospital admissions. Monitor data is readily available, but is incomplete over space and time. The atmospheric chemistry model output is spatially and temporally complete but may be less accurate than monitor data. The stochastic human exposure estimates account for human activity patterns and variability in pollutant concentration across microenvironments, but requires extensive input information and computation time. To compare these metrics, we consider a case study of the association between fine particulate matter and emergency hospital admissions for respiratory cases for the Medicare population across three counties in New York. Of particular interest is to quantify the impact and/or benefit to using the stochastic human exposure output to measure ambient exposure to fine particulate matter. Results indicate that the stochastic human exposure simulation output indicates approximately the same increase in the relative risk associated with emergency admissions as using a chemistry model or monitoring data as exposure metrics. However, the stochastic human exposure simulation output and the atmospheric chemistry model both bring additional information, which helps to reduce the uncertainly in our estimated risk. [ABSTRACT FROM AUTHOR]

Many epidemiologic studies of the health effects of exposure to ambient air pollution use measurements from central-site monitors as their exposure estimate. However, measurements from central-site monitors may lack the spatial and temporal resolution required to capture exposure variability in a study population, thus resulting in exposure error and biased estimates. Articles in this dedicated issue examine various approaches to predict or assign exposures to ambient pollutants. These methods include combining existing central-site pollution measurements with local- and/or regional-scale air quality models to create new or 'hybrid' models for pollutant exposure estimates and using exposure models to account for factors such as infiltration of pollutants indoors and human activity patterns. Key findings from these articles are summarized to provide lessons learned and recommendations for additional research on improving exposure estimation approaches for future epidemiological studies. In summary, when compared with use of central-site monitoring data, the enhanced spatial resolution of air quality or exposure models can have an impact on resultant health effect estimates, especially for pollutants derived from local sources such as traffic (e.g., EC, CO, and NOx). In addition, the optimal exposure estimation approach also depends upon the epidemiological study design. We recommend that future research develops pollutant-specific infiltration data (including for PM species) and improves existing data on human time-activity patterns and exposure to local source (e.g., traffic), in order to enhance human exposure modeling estimates. We also recommend comparing how various approaches to exposure estimation characterize relationships between multiple pollutants in time and space and investigating the impact of improved exposure estimates in chronic health studies. [ABSTRACT FROM AUTHOR]

Many analyses of the paleoclimate record include conclusions about extremes, with a focus on the unprecedented nature of recent climate events. While the use of extreme value theory is becoming common in the analysis of the instrumental climate record, applications of this framework to the spatio-temporal analysis of paleoclimate records remain limited. This article develops a Bayesian hierarchical model to investigate spatially varying trends and dependencies in the parameters characterizing the distribution of extremes of a proxy data set, and applies it to the site-wise decadal maxima and minima of a gridded network of temperature sensitive tree ring density time series over northern North America. The statistical analysis reveals significant spatial associations in the temporal trends of the location parameters of the generalized extreme value distributions: maxima are increasing as a function of time, with stronger increases in the north and east of North America; minima are significantly increasing in the west, possibly decreasing in the east, and exhibit no changes in the center of the region. Results indicate that the distribution varies as a function of both space and time, with tree ring density maxima becoming more extreme as a function of time and minima having diverging temporal trends, by spatial location. Results of this proxy-only analysis are a first step towards directly reconstructing extremal climate behavior, as opposed to mean climate behavior, by linking extremes in the proxy record to extremes in the instrumental record. [ABSTRACT FROM AUTHOR]