1. New steroidal glycosides from the fibrous roots of Ophiopogon japonicus.
- Author
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Duan, Chang-Ling, Li, Yu-Juan, Wang, Feng-Yun, Miao, Lan, and Tang, Xu-Dong
- Subjects
ANTINEOPLASTIC agents ,CHROMATOGRAPHIC analysis ,GLYCOSIDES ,HIGH performance liquid chromatography ,MOLECULAR structure ,NUCLEAR magnetic resonance spectroscopy ,RESEARCH funding ,PLANT roots ,SPECTRUM analysis ,PLANT extracts - Abstract
Two new steroidal glycosides (named fibrophiopogonins A, B), along with one known glycoside, were isolated from the fibrous roots of Ophiopogon japonicus (Liliaceae). Comprehensive spectroscopic analysis, including 2D NMR spectroscopy, and the results of acid hydrolysis allowed the chemical structure of the compounds to be assigned as 26-[(O-β-D-glucopyranosyl-(1 → 6)-D-glucopyranosyl)]-barogenin- 3-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside and (25R)-26-[(O- β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl)]- 3β,22α,26- trihydroxyfurost- 5-ene-3-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside. This is the first isolation of a cholestane glycoside with disaccharide moiety from a Ophiopogon species. The cytotoxic activities of 1~3 against A375 and MCF-7 cells are described. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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