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PET/CT was not performed prior to surgery but the localized nature of the lesion was confirmed by the negative post-surgery PET/CT after the complete resection of the lesion, which had been transformed to anaplastic large cell lymphoma (ALK-negative). It is important to note that there were no other patients within the two cohorts of pediatric and adult cHL patients with 9 and 410 relapsed/refractory cases respectively, in whom a surgery-only approach was applied and failed. At least 70-80% of the patients with Hodgkin lymphoma (HL) can be cured with first-line therapy with the improvement of staging methods and the introduction of increasingly effective chemotherapy regimens during the last 50 years [[1]]. [Extracted from the article]

Evaluates the histochemical expression of retinoblastoma gene product (pRb) and WAF1/Cip1 in patients with non-Hodgkin's lymphomas (NHL). Patient characteristics; Detection of pRb in all cases of NHL; Percent of cases with p21 protein detection; Absence of significant prognostic value of pRb and p21 expression.

Reports on a patient with primary non-Hodgkin's lymphoma of the gallbladder. Diagnosis of the patient as a T-cell lymphoblastic lymphoma; Inclusion of surgery and postoperative chemotherapy as part of treatment modalities; General prognosis for the disease; Achievement of complete remission.

The article features commentaries on the paper presented by Van Grotel and others on the treatment of pediatric nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL), with only chemotherapy without alkylating agents. While positively commenting on the work, further investigation of the results with the addition of rituximab to the standard anthracycline-based chemotherapy is recommended. NLPHL is considered an indolent disease, and less toxic treatment even in cases of multiple relapses.